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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN</title><author><name sortKey="Weinberg, Adriana" sort="Weinberg, Adriana" uniqKey="Weinberg A" first="Adriana" last="Weinberg">Adriana Weinberg</name><affiliation><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff></affiliation></author><author><name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name><affiliation><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ronald" sort="Bosch, Ronald" uniqKey="Bosch R" first="Ronald" last="Bosch">Ronald Bosch</name><affiliation><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Cho, Alice" sort="Cho, Alice" uniqKey="Cho A" first="Alice" last="Cho">Alice Cho</name><affiliation><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff></affiliation></author><author><name sortKey="Livingston, Elizabeth" sort="Livingston, Elizabeth" uniqKey="Livingston E" first="Elizabeth" last="Livingston">Elizabeth Livingston</name><affiliation><nlm:aff id="A3">Duke University Medical Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Aweeka, Fran" sort="Aweeka, Fran" uniqKey="Aweeka F" first="Fran" last="Aweeka">Fran Aweeka</name><affiliation><nlm:aff id="A4">University of California, San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Cramer, Yoninah" sort="Cramer, Yoninah" uniqKey="Cramer Y" first="Yoninah" last="Cramer">Yoninah Cramer</name><affiliation><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Watts, D Heather" sort="Watts, D Heather" uniqKey="Watts D" first="D. Heather" last="Watts">D. Heather Watts</name><affiliation><nlm:aff id="A5">Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington, DC</nlm:aff></affiliation></author><author><name sortKey="Luque, Amneris E" sort="Luque, Amneris E" uniqKey="Luque A" first="Amneris E." last="Luque">Amneris E. Luque</name><affiliation><nlm:aff id="A6">University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff></affiliation></author><author><name sortKey="Cohn, Susan E" sort="Cohn, Susan E" uniqKey="Cohn S" first="Susan E." last="Cohn">Susan E. Cohn</name><affiliation><nlm:aff id="A7">Northwestern University Feinberg School of Medicine, Chicago, IL</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26413850</idno><idno type="pmc">4712075</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712075</idno><idno type="RBID">PMC:4712075</idno><idno type="doi">10.1097/QAI.0000000000000850</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">001946</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001946</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN</title><author><name sortKey="Weinberg, Adriana" sort="Weinberg, Adriana" uniqKey="Weinberg A" first="Adriana" last="Weinberg">Adriana Weinberg</name><affiliation><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff></affiliation></author><author><name sortKey="Park, Jeong Gun" sort="Park, Jeong Gun" uniqKey="Park J" first="Jeong-Gun" last="Park">Jeong-Gun Park</name><affiliation><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Bosch, Ronald" sort="Bosch, Ronald" uniqKey="Bosch R" first="Ronald" last="Bosch">Ronald Bosch</name><affiliation><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Cho, Alice" sort="Cho, Alice" uniqKey="Cho A" first="Alice" last="Cho">Alice Cho</name><affiliation><nlm:aff id="A1">University of Colorado Denver Anschutz Medical Center, Aurora, CO</nlm:aff></affiliation></author><author><name sortKey="Livingston, Elizabeth" sort="Livingston, Elizabeth" uniqKey="Livingston E" first="Elizabeth" last="Livingston">Elizabeth Livingston</name><affiliation><nlm:aff id="A3">Duke University Medical Center, Durham, NC</nlm:aff></affiliation></author><author><name sortKey="Aweeka, Fran" sort="Aweeka, Fran" uniqKey="Aweeka F" first="Fran" last="Aweeka">Fran Aweeka</name><affiliation><nlm:aff id="A4">University of California, San Francisco, CA</nlm:aff></affiliation></author><author><name sortKey="Cramer, Yoninah" sort="Cramer, Yoninah" uniqKey="Cramer Y" first="Yoninah" last="Cramer">Yoninah Cramer</name><affiliation><nlm:aff id="A2">Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Watts, D Heather" sort="Watts, D Heather" uniqKey="Watts D" first="D. Heather" last="Watts">D. Heather Watts</name><affiliation><nlm:aff id="A5">Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington, DC</nlm:aff></affiliation></author><author><name sortKey="Luque, Amneris E" sort="Luque, Amneris E" uniqKey="Luque A" first="Amneris E." last="Luque">Amneris E. Luque</name><affiliation><nlm:aff id="A6">University of Rochester School of Medicine and Dentistry, Rochester, NY</nlm:aff></affiliation></author><author><name sortKey="Cohn, Susan E" sort="Cohn, Susan E" uniqKey="Cohn S" first="Susan E." last="Cohn">Susan E. Cohn</name><affiliation><nlm:aff id="A7">Northwestern University Feinberg School of Medicine, Chicago, IL</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of acquired immune deficiency syndromes (1999)</title><idno type="ISSN">1525-4135</idno><idno type="eISSN">1944-7884</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P1">Depot medroxyprogesterone acetate (DMPA) was associated with increased HIV transmission and accelerated disease progression in untreated women. The potential underlying mechanisms include immune-modulation. We evaluated the effect of a single DMPA injection on cell-mediated immunity (CMI), T cell activation (Tact), regulation (Treg) and inflammation in HIV-infected women on cART.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Women with HIV plasma RNA ≤400 c/mL on stable cART received DMPA and had immunologic and MPA measurements at baseline, 4 weeks [peak MPA concentration (Cmax)] and 12 weeks [highest MPA area under the concentration curve (AUC)].</p></sec><sec id="S3"><title>Results</title><p id="P3">At baseline, among 24 women with median 32 years of age and 622 CD4+ cells/μL, ≥68% had HIV, VZV, PHA and CD3/CD28 CMI measured by lymphocyte proliferation and/or IFNγ/IL2 dual-color fluorospot. CMI did not significantly change after DMPA administration except for a 1.4-fold increase in IL2/IFNγ VZV fluorospot at week 12. Tact decreased after DMPA administration, reaching statistical significance at week 12 for CD4+CD25+%. Treg behaved heterogeneously with an increase in CD8+FOXP3+% at week 4 and a decrease in CD4+IL35+% at week 12. There was a decrease in TGFβ at week 12 and no other changes in plasma biomarkers. Correlation analyses showed that high MPA Cmax and/or AUC were significantly associated with increases of IFNγ HIV ELISPOT, CD4+IL35+% and CD4+TGFβ+% Treg and decreases of plasma IL10 from baseline to weeks 4 and/or 12.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">A single dose of DMPA did not have immune-suppressive or pro-inflammatory effects in HIV-infected women on cART. Additional studies need to assess the effect of multiple doses.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">100892005</journal-id><journal-id journal-id-type="pubmed-jr-id">21821</journal-id><journal-id journal-id-type="nlm-ta">J Acquir Immune Defic Syndr</journal-id><journal-id journal-id-type="iso-abbrev">J. Acquir. Immune Defic. Syndr.</journal-id><journal-title-group><journal-title>Journal of acquired immune deficiency syndromes (1999)</journal-title></journal-title-group><issn pub-type="ppub">1525-4135</issn><issn pub-type="epub">1944-7884</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26413850</article-id><article-id pub-id-type="pmc">4712075</article-id><article-id pub-id-type="doi">10.1097/QAI.0000000000000850</article-id><article-id pub-id-type="manuscript">NIHMS721757</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>EFFECT OF DEPOT MEDOXYPROGESTERONE ACETATE ON IMMUNE FUNCTIONS AND INFLAMMATORY MARKERS OF HIV-INFECTED WOMEN</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Weinberg</surname><given-names>Adriana</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Jeong-Gun</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Bosch</surname><given-names>Ronald</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cho</surname><given-names>Alice</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Livingston</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Aweeka</surname><given-names>Fran</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Cramer</surname><given-names>Yoninah</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Watts</surname><given-names>D. Heather</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Luque</surname><given-names>Amneris E.</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref rid="FN1" ref-type="author-notes">b</xref></contrib><contrib contrib-type="author"><name><surname>Cohn</surname><given-names>Susan E.</given-names></name><xref ref-type="aff" rid="A7">7</xref><xref rid="FN1" ref-type="author-notes">b</xref></contrib></contrib-group><aff id="A1"><label>1</label>University of Colorado Denver Anschutz Medical Center, Aurora, CO</aff><aff id="A2"><label>2</label>Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA</aff><aff id="A3"><label>3</label>Duke University Medical Center, Durham, NC</aff><aff id="A4"><label>4</label>University of California, San Francisco, CA</aff><aff id="A5"><label>5</label>Office of the Global AIDS Coordinator and Health Diplomacy, U.S. Department of State, Washington, DC</aff><aff id="A6"><label>6</label>University of Rochester School of Medicine and Dentistry, Rochester, NY</aff><aff id="A7"><label>7</label>Northwestern University Feinberg School of Medicine, Chicago, IL</aff><author-notes><fn id="FN1" fn-type="equal"><label>b</label><p>Equally contributed to this work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>29</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>2</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2017</year></pub-date><volume>71</volume><issue>2</issue><fpage>137</fpage><lpage>145</lpage><pmc-comment>elocation-id from pubmed: 10.1097/QAI.0000000000000850</pmc-comment>
<abstract><sec id="S1"><title>Objectives</title><p id="P1">Depot medroxyprogesterone acetate (DMPA) was associated with increased HIV transmission and accelerated disease progression in untreated women. The potential underlying mechanisms include immune-modulation. We evaluated the effect of a single DMPA injection on cell-mediated immunity (CMI), T cell activation (Tact), regulation (Treg) and inflammation in HIV-infected women on cART.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Women with HIV plasma RNA ≤400 c/mL on stable cART received DMPA and had immunologic and MPA measurements at baseline, 4 weeks [peak MPA concentration (Cmax)] and 12 weeks [highest MPA area under the concentration curve (AUC)].</p></sec><sec id="S3"><title>Results</title><p id="P3">At baseline, among 24 women with median 32 years of age and 622 CD4+ cells/μL, ≥68% had HIV, VZV, PHA and CD3/CD28 CMI measured by lymphocyte proliferation and/or IFNγ/IL2 dual-color fluorospot. CMI did not significantly change after DMPA administration except for a 1.4-fold increase in IL2/IFNγ VZV fluorospot at week 12. Tact decreased after DMPA administration, reaching statistical significance at week 12 for CD4+CD25+%. Treg behaved heterogeneously with an increase in CD8+FOXP3+% at week 4 and a decrease in CD4+IL35+% at week 12. There was a decrease in TGFβ at week 12 and no other changes in plasma biomarkers. Correlation analyses showed that high MPA Cmax and/or AUC were significantly associated with increases of IFNγ HIV ELISPOT, CD4+IL35+% and CD4+TGFβ+% Treg and decreases of plasma IL10 from baseline to weeks 4 and/or 12.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">A single dose of DMPA did not have immune-suppressive or pro-inflammatory effects in HIV-infected women on cART. Additional studies need to assess the effect of multiple doses.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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