Knowledge sharing and collaboration in translational research, and the DC-THERA Directory
Identifieur interne : 000500 ( Pmc/Checkpoint ); précédent : 000499; suivant : 000501Knowledge sharing and collaboration in translational research, and the DC-THERA Directory
Auteurs : Andrea Splendiani ; Michaela Gündel ; Jonathan M. Austyn ; Duccio Cavalieri ; Ciro Scognamiglio ; Marco BrandiziSource :
- Briefings in Bioinformatics [ 1467-5463 ] ; 2011.
Abstract
Biomedical research relies increasingly on large collections of data sets and knowledge whose generation, representation and analysis often require large collaborative and interdisciplinary efforts. This dimension of ‘big data’ research calls for the development of computational tools to manage such a vast amount of data, as well as tools that can improve communication and access to information from collaborating researchers and from the wider community. Whenever research projects have a defined temporal scope, an additional issue of data management arises, namely how the knowledge generated within the project can be made available beyond its boundaries and life-time. DC-THERA is a European ‘Network of Excellence’ (NoE) that spawned a very large collaborative and interdisciplinary research community, focusing on the development of novel immunotherapies derived from fundamental research in dendritic cell immunobiology. In this article we introduce the DC-THERA Directory, which is an information system designed to support knowledge management for this research community and beyond. We present how the use of metadata and Semantic Web technologies can effectively help to organize the knowledge generated by modern collaborative research, how these technologies can enable effective data management solutions during and beyond the project lifecycle, and how resources such as the DC-THERA Directory fit into the larger context of e-science.
Url:
DOI: 10.1093/bib/bbr051
PubMed: 21969471
PubMed Central: 3220873
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Knowledge sharing and collaboration in translational research, and the DC-THERA Directory</title><author><name sortKey="Splendiani, Andrea" sort="Splendiani, Andrea" uniqKey="Splendiani A" first="Andrea" last="Splendiani">Andrea Splendiani</name></author><author><name sortKey="Gundel, Michaela" sort="Gundel, Michaela" uniqKey="Gundel M" first="Michaela" last="Gündel">Michaela Gündel</name></author><author><name sortKey="Austyn, Jonathan M" sort="Austyn, Jonathan M" uniqKey="Austyn J" first="Jonathan M." last="Austyn">Jonathan M. Austyn</name></author><author><name sortKey="Cavalieri, Duccio" sort="Cavalieri, Duccio" uniqKey="Cavalieri D" first="Duccio" last="Cavalieri">Duccio Cavalieri</name></author><author><name sortKey="Scognamiglio, Ciro" sort="Scognamiglio, Ciro" uniqKey="Scognamiglio C" first="Ciro" last="Scognamiglio">Ciro Scognamiglio</name></author><author><name sortKey="Brandizi, Marco" sort="Brandizi, Marco" uniqKey="Brandizi M" first="Marco" last="Brandizi">Marco Brandizi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21969471</idno><idno type="pmc">3220873</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220873</idno><idno type="RBID">PMC:3220873</idno><idno type="doi">10.1093/bib/bbr051</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000511</idno><idno type="wicri:Area/Pmc/Curation">000511</idno><idno type="wicri:Area/Pmc/Checkpoint">000500</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Knowledge sharing and collaboration in translational research, and the DC-THERA Directory</title><author><name sortKey="Splendiani, Andrea" sort="Splendiani, Andrea" uniqKey="Splendiani A" first="Andrea" last="Splendiani">Andrea Splendiani</name></author><author><name sortKey="Gundel, Michaela" sort="Gundel, Michaela" uniqKey="Gundel M" first="Michaela" last="Gündel">Michaela Gündel</name></author><author><name sortKey="Austyn, Jonathan M" sort="Austyn, Jonathan M" uniqKey="Austyn J" first="Jonathan M." last="Austyn">Jonathan M. Austyn</name></author><author><name sortKey="Cavalieri, Duccio" sort="Cavalieri, Duccio" uniqKey="Cavalieri D" first="Duccio" last="Cavalieri">Duccio Cavalieri</name></author><author><name sortKey="Scognamiglio, Ciro" sort="Scognamiglio, Ciro" uniqKey="Scognamiglio C" first="Ciro" last="Scognamiglio">Ciro Scognamiglio</name></author><author><name sortKey="Brandizi, Marco" sort="Brandizi, Marco" uniqKey="Brandizi M" first="Marco" last="Brandizi">Marco Brandizi</name></author></analytic><series><title level="j">Briefings in Bioinformatics</title><idno type="ISSN">1467-5463</idno><idno type="eISSN">1477-4054</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Biomedical research relies increasingly on large collections of data sets and knowledge whose generation, representation and analysis often require large collaborative and interdisciplinary efforts. This dimension of ‘big data’ research calls for the development of computational tools to manage such a vast amount of data, as well as tools that can improve communication and access to information from collaborating researchers and from the wider community. Whenever research projects have a defined temporal scope, an additional issue of data management arises, namely how the knowledge generated within the project can be made available beyond its boundaries and life-time. DC-THERA is a European ‘Network of Excellence’ (NoE) that spawned a very large collaborative and interdisciplinary research community, focusing on the development of novel immunotherapies derived from fundamental research in dendritic cell immunobiology. In this article we introduce the DC-THERA Directory, which is an information system designed to support knowledge management for this research community and beyond. We present how the use of metadata and Semantic Web technologies can effectively help to organize the knowledge generated by modern collaborative research, how these technologies can enable effective data management solutions during and beyond the project lifecycle, and how resources such as the DC-THERA Directory fit into the larger context of e-science.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Szalay, A" uniqKey="Szalay A">A Szalay</name></author><author><name sortKey="Gray, J" uniqKey="Gray J">J Gray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antezana, E" uniqKey="Antezana E">E Antezana</name></author><author><name sortKey="Kuiper, M" uniqKey="Kuiper M">M Kuiper</name></author><author><name sortKey="Mironov, V" uniqKey="Mironov V">V Mironov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rebholz Schuhmann, D" uniqKey="Rebholz Schuhmann D">D 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Brief Bioinform</journal-id><journal-id journal-id-type="publisher-id">bib</journal-id><journal-id journal-id-type="hwp">bib</journal-id><journal-title-group><journal-title>Briefings in Bioinformatics</journal-title></journal-title-group><issn pub-type="ppub">1467-5463</issn><issn pub-type="epub">1477-4054</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21969471</article-id><article-id pub-id-type="pmc">3220873</article-id><article-id pub-id-type="doi">10.1093/bib/bbr051</article-id><article-id pub-id-type="publisher-id">bbr051</article-id><article-categories><subj-group subj-group-type="heading"><subject>Special Issue Papers</subject></subj-group></article-categories><title-group><article-title>Knowledge sharing and collaboration in translational research, and the DC-THERA Directory</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Splendiani</surname><given-names>Andrea</given-names></name><bio><p><bold>Andrea Splendiani</bold> is a Founder of IntelliLeaf ltd and a Senior Bioinformatic Scientist at Rothamsted Research. His research interests are in Semantic Web technologies, biomedical ontologies and Systems Biology.</p></bio></contrib><contrib contrib-type="author"><name><surname>Gündel</surname><given-names>Michaela</given-names></name><bio><p><bold>Michaela Gündel</bold> holds an MSc degree in Life Science Informatics. Her main research interest lies in semantic knowledge management, ontology development and their application to the life sciences.</p></bio></contrib><contrib contrib-type="author"><name><surname>Austyn</surname><given-names>Jonathan M.</given-names></name><bio><p><bold>Jonathan M. Austyn</bold> is Professor of Immunobiology at the University of Oxford and Project Coordinator for the DC-THERA Network. His research interests are the immunobiology and therapeutic applications of dendritic cells.</p></bio></contrib><contrib contrib-type="author"><name><surname>Cavalieri</surname><given-names>Duccio</given-names></name><bio><p><bold>Duccio Cavalieri</bold> is Professor at the Faculty of Pharmacy, University of Florence, applies computational biology to the investigation of the signaling networks of the dendritic cells through pathway analysis of functional genomics data sets.</p></bio></contrib><contrib contrib-type="author"><name><surname>Scognamiglio</surname><given-names>Ciro</given-names></name><bio><p><bold>Ciro Scognamiglio</bold> is a Freelance Web Professional based in Paris. His main expertise is in Software Development and Unix System Administration.</p></bio></contrib><contrib contrib-type="author"><name><surname>Brandizi</surname><given-names>Marco</given-names></name><bio><p><bold>Marco Brandizi</bold> is a Founder of IntelliLeaf Ltd and a software engineer at the European Bioinformatics Institute, where he works on the management of microarray data and other multi-omics data.</p></bio></contrib></contrib-group><author-notes><corresp>Corresponding authors. Dr Andrea Splendiani, IntelliLeaf Ltd, Cambridge CB1 3UF, UK. Tel.: <phone>+44 (0) 1223 853544</phone>; Fax +39 02 42108159; E-mail: <email>andrea@leafbioscience.com</email> and Duccio Cavalieri, Dipartimento di Farmacologia, Università di Firenze, Viale Pieraccini 6, 50139, Firenze, Italia Tel: +39.055.4271327; Fax: +39.055.4271280; Email: <email>duccio.cavalieri@unifi.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>11</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>3</day><month>10</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>3</day><month>10</month><year>2011</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>12</volume><issue>6</issue><issue-title>Special Issue: Collaborative Bioinformatics and RNA Analysis</issue-title><fpage>562</fpage><lpage>575</lpage><history><date date-type="received"><day>13</day><month>5</month><year>2011</year></date><date date-type="rev-recd"><day>2</day><month>8</month><year>2011</year></date></history><permissions><copyright-statement>© The Author(s) 2011. Published by Oxford University Press.</copyright-statement><copyright-year>2011</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/3.0"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0">http://creativecommons.org/licenses/by-nc/3.0</ext-link>), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Biomedical research relies increasingly on large collections of data sets and knowledge whose generation, representation and analysis often require large collaborative and interdisciplinary efforts. This dimension of ‘big data’ research calls for the development of computational tools to manage such a vast amount of data, as well as tools that can improve communication and access to information from collaborating researchers and from the wider community. Whenever research projects have a defined temporal scope, an additional issue of data management arises, namely how the knowledge generated within the project can be made available beyond its boundaries and life-time. DC-THERA is a European ‘Network of Excellence’ (NoE) that spawned a very large collaborative and interdisciplinary research community, focusing on the development of novel immunotherapies derived from fundamental research in dendritic cell immunobiology. In this article we introduce the DC-THERA Directory, which is an information system designed to support knowledge management for this research community and beyond. We present how the use of metadata and Semantic Web technologies can effectively help to organize the knowledge generated by modern collaborative research, how these technologies can enable effective data management solutions during and beyond the project lifecycle, and how resources such as the DC-THERA Directory fit into the larger context of e-science.</p></abstract><kwd-group><kwd>semantic web</kwd><kwd>ontology</kwd><kwd>immunology</kwd><kwd>eScience</kwd><kwd>data integration</kwd></kwd-group><counts><page-count count="14"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Austyn, Jonathan M" sort="Austyn, Jonathan M" uniqKey="Austyn J" first="Jonathan M." last="Austyn">Jonathan M. Austyn</name><name sortKey="Brandizi, Marco" sort="Brandizi, Marco" uniqKey="Brandizi M" first="Marco" last="Brandizi">Marco Brandizi</name><name sortKey="Cavalieri, Duccio" sort="Cavalieri, Duccio" uniqKey="Cavalieri D" first="Duccio" last="Cavalieri">Duccio Cavalieri</name><name sortKey="Gundel, Michaela" sort="Gundel, Michaela" uniqKey="Gundel M" first="Michaela" last="Gündel">Michaela Gündel</name><name sortKey="Scognamiglio, Ciro" sort="Scognamiglio, Ciro" uniqKey="Scognamiglio C" first="Ciro" last="Scognamiglio">Ciro Scognamiglio</name><name sortKey="Splendiani, Andrea" sort="Splendiani, Andrea" uniqKey="Splendiani A" first="Andrea" last="Splendiani">Andrea Splendiani</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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