Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children
Identifieur interne : 003215 ( Ncbi/Checkpoint ); précédent : 003214; suivant : 003216Effectiveness of the First Dose of BCG against Tuberculosis among HIV-Infected, Predominantly Immunodeficient Children
Auteurs : Joaquim C. V. D. Van-Dunem [Angola] ; Laura C. Rodrigues [Royaume-Uni] ; Luiz Claudio Arraes Alencar [Brésil] ; Maria De Fátima Pessoa Militão-Albuquerque [Brésil] ; Ricardo Arraes De Alencar Ximenes [Brésil]Source :
- BioMed Research International [ 2314-6133 ] ; 2015.
Abstract
The objective of this study was to estimate the protective effect of Bacille Calmette-Guérin (BCG) vaccine against tuberculosis among (predominantly immunodeficient) HIV-infected children in Angola. A hospital-based case-control study was conducted with 230 cases, children coinfected with tuberculosis, and 672 controls, HIV-infected children from the same hospital, aged 18 months to 13 years. The presence of a vaccination scar was taken as a proxy marker for BCG vaccination. The crude effectiveness was 8% (95% CI: −26 to 32) and the adjusted effectiveness was 30% (95% CI: −75 to 72). The present study suggests that BCG does not have a protective effect against tuberculosis among immunodeficient HIV-infected children. Since BCG is no longer given to HIV-infected children, the study may not be replicated. Accepting that these findings should be considered with caution, they are nonetheless likely to be the last estimate of BCG efficacy in a sufficiently powered study.
Url:
DOI: 10.1155/2015/275029
PubMed: 26221585
PubMed Central: 4499653
Affiliations:
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A hospital-based case-control study was conducted with 230 cases, children coinfected with tuberculosis, and 672 controls, HIV-infected children from the same hospital, aged 18 months to 13 years. The presence of a vaccination scar was taken as a proxy marker for BCG vaccination. The crude effectiveness was 8% (95% CI: −26 to 32) and the adjusted effectiveness was 30% (95% CI: −75 to 72). The present study suggests that BCG does not have a protective effect against tuberculosis among immunodeficient HIV-infected children. Since BCG is no longer given to HIV-infected children, the study may not be replicated. Accepting that these findings should be considered with caution, they are nonetheless likely to be the last estimate of BCG efficacy in a sufficiently powered study.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fine, P E M" uniqKey="Fine P">P. E. M. 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Rodrigues</name></noRegion></country><country name="Brésil"><region name="Pernambuco"><name sortKey="Alencar, Luiz Claudio Arraes" sort="Alencar, Luiz Claudio Arraes" uniqKey="Alencar L" first="Luiz Claudio Arraes" last="Alencar">Luiz Claudio Arraes Alencar</name></region><name sortKey="Militao Albuquerque, Maria De Fatima Pessoa" sort="Militao Albuquerque, Maria De Fatima Pessoa" uniqKey="Militao Albuquerque M" first="Maria De Fátima Pessoa" last="Militão-Albuquerque">Maria De Fátima Pessoa Militão-Albuquerque</name><name sortKey="Militao Albuquerque, Maria De Fatima Pessoa" sort="Militao Albuquerque, Maria De Fatima Pessoa" uniqKey="Militao Albuquerque M" first="Maria De Fátima Pessoa" last="Militão-Albuquerque">Maria De Fátima Pessoa Militão-Albuquerque</name><name sortKey="Ximenes, Ricardo Arraes De Alencar" sort="Ximenes, Ricardo Arraes De Alencar" uniqKey="Ximenes R" first="Ricardo Arraes De Alencar" last="Ximenes">Ricardo Arraes De Alencar Ximenes</name><name sortKey="Ximenes, Ricardo Arraes De Alencar" sort="Ximenes, Ricardo Arraes De Alencar" uniqKey="Ximenes R" first="Ricardo Arraes De Alencar" last="Ximenes">Ricardo Arraes De Alencar Ximenes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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