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Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease

Identifieur interne : 000B98 ( Main/Merge ); précédent : 000B97; suivant : 000B99

Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease

Auteurs : John M. Hancock ; Ann-Marie Mallon ; Tim Beck ; Georgios V. Gkoutos ; Chris Mungall [États-Unis] ; Paul N. Schofield

Source :

Mammalian Genome [ 0938-8990 ] ; 2009.

RBID : PMC:2759022

Abstract

Now that the laboratory mouse genome is sequenced and the annotation of its gene content is improving, the next major challenge is the annotation of the phenotypic associations of mouse genes. This requires the development of systematic phenotyping pipelines that use standardized phenotyping procedures which allow comparison across laboratories. It also requires the development of a sophisticated informatics infrastructure for the description and interchange of phenotype data. Here we focus on the current state of the art in the description of data produced by systematic phenotyping approaches using ontologies, in particular, the EQ (Entity-Quality) approach, and what developments are required to facilitate the linking of phenotypic descriptions of mutant mice to human diseases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759022

DOI: 10.1007/s00335-009-9208-3
PubMed: 19649761
PubMed Central: 2759022

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PMC:2759022

Le document en format XML

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Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease

Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki