The role of biofilms as environmental reservoirs of antibiotic resistance
Identifieur interne : 000056 ( Pmc/Checkpoint ); précédent : 000055; suivant : 000057The role of biofilms as environmental reservoirs of antibiotic resistance
Auteurs : José L. Balcázar [Espagne] ; Jéssica Subirats [Espagne] ; Carles M. Borrego [Espagne]Source :
- Frontiers in Microbiology [ 1664-302X ] ; 2015.
Abstract
Antibiotic resistance has become a significant and growing threat to public and environmental health. To face this problem both at local and global scales, a better understanding of the sources and mechanisms that contribute to the emergence and spread of antibiotic resistance is required. Recent studies demonstrate that aquatic ecosystems are reservoirs of resistant bacteria and antibiotic resistance genes as well as potential conduits for their transmission to human pathogens. Despite the wealth of information about antibiotic pollution and its effect on the aquatic microbial resistome, the contribution of environmental biofilms to the acquisition and spread of antibiotic resistance has not been fully explored in aquatic systems. Biofilms are structured multicellular communities embedded in a self-produced extracellular matrix that acts as a barrier to antibiotic diffusion. High population densities and proximity of cells in biofilms also increases the chances for genetic exchange among bacterial species converting biofilms in hot spots of antibiotic resistance. This review focuses on the potential effect of antibiotic pollution on biofilm microbial communities, with special emphasis on ecological and evolutionary processes underlying acquired resistance to these compounds.
Url:
DOI: 10.3389/fmicb.2015.01216
PubMed: 26583011
PubMed Central: 4628128
Affiliations:
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Balcázar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Catalan Institute for Water Research</institution><country>Girona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Subirats, Jessica" sort="Subirats, Jessica" uniqKey="Subirats J" first="Jéssica" last="Subirats">Jéssica Subirats</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Catalan Institute for Water Research</institution><country>Girona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Borrego, Carles M" sort="Borrego, Carles M" uniqKey="Borrego C" first="Carles M." last="Borrego">Carles M. Borrego</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Catalan Institute for Water Research</institution><country>Girona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Group of Molecular Microbial Ecology, Institute of Aquatic Ecology, University of Girona</institution><country>Girona, Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Microbiology</title><idno type="eISSN">1664-302X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Antibiotic resistance has become a significant and growing threat to public and environmental health. To face this problem both at local and global scales, a better understanding of the sources and mechanisms that contribute to the emergence and spread of antibiotic resistance is required. Recent studies demonstrate that aquatic ecosystems are reservoirs of resistant bacteria and antibiotic resistance genes as well as potential conduits for their transmission to human pathogens. Despite the wealth of information about antibiotic pollution and its effect on the aquatic microbial resistome, the contribution of environmental biofilms to the acquisition and spread of antibiotic resistance has not been fully explored in aquatic systems. Biofilms are structured multicellular communities embedded in a self-produced extracellular matrix that acts as a barrier to antibiotic diffusion. High population densities and proximity of cells in biofilms also increases the chances for genetic exchange among bacterial species converting biofilms in hot spots of antibiotic resistance. This review focuses on the potential effect of antibiotic pollution on biofilm microbial communities, with special emphasis on ecological and evolutionary processes underlying acquired resistance to these compounds.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Allen, H K" uniqKey="Allen H">H. K. Allen</name></author><author><name sortKey="Donato, J" uniqKey="Donato J">J. Donato</name></author><author><name sortKey="Wang, H H" uniqKey="Wang H">H. H. Wang</name></author><author><name sortKey="Cloud Hansen, K A" uniqKey="Cloud Hansen K">K. A. Cloud-Hansen</name></author><author><name sortKey="Davies, J" uniqKey="Davies J">J. Davies</name></author><author><name sortKey="Handelsman, J" uniqKey="Handelsman J">J. Handelsman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderl, J N" uniqKey="Anderl J">J. N. Anderl</name></author><author><name sortKey="Franklin, M J" uniqKey="Franklin M">M. J. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Microbiol</journal-id><journal-id journal-id-type="publisher-id">Front. Microbiol.</journal-id><journal-title-group><journal-title>Frontiers in Microbiology</journal-title></journal-title-group><issn pub-type="epub">1664-302X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26583011</article-id><article-id pub-id-type="pmc">4628128</article-id><article-id pub-id-type="doi">10.3389/fmicb.2015.01216</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbiology</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>The role of biofilms as environmental reservoirs of antibiotic resistance</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Balcázar</surname><given-names>José L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/20266/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Subirats</surname><given-names>Jéssica</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/244487/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Borrego</surname><given-names>Carles M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/265887/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Catalan Institute for Water Research</institution><country>Girona, Spain</country></aff><aff id="aff2"><sup>2</sup><institution>Group of Molecular Microbial Ecology, Institute of Aquatic Ecology, University of Girona</institution><country>Girona, Spain</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: <italic>Maurizio Labbate, University of Technology Sydney, Australia</italic></p></fn><fn fn-type="edited-by"><p>Reviewed by: <italic>Michael R. Twiss, Clarkson University, USA; Hans-Peter Grossart, IGB-Leibniz-Institute of Freshwater Ecology and Inland Fisheries, Germany</italic></p></fn><corresp id="fn001">*Correspondence: <italic>José L. Balcázar, <email xlink:type="simple">jlbalcazar@icra.cat</email></italic></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Aquatic Microbiology, a section of the journal Frontiers in Microbiology</p></fn></author-notes><pub-date pub-type="epub"><day>31</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>6</volume><elocation-id>1216</elocation-id><history><date date-type="received"><day>09</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>19</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Balcázar, Subirats and Borrego.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Balcázar, Subirats and Borrego</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Antibiotic resistance has become a significant and growing threat to public and environmental health. To face this problem both at local and global scales, a better understanding of the sources and mechanisms that contribute to the emergence and spread of antibiotic resistance is required. Recent studies demonstrate that aquatic ecosystems are reservoirs of resistant bacteria and antibiotic resistance genes as well as potential conduits for their transmission to human pathogens. Despite the wealth of information about antibiotic pollution and its effect on the aquatic microbial resistome, the contribution of environmental biofilms to the acquisition and spread of antibiotic resistance has not been fully explored in aquatic systems. Biofilms are structured multicellular communities embedded in a self-produced extracellular matrix that acts as a barrier to antibiotic diffusion. High population densities and proximity of cells in biofilms also increases the chances for genetic exchange among bacterial species converting biofilms in hot spots of antibiotic resistance. This review focuses on the potential effect of antibiotic pollution on biofilm microbial communities, with special emphasis on ecological and evolutionary processes underlying acquired resistance to these compounds.</p></abstract><kwd-group><kwd>aquatic ecosystems</kwd><kwd>biofilms</kwd><kwd>mobile genetic elements</kwd><kwd>antibiotic resistance genes</kwd><kwd>aquatic resistome</kwd></kwd-group><funding-group><award-group><funding-source id="cn001">Seventh Framework Programme<named-content content-type="fundref-id">10.13039/501100004963</named-content></funding-source><award-id rid="cn001">603629-ENV-2013-6.2.1-GLOBAQUA</award-id></award-group></funding-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="85"></ref-count><page-count count="9"></page-count><word-count count="0"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Balcazar, Jose L" sort="Balcazar, Jose L" uniqKey="Balcazar J" first="José L." last="Balcázar">José L. Balcázar</name></noRegion><name sortKey="Borrego, Carles M" sort="Borrego, Carles M" uniqKey="Borrego C" first="Carles M." last="Borrego">Carles M. Borrego</name><name sortKey="Borrego, Carles M" sort="Borrego, Carles M" uniqKey="Borrego C" first="Carles M." last="Borrego">Carles M. Borrego</name><name sortKey="Subirats, Jessica" sort="Subirats, Jessica" uniqKey="Subirats J" first="Jéssica" last="Subirats">Jéssica Subirats</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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