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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments</title><author><name sortKey="Chodera, John D" sort="Chodera, John D" uniqKey="Chodera J" first="John D." last="Chodera">John D. Chodera</name><affiliation><nlm:aff id="A1">California Institute of Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720</nlm:aff></affiliation></author><author><name sortKey="Pande, Vijay S" sort="Pande, Vijay S" uniqKey="Pande V" first="Vijay S." last="Pande">Vijay S. Pande</name><affiliation><nlm:aff id="A2">Department of Chemistry, Stanford University, Stanford, CA 94305</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21929272</idno><idno type="pmc">4731355</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731355</idno><idno type="RBID">PMC:4731355</idno><idno type="doi">10.1103/PhysRevLett.107.098102</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000424</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments</title><author><name sortKey="Chodera, John D" sort="Chodera, John D" uniqKey="Chodera J" first="John D." last="Chodera">John D. Chodera</name><affiliation><nlm:aff id="A1">California Institute of Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720</nlm:aff></affiliation></author><author><name sortKey="Pande, Vijay S" sort="Pande, Vijay S" uniqKey="Pande V" first="Vijay S." last="Pande">Vijay S. Pande</name><affiliation><nlm:aff id="A2">Department of Chemistry, Stanford University, Stanford, CA 94305</nlm:aff></affiliation></author></analytic><series><title level="j">Physical review letters</title><idno type="ISSN">0031-9007</idno><idno type="eISSN">1079-7114</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0401141</journal-id><journal-id journal-id-type="pubmed-jr-id">21217</journal-id><journal-id journal-id-type="nlm-ta">Phys Rev Lett</journal-id><journal-id journal-id-type="iso-abbrev">Phys. Rev. Lett.</journal-id><journal-title-group><journal-title>Physical review letters</journal-title></journal-title-group><issn pub-type="ppub">0031-9007</issn><issn pub-type="epub">1079-7114</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21929272</article-id><article-id pub-id-type="pmc">4731355</article-id><article-id pub-id-type="doi">10.1103/PhysRevLett.107.098102</article-id><article-id pub-id-type="manuscript">NIHMS752756</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Splitting probabilities as a test of reaction coordinate choice in single-molecule experiments</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chodera</surname><given-names>John D.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="CR2">*</xref></contrib><contrib contrib-type="author"><name><surname>Pande</surname><given-names>Vijay S.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="CR1">†</xref></contrib></contrib-group><aff id="A1"><label>1</label>California Institute of Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720</aff><aff id="A2"><label>2</label>Department of Chemistry, Stanford University, Stanford, CA 94305</aff><author-notes><corresp id="CR1"><label>†</label> Corresponding author; <email>pande@stanford.edu</email></corresp><corresp id="CR2"><label>*</label><email>jchodera@berkeley.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>1</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>23</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="ppub"><day>26</day><month>8</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>29</day><month>1</month><year>2016</year></pub-date><volume>107</volume><issue>9</issue><fpage>098102</fpage><lpage>098102</lpage><pmc-comment>elocation-id from pubmed: 10.1103/PhysRevLett.107.098102</pmc-comment>
<abstract><p id="P1">To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed reaction coordinate. Comparison of the observed splitting probability with that computed from the kinetic model provides a simple test to reject poor reaction coordinates. We demonstrate this test for a force spectroscopy measurement of a DNA hairpin.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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