Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates
Identifieur interne : 000057 ( Pmc/Curation ); précédent : 000056; suivant : 000058Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates
Auteurs : Asher Haug-Baltzell [États-Unis] ; Erich D. Jarvis [États-Unis] ; Fiona M. Mccarthy [États-Unis] ; Eric Lyons [États-Unis]Source :
- Frontiers in Neuroscience [ 1662-4548 ] ; 2015.
Abstract
Dopamine is an important central nervous system transmitter that functions through two classes of receptors (D1 and D2) to influence a diverse range of biological processes in vertebrates. With roles in regulating neural activity, behavior, and gene expression, there has been great interest in understanding the function and evolution dopamine and its receptors. In this study, we use a combination of sequence analyses, microsynteny analyses, and phylogenetic relationships to identify and characterize both the D1 (DRD1A, DRD1B, DRD1C, and DRD1E) and D2 (DRD2, DRD3, and DRD4) dopamine receptor gene families in 43 recently sequenced bird genomes representing the major ordinal lineages across the avian family tree. We show that the common ancestor of all birds possessed at least seven D1 and D2 receptors, followed by subsequent independent losses in some lineages of modern birds. Through comparisons with other vertebrate and invertebrate species we show that two of the D1 receptors, DRD1A and DRD1B, and two of the D2 receptors, DRD2 and DRD3, originated from a whole genome duplication event early in the vertebrate lineage, providing the first conclusive evidence of the origin of these highly conserved receptors. Our findings provide insight into the evolutionary development of an important modulatory component of the central nervous system in vertebrates, and will help further unravel the complex evolutionary and functional relationships among dopamine receptors.
Url:
DOI: 10.3389/fnins.2015.00361
PubMed: 26500483
PubMed Central: 4595791
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<front><div type="abstract" xml:lang="en"><p>Dopamine is an important central nervous system transmitter that functions through two classes of receptors (D1 and D2) to influence a diverse range of biological processes in vertebrates. With roles in regulating neural activity, behavior, and gene expression, there has been great interest in understanding the function and evolution dopamine and its receptors. In this study, we use a combination of sequence analyses, microsynteny analyses, and phylogenetic relationships to identify and characterize both the D1 (DRD1A, DRD1B, DRD1C, and DRD1E) and D2 (DRD2, DRD3, and DRD4) dopamine receptor gene families in 43 recently sequenced bird genomes representing the major ordinal lineages across the avian family tree. We show that the common ancestor of all birds possessed at least seven D1 and D2 receptors, followed by subsequent independent losses in some lineages of modern birds. Through comparisons with other vertebrate and invertebrate species we show that two of the D1 receptors, DRD1A and DRD1B, and two of the D2 receptors, DRD2 and DRD3, originated from a whole genome duplication event early in the vertebrate lineage, providing the first conclusive evidence of the origin of these highly conserved receptors. Our findings provide insight into the evolutionary development of an important modulatory component of the central nervous system in vertebrates, and will help further unravel the complex evolutionary and functional relationships among dopamine receptors.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Neurosci</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Neurosci</journal-id>
<journal-id journal-id-type="publisher-id">Front. Neurosci.</journal-id>
<journal-title-group><journal-title>Frontiers in Neuroscience</journal-title>
</journal-title-group>
<issn pub-type="ppub">1662-4548</issn>
<issn pub-type="epub">1662-453X</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26500483</article-id>
<article-id pub-id-type="pmc">4595791</article-id>
<article-id pub-id-type="doi">10.3389/fnins.2015.00361</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Genetics</subject>
<subj-group><subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Identification of dopamine receptors across the extant avian family tree and analysis with other clades uncovers a polyploid expansion among vertebrates</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Haug-Baltzell</surname>
<given-names>Asher</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/259045/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Jarvis</surname>
<given-names>Erich D.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/47482/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>McCarthy</surname>
<given-names>Fiona M.</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/279413/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Lyons</surname>
<given-names>Eric</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/55438/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Arizona Biological/Biomedical Sciences Program, University of Arizona</institution>
<country>Tucson, AZ, USA</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Genetics GIDP, University of Arizona</institution>
<country>Tucson, AZ, USA</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Department of Neurobiology, Duke University Medical Center</institution>
<country>Durham, NC, USA</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Howard Hughes Medical Institute</institution>
<country>Chevy Chase, MD, USA</country>
</aff>
<aff id="aff5"><sup>5</sup>
<institution>School of Animal and Comparative Biomedical Sciences, University of Arizona</institution>
<country>Tucson, AZ, USA</country>
</aff>
<aff id="aff6"><sup>6</sup>
<institution>BIO5 Institute, University of Arizona</institution>
<country>Tucson, AZ, USA</country>
</aff>
<aff id="aff7"><sup>7</sup>
<institution>The School of Plant Sciences, University of Arizona</institution>
<country>Tucson, AZ, USA</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Igor Ponomarev, The University of Texas at Austin, USA</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Philippe Vernier, Centre National de la Recherche Scientifique, France; Carolina Frankl-Vilches, Max Planck Institute for Ornithology, Germany</p>
</fn>
<corresp id="fn001">*Correspondence: Eric Lyons, BIO5 Institute, School of Plant Science, University of Arizona, 1657 E. Helen St. Tucson, AZ 85745, USA <email xlink:type="simple">ericlyons@email.arizona.edu</email>
</corresp>
<fn fn-type="other" id="fn002"><p>This article was submitted to Neurogenomics, a section of the journal Frontiers in Neuroscience</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>07</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>9</volume>
<elocation-id>361</elocation-id>
<history><date date-type="received"><day>26</day>
<month>7</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>21</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 Haug-Baltzell, Jarvis, McCarthy and Lyons.</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>Haug-Baltzell, Jarvis, McCarthy and Lyons</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Dopamine is an important central nervous system transmitter that functions through two classes of receptors (D1 and D2) to influence a diverse range of biological processes in vertebrates. With roles in regulating neural activity, behavior, and gene expression, there has been great interest in understanding the function and evolution dopamine and its receptors. In this study, we use a combination of sequence analyses, microsynteny analyses, and phylogenetic relationships to identify and characterize both the D1 (DRD1A, DRD1B, DRD1C, and DRD1E) and D2 (DRD2, DRD3, and DRD4) dopamine receptor gene families in 43 recently sequenced bird genomes representing the major ordinal lineages across the avian family tree. We show that the common ancestor of all birds possessed at least seven D1 and D2 receptors, followed by subsequent independent losses in some lineages of modern birds. Through comparisons with other vertebrate and invertebrate species we show that two of the D1 receptors, DRD1A and DRD1B, and two of the D2 receptors, DRD2 and DRD3, originated from a whole genome duplication event early in the vertebrate lineage, providing the first conclusive evidence of the origin of these highly conserved receptors. Our findings provide insight into the evolutionary development of an important modulatory component of the central nervous system in vertebrates, and will help further unravel the complex evolutionary and functional relationships among dopamine receptors.</p>
</abstract>
<kwd-group><kwd>dopamine receptors</kwd>
<kwd>comparative genomics</kwd>
<kwd>genome evolution</kwd>
<kwd>polyploidy</kwd>
<kwd>whole genome duplication</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">U.S. Department of Agriculture<named-content content-type="fundref-id">10.13039/100000199</named-content>
</funding-source>
<award-id rid="cn001">GRANT11301623</award-id>
</award-group>
<award-group><funding-source id="cn002">National Science Foundation<named-content content-type="fundref-id">10.13039/100000001</named-content>
</funding-source>
<award-id rid="cn002">IOS – 1339156</award-id>
</award-group>
<award-group><funding-source id="cn003">Gordon and Betty Moore Foundation<named-content content-type="fundref-id">10.13039/100000936</named-content>
</funding-source>
<award-id rid="cn003">3383</award-id>
</award-group>
</funding-group>
<counts><fig-count count="7"></fig-count>
<table-count count="3"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="52"></ref-count>
<page-count count="16"></page-count>
<word-count count="9161"></word-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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