CYberinfrastructure for COmparative effectiveness REsearch (CYCORE): improving data from cancer clinical trials
Identifieur interne : 000213 ( Ncbi/Merge ); précédent : 000212; suivant : 000214CYberinfrastructure for COmparative effectiveness REsearch (CYCORE): improving data from cancer clinical trials
Auteurs : Kevin Patrick [États-Unis] ; Laura Wolszon [États-Unis] ; Karen M. Basen-Engquist [États-Unis] ; Wendy Demark-Wahnefried [États-Unis] ; Alex V. Prokhorov [États-Unis] ; Stephanie Barrera [États-Unis] ; Chaitan Baru [États-Unis] ; Emilia Farcas [États-Unis] ; Ingolf Krueger [États-Unis] ; Doug Palmer [États-Unis] ; Fred Raab [États-Unis] ; Phil Rios [États-Unis] ; Celal Ziftci [États-Unis] ; Susan Peterson [États-Unis]Source :
- Translational behavioral medicine [ 1869-6716 ] ; 2010.
Abstract
Improved approaches and methodologies are needed to conduct comparative effectiveness research (CER) in oncology. While cancer therapies continue to emerge at a rapid pace, the review, synthesis, and dissemination of evidence-based interventions across clinical trials lag in comparison. Rigorous and systematic testing of competing therapies has been clouded by age-old problems: poor patient adherence, inability to objectively measure the environmental influences on health, lack of knowledge about patients’ lifestyle behaviors that may affect cancer’s progression and recurrence, and limited ability to compile and interpret the wide range of variables that must be considered in the cancer treatment. This lack of data integration limits the potential for patients and clinicians to engage in fully informed decision-making regarding cancer prevention, treatment, and survivorship care, and the translation of research results into mainstream medical care. Particularly important, as noted in a 2009 report on CER to the President and Congress, the limited focus on health behavior-change interventions was a major hindrance in this research landscape (DHHS
Url:
DOI: 10.1007/s13142-010-0005-z
PubMed: 21516142
PubMed Central: 3065645
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PMC:3065645Le document en format XML
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<series><title level="j">Translational behavioral medicine</title>
<idno type="ISSN">1869-6716</idno>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Improved approaches and methodologies are needed to conduct comparative effectiveness research (CER) in oncology. While cancer therapies continue to emerge at a rapid pace, the review, synthesis, and dissemination of evidence-based interventions across clinical trials lag in comparison. Rigorous and systematic testing of competing therapies has been clouded by age-old problems: poor patient adherence, inability to objectively measure the environmental influences on health, lack of knowledge about patients’ lifestyle behaviors that may affect cancer’s progression and recurrence, and limited ability to compile and interpret the wide range of variables that must be considered in the cancer treatment. This lack of data integration limits the potential for patients and clinicians to engage in fully informed decision-making regarding cancer prevention, treatment, and survivorship care, and the translation of research results into mainstream medical care. Particularly important, as noted in a 2009 report on CER to the President and Congress, the limited focus on health behavior-change interventions was a major hindrance in this research landscape (DHHS <xref ref-type="bibr" rid="CR1">2009</xref>
). This paper describes an initiative to improve CER for cancer by addressing several of these limitations. The Cyberinfrastructure for Comparative Effectiveness Research (CYCORE) project, informed by the National Science Foundation’s 2007 report “Cyberinfrastructure Vision for 21<sup>st</sup>
Century Discovery” has, as its central aim, the creation of a prototype for a user-friendly, open-source cyberinfrastructure (CI) that supports acquisition, storage, visualization, analysis, and sharing of data important for cancer-related CER. Although still under development, the process of gathering requirements for CYCORE has revealed new ways in which CI design can significantly improve the collection and analysis of a wide variety of data types, and has resulted in new and important partnerships among cancer researchers engaged in advancing health-related CI.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Gritz, Er" uniqKey="Gritz E">ER Gritz</name>
</author>
<author><name sortKey="Dresler, C" uniqKey="Dresler C">C Dresler</name>
</author>
<author><name sortKey="Sarna, L" uniqKey="Sarna L">L Sarna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bairati, I" uniqKey="Bairati I">I Bairati</name>
</author>
<author><name sortKey="Meyer, F" uniqKey="Meyer F">F Meyer</name>
</author>
<author><name sortKey="Jobin, E" uniqKey="Jobin E">E Jobin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name>
</author>
<author><name sortKey="Aiello, E" uniqKey="Aiello E">E Aiello</name>
</author>
<author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holmes, Md" uniqKey="Holmes M">MD Holmes</name>
</author>
<author><name sortKey="Chen, Wy" uniqKey="Chen W">WY Chen</name>
</author>
<author><name sortKey="Feskanich, D" uniqKey="Feskanich D">D Feskanich</name>
</author>
<author><name sortKey="Kroenke, Ch" uniqKey="Kroenke C">CH Kroenke</name>
</author>
<author><name sortKey="Colditz, Ga" uniqKey="Colditz G">GA Colditz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meyerhardt, Ja" uniqKey="Meyerhardt J">JA Meyerhardt</name>
</author>
<author><name sortKey="Heseltine, D" uniqKey="Heseltine D">D Heseltine</name>
</author>
<author><name sortKey="Niedzwiecki, D" uniqKey="Niedzwiecki D">D Niedzwiecki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Velicer, Cm" uniqKey="Velicer C">CM Velicer</name>
</author>
<author><name sortKey="Ulrich, Cm" uniqKey="Ulrich C">CM Ulrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arrott, M" uniqKey="Arrott M">M Arrott</name>
</author>
<author><name sortKey="Demchak, B" uniqKey="Demchak B">B Demchak</name>
</author>
<author><name sortKey="Ermagan, V" uniqKey="Ermagan V">V Ermagan</name>
</author>
<author><name sortKey="Farcas, C" uniqKey="Farcas C">C Farcas</name>
</author>
<author><name sortKey="Farcas, E" uniqKey="Farcas E">E Farcas</name>
</author>
<author><name sortKey="Kruger, Ih" uniqKey="Kruger I">IH Krüger</name>
</author>
<author><name sortKey="Menarini, M" uniqKey="Menarini M">M Menarini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baru, C" uniqKey="Baru C">C Baru</name>
</author>
<author><name sortKey="Lin, K" uniqKey="Lin K">K Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krichmar, Jl" uniqKey="Krichmar J">JL Krichmar</name>
</author>
<author><name sortKey="Edelman, Gm" uniqKey="Edelman G">GM Edelman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edelman, Db" uniqKey="Edelman D">DB Edelman</name>
</author>
<author><name sortKey="Baars, Bj" uniqKey="Baars B">BJ Baars</name>
</author>
<author><name sortKey="Seth, Ak" uniqKey="Seth A">AK Seth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seth, Ak" uniqKey="Seth A">AK Seth</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
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<double pmid="21516142"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CYberinfrastructure for COmparative effectiveness REsearch (CYCORE): improving data from cancer clinical trials</title>
<author><name sortKey="Patrick, Kevin" sort="Patrick, Kevin" uniqKey="Patrick K" first="Kevin" last="Patrick">Kevin Patrick</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
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<affiliation wicri:level="2"><nlm:aff id="Aff2">Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wolszon, Laura" sort="Wolszon, Laura" uniqKey="Wolszon L" first="Laura" last="Wolszon">Laura Wolszon</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Basen Engquist, Karen M" sort="Basen Engquist, Karen M" uniqKey="Basen Engquist K" first="Karen M" last="Basen-Engquist">Karen M. Basen-Engquist</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">UAB Comprehensive Cancer Center, NP 2514, 1530 3rd Ave. S., Birmingham, AL 35294-3360 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
<wicri:cityArea>UAB Comprehensive Cancer Center, NP 2514, 1530 3rd Ave. S., Birmingham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Prokhorov, Alex V" sort="Prokhorov, Alex V" uniqKey="Prokhorov A" first="Alex V" last="Prokhorov">Alex V. Prokhorov</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barrera, Stephanie" sort="Barrera, Stephanie" uniqKey="Barrera S" first="Stephanie" last="Barrera">Stephanie Barrera</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baru, Chaitan" sort="Baru, Chaitan" uniqKey="Baru C" first="Chaitan" last="Baru">Chaitan Baru</name>
<affiliation wicri:level="2"><nlm:aff id="Aff6">UC, San Diego Supercomputing Center, 9500 Gilman Drive, MC 0505, La Jolla, CA 92093-0505 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC, San Diego Supercomputing Center, 9500 Gilman Drive, MC 0505, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Farcas, Emilia" sort="Farcas, Emilia" uniqKey="Farcas E" first="Emilia" last="Farcas">Emilia Farcas</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla, CA 92093-0404 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Krueger, Ingolf" sort="Krueger, Ingolf" uniqKey="Krueger I" first="Ingolf" last="Krueger">Ingolf Krueger</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla, CA 92093-0404 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Palmer, Doug" sort="Palmer, Doug" uniqKey="Palmer D" first="Doug" last="Palmer">Doug Palmer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Raab, Fred" sort="Raab, Fred" uniqKey="Raab F" first="Fred" last="Raab">Fred Raab</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rios, Phil" sort="Rios, Phil" uniqKey="Rios P" first="Phil" last="Rios">Phil Rios</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ziftci, Celal" sort="Ziftci, Celal" uniqKey="Ziftci C" first="Celal" last="Ziftci">Celal Ziftci</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla, CA 92093-0404 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peterson, Susan" sort="Peterson, Susan" uniqKey="Peterson S" first="Susan" last="Peterson">Susan Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21516142</idno>
<idno type="pmc">3065645</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065645</idno>
<idno type="RBID">PMC:3065645</idno>
<idno type="doi">10.1007/s13142-010-0005-z</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000192</idno>
<idno type="wicri:Area/Pmc/Curation">000192</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000594</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CYberinfrastructure for COmparative effectiveness REsearch (CYCORE): improving data from cancer clinical trials</title>
<author><name sortKey="Patrick, Kevin" sort="Patrick, Kevin" uniqKey="Patrick K" first="Kevin" last="Patrick">Kevin Patrick</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wolszon, Laura" sort="Wolszon, Laura" uniqKey="Wolszon L" first="Laura" last="Wolszon">Laura Wolszon</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Basen Engquist, Karen M" sort="Basen Engquist, Karen M" uniqKey="Basen Engquist K" first="Karen M" last="Basen-Engquist">Karen M. Basen-Engquist</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">UAB Comprehensive Cancer Center, NP 2514, 1530 3rd Ave. S., Birmingham, AL 35294-3360 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
<wicri:cityArea>UAB Comprehensive Cancer Center, NP 2514, 1530 3rd Ave. S., Birmingham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Prokhorov, Alex V" sort="Prokhorov, Alex V" uniqKey="Prokhorov A" first="Alex V" last="Prokhorov">Alex V. Prokhorov</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Barrera, Stephanie" sort="Barrera, Stephanie" uniqKey="Barrera S" first="Stephanie" last="Barrera">Stephanie Barrera</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Baru, Chaitan" sort="Baru, Chaitan" uniqKey="Baru C" first="Chaitan" last="Baru">Chaitan Baru</name>
<affiliation wicri:level="2"><nlm:aff id="Aff6">UC, San Diego Supercomputing Center, 9500 Gilman Drive, MC 0505, La Jolla, CA 92093-0505 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC, San Diego Supercomputing Center, 9500 Gilman Drive, MC 0505, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Farcas, Emilia" sort="Farcas, Emilia" uniqKey="Farcas E" first="Emilia" last="Farcas">Emilia Farcas</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla, CA 92093-0404 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Krueger, Ingolf" sort="Krueger, Ingolf" uniqKey="Krueger I" first="Ingolf" last="Krueger">Ingolf Krueger</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla, CA 92093-0404 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Palmer, Doug" sort="Palmer, Doug" uniqKey="Palmer D" first="Doug" last="Palmer">Doug Palmer</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Raab, Fred" sort="Raab, Fred" uniqKey="Raab F" first="Fred" last="Raab">Fred Raab</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Family and Preventive Medicine, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Center for Wireless and Population Health Systems, UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Rios, Phil" sort="Rios, Phil" uniqKey="Rios P" first="Phil" last="Rios">Phil Rios</name>
<affiliation wicri:level="2"><nlm:aff id="Aff3">UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla, CA 92093-0811 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>UC San Diego, Calit2, 9500 Gilman Drive, MC 0811, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ziftci, Celal" sort="Ziftci, Celal" uniqKey="Ziftci C" first="Celal" last="Ziftci">Celal Ziftci</name>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla, CA 92093-0404 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Computer Science and Engineering, UC San Diego, 9500 Gilman Drive, MC 0404, La Jolla</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Peterson, Susan" sort="Peterson, Susan" uniqKey="Peterson S" first="Susan" last="Peterson">Susan Peterson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston, TX 77030 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Behavioral Science, The University of Texas, MD Anderson Cancer Center, P.O. Box 301439, Houston</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Translational behavioral medicine</title>
<idno type="ISSN">1869-6716</idno>
<idno type="eISSN">1613-9860</idno>
<imprint><date when="2010">2010</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Improved approaches and methodologies are needed to conduct comparative effectiveness research (CER) in oncology. While cancer therapies continue to emerge at a rapid pace, the review, synthesis, and dissemination of evidence-based interventions across clinical trials lag in comparison. Rigorous and systematic testing of competing therapies has been clouded by age-old problems: poor patient adherence, inability to objectively measure the environmental influences on health, lack of knowledge about patients’ lifestyle behaviors that may affect cancer’s progression and recurrence, and limited ability to compile and interpret the wide range of variables that must be considered in the cancer treatment. This lack of data integration limits the potential for patients and clinicians to engage in fully informed decision-making regarding cancer prevention, treatment, and survivorship care, and the translation of research results into mainstream medical care. Particularly important, as noted in a 2009 report on CER to the President and Congress, the limited focus on health behavior-change interventions was a major hindrance in this research landscape (DHHS <xref ref-type="bibr" rid="CR1">2009</xref>
). This paper describes an initiative to improve CER for cancer by addressing several of these limitations. The Cyberinfrastructure for Comparative Effectiveness Research (CYCORE) project, informed by the National Science Foundation’s 2007 report “Cyberinfrastructure Vision for 21<sup>st</sup>
Century Discovery” has, as its central aim, the creation of a prototype for a user-friendly, open-source cyberinfrastructure (CI) that supports acquisition, storage, visualization, analysis, and sharing of data important for cancer-related CER. Although still under development, the process of gathering requirements for CYCORE has revealed new ways in which CI design can significantly improve the collection and analysis of a wide variety of data types, and has resulted in new and important partnerships among cancer researchers engaged in advancing health-related CI.</p>
</div>
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<biblStruct><analytic><author><name sortKey="Gritz, Er" uniqKey="Gritz E">ER Gritz</name>
</author>
<author><name sortKey="Dresler, C" uniqKey="Dresler C">C Dresler</name>
</author>
<author><name sortKey="Sarna, L" uniqKey="Sarna L">L Sarna</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bairati, I" uniqKey="Bairati I">I Bairati</name>
</author>
<author><name sortKey="Meyer, F" uniqKey="Meyer F">F Meyer</name>
</author>
<author><name sortKey="Jobin, E" uniqKey="Jobin E">E Jobin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chlebowski, Rt" uniqKey="Chlebowski R">RT Chlebowski</name>
</author>
<author><name sortKey="Aiello, E" uniqKey="Aiello E">E Aiello</name>
</author>
<author><name sortKey="Mctiernan, A" uniqKey="Mctiernan A">A McTiernan</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Chen, Wy" uniqKey="Chen W">WY Chen</name>
</author>
<author><name sortKey="Feskanich, D" uniqKey="Feskanich D">D Feskanich</name>
</author>
<author><name sortKey="Kroenke, Ch" uniqKey="Kroenke C">CH Kroenke</name>
</author>
<author><name sortKey="Colditz, Ga" uniqKey="Colditz G">GA Colditz</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Heseltine, D" uniqKey="Heseltine D">D Heseltine</name>
</author>
<author><name sortKey="Niedzwiecki, D" uniqKey="Niedzwiecki D">D Niedzwiecki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Velicer, Cm" uniqKey="Velicer C">CM Velicer</name>
</author>
<author><name sortKey="Ulrich, Cm" uniqKey="Ulrich C">CM Ulrich</name>
</author>
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</biblStruct>
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</author>
<author><name sortKey="Demchak, B" uniqKey="Demchak B">B Demchak</name>
</author>
<author><name sortKey="Ermagan, V" uniqKey="Ermagan V">V Ermagan</name>
</author>
<author><name sortKey="Farcas, C" uniqKey="Farcas C">C Farcas</name>
</author>
<author><name sortKey="Farcas, E" uniqKey="Farcas E">E Farcas</name>
</author>
<author><name sortKey="Kruger, Ih" uniqKey="Kruger I">IH Krüger</name>
</author>
<author><name sortKey="Menarini, M" uniqKey="Menarini M">M Menarini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baru, C" uniqKey="Baru C">C Baru</name>
</author>
<author><name sortKey="Lin, K" uniqKey="Lin K">K Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krichmar, Jl" uniqKey="Krichmar J">JL Krichmar</name>
</author>
<author><name sortKey="Edelman, Gm" uniqKey="Edelman G">GM Edelman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edelman, Db" uniqKey="Edelman D">DB Edelman</name>
</author>
<author><name sortKey="Baars, Bj" uniqKey="Baars B">BJ Baars</name>
</author>
<author><name sortKey="Seth, Ak" uniqKey="Seth A">AK Seth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seth, Ak" uniqKey="Seth A">AK Seth</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
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</author>
<author><name sortKey="Wolszon, Laura" sort="Wolszon, Laura" uniqKey="Wolszon L" first="Laura" last="Wolszon">Laura Wolszon</name>
</author>
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<author><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name>
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<author><name sortKey="Prokhorov, Alex V" sort="Prokhorov, Alex V" uniqKey="Prokhorov A" first="Alex V" last="Prokhorov">Alex V. Prokhorov</name>
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<author><name sortKey="Barrera, Stephanie" sort="Barrera, Stephanie" uniqKey="Barrera S" first="Stephanie" last="Barrera">Stephanie Barrera</name>
</author>
<author><name sortKey="Baru, Chaitan" sort="Baru, Chaitan" uniqKey="Baru C" first="Chaitan" last="Baru">Chaitan Baru</name>
</author>
<author><name sortKey="Farcas, Emilia" sort="Farcas, Emilia" uniqKey="Farcas E" first="Emilia" last="Farcas">Emilia Farcas</name>
</author>
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</author>
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</author>
<author><name sortKey="Raab, Fred" sort="Raab, Fred" uniqKey="Raab F" first="Fred" last="Raab">Fred Raab</name>
</author>
<author><name sortKey="Rios, Phil" sort="Rios, Phil" uniqKey="Rios P" first="Phil" last="Rios">Phil Rios</name>
</author>
<author><name sortKey="Ziftci, Celal" sort="Ziftci, Celal" uniqKey="Ziftci C" first="Celal" last="Ziftci">Celal Ziftci</name>
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<idno type="doi">10.1007/s13142-010-0005-z</idno>
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</author>
<author><name sortKey="Wolszon, Laura" sort="Wolszon, Laura" uniqKey="Wolszon L" first="Laura" last="Wolszon">Laura Wolszon</name>
</author>
<author><name sortKey="Basen Engquist, Karen M" sort="Basen Engquist, Karen M" uniqKey="Basen Engquist K" first="Karen M" last="Basen-Engquist">Karen M. Basen-Engquist</name>
</author>
<author><name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name>
</author>
<author><name sortKey="Prokhorov, Alex V" sort="Prokhorov, Alex V" uniqKey="Prokhorov A" first="Alex V" last="Prokhorov">Alex V. Prokhorov</name>
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</author>
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</author>
<author><name sortKey="Rios, Phil" sort="Rios, Phil" uniqKey="Rios P" first="Phil" last="Rios">Phil Rios</name>
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<series><title level="j">Translational behavioral medicine</title>
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<front><div type="abstract" xml:lang="en">Improved approaches and methodologies are needed to conduct comparative effectiveness research (CER) in oncology. While cancer therapies continue to emerge at a rapid pace, the review, synthesis, and dissemination of evidence-based interventions across clinical trials lag in comparison. Rigorous and systematic testing of competing therapies has been clouded by age-old problems: poor patient adherence, inability to objectively measure the environmental influences on health, lack of knowledge about patients' lifestyle behaviors that may affect cancer's progression and recurrence, and limited ability to compile and interpret the wide range of variables that must be considered in the cancer treatment. This lack of data integration limits the potential for patients and clinicians to engage in fully informed decision-making regarding cancer prevention, treatment, and survivorship care, and the translation of research results into mainstream medical care. Particularly important, as noted in a 2009 report on CER to the President and Congress, the limited focus on health behavior-change interventions was a major hindrance in this research landscape (DHHS 2009). This paper describes an initiative to improve CER for cancer by addressing several of these limitations. The Cyberinfrastructure for Comparative Effectiveness Research (CYCORE) project, informed by the National Science Foundation's 2007 report "Cyberinfrastructure Vision for 21(st) Century Discovery" has, as its central aim, the creation of a prototype for a user-friendly, open-source cyberinfrastructure (CI) that supports acquisition, storage, visualization, analysis, and sharing of data important for cancer-related CER. Although still under development, the process of gathering requirements for CYCORE has revealed new ways in which CI design can significantly improve the collection and analysis of a wide variety of data types, and has resulted in new and important partnerships among cancer researchers engaged in advancing health-related CI.</div>
</front>
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