Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model1[C][W][OPEN]
Identifieur interne : 000385 ( Pmc/Corpus ); précédent : 000384; suivant : 000386Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model1[C][W][OPEN]
Auteurs : Margaret Simons ; Rajib Saha ; Nardjis Amiour ; Akhil Kumar ; Lenaïg Guillard ; Gilles Clément ; Martine Miquel ; Zhenni Li ; Gregory Mouille ; Peter J. Lea ; Bertrand Hirel ; Costas D. MaranasSource :
- Plant Physiology [ 0032-0889 ] ; 2014.
Abstract
Url:
DOI: 10.1104/pp.114.245787
PubMed: 25248718
PubMed Central: 4226342
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model<xref ref-type="fn" rid="fn1"><sup>1</sup>
</xref>
<xref ref-type="fn" rid="fn2"><sup>[C]</sup>
</xref>
<xref ref-type="fn" rid="fn3"><sup>[W]</sup>
</xref>
<xref ref-type="fn" rid="fn4"><sup>[OPEN]</sup>
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<author><name sortKey="Simons, Margaret" sort="Simons, Margaret" uniqKey="Simons M" first="Margaret" last="Simons">Margaret Simons</name>
</author>
<author><name sortKey="Saha, Rajib" sort="Saha, Rajib" uniqKey="Saha R" first="Rajib" last="Saha">Rajib Saha</name>
</author>
<author><name sortKey="Amiour, Nardjis" sort="Amiour, Nardjis" uniqKey="Amiour N" first="Nardjis" last="Amiour">Nardjis Amiour</name>
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<author><name sortKey="Kumar, Akhil" sort="Kumar, Akhil" uniqKey="Kumar A" first="Akhil" last="Kumar">Akhil Kumar</name>
</author>
<author><name sortKey="Guillard, Lenaig" sort="Guillard, Lenaig" uniqKey="Guillard L" first="Lenaïg" last="Guillard">Lenaïg Guillard</name>
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<author><name sortKey="Clement, Gilles" sort="Clement, Gilles" uniqKey="Clement G" first="Gilles" last="Clément">Gilles Clément</name>
</author>
<author><name sortKey="Miquel, Martine" sort="Miquel, Martine" uniqKey="Miquel M" first="Martine" last="Miquel">Martine Miquel</name>
</author>
<author><name sortKey="Li, Zhenni" sort="Li, Zhenni" uniqKey="Li Z" first="Zhenni" last="Li">Zhenni Li</name>
</author>
<author><name sortKey="Mouille, Gregory" sort="Mouille, Gregory" uniqKey="Mouille G" first="Gregory" last="Mouille">Gregory Mouille</name>
</author>
<author><name sortKey="Lea, Peter J" sort="Lea, Peter J" uniqKey="Lea P" first="Peter J." last="Lea">Peter J. Lea</name>
</author>
<author><name sortKey="Hirel, Bertrand" sort="Hirel, Bertrand" uniqKey="Hirel B" first="Bertrand" last="Hirel">Bertrand Hirel</name>
</author>
<author><name sortKey="Maranas, Costas D" sort="Maranas, Costas D" uniqKey="Maranas C" first="Costas D." last="Maranas">Costas D. Maranas</name>
</author>
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<idno type="pmid">25248718</idno>
<idno type="pmc">4226342</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226342</idno>
<idno type="RBID">PMC:4226342</idno>
<idno type="doi">10.1104/pp.114.245787</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000385</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model<xref ref-type="fn" rid="fn1"><sup>1</sup>
</xref>
<xref ref-type="fn" rid="fn2"><sup>[C]</sup>
</xref>
<xref ref-type="fn" rid="fn3"><sup>[W]</sup>
</xref>
<xref ref-type="fn" rid="fn4"><sup>[OPEN]</sup>
</xref>
</title>
<author><name sortKey="Simons, Margaret" sort="Simons, Margaret" uniqKey="Simons M" first="Margaret" last="Simons">Margaret Simons</name>
</author>
<author><name sortKey="Saha, Rajib" sort="Saha, Rajib" uniqKey="Saha R" first="Rajib" last="Saha">Rajib Saha</name>
</author>
<author><name sortKey="Amiour, Nardjis" sort="Amiour, Nardjis" uniqKey="Amiour N" first="Nardjis" last="Amiour">Nardjis Amiour</name>
</author>
<author><name sortKey="Kumar, Akhil" sort="Kumar, Akhil" uniqKey="Kumar A" first="Akhil" last="Kumar">Akhil Kumar</name>
</author>
<author><name sortKey="Guillard, Lenaig" sort="Guillard, Lenaig" uniqKey="Guillard L" first="Lenaïg" last="Guillard">Lenaïg Guillard</name>
</author>
<author><name sortKey="Clement, Gilles" sort="Clement, Gilles" uniqKey="Clement G" first="Gilles" last="Clément">Gilles Clément</name>
</author>
<author><name sortKey="Miquel, Martine" sort="Miquel, Martine" uniqKey="Miquel M" first="Martine" last="Miquel">Martine Miquel</name>
</author>
<author><name sortKey="Li, Zhenni" sort="Li, Zhenni" uniqKey="Li Z" first="Zhenni" last="Li">Zhenni Li</name>
</author>
<author><name sortKey="Mouille, Gregory" sort="Mouille, Gregory" uniqKey="Mouille G" first="Gregory" last="Mouille">Gregory Mouille</name>
</author>
<author><name sortKey="Lea, Peter J" sort="Lea, Peter J" uniqKey="Lea P" first="Peter J." last="Lea">Peter J. Lea</name>
</author>
<author><name sortKey="Hirel, Bertrand" sort="Hirel, Bertrand" uniqKey="Hirel B" first="Bertrand" last="Hirel">Bertrand Hirel</name>
</author>
<author><name sortKey="Maranas, Costas D" sort="Maranas, Costas D" uniqKey="Maranas C" first="Costas D." last="Maranas">Costas D. Maranas</name>
</author>
</analytic>
<series><title level="j">Plant Physiology</title>
<idno type="ISSN">0032-0889</idno>
<idno type="eISSN">1532-2548</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p><italic>A cell type- and leaf tissue-specific model provides new insights into nitrogen metabolism in the maize leaf</italic>
.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Plant Physiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Plant Physiol</journal-id>
<journal-id journal-id-type="hwp">plantphysiol</journal-id>
<journal-id journal-id-type="publisher-id">aspb</journal-id>
<journal-title-group><journal-title>Plant Physiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0032-0889</issn>
<issn pub-type="epub">1532-2548</issn>
<publisher><publisher-name>American Society of Plant Biologists</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25248718</article-id>
<article-id pub-id-type="pmc">4226342</article-id>
<article-id pub-id-type="publisher-id">245787</article-id>
<article-id pub-id-type="doi">10.1104/pp.114.245787</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
<subj-group subj-group-type="heading"><subject>Systems and Synthetic Biology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Assessing the Metabolic Impact of Nitrogen Availability Using a Compartmentalized Maize Leaf Genome-Scale Model<xref ref-type="fn" rid="fn1"><sup>1</sup>
</xref>
<xref ref-type="fn" rid="fn2"><sup>[C]</sup>
</xref>
<xref ref-type="fn" rid="fn3"><sup>[W]</sup>
</xref>
<xref ref-type="fn" rid="fn4"><sup>[OPEN]</sup>
</xref>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Simons</surname>
<given-names>Margaret</given-names>
</name>
<xref ref-type="author-notes" rid="afn1"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saha</surname>
<given-names>Rajib</given-names>
</name>
<xref ref-type="author-notes" rid="afn1"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Amiour</surname>
<given-names>Nardjis</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Kumar</surname>
<given-names>Akhil</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Guillard</surname>
<given-names>Lenaïg</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Clément</surname>
<given-names>Gilles</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Miquel</surname>
<given-names>Martine</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Zhenni</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Mouille</surname>
<given-names>Gregory</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Lea</surname>
<given-names>Peter J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Hirel</surname>
<given-names>Bertrand</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Maranas</surname>
<given-names>Costas D.</given-names>
</name>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="aff1">Departments of Chemical Engineering (M.S., R.S., C.D.M.) and Bioinformatics and Genomics, Huck Institutes of the Life Sciences (A.K.), Pennsylvania State University, University Park, Pennsylvania 16802;</aff>
<aff id="aff2">Institut Jean-Pierre Bourgin, Institut National de la Recherche Agronomique, Centre de Versailles-Grignon, Unité Mixte de Recherche 1318 Institut National de la Recherche Agronomique-Agro-ParisTech, Equipe de Recherce Labellisée, Centre National de la Recherche Scientifique 3559, F–78026 Versailles cedex, France (N.A., L.G., G.C., M.M., Z.L., G.M., B.H.); and</aff>
<aff id="aff3">Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, United Kingdom (P.J.L.)</aff>
</contrib-group>
<author-notes><fn><p><ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org/cgi/doi/10.1104/pp.114.245787">www.plantphysiol.org/cgi/doi/10.1104/pp.114.245787</ext-link>
</p>
</fn>
<fn id="afn1" fn-type="equal"><label>2</label>
<p>These authors contributed equally to the article.</p>
</fn>
<corresp id="cor1"><label>*</label>
Address correspondence to <email>costas@psu.edu</email>
.</corresp>
<fn id="afn2"><p>The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (<ext-link ext-link-type="uri" xlink:href="http://www.plantphysiol.org">www.plantphysiol.org</ext-link>
) is: Costas D. Maranas (<email>costas@psu.edu</email>
).</p>
</fn>
</author-notes>
<pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>9</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>9</month>
<year>2014</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>166</volume>
<issue>3</issue>
<fpage>1659</fpage>
<lpage>1674</lpage>
<history><date date-type="received"><day>25</day>
<month>6</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>19</day>
<month>9</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 American Society of Plant Biologists. All Rights Reserved.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<self-uri xlink:role="icon" xlink:type="simple" xlink:href="PP_245787_ic1.gif"></self-uri>
<self-uri content-type="alt-lang-pdf zh" xlink:type="simple" xlink:href="1659.chinese.pdf"></self-uri>
<abstract abstract-type="precis"><p><italic>A cell type- and leaf tissue-specific model provides new insights into nitrogen metabolism in the maize leaf</italic>
.</p>
</abstract>
<abstract><p>Maize (<italic>Zea mays</italic>
) is an important C<sub>4</sub>
plant due to its widespread use as a cereal and energy crop. A second-generation genome-scale metabolic model for the maize leaf was created to capture C<sub>4</sub>
carbon fixation and investigate nitrogen (<xref ref-type="def" rid="def4">N</xref>
) assimilation by modeling the interactions between the bundle sheath and mesophyll cells. The model contains gene-protein-reaction relationships, elemental and charge-balanced reactions, and incorporates experimental evidence pertaining to the biomass composition, compartmentalization, and flux constraints. Condition-specific biomass descriptions were introduced that account for amino acids, fatty acids, soluble sugars, proteins, chlorophyll, lignocellulose, and nucleic acids as experimentally measured biomass constituents. Compartmentalization of the model is based on proteomic/transcriptomic data and literature evidence. With the incorporation of information from the MetaCrop and MaizeCyc databases, this updated model spans 5,824 genes, 8,525 reactions, and 9,153 metabolites, an increase of approximately 4 times the size of the earlier <italic>i</italic>
RS1563 model. Transcriptomic and proteomic data have also been used to introduce regulatory constraints in the model to simulate an <xref ref-type="def" rid="def4">N</xref>
-limited condition and mutants deficient in glutamine synthetase, <italic>gln1-3</italic>
and <italic>gln1-4</italic>
. Model-predicted results achieved 90% accuracy when comparing the wild type grown under an <xref ref-type="def" rid="def4">N</xref>
-complete condition with the wild type grown under an <xref ref-type="def" rid="def4">N</xref>
-deficient condition.</p>
</abstract>
<counts><page-count count="16"></page-count>
</counts>
</article-meta>
<notes><glossary><title>Glossary</title>
<def-list><def-item><term id="term1">GSM</term>
<def id="def1"><p>genome-scale metabolic model</p>
</def>
</def-item>
<def-item><term id="term2">N<sup>+</sup>
WT</term>
<def id="def2"><p>wild-type plants grown under optimal nitrogen conditions</p>
</def>
</def-item>
<def-item><term id="term3">N<sup>−</sup>
WT</term>
<def id="def3"><p>wild-type plants grown under limited nitrogen conditions</p>
</def>
</def-item>
<def-item><term id="term4">N</term>
<def id="def4"><p>nitrogen</p>
</def>
</def-item>
<def-item><term id="term5">NUE</term>
<def id="def5"><p>nitrogen use efficiency</p>
</def>
</def-item>
<def-item><term id="term6">FBA</term>
<def id="def6"><p>flux balance analysis</p>
</def>
</def-item>
<def-item><term id="term7">GPR</term>
<def id="def7"><p>gene-protein-reaction</p>
</def>
</def-item>
<def-item><term id="term8">qRT</term>
<def id="def8"><p>quantitative real-time</p>
</def>
</def-item>
<def-item><term id="term9">ACN</term>
<def id="def9"><p>acetonitrile</p>
</def>
</def-item>
<def-item><term id="term10">RPKM</term>
<def id="def10"><p>reads per kilobase per million mapped reads</p>
</def>
</def-item>
<def-item><term id="term11">adjSPC</term>
<def id="def11"><p>adjusted spectral count</p>
</def>
</def-item>
</def-list>
</glossary>
</notes>
</front>
</pmc>
</record>
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