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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda</title><author><name sortKey="Horacio, Ruise Or Escudero" sort="Horacio, Ruise Or Escudero" uniqKey="Horacio R" first="Ruise Or-Escudero" last="Horacio">Ruise Or-Escudero Horacio</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Itziar, Familiar Lopez" sort="Itziar, Familiar Lopez" uniqKey="Itziar F" first="Familiar-Lopez" last="Itziar">Familiar-Lopez Itziar</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Alla, Sikorskii" sort="Alla, Sikorskii" uniqKey="Alla S" first="Sikorskii" last="Alla">Sikorskii Alla</name><affiliation><nlm:aff id="A2">Department of Statistics and Probability, Michigan State University, 619 Red Cedar Road., C423, East Lansing, MI 48824,<email>sikorska@stt.msu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Nikita, Jambulingam" sort="Nikita, Jambulingam" uniqKey="Nikita J" first="Jambulingam" last="Nikita">Jambulingam Nikita</name><affiliation><nlm:aff id="A3">University of Michigan Medical School. 500 Catherine St, Apartment 2, Ann Arbor, MI 48104,<email>nikitaj@med.umich.edu</email></nlm:aff></affiliation></author><author><name sortKey="Noelline, Nakasujja" sort="Noelline, Nakasujja" uniqKey="Noelline N" first="Nakasujja" last="Noelline">Nakasujja Noelline</name><affiliation><nlm:aff id="A4">Department of Psychiatry, College of Health Sciences, Makerere University, Box 7072, Kampala, Uganda,<email>drnoeline@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Robert, Opoka" sort="Robert, Opoka" uniqKey="Robert O" first="Opoka" last="Robert">Opoka Robert</name><affiliation><nlm:aff id="A5">Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda,<email>opokabob@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Judith, Bass" sort="Judith, Bass" uniqKey="Judith B" first="Bass" last="Judith">Bass Judith</name><affiliation><nlm:aff id="A6">Mental Health Department, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway Street, Hampton House Room 861, Baltimore MD 21205,<email>jbass1@jhu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Michael, Boivin" sort="Michael, Boivin" uniqKey="Michael B" first="Boivin" last="Michael">Boivin Michael</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26605506</idno><idno type="pmc">4788522</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788522</idno><idno type="RBID">PMC:4788522</idno><idno type="doi">10.1097/QAI.0000000000000905</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001947</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001947</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda</title><author><name sortKey="Horacio, Ruise Or Escudero" sort="Horacio, Ruise Or Escudero" uniqKey="Horacio R" first="Ruise Or-Escudero" last="Horacio">Ruise Or-Escudero Horacio</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Itziar, Familiar Lopez" sort="Itziar, Familiar Lopez" uniqKey="Itziar F" first="Familiar-Lopez" last="Itziar">Familiar-Lopez Itziar</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Alla, Sikorskii" sort="Alla, Sikorskii" uniqKey="Alla S" first="Sikorskii" last="Alla">Sikorskii Alla</name><affiliation><nlm:aff id="A2">Department of Statistics and Probability, Michigan State University, 619 Red Cedar Road., C423, East Lansing, MI 48824,<email>sikorska@stt.msu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Nikita, Jambulingam" sort="Nikita, Jambulingam" uniqKey="Nikita J" first="Jambulingam" last="Nikita">Jambulingam Nikita</name><affiliation><nlm:aff id="A3">University of Michigan Medical School. 500 Catherine St, Apartment 2, Ann Arbor, MI 48104,<email>nikitaj@med.umich.edu</email></nlm:aff></affiliation></author><author><name sortKey="Noelline, Nakasujja" sort="Noelline, Nakasujja" uniqKey="Noelline N" first="Nakasujja" last="Noelline">Nakasujja Noelline</name><affiliation><nlm:aff id="A4">Department of Psychiatry, College of Health Sciences, Makerere University, Box 7072, Kampala, Uganda,<email>drnoeline@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Robert, Opoka" sort="Robert, Opoka" uniqKey="Robert O" first="Opoka" last="Robert">Opoka Robert</name><affiliation><nlm:aff id="A5">Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda,<email>opokabob@yahoo.com</email></nlm:aff></affiliation></author><author><name sortKey="Judith, Bass" sort="Judith, Bass" uniqKey="Judith B" first="Bass" last="Judith">Bass Judith</name><affiliation><nlm:aff id="A6">Mental Health Department, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway Street, Hampton House Room 861, Baltimore MD 21205,<email>jbass1@jhu.edu</email></nlm:aff></affiliation></author><author><name sortKey="Michael, Boivin" sort="Michael, Boivin" uniqKey="Michael B" first="Boivin" last="Michael">Boivin Michael</name><affiliation><nlm:aff id="A1">Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda.</p></sec><sec id="S2"><title>Design</title><p id="P2">This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children ages 1–6 years participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda.</p></sec><sec id="S3"><title>Methods</title><p id="P3">Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z-scores (WAZ), antiretroviral therapy (ART) status and immunological biomarkers.</p></sec><sec id="S4"><title>Results</title><p id="P4">111 children were included in the final analysis. Lower levels of CD4<sup>+</sup> CD38<sup>+</sup> T-cells (p=0.04) were associated to higher Immediate and Total Recall scores (p=0.04). Higher levels of CD8<sup>+</sup> HLA-DR<sup>+</sup> T-cells were associated with higher Total Recall score (p=0.04) of the COAT. Higher CD4<sup>+</sup> CD38<sup>+</sup> HLA-DR<sup>+</sup> T-cells levels were associated with higher Gross Motor scores of the MSEL (p=0.02). WAZ was positively correlated to Visual Reception, Fine Motor, Expressive Language and composite score of the MSEL.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4<sup>+</sup> CD38<sup>+</sup> T-cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100892005</journal-id><journal-id journal-id-type="pubmed-jr-id">21821</journal-id><journal-id journal-id-type="nlm-ta">J Acquir Immune Defic Syndr</journal-id><journal-id journal-id-type="iso-abbrev">J. Acquir. Immune Defic. Syndr.</journal-id><journal-title-group><journal-title>Journal of acquired immune deficiency syndromes (1999)</journal-title></journal-title-group><issn pub-type="ppub">1525-4135</issn><issn pub-type="epub">1944-7884</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26605506</article-id><article-id pub-id-type="pmc">4788522</article-id><article-id pub-id-type="doi">10.1097/QAI.0000000000000905</article-id><article-id pub-id-type="manuscript">NIHMS738143</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Nutritional and immunological correlates of memory and neurocognitive development among HIV infected children living in Kayunga, Uganda</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Horacio</surname><given-names>Ruiseñor-Escudero</given-names></name><degrees>PhD MD MSc</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Itziar</surname><given-names>Familiar-Lopez</given-names></name><degrees>PhD MD MPH</degrees><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Alla</surname><given-names>Sikorskii</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Nikita</surname><given-names>Jambulingam</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Noelline</surname><given-names>Nakasujja</given-names></name><degrees>PhD MD</degrees><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Robert</surname><given-names>Opoka</given-names></name><degrees>MD MPH</degrees><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Judith</surname><given-names>Bass</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Michael</surname><given-names>Boivin</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824,<email>familiar@msu.edu</email>,<email>huiseore@msu.edu</email>,<email>Michael.Boivin@hc.msu.edu</email></aff><aff id="A2"><label>b</label>Department of Statistics and Probability, Michigan State University, 619 Red Cedar Road., C423, East Lansing, MI 48824,<email>sikorska@stt.msu.edu</email></aff><aff id="A3"><label>c</label>University of Michigan Medical School. 500 Catherine St, Apartment 2, Ann Arbor, MI 48104,<email>nikitaj@med.umich.edu</email></aff><aff id="A4"><label>d</label>Department of Psychiatry, College of Health Sciences, Makerere University, Box 7072, Kampala, Uganda,<email>drnoeline@yahoo.com</email></aff><aff id="A5"><label>e</label>Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, PO Box 7072, Kampala, Uganda,<email>opokabob@yahoo.com</email></aff><aff id="A6"><label>f</label>Mental Health Department, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway Street, Hampton House Room 861, Baltimore MD 21205,<email>jbass1@jhu.edu</email></aff><author-notes><corresp id="cor1">Corresponding author: Dr. Horacio Ruiseñor-Escudero, Department of Psychiatry, Michigan State University, 965 Fee Road, East Fee Hall A227, Lansing MI 48824, Phone: 001(517) 432-4204 | Fax: 001 (517) 432-2893, <email>huiseore@msu.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>15</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>4</month><year>2017</year></pub-date><volume>71</volume><issue>5</issue><fpage>522</fpage><lpage>529</lpage><pmc-comment>elocation-id from pubmed: 10.1097/QAI.0000000000000905</pmc-comment>
<abstract><sec id="S1"><title>Objective</title><p id="P1">To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda.</p></sec><sec id="S2"><title>Design</title><p id="P2">This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children ages 1–6 years participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda.</p></sec><sec id="S3"><title>Methods</title><p id="P3">Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z-scores (WAZ), antiretroviral therapy (ART) status and immunological biomarkers.</p></sec><sec id="S4"><title>Results</title><p id="P4">111 children were included in the final analysis. Lower levels of CD4<sup>+</sup> CD38<sup>+</sup> T-cells (p=0.04) were associated to higher Immediate and Total Recall scores (p=0.04). Higher levels of CD8<sup>+</sup> HLA-DR<sup>+</sup> T-cells were associated with higher Total Recall score (p=0.04) of the COAT. Higher CD4<sup>+</sup> CD38<sup>+</sup> HLA-DR<sup>+</sup> T-cells levels were associated with higher Gross Motor scores of the MSEL (p=0.02). WAZ was positively correlated to Visual Reception, Fine Motor, Expressive Language and composite score of the MSEL.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4<sup>+</sup> CD38<sup>+</sup> T-cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.</p></sec></abstract><kwd-group><kwd>HIV</kwd><kwd>COAT</kwd><kwd>MSEL</kwd><kwd>children</kwd><kwd>WAZ</kwd><kwd>immunological</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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