Light microscopy applications in systems biology: opportunities and challenges
Identifieur interne : 000684 ( Pmc/Curation ); précédent : 000683; suivant : 000685Light microscopy applications in systems biology: opportunities and challenges
Auteurs : Paul Michel Aloyse Antony [Luxembourg (pays)] ; Christophe Trefois [Luxembourg (pays)] ; Aleksandar Stojanovic [Luxembourg (pays)] ; Aidos Sagatovich Baumuratov [Luxembourg (pays)] ; Karol Kozak [Suisse, Allemagne]Source :
- Cell Communication and Signaling : CCS [ 1478-811X ] ; 2013.
Abstract
Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biological scales in living cells. The combination of molecular biology and imaging provides a bottom-up tool for direct insight into how molecular processes work on a cellular scale. However, imaging can also be used as a top-down approach to study the behavior of a system without detailed prior knowledge about its underlying molecular mechanisms. In this review, we highlight the recent developments on microscopy-based systems analyses and discuss the complementary opportunities and different challenges with high-content screening and high-throughput imaging. Furthermore, we provide a comprehensive overview of the available platforms that can be used for image analysis, which enable community-driven efforts in the development of image-based systems biology.
Url:
DOI: 10.1186/1478-811X-11-24
PubMed: 23578051
PubMed Central: 3627909
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Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette</wicri:regionArea></affiliation></author><author><name sortKey="Stojanovic, Aleksandar" sort="Stojanovic, Aleksandar" uniqKey="Stojanovic A" first="Aleksandar" last="Stojanovic">Aleksandar Stojanovic</name><affiliation wicri:level="1"><nlm:aff id="I2">Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg, Luxembourg City, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg, Luxembourg City</wicri:regionArea></affiliation></author><author><name sortKey="Baumuratov, Aidos Sagatovich" sort="Baumuratov, Aidos Sagatovich" uniqKey="Baumuratov A" first="Aidos Sagatovich" last="Baumuratov">Aidos Sagatovich Baumuratov</name><affiliation wicri:level="1"><nlm:aff id="I1">Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette</wicri:regionArea></affiliation></author><author><name sortKey="Kozak, Karol" sort="Kozak, Karol" uniqKey="Kozak K" first="Karol" last="Kozak">Karol Kozak</name><affiliation wicri:level="1"><nlm:aff id="I3">Light Microscopy Centre (LMSC), Institute for Biochemistry, ETH Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Light Microscopy Centre (LMSC), Institute for Biochemistry, ETH Zurich, Zurich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Medical Faculty, Technical University Dresden, Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Faculty, Technical University 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xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette</wicri:regionArea></affiliation></author><author><name sortKey="Trefois, Christophe" sort="Trefois, Christophe" uniqKey="Trefois C" first="Christophe" last="Trefois">Christophe Trefois</name><affiliation wicri:level="1"><nlm:aff id="I1">Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette</wicri:regionArea></affiliation></author><author><name sortKey="Stojanovic, Aleksandar" sort="Stojanovic, Aleksandar" uniqKey="Stojanovic A" first="Aleksandar" last="Stojanovic">Aleksandar Stojanovic</name><affiliation wicri:level="1"><nlm:aff id="I2">Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg, Luxembourg City, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg, Luxembourg City</wicri:regionArea></affiliation></author><author><name sortKey="Baumuratov, Aidos Sagatovich" sort="Baumuratov, Aidos Sagatovich" uniqKey="Baumuratov A" first="Aidos Sagatovich" last="Baumuratov">Aidos Sagatovich Baumuratov</name><affiliation wicri:level="1"><nlm:aff id="I1">Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg</nlm:aff><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette</wicri:regionArea></affiliation></author><author><name sortKey="Kozak, Karol" sort="Kozak, Karol" uniqKey="Kozak K" first="Karol" last="Kozak">Karol Kozak</name><affiliation wicri:level="1"><nlm:aff id="I3">Light Microscopy Centre (LMSC), Institute for Biochemistry, ETH Zurich, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Light Microscopy Centre (LMSC), Institute for Biochemistry, ETH Zurich, Zurich</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Medical Faculty, Technical University Dresden, Dresden, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Medical Faculty, Technical University Dresden, Dresden</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Communication and Signaling : CCS</title><idno type="eISSN">1478-811X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biological scales in living cells. The combination of molecular biology and imaging provides a bottom-up tool for direct insight into how molecular processes work on a cellular scale. However, imaging can also be used as a top-down approach to study the behavior of a system without detailed prior knowledge about its underlying molecular mechanisms. In this review, we highlight the recent developments on microscopy-based systems analyses and discuss the complementary opportunities and different challenges with high-content screening and high-throughput imaging. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Commun Signal</journal-id><journal-id journal-id-type="iso-abbrev">Cell Commun. Signal</journal-id><journal-title-group><journal-title>Cell Communication and Signaling : CCS</journal-title></journal-title-group><issn pub-type="epub">1478-811X</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23578051</article-id><article-id pub-id-type="pmc">3627909</article-id><article-id pub-id-type="publisher-id">1478-811X-11-24</article-id><article-id pub-id-type="doi">10.1186/1478-811X-11-24</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Light microscopy applications in systems biology: opportunities and challenges</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Antony</surname><given-names>Paul Michel Aloyse</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>paul.antony@uni.lu</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Trefois</surname><given-names>Christophe</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>christophe.trefois@uni.lu</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Stojanovic</surname><given-names>Aleksandar</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>aleksandar.stojanovic@uni.lu</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Baumuratov</surname><given-names>Aidos Sagatovich</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>aidos.baumuratov@uni.lu</email></contrib><contrib contrib-type="author" id="A5"><name><surname>Kozak</surname><given-names>Karol</given-names></name><xref ref-type="aff" rid="I3">3</xref><xref ref-type="aff" rid="I4">4</xref><email>karol.kozak@lmc.biol.ethz.ch</email></contrib></contrib-group><aff id="I1"><label>1</label>Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg</aff><aff id="I2"><label>2</label>Interdisciplinary Centre for Security, Reliability and Trust (SnT), University of Luxembourg, Luxembourg City, Luxembourg</aff><aff id="I3"><label>3</label>Light Microscopy Centre (LMSC), Institute for Biochemistry, ETH Zurich, Zurich, Switzerland</aff><aff id="I4"><label>4</label>Medical Faculty, Technical University Dresden, Dresden, Germany</aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>11</day><month>4</month><year>2013</year></pub-date><volume>11</volume><fpage>24</fpage><lpage>24</lpage><history><date date-type="received"><day>26</day><month>2</month><year>2013</year></date><date date-type="accepted"><day>28</day><month>3</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Antony et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Antony et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.biosignaling.com/content/11/1/24"></self-uri><abstract><p>Biological systems present multiple scales of complexity, ranging from molecules to entire populations. Light microscopy is one of the least invasive techniques used to access information from various biological scales in living cells. The combination of molecular biology and imaging provides a bottom-up tool for direct insight into how molecular processes work on a cellular scale. However, imaging can also be used as a top-down approach to study the behavior of a system without detailed prior knowledge about its underlying molecular mechanisms. In this review, we highlight the recent developments on microscopy-based systems analyses and discuss the complementary opportunities and different challenges with high-content screening and high-throughput imaging. Furthermore, we provide a comprehensive overview of the available platforms that can be used for image analysis, which enable community-driven efforts in the development of image-based systems biology.</p></abstract><kwd-group><kwd>Microscopy</kwd><kwd>Systems biology</kwd><kwd>Image analysis</kwd><kwd>Segmentation</kwd><kwd>Features</kwd><kwd>Machine learning</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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