HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population
Identifieur interne : 000024 ( Pmc/Curation ); précédent : 000023; suivant : 000025HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population
Auteurs : Abdelhafidh Hajjej [Tunisie] ; Wassim Y. Almawi [Bahreïn] ; Lasmar Hattab [Tunisie] ; Amel El-Gaaied [Tunisie] ; Slama Hmida [Tunisie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total of 376 unrelated Tunisian individuals of both genders were genotyped for HLA class I (A, B) and class II (DRB1, DQB1), using reverse dot-blot hybridization (PCR-SSO) method. Statistical analysis was performed using Arlequin software. Phylogenetic trees were constructed by DISPAN software, and correspondence analysis was carried out by VISTA software. One hundred fifty-three HLA alleles were identified in the studied sample, which comprised 41, 50, 40 and 22 alleles at HLA-A,-B,-DRB1 and -DQB1 loci, respectively. The most frequent alleles were HLA-A*02:01 (16.76%), HLA-B*44:02/03 (17.82%), HLA-DRB1*07:01 (19.02%), and HLA-DQB1*03:01 (17.95%). Four-locus haplotype analysis identified HLA-A*02:01-B*50:01-DRB1*07:01-DQB1*02:02 (2.2%) as the common haplotype in Tunisians. Compared to other nearby populations, Tunisians appear to be genetically related to Western Mediterranean population, in particular North Africans and Berbers. In conclusion, HLA genotype results indicate that Tunisians are related to present-day North Africans, Berbers and to Iberians, but not to Eastern Arabs (Palestinians, Jordanians and Lebanese). This suggests that the genetic contribution of Arab invasion of 7th-11th century A.D. had little impact of the North African gene pool.
Url:
DOI: 10.1371/journal.pone.0136909
PubMed: 26317228
PubMed Central: 4552629
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000024
Links to Exploration step
PMC:4552629Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population</title><author><name sortKey="Hajjej, Abdelhafidh" sort="Hajjej, Abdelhafidh" uniqKey="Hajjej A" first="Abdelhafidh" last="Hajjej">Abdelhafidh Hajjej</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Immunogenetics, National Blood Transfusion Center, Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Almawi, Wassim Y" sort="Almawi, Wassim Y" uniqKey="Almawi W" first="Wassim Y." last="Almawi">Wassim Y. Almawi</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain</addr-line></nlm:aff><country xml:lang="fr">Bahreïn</country><wicri:regionArea>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama</wicri:regionArea></affiliation></author><author><name sortKey="Hattab, Lasmar" sort="Hattab, Lasmar" uniqKey="Hattab L" first="Lasmar" last="Hattab">Lasmar Hattab</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medical Analysis, Regional Hospital of Gabes, Gabes, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Medical Analysis, Regional Hospital of Gabes, Gabes</wicri:regionArea></affiliation></author><author><name sortKey="El Gaaied, Amel" sort="El Gaaied, Amel" uniqKey="El Gaaied A" first="Amel" last="El-Gaaied">Amel El-Gaaied</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Hmida, Slama" sort="Hmida, Slama" uniqKey="Hmida S" first="Slama" last="Hmida">Slama Hmida</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Immunogenetics, National Blood Transfusion Center, Tunis</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26317228</idno><idno type="pmc">4552629</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552629</idno><idno type="RBID">PMC:4552629</idno><idno type="doi">10.1371/journal.pone.0136909</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000024</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000024</idno><idno type="wicri:Area/Pmc/Curation">000024</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000024</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population</title><author><name sortKey="Hajjej, Abdelhafidh" sort="Hajjej, Abdelhafidh" uniqKey="Hajjej A" first="Abdelhafidh" last="Hajjej">Abdelhafidh Hajjej</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Immunogenetics, National Blood Transfusion Center, Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Almawi, Wassim Y" sort="Almawi, Wassim Y" uniqKey="Almawi W" first="Wassim Y." last="Almawi">Wassim Y. Almawi</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain</addr-line></nlm:aff><country xml:lang="fr">Bahreïn</country><wicri:regionArea>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama</wicri:regionArea></affiliation></author><author><name sortKey="Hattab, Lasmar" sort="Hattab, Lasmar" uniqKey="Hattab L" first="Lasmar" last="Hattab">Lasmar Hattab</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medical Analysis, Regional Hospital of Gabes, Gabes, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Medical Analysis, Regional Hospital of Gabes, Gabes</wicri:regionArea></affiliation></author><author><name sortKey="El Gaaied, Amel" sort="El Gaaied, Amel" uniqKey="El Gaaied A" first="Amel" last="El-Gaaied">Amel El-Gaaied</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis</wicri:regionArea></affiliation></author><author><name sortKey="Hmida, Slama" sort="Hmida, Slama" uniqKey="Hmida S" first="Slama" last="Hmida">Slama Hmida</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Immunogenetics, National Blood Transfusion Center, Tunis</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total of 376 unrelated Tunisian individuals of both genders were genotyped for HLA class I (A, B) and class II (DRB1, DQB1), using reverse dot-blot hybridization (PCR-SSO) method. Statistical analysis was performed using Arlequin software. Phylogenetic trees were constructed by DISPAN software, and correspondence analysis was carried out by VISTA software. One hundred fifty-three HLA alleles were identified in the studied sample, which comprised 41, 50, 40 and 22 alleles at HLA-A,-B,-DRB1 and -DQB1 loci, respectively. The most frequent alleles were HLA-A*02:01 (16.76%), HLA-B*44:02/03 (17.82%), HLA-DRB1*07:01 (19.02%), and HLA-DQB1*03:01 (17.95%). Four-locus haplotype analysis identified HLA-A*02:01-B*50:01-DRB1*07:01-DQB1*02:02 (2.2%) as the common haplotype in Tunisians. Compared to other nearby populations, Tunisians appear to be genetically related to Western Mediterranean population, in particular North Africans and Berbers. In conclusion, HLA genotype results indicate that Tunisians are related to present-day North Africans, Berbers and to Iberians, but not to Eastern Arabs (Palestinians, Jordanians and Lebanese). This suggests that the genetic contribution of Arab invasion of 7<sup>th</sup>-11<sup>th</sup> century A.D. had little impact of the North African gene pool.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mungall, Aj" uniqKey="Mungall A">AJ Mungall</name></author><author><name sortKey="Palmer, Sa" uniqKey="Palmer S">SA Palmer</name></author><author><name sortKey="Sims, Sk" uniqKey="Sims S">SK Sims</name></author><author><name sortKey="Edwards, Ca" uniqKey="Edwards C">CA Edwards</name></author><author><name sortKey="Ashurst, Jl" uniqKey="Ashurst J">JL Ashurst</name></author><author><name sortKey="Wilming, L" uniqKey="Wilming L">L Wilming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Mazas, A" uniqKey="Sanchez Mazas A">A Sanchez-Mazas</name></author><author><name sortKey="Fernandez Vi A, M" uniqKey="Fernandez Vi A M">M Fernandez-Viña</name></author><author><name sortKey="Middleton, D" uniqKey="Middleton D">D Middleton</name></author><author><name sortKey="Hollenbach, Ja" uniqKey="Hollenbach J">JA Hollenbach</name></author><author><name sortKey="Buhler, S" uniqKey="Buhler S">S Buhler</name></author><author><name sortKey="Di, D" uniqKey="Di D">D Di</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Solberg, Od" uniqKey="Solberg O">OD Solberg</name></author><author><name sortKey="Mack, Sj" uniqKey="Mack S">SJ Mack</name></author><author><name sortKey="Lancaster, Ak" uniqKey="Lancaster A">AK Lancaster</name></author><author><name sortKey="Single, Rm" uniqKey="Single R">RM Single</name></author><author><name sortKey="Tsai, Y" uniqKey="Tsai Y">Y Tsai</name></author><author><name sortKey="Sanchez Mazas, A" uniqKey="Sanchez Mazas A">A Sanchez-Mazas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gourraud, Pa" uniqKey="Gourraud P">PA Gourraud</name></author><author><name sortKey="Barnetche, T" uniqKey="Barnetche T">T Barnetche</name></author><author><name sortKey="Vidan Jeras, B" uniqKey="Vidan Jeras B">B Vidan-Jeras</name></author><author><name sortKey="Cambon Thomsen, A" uniqKey="Cambon Thomsen A">A Cambon-Thomsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brett, M" uniqKey="Brett M">M Brett</name></author><author><name sortKey="Fentress, E" uniqKey="Fentress E">E Fentress</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosworth, Ce" uniqKey="Bosworth C">CE Bosworth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lapidus, Im" uniqKey="Lapidus I">IM Lapidus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stearns, Pn" uniqKey="Stearns P">PN Stearns</name></author><author><name sortKey="Leonard Langer, W" uniqKey="Leonard Langer W">W Leonard Langer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clancy Smith, Ja" uniqKey="Clancy Smith J">JA Clancy-Smith</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Sa" uniqKey="Miller S">SA Miller</name></author><author><name sortKey="Dykes, Dd" uniqKey="Dykes D">DD Dykes</name></author><author><name sortKey="Polesky, Hf" uniqKey="Polesky H">HF Polesky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buyse, I" uniqKey="Buyse I">I Buyse</name></author><author><name sortKey="Decorte, R" uniqKey="Decorte R">R Decorte</name></author><author><name sortKey="Baens, M" uniqKey="Baens M">M Baens</name></author><author><name sortKey="Cuppens, H" uniqKey="Cuppens H">H Cuppens</name></author><author><name sortKey="Semana, G" uniqKey="Semana G">G Semana</name></author><author><name sortKey="Emonds, Mp" uniqKey="Emonds M">MP Emonds</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hmida, S" uniqKey="Hmida S">S Hmida</name></author><author><name sortKey="Gauthier, A" uniqKey="Gauthier A">A Gauthier</name></author><author><name sortKey="Dridi, A" uniqKey="Dridi A">A Dridi</name></author><author><name sortKey="Quillivic, F" uniqKey="Quillivic F">F Quillivic</name></author><author><name sortKey="Genetet, B" uniqKey="Genetet B">B Genetet</name></author><author><name sortKey="Boukef, K" uniqKey="Boukef K">K Boukef</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dempster, Ap" uniqKey="Dempster A">AP Dempster</name></author><author><name sortKey="Laird, Nm" uniqKey="Laird N">NM Laird</name></author><author><name sortKey="Rubin, Dm" uniqKey="Rubin D">DM Rubin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Excoffier, L" uniqKey="Excoffier L">L Excoffier</name></author><author><name sortKey="Slatkin, M" uniqKey="Slatkin M">M Slatkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schneider, S" uniqKey="Schneider S">S Schneider</name></author><author><name sortKey="Kueffer, Jm" uniqKey="Kueffer J">JM Kueffer</name></author><author><name sortKey="Roessli, D" uniqKey="Roessli D">D Roessli</name></author><author><name sortKey="Excoffier, L" uniqKey="Excoffier L">L Excoffier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Sw" uniqKey="Guo S">SW Guo</name></author><author><name sortKey="Thompson, Ea" uniqKey="Thompson E">EA Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imanishi, T" uniqKey="Imanishi T">T Imanishi</name></author><author><name sortKey="Akaza, T" uniqKey="Akaza T">T Akaza</name></author><author><name sortKey="Kimura, A" uniqKey="Kimura A">A Kimura</name></author><author><name sortKey="Tokunaga, K" uniqKey="Tokunaga K">K Tokunaga</name></author><author><name sortKey="Gojrobi, T" uniqKey="Gojrobi T">T Gojrobi</name></author><author><name sortKey="Tsuji, K" uniqKey="Tsuji K">K Tsuji</name></author><author><name sortKey="Aizawa, M" uniqKey="Aizawa M">M Aizawa</name></author><author><name sortKey="Sasazuki, T" uniqKey="Sasazuki T">T Sasazuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saitou, N" uniqKey="Saitou N">N Saitou</name></author><author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nei, M" uniqKey="Nei M">M Nei</name></author><author><name sortKey="Tajima, Y" uniqKey="Tajima Y">Y Tajima</name></author><author><name sortKey="Tateno, Y" uniqKey="Tateno Y">Y Tateno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Fw" uniqKey="Young F">FW Young</name></author><author><name sortKey="Bann, Cm" uniqKey="Bann C">CM Bann</name></author><author><name sortKey="Stine, Ra" uniqKey="Stine R">RA Stine</name></author><author><name sortKey="Fox, J" uniqKey="Fox J">J Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gomez Casado, E" uniqKey="Gomez Casado E">E Gomez-Casado</name></author><author><name sortKey="Del Moral, P" uniqKey="Del Moral P">P del Moral</name></author><author><name sortKey="Martinez Laso, J" uniqKey="Martinez Laso J">J Martinez-Laso</name></author><author><name sortKey="Garcia G Mez, A" uniqKey="Garcia G Mez A">A García-Gómez</name></author><author><name sortKey="Allende, L" uniqKey="Allende L">L Allende</name></author><author><name sortKey="Silvera Redondo, C" uniqKey="Silvera Redondo C">C Silvera-Redondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Comas, D" uniqKey="Comas D">D Comas</name></author><author><name sortKey="Mateu, E" uniqKey="Mateu E">E Mateu</name></author><author><name sortKey="Calafell, F" uniqKey="Calafell F">F Calafell</name></author><author><name sortKey="Perez Lezaun, A" uniqKey="Perez Lezaun A">A Pérez-Lezaun</name></author><author><name sortKey="Bosch, E" uniqKey="Bosch E">E Bosch</name></author><author><name sortKey="Martinez Arias, R" uniqKey="Martinez Arias R">R Martínez-Arias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clayton, J" uniqKey="Clayton J">J Clayton</name></author><author><name sortKey="Lonjou, C" uniqKey="Lonjou C">C Lonjou</name></author><author><name sortKey="Charron, D" uniqKey="Charron D">D Charron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author><author><name sortKey="Benmamar, D" uniqKey="Benmamar D">D Benmamar</name></author><author><name sortKey="Alvarez, M" uniqKey="Alvarez M">M Alvarez</name></author><author><name sortKey="Diaz Campos, N" uniqKey="Diaz Campos N">N Diaz-Campos</name></author><author><name sortKey="Varela, P" uniqKey="Varela P">P Varela</name></author><author><name sortKey="Gomez Casado, E" uniqKey="Gomez Casado E">E Gomez-Casado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galgani, A" uniqKey="Galgani A">A Galgani</name></author><author><name sortKey="Mancino, G" uniqKey="Mancino G">G Mancino</name></author><author><name sortKey="Martinez Labarga, C" uniqKey="Martinez Labarga C">C Martínez-Labarga</name></author><author><name sortKey="Cicconi, R" uniqKey="Cicconi R">R Cicconi</name></author><author><name sortKey="Mattei, M" uniqKey="Mattei M">M Mattei</name></author><author><name sortKey="Amicosante, M" uniqKey="Amicosante M">M Amicosante</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Velasco, P" uniqKey="Sanchez Velasco P">P Sánchez-Velasco</name></author><author><name sortKey="Karadsheh, Ns" uniqKey="Karadsheh N">NS Karadsheh</name></author><author><name sortKey="Garcia Martin, A" uniqKey="Garcia Martin A">A García-Martín</name></author><author><name sortKey="Ruiz De Alegria, C" uniqKey="Ruiz De Alegria C">C Ruíz de Alegría</name></author><author><name sortKey="Leyva Cobian, F" uniqKey="Leyva Cobian F">F Leyva-Cobián</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author><author><name sortKey="Elaiwa, N" uniqKey="Elaiwa N">N Elaiwa</name></author><author><name sortKey="Silvera, C" uniqKey="Silvera C">C Silvera</name></author><author><name sortKey="Rostom, A" uniqKey="Rostom A">A Rostom</name></author><author><name sortKey="Moscoso, J" uniqKey="Moscoso J">J Moscoso</name></author><author><name sortKey="G Mez Casado, E" uniqKey="G Mez Casado E">E Gómez-Casado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayed, K" uniqKey="Ayed K">K Ayed</name></author><author><name sortKey="Ayed Jendoubi, S" uniqKey="Ayed Jendoubi S">S Ayed-Jendoubi</name></author><author><name sortKey="Sfar, I" uniqKey="Sfar I">I Sfar</name></author><author><name sortKey="Labonne, Mp" uniqKey="Labonne M">MP Labonne</name></author><author><name sortKey="Gebuhrer, L" uniqKey="Gebuhrer L">L Gebuhrer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grimaldi, Mc" uniqKey="Grimaldi M">MC Grimaldi</name></author><author><name sortKey="Crouau Roy, B" uniqKey="Crouau Roy B">B Crouau-Roy</name></author><author><name sortKey="Amoros, Jp" uniqKey="Amoros J">JP Amoros</name></author><author><name sortKey="Cambon Thomsen, A" uniqKey="Cambon Thomsen A">A Cambon-Thomsen</name></author><author><name sortKey="Carcassi, C" uniqKey="Carcassi C">C Carcassi</name></author><author><name sortKey="Orru, S" uniqKey="Orru S">S Orru</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hajjej, A" uniqKey="Hajjej A">A Hajjej</name></author><author><name sortKey="Kaabi, H" uniqKey="Kaabi H">H Kâabi</name></author><author><name sortKey="Sellami, Mh" uniqKey="Sellami M">MH Sellami</name></author><author><name sortKey="Dridi, A" uniqKey="Dridi A">A Dridi</name></author><author><name sortKey="Jeridi, A" uniqKey="Jeridi A">A Jeridi</name></author><author><name sortKey="El Borgi, W" uniqKey="El Borgi W">W El borgi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hajjej, A" uniqKey="Hajjej A">A Hajjej</name></author><author><name sortKey="Sellami, Mh" uniqKey="Sellami M">MH Sellami</name></author><author><name sortKey="Kaabi, H" uniqKey="Kaabi H">H Kaabi</name></author><author><name sortKey="Hajjej, G" uniqKey="Hajjej G">G Hajjej</name></author><author><name sortKey="El Gaaied, A" uniqKey="El Gaaied A">A El-Gaaied</name></author><author><name sortKey="Boukef, K" uniqKey="Boukef K">K Boukef</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hajjej, A" uniqKey="Hajjej A">A Hajjej</name></author><author><name sortKey="Hmida, S" uniqKey="Hmida S">S Hmida</name></author><author><name sortKey="Kaabi, H" uniqKey="Kaabi H">H Kaabi</name></author><author><name sortKey="Dridi, A" uniqKey="Dridi A">A Dridi</name></author><author><name sortKey="Jridi, A" uniqKey="Jridi A">A Jridi</name></author><author><name sortKey="El Gaaled, A" uniqKey="El Gaaled A">A El Gaaled</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Izaabel, H" uniqKey="Izaabel H">H Izaabel</name></author><author><name sortKey="Garchon, Hj" uniqKey="Garchon H">HJ Garchon</name></author><author><name sortKey="Caillat Zucman, S" uniqKey="Caillat Zucman S">S Caillat-Zucman</name></author><author><name sortKey="Beaurain, G" uniqKey="Beaurain G">G Beaurain</name></author><author><name sortKey="Akhayat, O" uniqKey="Akhayat O">O Akhayat</name></author><author><name sortKey="Bach, Jf" uniqKey="Bach J">JF Bach</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Hajjej, A" uniqKey="Hajjej A">A Hajjej</name></author><author><name sortKey="Hajjej, G" uniqKey="Hajjej G">G Hajjej</name></author><author><name sortKey="Almawi, Wy" uniqKey="Almawi W">WY Almawi</name></author><author><name sortKey="Kaabi, H" uniqKey="Kaabi H">H Kaabi</name></author><author><name sortKey="El Gaaied, A" uniqKey="El Gaaied A">A El-Gaaied</name></author><author><name sortKey="Hmida, S" uniqKey="Hmida S">S Hmida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author><author><name sortKey="Dimitroski, K" uniqKey="Dimitroski K">K Dimitroski</name></author><author><name sortKey="Pacho, A" uniqKey="Pacho A">A Pacho</name></author><author><name sortKey="Moscoso, J" uniqKey="Moscoso J">J Moscoso</name></author><author><name sortKey="G Mez Casado, E" uniqKey="G Mez Casado E">E Gómez-Casado</name></author><author><name sortKey="Silvera Redondo, C" uniqKey="Silvera Redondo C">C Silvera-Redondo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author><author><name sortKey="Gomez Casado, E" uniqKey="Gomez Casado E">E Gomez-Casado</name></author><author><name sortKey="Martinez Laso, J" uniqKey="Martinez Laso J">J Martinez-Laso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author><author><name sortKey="Iliakis, P" uniqKey="Iliakis P">P Iliakis</name></author><author><name sortKey="Gonzalez Hevilla, M" uniqKey="Gonzalez Hevilla M">M González-Hevilla</name></author><author><name sortKey="Longas, J" uniqKey="Longas J">J Longás</name></author><author><name sortKey="G Mez Casado, E" uniqKey="G Mez Casado E">E Gómez-Casado</name></author><author><name sortKey="Sfyridaki, K" uniqKey="Sfyridaki K">K Sfyridaki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Laso, J" uniqKey="Martinez Laso J">J Martinez-Laso</name></author><author><name sortKey="De Juan, D" uniqKey="De Juan D">D De Juan</name></author><author><name sortKey="Martinez Quiles, N" uniqKey="Martinez Quiles N">N Martinez-Quiles</name></author><author><name sortKey="Gomez Casado, E" uniqKey="Gomez Casado E">E Gomez-Casado</name></author><author><name sortKey="Cuadrado, E" uniqKey="Cuadrado E">E Cuadrado</name></author><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imanishi, T" uniqKey="Imanishi T">T Imanishi</name></author><author><name sortKey="Akaza, T" uniqKey="Akaza T">T Akaza</name></author><author><name sortKey="Kimura, A" uniqKey="Kimura A">A Kimura</name></author><author><name sortKey="Tokunaga, K" uniqKey="Tokunaga K">K Tokunaga</name></author><author><name sortKey="Gjobori, T" uniqKey="Gjobori T">T Gjobori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roitberg Tambur, A" uniqKey="Roitberg Tambur A">A Roitberg-Tambur</name></author><author><name sortKey="Witt, Cs" uniqKey="Witt C">CS Witt</name></author><author><name sortKey="Friedmann, A" uniqKey="Friedmann A">A Friedmann</name></author><author><name sortKey="Safirman, C" uniqKey="Safirman C">C Safirman</name></author><author><name sortKey="Sherman, L" uniqKey="Sherman L">L Sherman</name></author><author><name sortKey="Battat, S" uniqKey="Battat S">S Battat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author><author><name sortKey="Karin, M" uniqKey="Karin M">M Karin</name></author><author><name sortKey="Bendikuze, N" uniqKey="Bendikuze N">N Bendikuze</name></author><author><name sortKey="Gomez Casado, E" uniqKey="Gomez Casado E">E Gomez-Casado</name></author><author><name sortKey="Moscoso, J" uniqKey="Moscoso J">J Moscoso</name></author><author><name sortKey="Silvera, C" uniqKey="Silvera C">C Silvera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahfoudh, N" uniqKey="Mahfoudh N">N Mahfoudh</name></author><author><name sortKey="Ayadi, I" uniqKey="Ayadi I">I Ayadi</name></author><author><name sortKey="Kamoun, A" uniqKey="Kamoun A">A Kamoun</name></author><author><name sortKey="Ammar, R" uniqKey="Ammar R">R Ammar</name></author><author><name sortKey="Mallek, B" uniqKey="Mallek B">B Mallek</name></author><author><name sortKey="Maalej, L" uniqKey="Maalej L">L Maalej</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Velasco, P" uniqKey="Sanchez Velasco P">P Sanchez-Velasco</name></author><author><name sortKey="Gomez Casado, E" uniqKey="Gomez Casado E">E Gomez-Casado</name></author><author><name sortKey="Martinez Laso, J" uniqKey="Martinez Laso J">J Martinez-Laso</name></author><author><name sortKey="Moscoso, J" uniqKey="Moscoso J">J Moscoso</name></author><author><name sortKey="Zamora, J" uniqKey="Zamora J">J Zamora</name></author><author><name sortKey="Lowy, E" uniqKey="Lowy E">E Lowy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Mazas, A" uniqKey="Sanchez Mazas A">A Sanchez-Mazas</name></author><author><name sortKey="Arnaiz Villena, A" uniqKey="Arnaiz Villena A">A Arnaiz-Villena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brett, M" uniqKey="Brett M">M Brett</name></author><author><name sortKey="Fentress, E" uniqKey="Fentress E">E Fentress</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodd, F" uniqKey="Rodd F">F Rodd</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, B" uniqKey="Lewis B">B Lewis</name></author><author><name sortKey="Ayalon, David" uniqKey="Ayalon D">David Ayalon</name></author><author><name sortKey="Sharon, Moshe" uniqKey="Sharon M">Moshe Sharon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camps, G" uniqKey="Camps G">G Camps</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Abun Nasr, Jm" uniqKey="Abun Nasr J">JM Abun-Nasr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, T" uniqKey="Fischer T">T Fischer</name></author><author><name sortKey="Mill" uniqKey="Mill">Mill</name></author><author><name sortKey="Hugh, Robert" uniqKey="Hugh R">Robert Hugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sams, J" uniqKey="Sams J">J Samsó</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26317228</article-id><article-id pub-id-type="pmc">4552629</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0136909</article-id><article-id pub-id-type="publisher-id">PONE-D-15-24587</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population</article-title><alt-title alt-title-type="running-head">HLA Genes in Tunisians</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hajjej</surname><given-names>Abdelhafidh</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib><contrib contrib-type="author"><name><surname>Almawi</surname><given-names>Wassim Y.</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hattab</surname><given-names>Lasmar</given-names></name><xref ref-type="aff" rid="aff003"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>El-Gaaied</surname><given-names>Amel</given-names></name><xref ref-type="aff" rid="aff004"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hmida</surname><given-names>Slama</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain</addr-line></aff><aff id="aff003"><label>3</label><addr-line>Department of Medical Analysis, Regional Hospital of Gabes, Gabes, Tunisia</addr-line></aff><aff id="aff004"><label>4</label><addr-line>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis, Tunisia</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Goldberg</surname><given-names>Anna Carla</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Hospital Israelita Albert Einstein, BRAZIL</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: AH SH AE WYA. Performed the experiments: AH LH SH. Analyzed the data: AH SH WYA AE. Contributed reagents/materials/analysis tools: SH AE WYA AH. Wrote the paper: AH WYA AE SH.</p></fn><corresp id="cor001">* E-mail: <email>hajjejj@yahoo.fr</email></corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>8</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>10</volume><issue>8</issue><elocation-id>e0136909</elocation-id><history><date date-type="received"><day>9</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>9</day><month>8</month><year>2015</year></date></history><permissions><copyright-year>2015</copyright-year><copyright-holder>Hajjej et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0136909.pdf"></self-uri><abstract><p>In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total of 376 unrelated Tunisian individuals of both genders were genotyped for HLA class I (A, B) and class II (DRB1, DQB1), using reverse dot-blot hybridization (PCR-SSO) method. Statistical analysis was performed using Arlequin software. Phylogenetic trees were constructed by DISPAN software, and correspondence analysis was carried out by VISTA software. One hundred fifty-three HLA alleles were identified in the studied sample, which comprised 41, 50, 40 and 22 alleles at HLA-A,-B,-DRB1 and -DQB1 loci, respectively. The most frequent alleles were HLA-A*02:01 (16.76%), HLA-B*44:02/03 (17.82%), HLA-DRB1*07:01 (19.02%), and HLA-DQB1*03:01 (17.95%). Four-locus haplotype analysis identified HLA-A*02:01-B*50:01-DRB1*07:01-DQB1*02:02 (2.2%) as the common haplotype in Tunisians. Compared to other nearby populations, Tunisians appear to be genetically related to Western Mediterranean population, in particular North Africans and Berbers. In conclusion, HLA genotype results indicate that Tunisians are related to present-day North Africans, Berbers and to Iberians, but not to Eastern Arabs (Palestinians, Jordanians and Lebanese). This suggests that the genetic contribution of Arab invasion of 7<sup>th</sup>-11<sup>th</sup> century A.D. had little impact of the North African gene pool.</p></abstract><funding-group><funding-statement>The authors have no support or funding to report.</funding-statement></funding-group><counts><fig-count count="4"></fig-count><table-count count="5"></table-count><page-count count="16"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All data are available in the paper.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All data are available in the paper.</p></notes></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Linguistique/explor/TamazightV2/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000024 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000024 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Linguistique
|area= TamazightV2
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4552629
|texte= HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26317228" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a TamazightV2
| This area was generated with Dilib version V0.6.33. |  |