Altered and Conventional Fractionated Radiotherapy in Locoregional Control and Survival of Patients with Squamous Cell Carcinoma of the Larynx, Oropharynx, and Hypopharynx
Identifieur interne : 000056 ( Ncbi/Merge ); précédent : 000055; suivant : 000057Altered and Conventional Fractionated Radiotherapy in Locoregional Control and Survival of Patients with Squamous Cell Carcinoma of the Larynx, Oropharynx, and Hypopharynx
Auteurs : Valentina Krstevska ; Simonida CrvenkovaSource :
- Croatian medical journal [ 0353-9504 ] ; 2006.
Abstract
To compare the efficacy of two altered fractionation radiotherapy treatment protocols (hyperfractionation and accelerated fractionation with concomitant boost) with conventional fractionation in improvement of locoregional disease control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, or hypopharynx.
From March 1999 to December 2000, 51 patients with previously untreated squamous cell carcinoma of the larynx, oropharynx or hypopharynx underwent conventionally fractionated radiotherapy and received 66-70 Gy in 6˝-7 weeks (2 Gy per fraction a day, 5 fractions a week). From January 2001 to June 2004, 101 patients with the same diagnoses underwent either hyperfractionated radiotherapy, with 74.4-79.2 Gy delivered in 6.2-7 weeks (1.2 Gy per fraction twice a day), or accelerated fractionation with concomitant boost, which delivered 68.7-72 Gy in 6 weeks (1.8 Gy per fraction a day and 1.5 Gy per fraction a day to a boost filed as a second daily treatment for the last 11-12 treatment days). Locoregional relapse and overall survival were recorded.
Complete response to treatment was obtained in 31 of 51 patients treated with conventional fractionation, 33 of 50 patients treated with hyperfractionation, and 36 of 51 patients treated with accelerated fractionation. No significant differences were observed among the patients treated with conventional, hyperfractionated, or accelerated radiotherapy modalities either in locoregional control rate (41% vs 35% vs 49%, respectively;
Altered fractionation regimens were not more efficacious than conventional fractionation in the treatment of previously untreated head and neck carcinoma.
ClinicalTrials.gov Identifier: NCT00291434
Url:
PubMed: 16489696
PubMed Central: 2080358
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered and Conventional Fractionated Radiotherapy in Locoregional Control and Survival of Patients with Squamous Cell Carcinoma of the Larynx, Oropharynx, and Hypopharynx</title><author><name sortKey="Krstevska, Valentina" sort="Krstevska, Valentina" uniqKey="Krstevska V" first="Valentina" last="Krstevska">Valentina Krstevska</name></author><author><name sortKey="Crvenkova, Simonida" sort="Crvenkova, Simonida" uniqKey="Crvenkova S" first="Simonida" last="Crvenkova">Simonida Crvenkova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16489696</idno><idno type="pmc">2080358</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2080358</idno><idno type="RBID">PMC:2080358</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000281</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000281</idno><idno type="wicri:Area/Pmc/Curation">000280</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000280</idno><idno type="wicri:Area/Pmc/Checkpoint">000359</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000359</idno><idno type="wicri:Area/Ncbi/Merge">000056</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Altered and Conventional Fractionated Radiotherapy in Locoregional Control and Survival of Patients with Squamous Cell Carcinoma of the Larynx, Oropharynx, and Hypopharynx</title><author><name sortKey="Krstevska, Valentina" sort="Krstevska, Valentina" uniqKey="Krstevska V" first="Valentina" last="Krstevska">Valentina Krstevska</name></author><author><name sortKey="Crvenkova, Simonida" sort="Crvenkova, Simonida" uniqKey="Crvenkova S" first="Simonida" last="Crvenkova">Simonida Crvenkova</name></author></analytic><series><title level="j">Croatian medical journal</title><idno type="ISSN">0353-9504</idno><idno type="eISSN">1332-8166</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>To compare the efficacy of two altered fractionation radiotherapy treatment protocols (hyperfractionation and accelerated fractionation with concomitant boost) with conventional fractionation in improvement of locoregional disease control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, or hypopharynx.</p></sec><sec sec-type="methods"><title>Methods</title><p>From March 1999 to December 2000, 51 patients with previously untreated squamous cell carcinoma of the larynx, oropharynx or hypopharynx underwent conventionally fractionated radiotherapy and received 66-70 Gy in 6˝-7 weeks (2 Gy per fraction a day, 5 fractions a week). From January 2001 to June 2004, 101 patients with the same diagnoses underwent either hyperfractionated radiotherapy, with 74.4-79.2 Gy delivered in 6.2-7 weeks (1.2 Gy per fraction twice a day), or accelerated fractionation with concomitant boost, which delivered 68.7-72 Gy in 6 weeks (1.8 Gy per fraction a day and 1.5 Gy per fraction a day to a boost filed as a second daily treatment for the last 11-12 treatment days). Locoregional relapse and overall survival were recorded.</p></sec><sec><title>Results</title><p>Complete response to treatment was obtained in 31 of 51 patients treated with conventional fractionation, 33 of 50 patients treated with hyperfractionation, and 36 of 51 patients treated with accelerated fractionation. No significant differences were observed among the patients treated with conventional, hyperfractionated, or accelerated radiotherapy modalities either in locoregional control rate (41% vs 35% vs 49%, respectively; <italic>P</italic> = 0.690) or overall survival rate (50% vs 40% vs 51%, respectively; <italic>P</italic> = 0.760). The grade of acute reactions of the larynx significantly differed among the treatment groups (Fisher exact test; <italic>P</italic> = 0.039). The difference in the grade of acute side effects in the skin among the treatment groups was of borderline significance (χ<sup>2</sup><sub>2</sub> test; <italic>P</italic> = 0.054). There was also a borderline difference among the groups in the grade of late side effects in the mucous membrane (χ<sup>2</sup><sub>2</sub> test; <italic>P</italic> = 0.055).</p></sec><sec><title>Conclusion</title><p>Altered fractionation regimens were not more efficacious than conventional fractionation in the treatment of previously untreated head and neck carcinoma.</p></sec><sec><title>Clinical Trial Registration</title><p>ClinicalTrials.gov Identifier: NCT00291434</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Croat Med J</journal-id><journal-id journal-id-type="publisher-id">CMJ</journal-id><journal-title>Croatian medical journal</journal-title><issn pub-type="ppub">0353-9504</issn><issn pub-type="epub">1332-8166</issn><publisher><publisher-name>Croatian Medical Schools</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16489696</article-id><article-id pub-id-type="pmc">2080358</article-id><article-id pub-id-type="publisher-id">278_05</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Science</subject></subj-group></article-categories><title-group><article-title>Altered and Conventional Fractionated Radiotherapy in Locoregional Control and Survival of Patients with Squamous Cell Carcinoma of the Larynx, Oropharynx, and Hypopharynx</article-title><alt-title alt-title-type="running-head">Krstevska and Crvenkova: Altered Fractionation Radiotherapy in Throat Cancer</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Krstevska</surname><given-names>Valentina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Crvenkova</surname><given-names>Simonida</given-names></name></contrib><aff id="aff1">Institute of Radiotherapy and Oncology, Clinical Center, Skopje, R. Macedonia</aff></contrib-group><author-notes><corresp id="cor1"><bold>Correspondence to:</bold>
Valentina Krstevska
Institute of Radiotherapy and Oncology, Clinical Center
Vodnjanska 17
1000 Skopje
R. Macedonia
<italic><email xlink:href="krstevskav@yahoo.it">krstevskav@yahoo.it</email></italic></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2006</year></pub-date><volume>47</volume><issue>1</issue><fpage>42</fpage><lpage>52</lpage><history><date date-type="received"><day>21</day><month>9</month><year>2005</year></date><date date-type="accepted"><day>09</day><month>1</month><year>2006</year></date></history><copyright-statement>Copyright © 2006 by the Croatian Medical Journal. All rights reserved.</copyright-statement><copyright-year>2006</copyright-year><abstract><sec><title>Aim</title><p>To compare the efficacy of two altered fractionation radiotherapy treatment protocols (hyperfractionation and accelerated fractionation with concomitant boost) with conventional fractionation in improvement of locoregional disease control and survival of patients with squamous cell carcinoma of the larynx, oropharynx, or hypopharynx.</p></sec><sec sec-type="methods"><title>Methods</title><p>From March 1999 to December 2000, 51 patients with previously untreated squamous cell carcinoma of the larynx, oropharynx or hypopharynx underwent conventionally fractionated radiotherapy and received 66-70 Gy in 6˝-7 weeks (2 Gy per fraction a day, 5 fractions a week). From January 2001 to June 2004, 101 patients with the same diagnoses underwent either hyperfractionated radiotherapy, with 74.4-79.2 Gy delivered in 6.2-7 weeks (1.2 Gy per fraction twice a day), or accelerated fractionation with concomitant boost, which delivered 68.7-72 Gy in 6 weeks (1.8 Gy per fraction a day and 1.5 Gy per fraction a day to a boost filed as a second daily treatment for the last 11-12 treatment days). Locoregional relapse and overall survival were recorded.</p></sec><sec><title>Results</title><p>Complete response to treatment was obtained in 31 of 51 patients treated with conventional fractionation, 33 of 50 patients treated with hyperfractionation, and 36 of 51 patients treated with accelerated fractionation. No significant differences were observed among the patients treated with conventional, hyperfractionated, or accelerated radiotherapy modalities either in locoregional control rate (41% vs 35% vs 49%, respectively; <italic>P</italic> = 0.690) or overall survival rate (50% vs 40% vs 51%, respectively; <italic>P</italic> = 0.760). The grade of acute reactions of the larynx significantly differed among the treatment groups (Fisher exact test; <italic>P</italic> = 0.039). The difference in the grade of acute side effects in the skin among the treatment groups was of borderline significance (χ<sup>2</sup><sub>2</sub> test; <italic>P</italic> = 0.054). There was also a borderline difference among the groups in the grade of late side effects in the mucous membrane (χ<sup>2</sup><sub>2</sub> test; <italic>P</italic> = 0.055).</p></sec><sec><title>Conclusion</title><p>Altered fractionation regimens were not more efficacious than conventional fractionation in the treatment of previously untreated head and neck carcinoma.</p></sec><sec><title>Clinical Trial Registration</title><p>ClinicalTrials.gov Identifier: NCT00291434</p></sec></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Crvenkova, Simonida" sort="Crvenkova, Simonida" uniqKey="Crvenkova S" first="Simonida" last="Crvenkova">Simonida Crvenkova</name><name sortKey="Krstevska, Valentina" sort="Krstevska, Valentina" uniqKey="Krstevska V" first="Valentina" last="Krstevska">Valentina Krstevska</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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