Frequent Detection of HPV before and after Initiation of Antiretroviral Therapy among HIV/HSV-2 Co-Infected Women in Uganda
Identifieur interne : 000389 ( Ncbi/Merge ); précédent : 000388; suivant : 000390Frequent Detection of HPV before and after Initiation of Antiretroviral Therapy among HIV/HSV-2 Co-Infected Women in Uganda
Auteurs : Anne F. Rositch [États-Unis] ; Patti E. Gravitt [États-Unis, Malaisie] ; Aaron A. R. Tobian [États-Unis] ; Kevin Newell ; Thomas C. Quinn [États-Unis] ; David Serwadda [Ouganda] ; Paschal Ssebbowa [Ouganda] ; Valerian Kiggundu [Ouganda] ; Ronald H. Gray [États-Unis, Ouganda] ; Steven J. Reynolds [Ouganda, États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
Most data on HPV and antiretroviral therapy (ART) come from high-resource countries with infrequent sampling for HPV pre- and post-ART initiation. Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda.
Linear Array was used to detect 37 HPV genotypes in self-collected cervicovaginal swabs from 96 women who initiated ART. Random-effects log-binomial regression was used to compare the prevalence of HPV detection in the pre- and post-ART periods and determine other potential risk factors, including CD4 counts and HIV viral load.
Nearly all women had detectable HPV in the 6 months preceding ART initiation (92%) and the cumulative prevalence remained high following initiation of therapy (90%). We found no effect of ART on monthly HPV DNA detection (prevalence ratio: 1.0; 95% confidence interval: 0.96, 1.08), regardless of immune reconstitution or HIV viral suppression. Older age and higher pre-ART CD4 counts were associated with a significantly lower risk of HPV DNA detection.
ART did not impact HPV detection within 6 months of therapy initiation, highlighting the importance of continued and consistent screening, even after ART-initiation and immune reconstitution.
Url:
DOI: 10.1371/journal.pone.0055383
PubMed: 23383171
PubMed Central: 3558485
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000618
- to stream Pmc, to step Curation: 000618
- to stream Pmc, to step Checkpoint: 000327
Links to Exploration step
PMC:3558485Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Frequent Detection of HPV before and after Initiation of Antiretroviral Therapy among HIV/HSV-2 Co-Infected Women in Uganda</title><author><name sortKey="Rositch, Anne F" sort="Rositch, Anne F" uniqKey="Rositch A" first="Anne F." last="Rositch">Anne F. Rositch</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gravitt, Patti E" sort="Gravitt, Patti E" uniqKey="Gravitt P" first="Patti E." last="Gravitt">Patti E. Gravitt</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Perdana University Graduate School of Medicine, Serdang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Perdana University Graduate School of Medicine, Serdang</wicri:regionArea><wicri:noRegion>Serdang</wicri:noRegion></affiliation></author><author><name sortKey="Tobian, Aaron A R" sort="Tobian, Aaron A R" uniqKey="Tobian A" first="Aaron A. R." last="Tobian">Aaron A. R. Tobian</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Newell, Kevin" sort="Newell, Kevin" uniqKey="Newell K" first="Kevin" last="Newell">Kevin Newell</name><affiliation><nlm:aff id="aff5"><addr-line>Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland United States of America</addr-line></nlm:aff><wicri:noCountry code="subfield">Maryland United States of America</wicri:noCountry></affiliation></author><author><name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Serwadda, David" sort="Serwadda, David" uniqKey="Serwadda D" first="David" last="Serwadda">David Serwadda</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Ssebbowa, Paschal" sort="Ssebbowa, Paschal" uniqKey="Ssebbowa P" first="Paschal" last="Ssebbowa">Paschal Ssebbowa</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Kiggundu, Valerian" sort="Kiggundu, Valerian" uniqKey="Kiggundu V" first="Valerian" last="Kiggundu">Valerian Kiggundu</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Gray, Ronald H" sort="Gray, Ronald H" uniqKey="Gray R" first="Ronald H." last="Gray">Ronald H. Gray</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23383171</idno><idno type="pmc">3558485</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558485</idno><idno type="RBID">PMC:3558485</idno><idno type="doi">10.1371/journal.pone.0055383</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000618</idno><idno type="wicri:Area/Pmc/Curation">000618</idno><idno type="wicri:Area/Pmc/Checkpoint">000327</idno><idno type="wicri:Area/Ncbi/Merge">000389</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Frequent Detection of HPV before and after Initiation of Antiretroviral Therapy among HIV/HSV-2 Co-Infected Women in Uganda</title><author><name sortKey="Rositch, Anne F" sort="Rositch, Anne F" uniqKey="Rositch A" first="Anne F." last="Rositch">Anne F. Rositch</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gravitt, Patti E" sort="Gravitt, Patti E" uniqKey="Gravitt P" first="Patti E." last="Gravitt">Patti E. Gravitt</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Perdana University Graduate School of Medicine, Serdang, Malaysia</addr-line></nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Perdana University Graduate School of Medicine, Serdang</wicri:regionArea><wicri:noRegion>Serdang</wicri:noRegion></affiliation></author><author><name sortKey="Tobian, Aaron A R" sort="Tobian, Aaron A R" uniqKey="Tobian A" first="Aaron A. R." last="Tobian">Aaron A. R. Tobian</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Newell, Kevin" sort="Newell, Kevin" uniqKey="Newell K" first="Kevin" last="Newell">Kevin Newell</name><affiliation><nlm:aff id="aff5"><addr-line>Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland United States of America</addr-line></nlm:aff><wicri:noCountry code="subfield">Maryland United States of America</wicri:noCountry></affiliation></author><author><name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Serwadda, David" sort="Serwadda, David" uniqKey="Serwadda D" first="David" last="Serwadda">David Serwadda</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Ssebbowa, Paschal" sort="Ssebbowa, Paschal" uniqKey="Ssebbowa P" first="Paschal" last="Ssebbowa">Paschal Ssebbowa</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Kiggundu, Valerian" sort="Kiggundu, Valerian" uniqKey="Kiggundu V" first="Valerian" last="Kiggundu">Valerian Kiggundu</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Gray, Ronald H" sort="Gray, Ronald H" uniqKey="Gray R" first="Ronald H." last="Gray">Ronald H. Gray</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Rakai Health Sciences Program, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>Most data on HPV and antiretroviral therapy (ART) come from high-resource countries with infrequent sampling for HPV pre- and post-ART initiation. Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda.</p></sec><sec><title>Methods</title><p>Linear Array was used to detect 37 HPV genotypes in self-collected cervicovaginal swabs from 96 women who initiated ART. Random-effects log-binomial regression was used to compare the prevalence of HPV detection in the pre- and post-ART periods and determine other potential risk factors, including CD4 counts and HIV viral load.</p></sec><sec><title>Results</title><p>Nearly all women had detectable HPV in the 6 months preceding ART initiation (92%) and the cumulative prevalence remained high following initiation of therapy (90%). We found no effect of ART on monthly HPV DNA detection (prevalence ratio: 1.0; 95% confidence interval: 0.96, 1.08), regardless of immune reconstitution or HIV viral suppression. Older age and higher pre-ART CD4 counts were associated with a significantly lower risk of HPV DNA detection.</p></sec><sec><title>Conclusions</title><p>ART did not impact HPV detection within 6 months of therapy initiation, highlighting the importance of continued and consistent screening, even after ART-initiation and immune reconstitution.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Munoz, N" uniqKey="Munoz N">N Munoz</name></author><author><name sortKey="Bosch, Fx" uniqKey="Bosch F">FX Bosch</name></author><author><name sortKey="De Sanjose, S" uniqKey="De Sanjose S">S de Sanjose</name></author><author><name sortKey="Herrero, R" uniqKey="Herrero R">R Herrero</name></author><author><name sortKey="Castellsague, X" uniqKey="Castellsague X">X Castellsague</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosch, Fx" uniqKey="Bosch F">FX Bosch</name></author><author><name sortKey="Lorincz, A" uniqKey="Lorincz A">A Lorincz</name></author><author><name sortKey="Munoz, N" uniqKey="Munoz N">N Munoz</name></author><author><name sortKey="Meijer, Cj" uniqKey="Meijer C">CJ Meijer</name></author><author><name sortKey="Shah, Kv" uniqKey="Shah K">KV Shah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walboomers, Jm" uniqKey="Walboomers J">JM Walboomers</name></author><author><name sortKey="Jacobs, Mv" uniqKey="Jacobs M">MV Jacobs</name></author><author><name sortKey="Manos, Mm" uniqKey="Manos M">MM Manos</name></author><author><name sortKey="Bosch, Fx" uniqKey="Bosch F">FX Bosch</name></author><author><name sortKey="Kummer, Ja" uniqKey="Kummer J">JA Kummer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Pokomandy, A" uniqKey="De Pokomandy A">A de Pokomandy</name></author><author><name sortKey="Rouleau, D" uniqKey="Rouleau D">D Rouleau</name></author><author><name sortKey="Ghattas, G" uniqKey="Ghattas G">G Ghattas</name></author><author><name sortKey="Vezina, S" uniqKey="Vezina S">S Vezina</name></author><author><name sortKey="Cote, P" uniqKey="Cote P">P Cote</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahdieh, L" uniqKey="Ahdieh L">L Ahdieh</name></author><author><name sortKey="Klein, Rs" uniqKey="Klein R">RS Klein</name></author><author><name sortKey="Burk, R" uniqKey="Burk R">R Burk</name></author><author><name sortKey="Cu Uvin, S" uniqKey="Cu Uvin S">S Cu-Uvin</name></author><author><name sortKey="Schuman, P" uniqKey="Schuman P">P Schuman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahdieh, L" uniqKey="Ahdieh L">L Ahdieh</name></author><author><name sortKey="Munoz, A" uniqKey="Munoz A">A Munoz</name></author><author><name sortKey="Vlahov, D" uniqKey="Vlahov D">D Vlahov</name></author><author><name sortKey="Trimble, Cl" uniqKey="Trimble C">CL Trimble</name></author><author><name sortKey="Timpson, La" uniqKey="Timpson L">LA Timpson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="La Ruche, G" uniqKey="La Ruche G">G La Ruche</name></author><author><name sortKey="You, B" uniqKey="You B">B You</name></author><author><name sortKey="Mensah Ado, I" uniqKey="Mensah Ado I">I Mensah-Ado</name></author><author><name sortKey="Bergeron, C" uniqKey="Bergeron C">C Bergeron</name></author><author><name sortKey="Montcho, C" uniqKey="Montcho C">C Montcho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strickler, Hd" uniqKey="Strickler H">HD Strickler</name></author><author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name></author><author><name sortKey="Fazzari, M" uniqKey="Fazzari M">M Fazzari</name></author><author><name sortKey="Anastos, K" uniqKey="Anastos K">K Anastos</name></author><author><name sortKey="Minkoff, H" uniqKey="Minkoff H">H Minkoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Safaeian, M" uniqKey="Safaeian M">M Safaeian</name></author><author><name sortKey="Kiddugavu, M" uniqKey="Kiddugavu M">M Kiddugavu</name></author><author><name sortKey="Gravitt, Pe" uniqKey="Gravitt P">PE Gravitt</name></author><author><name sortKey="Gange, Sj" uniqKey="Gange S">SJ Gange</name></author><author><name sortKey="Ssekasanvu, J" uniqKey="Ssekasanvu J">J Ssekasanvu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Vuyst, H" uniqKey="De Vuyst H">H De Vuyst</name></author><author><name sortKey="Lillo, F" uniqKey="Lillo F">F Lillo</name></author><author><name sortKey="Broutet, N" uniqKey="Broutet N">N Broutet</name></author><author><name sortKey="Smith, Js" uniqKey="Smith J">JS Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Strickler, Hd" uniqKey="Strickler H">HD Strickler</name></author><author><name sortKey="Palefsky, Jm" uniqKey="Palefsky J">JM Palefsky</name></author><author><name sortKey="Shah, Kv" uniqKey="Shah K">KV Shah</name></author><author><name sortKey="Anastos, K" uniqKey="Anastos K">K Anastos</name></author><author><name sortKey="Klein, Rs" uniqKey="Klein R">RS Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shrestha, S" uniqKey="Shrestha S">S Shrestha</name></author><author><name sortKey="Sudenga, Sl" uniqKey="Sudenga S">SL Sudenga</name></author><author><name sortKey="Smith, Js" uniqKey="Smith J">JS Smith</name></author><author><name sortKey="Bachmann, Lh" uniqKey="Bachmann L">LH Bachmann</name></author><author><name sortKey="Wilson, Cm" uniqKey="Wilson C">CM Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Minkoff, H" uniqKey="Minkoff H">H Minkoff</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y Zhong</name></author><author><name sortKey="Burk, Rd" uniqKey="Burk R">RD Burk</name></author><author><name sortKey="Palefsky, Jm" uniqKey="Palefsky J">JM Palefsky</name></author><author><name sortKey="Xue, X" uniqKey="Xue X">X Xue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lillo, Fb" uniqKey="Lillo F">FB Lillo</name></author><author><name sortKey="Ferrari, D" uniqKey="Ferrari D">D Ferrari</name></author><author><name sortKey="Veglia, F" uniqKey="Veglia F">F Veglia</name></author><author><name sortKey="Origoni, M" uniqKey="Origoni M">M Origoni</name></author><author><name sortKey="Grasso, Ma" uniqKey="Grasso M">MA Grasso</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynolds, Sj" uniqKey="Reynolds S">SJ Reynolds</name></author><author><name sortKey="Makumbi, F" uniqKey="Makumbi F">F Makumbi</name></author><author><name sortKey="Newell, K" uniqKey="Newell K">K Newell</name></author><author><name sortKey="Kiwanuka, N" uniqKey="Kiwanuka N">N Kiwanuka</name></author><author><name sortKey="Ssebbowa, P" uniqKey="Ssebbowa P">P Ssebbowa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuboi, Sh" uniqKey="Tuboi S">SH Tuboi</name></author><author><name sortKey="Pacheco, Ag" uniqKey="Pacheco A">AG Pacheco</name></author><author><name sortKey="Harrison, Lh" uniqKey="Harrison L">LH Harrison</name></author><author><name sortKey="Stone, Ra" uniqKey="Stone R">RA Stone</name></author><author><name sortKey="May, M" uniqKey="May M">M May</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marks, Ma" uniqKey="Marks M">MA Marks</name></author><author><name sortKey="Viscidi, Rp" uniqKey="Viscidi R">RP Viscidi</name></author><author><name sortKey="Chang, K" uniqKey="Chang K">K Chang</name></author><author><name sortKey="Silver, M" uniqKey="Silver M">M Silver</name></author><author><name sortKey="Burke, A" uniqKey="Burke A">A Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gravitt, Pe" uniqKey="Gravitt P">PE Gravitt</name></author><author><name sortKey="Peyton, Cl" uniqKey="Peyton C">CL Peyton</name></author><author><name sortKey="Alessi, Tq" uniqKey="Alessi T">TQ Alessi</name></author><author><name sortKey="Wheeler, Cm" uniqKey="Wheeler C">CM Wheeler</name></author><author><name sortKey="Coutlee, F" uniqKey="Coutlee F">F Coutlee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coutlee, F" uniqKey="Coutlee F">F Coutlee</name></author><author><name sortKey="Gravitt, P" uniqKey="Gravitt P">P Gravitt</name></author><author><name sortKey="Kornegay, J" uniqKey="Kornegay J">J Kornegay</name></author><author><name sortKey="Hankins, C" uniqKey="Hankins C">C Hankins</name></author><author><name sortKey="Richardson, H" uniqKey="Richardson H">H Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Del Mistro, A" uniqKey="Del Mistro A">A Del Mistro</name></author><author><name sortKey="Bertorelle, R" uniqKey="Bertorelle R">R Bertorelle</name></author><author><name sortKey="Franzetti, M" uniqKey="Franzetti M">M Franzetti</name></author><author><name sortKey="Cattelan, A" uniqKey="Cattelan A">A Cattelan</name></author><author><name sortKey="Torrisi, A" uniqKey="Torrisi A">A Torrisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fife, Kh" uniqKey="Fife K">KH Fife</name></author><author><name sortKey="Wu, Jw" uniqKey="Wu J">JW Wu</name></author><author><name sortKey="Squires, Ke" uniqKey="Squires K">KE Squires</name></author><author><name sortKey="Watts, Dh" uniqKey="Watts D">DH Watts</name></author><author><name sortKey="Andersen, Jw" uniqKey="Andersen J">JW Andersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaturvedi, Ak" uniqKey="Chaturvedi A">AK Chaturvedi</name></author><author><name sortKey="Madeleine, Mm" uniqKey="Madeleine M">MM Madeleine</name></author><author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name></author><author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bratcher, Lf" uniqKey="Bratcher L">LF Bratcher</name></author><author><name sortKey="Sahasrabuddhe, Vv" uniqKey="Sahasrabuddhe V">VV Sahasrabuddhe</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ahdieh Grant, L" uniqKey="Ahdieh Grant L">L Ahdieh-Grant</name></author><author><name sortKey="Li, R" uniqKey="Li R">R Li</name></author><author><name sortKey="Levine, Am" uniqKey="Levine A">AM Levine</name></author><author><name sortKey="Massad, Ls" uniqKey="Massad L">LS Massad</name></author><author><name sortKey="Strickler, Hd" uniqKey="Strickler H">HD Strickler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soncini, E" uniqKey="Soncini E">E Soncini</name></author><author><name sortKey="Zoncada, A" uniqKey="Zoncada A">A Zoncada</name></author><author><name sortKey="Condemi, V" uniqKey="Condemi V">V Condemi</name></author><author><name sortKey="Antoni, Ad" uniqKey="Antoni A">AD Antoni</name></author><author><name sortKey="Bocchialini, E" uniqKey="Bocchialini E">E Bocchialini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heard, I" uniqKey="Heard I">I Heard</name></author><author><name sortKey="Tassie, Jm" uniqKey="Tassie J">JM Tassie</name></author><author><name sortKey="Kazatchkine, Md" uniqKey="Kazatchkine M">MD Kazatchkine</name></author><author><name sortKey="Orth, G" uniqKey="Orth G">G Orth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sirera, G" uniqKey="Sirera G">G Sirera</name></author><author><name sortKey="Videla, S" uniqKey="Videla S">S Videla</name></author><author><name sortKey="Lopez Blazquez, R" uniqKey="Lopez Blazquez R">R Lopez-Blazquez</name></author><author><name sortKey="Llatjos, M" uniqKey="Llatjos M">M Llatjos</name></author><author><name sortKey="Tarrats, A" uniqKey="Tarrats A">A Tarrats</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuman, P" uniqKey="Schuman P">P Schuman</name></author><author><name sortKey="Ohmit, Se" uniqKey="Ohmit S">SE Ohmit</name></author><author><name sortKey="Klein, Rs" uniqKey="Klein R">RS Klein</name></author><author><name sortKey="Duerr, A" uniqKey="Duerr A">A Duerr</name></author><author><name sortKey="Cu Uvin, S" uniqKey="Cu Uvin S">S Cu-Uvin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellerbrock, Tv" uniqKey="Ellerbrock T">TV Ellerbrock</name></author><author><name sortKey="Chiasson, Ma" uniqKey="Chiasson M">MA Chiasson</name></author><author><name sortKey="Bush, Tj" uniqKey="Bush T">TJ Bush</name></author><author><name sortKey="Sun, Xw" uniqKey="Sun X">XW Sun</name></author><author><name sortKey="Sawo, D" uniqKey="Sawo D">D Sawo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heard, I" uniqKey="Heard I">I Heard</name></author><author><name sortKey="Potard, V" uniqKey="Potard V">V Potard</name></author><author><name sortKey="Costagliola, D" uniqKey="Costagliola D">D Costagliola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palefsky, Jm" uniqKey="Palefsky J">JM Palefsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sterne, Ja" uniqKey="Sterne J">JA Sterne</name></author><author><name sortKey="May, M" uniqKey="May M">M May</name></author><author><name sortKey="Costagliola, D" uniqKey="Costagliola D">D Costagliola</name></author><author><name sortKey="De Wolf, F" uniqKey="De Wolf F">F de Wolf</name></author><author><name sortKey="Phillips, An" uniqKey="Phillips A">AN Phillips</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cohen, Ms" uniqKey="Cohen M">MS Cohen</name></author><author><name sortKey="Chen, Yq" uniqKey="Chen Y">YQ Chen</name></author><author><name sortKey="Mccauley, M" uniqKey="Mccauley M">M McCauley</name></author><author><name sortKey="Gamble, T" uniqKey="Gamble T">T Gamble</name></author><author><name sortKey="Hosseinipour, Mc" uniqKey="Hosseinipour M">MC Hosseinipour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mugo, N" uniqKey="Mugo N">N Mugo</name></author><author><name sortKey="Dadabhai, Ss" uniqKey="Dadabhai S">SS Dadabhai</name></author><author><name sortKey="Bunnell, R" uniqKey="Bunnell R">R Bunnell</name></author><author><name sortKey="Williamson, J" uniqKey="Williamson J">J Williamson</name></author><author><name sortKey="Bennett, E" uniqKey="Bennett E">E Bennett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blizzard, L" uniqKey="Blizzard L">L Blizzard</name></author><author><name sortKey="Hosmer, Dw" uniqKey="Hosmer D">DW Hosmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zocchetti, C" uniqKey="Zocchetti C">C Zocchetti</name></author><author><name sortKey="Consonni, D" uniqKey="Consonni D">D Consonni</name></author><author><name sortKey="Bertazzi, Pa" uniqKey="Bertazzi P">PA Bertazzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banura, C" uniqKey="Banura C">C Banura</name></author><author><name sortKey="Mirembe, Fm" uniqKey="Mirembe F">FM Mirembe</name></author><author><name sortKey="Katahoire, Ar" uniqKey="Katahoire A">AR Katahoire</name></author><author><name sortKey="Namujju, Pb" uniqKey="Namujju P">PB Namujju</name></author><author><name sortKey="Mbonye, Ak" uniqKey="Mbonye A">AK Mbonye</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23383171</article-id><article-id pub-id-type="pmc">3558485</article-id><article-id pub-id-type="publisher-id">PONE-D-12-33722</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0055383</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Clinical Research Design</subject><subj-group><subject>Epidemiology</subject><subject>Longitudinal Studies</subject></subj-group></subj-group><subj-group><subject>Epidemiology</subject><subj-group><subject>Infectious Disease Epidemiology</subject></subj-group></subj-group><subj-group><subject>Global Health</subject></subj-group><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Sexually Transmitted Diseases</subject><subj-group><subject>AIDS</subject><subject>Herpes Simplex</subject><subject>Human Papillomavirus Infection</subject></subj-group></subj-group><subj-group><subject>Viral Diseases</subject><subj-group><subject>HIV</subject><subj-group><subject>HIV opportunistic infections</subject></subj-group></subj-group><subj-group><subject>Herpes Simplex</subject><subject>Human Papillomavirus Infection</subject></subj-group></subj-group></subj-group><subj-group><subject>Obstetrics and Gynecology</subject><subj-group><subject>Female Genital Diseases</subject><subject>Gynecologic Cancers</subject><subject>Gynecologic Infections</subject></subj-group></subj-group><subj-group><subject>Oncology</subject><subj-group><subject>Cancers and Neoplasms</subject><subj-group><subject>AIDS-related cancers</subject></subj-group></subj-group></subj-group><subj-group><subject>Public Health</subject><subj-group><subject>Health Screening</subject></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Frequent Detection of HPV before and after Initiation of Antiretroviral Therapy among HIV/HSV-2 Co-Infected Women in Uganda</article-title><alt-title alt-title-type="running-head">Frequent HPV Detection Pre/Post-ART Initiation</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Rositch</surname><given-names>Anne F.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gravitt</surname><given-names>Patti E.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tobian</surname><given-names>Aaron A. R.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Newell</surname><given-names>Kevin</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Quinn</surname><given-names>Thomas C.</given-names></name><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Serwadda</surname><given-names>David</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ssebbowa</surname><given-names>Paschal</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kiggundu</surname><given-names>Valerian</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gray</surname><given-names>Ronald H.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Reynolds</surname><given-names>Steven J.</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Perdana University Graduate School of Medicine, Serdang, Malaysia</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></aff><aff id="aff5"><label>5</label><addr-line>Clinical Research Directorate/Clinical Monitoring Research Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland United States of America</addr-line></aff><aff id="aff6"><label>6</label><addr-line>Rakai Health Sciences Program, Entebbe, Uganda</addr-line></aff><aff id="aff7"><label>7</label><addr-line>Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America</addr-line></aff><aff id="aff8"><label>8</label><addr-line>Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Sued</surname><given-names>Omar</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Fundacion Huesped, Argentina</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>arositch@jhsph.edu</email></corresp><fn fn-type="conflict"><p><bold>Competing Interests: </bold>K. Newell is a Clinical Project Manager I (contractor) at SAIC-Frederick, Inc. providing support to National Institutes of Health-Uganda and Office of Cyber Infrastructure and Computational Biology. However, this affiliation does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The remaining authors have no conflicts of interest to declare.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: SJR DS TCQ RHG PEG. Performed the experiments: SJR PS KN VK DS AART. Analyzed the data: AFR AART. Contributed reagents/materials/analysis tools: KN. Wrote the paper: AFR PEG. Critical review of the manuscript: AART KN PS VK TCQ DS RHG SJR.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>29</day><month>1</month><year>2013</year></pub-date><volume>8</volume><issue>1</issue><elocation-id>e55383</elocation-id><history><date date-type="received"><day>18</day><month>10</month><year>2012</year></date><date date-type="accepted"><day>21</day><month>12</month><year>2012</year></date></history><permissions><copyright-year>2013</copyright-year><copyright-holder>Rositch et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Objectives</title><p>Most data on HPV and antiretroviral therapy (ART) come from high-resource countries with infrequent sampling for HPV pre- and post-ART initiation. Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda.</p></sec><sec><title>Methods</title><p>Linear Array was used to detect 37 HPV genotypes in self-collected cervicovaginal swabs from 96 women who initiated ART. Random-effects log-binomial regression was used to compare the prevalence of HPV detection in the pre- and post-ART periods and determine other potential risk factors, including CD4 counts and HIV viral load.</p></sec><sec><title>Results</title><p>Nearly all women had detectable HPV in the 6 months preceding ART initiation (92%) and the cumulative prevalence remained high following initiation of therapy (90%). We found no effect of ART on monthly HPV DNA detection (prevalence ratio: 1.0; 95% confidence interval: 0.96, 1.08), regardless of immune reconstitution or HIV viral suppression. Older age and higher pre-ART CD4 counts were associated with a significantly lower risk of HPV DNA detection.</p></sec><sec><title>Conclusions</title><p>ART did not impact HPV detection within 6 months of therapy initiation, highlighting the importance of continued and consistent screening, even after ART-initiation and immune reconstitution.</p></sec></abstract><funding-group><funding-statement>A. F. Rositch was supported by the Institutional Research Cancer Epidemiology Fellowship funded by the National Cancer Institute T32 CA0009314. A.A.R. Tobian was supported by the National Institutes of Health (NIH) 1K23AI093152-01A1 and the Doris Duke Charitable Foundation Clinician Scientist Development Award (22006.02). The trial was supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, and in part through program project grant PO1 AI-30731-19. This project has been funded in part by the National Cancer Institute, NIH under contract number HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the United States Government. This research was supported [in part] by the National Institute of Allergy and Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="7"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Malaisie</li><li>Ouganda</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Newell, Kevin" sort="Newell, Kevin" uniqKey="Newell K" first="Kevin" last="Newell">Kevin Newell</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Rositch, Anne F" sort="Rositch, Anne F" uniqKey="Rositch A" first="Anne F." last="Rositch">Anne F. Rositch</name></region><name sortKey="Gravitt, Patti E" sort="Gravitt, Patti E" uniqKey="Gravitt P" first="Patti E." last="Gravitt">Patti E. Gravitt</name><name sortKey="Gravitt, Patti E" sort="Gravitt, Patti E" uniqKey="Gravitt P" first="Patti E." last="Gravitt">Patti E. Gravitt</name><name sortKey="Gray, Ronald H" sort="Gray, Ronald H" uniqKey="Gray R" first="Ronald H." last="Gray">Ronald H. Gray</name><name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name><name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name><name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name><name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name><name sortKey="Tobian, Aaron A R" sort="Tobian, Aaron A R" uniqKey="Tobian A" first="Aaron A. R." last="Tobian">Aaron A. R. Tobian</name><name sortKey="Tobian, Aaron A R" sort="Tobian, Aaron A R" uniqKey="Tobian A" first="Aaron A. R." last="Tobian">Aaron A. R. Tobian</name></country><country name="Malaisie"><noRegion><name sortKey="Gravitt, Patti E" sort="Gravitt, Patti E" uniqKey="Gravitt P" first="Patti E." last="Gravitt">Patti E. Gravitt</name></noRegion></country><country name="Ouganda"><noRegion><name sortKey="Serwadda, David" sort="Serwadda, David" uniqKey="Serwadda D" first="David" last="Serwadda">David Serwadda</name></noRegion><name sortKey="Gray, Ronald H" sort="Gray, Ronald H" uniqKey="Gray R" first="Ronald H." last="Gray">Ronald H. Gray</name><name sortKey="Kiggundu, Valerian" sort="Kiggundu, Valerian" uniqKey="Kiggundu V" first="Valerian" last="Kiggundu">Valerian Kiggundu</name><name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name><name sortKey="Ssebbowa, Paschal" sort="Ssebbowa, Paschal" uniqKey="Ssebbowa P" first="Paschal" last="Ssebbowa">Paschal Ssebbowa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000389 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000389 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= CyberinfraV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:3558485
|texte= Frequent Detection of HPV before and after Initiation of Antiretroviral Therapy among HIV/HSV-2 Co-Infected Women in Uganda
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:23383171" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a CyberinfraV1
| This area was generated with Dilib version V0.6.25. |  |