Cytomegalovirus and paediatric HIV infection
Identifieur interne : 002F42 ( Pmc/Checkpoint ); précédent : 002F41; suivant : 002F43Cytomegalovirus and paediatric HIV infection
Auteurs : Jennifer A. SlykerSource :
- Journal of Virus Eradication [ 2055-6640 ] ; ????.
Abstract
Cytomegalovirus (CMV) was among the most common AIDS-defining illnesses prior to the advent of combination antiretroviral therapy (ART). In the ART era, CMV disease remains a significant public health threat among HIV-infected adults and children with delayed HIV diagnosis. CMV co-infection may additionally contribute to accelerated HIV progression, development of inflammation-related comorbidities, immune senescence and developmental deficits. Elimination of CMV would have tremendous public health significance and is an important priority; however, current vaccine strategies are not targeted at HIV-infected individuals. Antivirals active against CMV may be a novel strategy to prevent acquisition and improve outcomes, but haematological side effects are common and necessitate cautious use in pregnant women and infants. Studies in HIV-infected children on ART lag behind adults, and the clinical significance of CMV in this population is not well understood. Furthermore, the effects of CMV in HIV-exposed uninfected (HEU) children need to be clarified to understand whether CMV interventions should also be a priority for this growing population. This review discusses our current understanding of CMV transmission and pathogenesis in HIV-exposed children and highlights unanswered questions for future research.
Url:
PubMed: 27781102
PubMed Central: 5075347
Affiliations:
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p id="jve8-para-0005">Cytomegalovirus (CMV) was among the most common AIDS-defining illnesses prior to the advent of combination antiretroviral therapy (ART). In the ART era, CMV disease remains a significant public health threat among HIV-infected adults and children with delayed HIV diagnosis. CMV co-infection may additionally contribute to accelerated HIV progression, development of inflammation-related comorbidities, immune senescence and developmental deficits. Elimination of CMV would have tremendous public health significance and is an important priority; however, current vaccine strategies are not targeted at HIV-infected individuals. Antivirals active against CMV may be a novel strategy to prevent acquisition and improve outcomes, but haematological side effects are common and necessitate cautious use in pregnant women and infants. Studies in HIV-infected children on ART lag behind adults, and the clinical significance of CMV in this population is not well understood. Furthermore, the effects of CMV in HIV-exposed uninfected (HEU) children need to be clarified to understand whether CMV interventions should also be a priority for this growing population. This review discusses our current understanding of CMV transmission and pathogenesis in HIV-exposed children and highlights unanswered questions for future research.</p>
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</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virus Erad</journal-id>
<journal-id journal-id-type="iso-abbrev">J Virus Erad</journal-id>
<journal-id journal-id-type="publisher-id">JOURNAL OF VIRUS ERADICATION</journal-id>
<journal-title-group><journal-title>Journal of Virus Eradication</journal-title>
</journal-title-group>
<issn pub-type="ppub">2055-6640</issn>
<issn pub-type="epub">2055-6659</issn>
<publisher><publisher-name>Mediscript Ltd</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27781102</article-id>
<article-id pub-id-type="pmc">5075347</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cytomegalovirus and paediatric HIV infection</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Slyker</surname>
<given-names>Jennifer A</given-names>
</name>
<xref ref-type="aff" rid="jve8-aff-0001"></xref>
<xref ref-type="corresp" rid="an1">*</xref>
</contrib>
<aff id="jve8-aff-0001"><institution>University of Washington</institution>
,<institution>Department of Global Health</institution>
,<addr-line>Seattle</addr-line>
,<addr-line>Washington</addr-line>
,<country>USA</country>
</aff>
</contrib-group>
<author-notes><corresp id="an1"><label>*</label>
Corresponding author: Jennifer Slyker,
<institution>Harborview Medical Center</institution>
,
<addr-line>325 9<sup>th</sup>
Ave</addr-line>
,
<addr-line>Seattle</addr-line>
<addr-line>WA</addr-line>
<addr-line>98118</addr-line>
,
<country>USA</country>
Email:
<email>jslyker@uw.edu</email>
</corresp>
</author-notes>
<pub-date date-type="collection" publication-format="electronic"><month>10</month>
<year>2016</year>
</pub-date>
<pub-date date-type="pub" publication-format="electronic"><day>5</day>
<month>10</month>
<year>2016</year>
</pub-date>
<volume>2</volume>
<issue>4</issue>
<fpage>208</fpage>
<lpage>214</lpage>
<permissions><copyright-statement>© 2016 The Authors. <italic>Journal of Virus Eradication</italic>
published by Mediscript Ltd</copyright-statement>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an open access article published under the terms of a Creative Commons License.</license-p>
</license>
</permissions>
<abstract id="jve8-abs-0001"><title>Abstract</title>
<p id="jve8-para-0005">Cytomegalovirus (CMV) was among the most common AIDS-defining illnesses prior to the advent of combination antiretroviral therapy (ART). In the ART era, CMV disease remains a significant public health threat among HIV-infected adults and children with delayed HIV diagnosis. CMV co-infection may additionally contribute to accelerated HIV progression, development of inflammation-related comorbidities, immune senescence and developmental deficits. Elimination of CMV would have tremendous public health significance and is an important priority; however, current vaccine strategies are not targeted at HIV-infected individuals. Antivirals active against CMV may be a novel strategy to prevent acquisition and improve outcomes, but haematological side effects are common and necessitate cautious use in pregnant women and infants. Studies in HIV-infected children on ART lag behind adults, and the clinical significance of CMV in this population is not well understood. Furthermore, the effects of CMV in HIV-exposed uninfected (HEU) children need to be clarified to understand whether CMV interventions should also be a priority for this growing population. This review discusses our current understanding of CMV transmission and pathogenesis in HIV-exposed children and highlights unanswered questions for future research.</p>
</abstract>
<kwd-group kwd-group-type="author"><title id="jve8-title-0002">Keywords</title>
<kwd>cytomegalovirus</kwd>
<kwd>paediatrics</kwd>
<kwd>human immunodeficiency virus</kwd>
<kwd>HIV-exposed uninfected</kwd>
<kwd>pathogenesis</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Slyker, Jennifer A" sort="Slyker, Jennifer A" uniqKey="Slyker J" first="Jennifer A" last="Slyker">Jennifer A. Slyker</name>
</noCountry>
</tree>
</affiliations>
</record>
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