Phylogenomics Reveals a Diverse Rickettsiales Type IV Secretion System▿ † ‡
Identifieur interne : 000122 ( Ncbi/Checkpoint ); précédent : 000121; suivant : 000123Phylogenomics Reveals a Diverse Rickettsiales Type IV Secretion System▿ † ‡
Auteurs : Joseph J. Gillespie ; Kelly A. Brayton ; Kelly P. Williams ; Marco A. Quevedo Diaz ; Wendy C. Brown ; Abdu F. Azad ; Bruno W. SobralSource :
- Infection and Immunity [ 0019-9567 ] ; 2010.
Abstract
With an obligate intracellular lifestyle,
Url:
DOI: 10.1128/IAI.01384-09
PubMed: 20176788
PubMed Central: 2863512
Affiliations:
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<xref ref-type="fn" rid="fn4">‡</xref>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Phylogenomics Reveals a Diverse <italic>Rickettsiales</italic>
Type IV Secretion System<xref ref-type="fn" rid="fn3">▿</xref>
<xref ref-type="fn" rid="fn2">†</xref>
<xref ref-type="fn" rid="fn4">‡</xref>
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<series><title level="j">Infection and Immunity</title>
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<front><div type="abstract" xml:lang="en"><p>With an obligate intracellular lifestyle, <italic>Alphaproteobacteria</italic>
of the order <italic>Rickettsiales</italic>
have inextricably coevolved with their various eukaryotic hosts, resulting in small, reductive genomes and strict dependency on host resources. Unsurprisingly, large portions of <italic>Rickettsiales</italic>
genomes encode proteins involved in transport and secretion. One particular transporter that has garnered recent attention from researchers is the type IV secretion system (T4SS). Homologous to the well-studied archetypal <italic>vir</italic>
T4SS of <italic>Agrobacterium tumefaciens</italic>
, the <underline><italic>R</italic>
</underline>
<italic>ickettsiales</italic>
<underline><italic>v</italic>
</underline>
<italic>ir</italic>
<underline>h</underline>
omolog (<italic>rvh</italic>
) T4SS is characterized primarily by duplication of several of its genes and scattered genomic distribution of all components in several conserved islets. Phylogeny estimation suggests a single event of ancestral acquirement of the <italic>rvh</italic>
T4SS, likely from a nonalphaproteobacterial origin. Bioinformatics analysis of over 30 <italic>Rickettsiales</italic>
genome sequences illustrates a conserved core <italic>rvh</italic>
scaffold (lacking only a <italic>virB5</italic>
homolog), with lineage-specific diversification of several components (<italic>rvhB1</italic>
, <italic>rvhB2</italic>
, and <italic>rvhB9b</italic>
), likely a result of modifications to cell envelope structure. This coevolution of the <italic>rvh</italic>
T4SS and cell envelope morphology is probably driven by adaptations to various host cells, identifying the transporter as an important target for vaccine development. Despite the genetic intractability of <italic>Rickettsiales</italic>
, recent advancements have been made in the characterization of several components of the <italic>rvh</italic>
T4SS, as well as its putative regulators and substrates. While current data favor a role in effector translocation, functions in DNA uptake and release and/or conjugation cannot at present be ruled out, especially considering that a mechanism for plasmid transfer in <italic>Rickettsia</italic>
spp. has yet to be proposed.</p>
</div>
</front>
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<tree><noCountry><name sortKey="Azad, Abdu F" sort="Azad, Abdu F" uniqKey="Azad A" first="Abdu F." last="Azad">Abdu F. Azad</name>
<name sortKey="Brayton, Kelly A" sort="Brayton, Kelly A" uniqKey="Brayton K" first="Kelly A." last="Brayton">Kelly A. Brayton</name>
<name sortKey="Brown, Wendy C" sort="Brown, Wendy C" uniqKey="Brown W" first="Wendy C." last="Brown">Wendy C. Brown</name>
<name sortKey="Gillespie, Joseph J" sort="Gillespie, Joseph J" uniqKey="Gillespie J" first="Joseph J." last="Gillespie">Joseph J. Gillespie</name>
<name sortKey="Quevedo Diaz, Marco A" sort="Quevedo Diaz, Marco A" uniqKey="Quevedo Diaz M" first="Marco A." last="Quevedo Diaz">Marco A. Quevedo Diaz</name>
<name sortKey="Sobral, Bruno W" sort="Sobral, Bruno W" uniqKey="Sobral B" first="Bruno W." last="Sobral">Bruno W. Sobral</name>
<name sortKey="Williams, Kelly P" sort="Williams, Kelly P" uniqKey="Williams K" first="Kelly P." last="Williams">Kelly P. Williams</name>
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