Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds
Identifieur interne : 000204 ( Pmc/Checkpoint ); précédent : 000203; suivant : 000205Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds
Auteurs : Javier Rocha-Martin ; Catriona Harrington ; Alan D. W. Dobson [Irlande (pays)] ; Fergal O Ara [Irlande (pays), Australie]Source :
- Marine Drugs [ 1660-3397 ] ; 2014.
Abstract
Marine microorganisms continue to be a source of structurally and biologically novel compounds with potential use in the biotechnology industry. The unique physiochemical properties of the marine environment (such as pH, pressure, temperature, osmolarity) and uncommon functional groups (such as isonitrile, dichloroimine, isocyanate, and halogenated functional groups) are frequently found in marine metabolites. These facts have resulted in the production of bioactive substances with different properties than those found in terrestrial habitats. In fact, the marine environment contains a relatively untapped reservoir of bioactivity. Recent advances in genomics, metagenomics, proteomics, combinatorial biosynthesis, synthetic biology, screening methods, expression systems, bioinformatics, and the ever increasing availability of sequenced genomes provides us with more opportunities than ever in the discovery of novel bioactive compounds and biocatalysts. The combination of these advanced techniques with traditional techniques, together with the use of dereplication strategies to eliminate known compounds, provides a powerful tool in the discovery of novel marine bioactive compounds. This review outlines and discusses the emerging strategies for the biodiscovery of these bioactive compounds.
Url:
DOI: 10.3390/md12063516
PubMed: 24918453
PubMed Central: 4071589
Affiliations:
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PMC:4071589Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Marine microorganisms continue to be a source of structurally and biologically novel compounds with potential use in the biotechnology industry. The unique physiochemical properties of the marine environment (such as pH, pressure, temperature, osmolarity) and uncommon functional groups (such as isonitrile, dichloroimine, isocyanate, and halogenated functional groups) are frequently found in marine metabolites. These facts have resulted in the production of bioactive substances with different properties than those found in terrestrial habitats. In fact, the marine environment contains a relatively untapped reservoir of bioactivity. Recent advances in genomics, metagenomics, proteomics, combinatorial biosynthesis, synthetic biology, screening methods, expression systems, bioinformatics, and the ever increasing availability of sequenced genomes provides us with more opportunities than ever in the discovery of novel bioactive compounds and biocatalysts. The combination of these advanced techniques with traditional techniques, together with the use of dereplication strategies to eliminate known compounds, provides a powerful tool in the discovery of novel marine bioactive compounds. This review outlines and discusses the emerging strategies for the biodiscovery of these bioactive compounds.</p>
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<author><name sortKey="Pagnocca, F C" uniqKey="Pagnocca F">F.C. Pagnocca</name>
</author>
<author><name sortKey="Sette, L D" uniqKey="Sette L">L.D. Sette</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carr, P A" uniqKey="Carr P">P.A. Carr</name>
</author>
<author><name sortKey="Wang, H H" uniqKey="Wang H">H.H. Wang</name>
</author>
<author><name sortKey="Sterling, B" uniqKey="Sterling B">B. Sterling</name>
</author>
<author><name sortKey="Isaacs, F J" uniqKey="Isaacs F">F.J. Isaacs</name>
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<author><name sortKey="Lajoie, M J" uniqKey="Lajoie M">M.J. Lajoie</name>
</author>
<author><name sortKey="Xu, G" uniqKey="Xu G">G. Xu</name>
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<author><name sortKey="Church, G M" uniqKey="Church G">G.M. Church</name>
</author>
<author><name sortKey="Jacobson, J M" uniqKey="Jacobson J">J.M. Jacobson</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id>
<journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id>
<journal-id journal-id-type="publisher-id">marinedrugs</journal-id>
<journal-title-group><journal-title>Marine Drugs</journal-title>
</journal-title-group>
<issn pub-type="epub">1660-3397</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24918453</article-id>
<article-id pub-id-type="pmc">4071589</article-id>
<article-id pub-id-type="doi">10.3390/md12063516</article-id>
<article-id pub-id-type="publisher-id">marinedrugs-12-03516</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Emerging Strategies and Integrated Systems Microbiology Technologies for Biodiscovery of Marine Bioactive Compounds</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rocha-Martin</surname>
<given-names>Javier</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-12-03516">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Harrington</surname>
<given-names>Catriona</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-12-03516">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dobson</surname>
<given-names>Alan D.W.</given-names>
</name>
<xref ref-type="aff" rid="af2-marinedrugs-12-03516">2</xref>
<xref ref-type="aff" rid="af3-marinedrugs-12-03516">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>O’Gara</surname>
<given-names>Fergal</given-names>
</name>
<xref ref-type="aff" rid="af1-marinedrugs-12-03516">1</xref>
<xref ref-type="aff" rid="af2-marinedrugs-12-03516">2</xref>
<xref ref-type="aff" rid="af3-marinedrugs-12-03516">3</xref>
<xref ref-type="aff" rid="af4-marinedrugs-12-03516">4</xref>
<xref rid="c1-marinedrugs-12-03516" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-marinedrugs-12-03516"><label>1</label>
BIOMERIT Research Centre, School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland; E-Mails:<email>jrocha@ucc.ie</email>
(J.R.-M.);<email>catriona.harrington@ucc.ie</email>
(C.H.)</aff>
<aff id="af2-marinedrugs-12-03516"><label>2</label>
School of Microbiology, University College Cork, National University of Ireland, Cork, Ireland; E-Mail:<email>a.dobson@ucc.ie</email>
</aff>
<aff id="af3-marinedrugs-12-03516"><label>3</label>
Marine Biotechnology Centre, Environmental Research Institute, University College Cork, National University of Ireland, Cork, Ireland</aff>
<aff id="af4-marinedrugs-12-03516"><label>4</label>
School of Biomedical Sciences, Curtin University, Perth, WA 6102, Australia</aff>
<author-notes><corresp id="c1-marinedrugs-12-03516"><label>*</label>
Author to whom correspondence should be addressed; E-Mail: <email>f.ogara@ucc.ie</email>
; Tel.: +353-21-490-2646; Fax: +353-21-427-5934.</corresp>
</author-notes>
<pub-date pub-type="epub"><day>10</day>
<month>6</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><month>6</month>
<year>2014</year>
</pub-date>
<volume>12</volume>
<issue>6</issue>
<fpage>3516</fpage>
<lpage>3559</lpage>
<history><date date-type="received"><day>08</day>
<month>4</month>
<year>2014</year>
</date>
<date date-type="rev-recd"><day>21</day>
<month>5</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>22</day>
<month>5</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© 2014 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement>
<copyright-year>2014</copyright-year>
<license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>Marine microorganisms continue to be a source of structurally and biologically novel compounds with potential use in the biotechnology industry. The unique physiochemical properties of the marine environment (such as pH, pressure, temperature, osmolarity) and uncommon functional groups (such as isonitrile, dichloroimine, isocyanate, and halogenated functional groups) are frequently found in marine metabolites. These facts have resulted in the production of bioactive substances with different properties than those found in terrestrial habitats. In fact, the marine environment contains a relatively untapped reservoir of bioactivity. Recent advances in genomics, metagenomics, proteomics, combinatorial biosynthesis, synthetic biology, screening methods, expression systems, bioinformatics, and the ever increasing availability of sequenced genomes provides us with more opportunities than ever in the discovery of novel bioactive compounds and biocatalysts. The combination of these advanced techniques with traditional techniques, together with the use of dereplication strategies to eliminate known compounds, provides a powerful tool in the discovery of novel marine bioactive compounds. This review outlines and discusses the emerging strategies for the biodiscovery of these bioactive compounds.</p>
</abstract>
<kwd-group><kwd>marine bioactive compounds</kwd>
<kwd>metagenomics</kwd>
<kwd>synthetic biology</kwd>
<kwd>biocatalyst discovery</kwd>
<kwd>metaproteomic</kwd>
<kwd>dereplication</kwd>
<kwd>omic approaches</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>Irlande (pays)</li>
</country>
</list>
<tree><noCountry><name sortKey="Harrington, Catriona" sort="Harrington, Catriona" uniqKey="Harrington C" first="Catriona" last="Harrington">Catriona Harrington</name>
<name sortKey="Rocha Martin, Javier" sort="Rocha Martin, Javier" uniqKey="Rocha Martin J" first="Javier" last="Rocha-Martin">Javier Rocha-Martin</name>
</noCountry>
<country name="Irlande (pays)"><noRegion><name sortKey="Dobson, Alan D W" sort="Dobson, Alan D W" uniqKey="Dobson A" first="Alan D. W." last="Dobson">Alan D. W. Dobson</name>
</noRegion>
<name sortKey="O Ara, Fergal" sort="O Ara, Fergal" uniqKey="O Ara F" first="Fergal" last="O Ara">Fergal O Ara</name>
</country>
<country name="Australie"><noRegion><name sortKey="O Ara, Fergal" sort="O Ara, Fergal" uniqKey="O Ara F" first="Fergal" last="O Ara">Fergal O Ara</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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