Free energy landscapes for initiation and branching of protein aggregation
Identifieur interne : 000350 ( Main/Merge ); précédent : 000349; suivant : 000351Free energy landscapes for initiation and branching of protein aggregation
Auteurs : Weihua Zheng ; Nicholas P. Schafer ; Peter G. WolynesSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2013.
Abstract
This study leverages a predictive protein-folding simulation model to study the free energy landscapes of fused oligomeric constructs to quantify the conditions under which these constructs spontaneously misfold. Constructs of this type have been used to probe the early stages of aggregation in the laboratory. Oligomeric species may be the toxic agents in misfolding-related diseases. The critical structures that initiate aggregation are shown to depend on specific sequence signals and thermodynamic conditions. Our results also suggest that branching due to the presence of multiple amyloidogenic segments may determine the morphology of protein aggregates.
Url:
DOI: 10.1073/pnas.1320483110
PubMed: 24284165
PubMed Central: 3870682
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000406
- to stream Pmc, to step Curation: 000406
- to stream Pmc, to step Checkpoint: 000328
- to stream Ncbi, to step Merge: 000479
- to stream Ncbi, to step Curation: 000479
- to stream Ncbi, to step Checkpoint: 000479
Links to Exploration step
PMC:3870682Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Free energy landscapes for initiation and branching of protein aggregation</title><author><name sortKey="Zheng, Weihua" sort="Zheng, Weihua" uniqKey="Zheng W" first="Weihua" last="Zheng">Weihua Zheng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Physics and Astronomy</nlm:aff></affiliation></author><author><name sortKey="Schafer, Nicholas P" sort="Schafer, Nicholas P" uniqKey="Schafer N" first="Nicholas P." last="Schafer">Nicholas P. Schafer</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Physics and Astronomy</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Center for Theoretical Biological Physics,<institution>Rice University</institution>, Houston,<addr-line>TX</addr-line> 77005</nlm:aff></affiliation></author><author><name sortKey="Wolynes, Peter G" sort="Wolynes, Peter G" uniqKey="Wolynes P" first="Peter G." last="Wolynes">Peter G. Wolynes</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Physics and Astronomy</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Center for Theoretical Biological Physics,<institution>Rice University</institution>, Houston,<addr-line>TX</addr-line> 77005</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24284165</idno><idno type="pmc">3870682</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870682</idno><idno type="RBID">PMC:3870682</idno><idno type="doi">10.1073/pnas.1320483110</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000406</idno><idno type="wicri:Area/Pmc/Curation">000406</idno><idno type="wicri:Area/Pmc/Checkpoint">000328</idno><idno type="wicri:Area/Ncbi/Merge">000479</idno><idno type="wicri:Area/Ncbi/Curation">000479</idno><idno type="wicri:Area/Ncbi/Checkpoint">000479</idno><idno type="wicri:doubleKey">0027-8424:2013:Zheng W:free:energy:landscapes</idno><idno type="wicri:Area/Main/Merge">000350</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Free energy landscapes for initiation and branching of protein aggregation</title><author><name sortKey="Zheng, Weihua" sort="Zheng, Weihua" uniqKey="Zheng W" first="Weihua" last="Zheng">Weihua Zheng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Physics and Astronomy</nlm:aff></affiliation></author><author><name sortKey="Schafer, Nicholas P" sort="Schafer, Nicholas P" uniqKey="Schafer N" first="Nicholas P." last="Schafer">Nicholas P. Schafer</name><affiliation><nlm:aff wicri:cut=", and" id="aff2">Physics and Astronomy</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Center for Theoretical Biological Physics,<institution>Rice University</institution>, Houston,<addr-line>TX</addr-line> 77005</nlm:aff></affiliation></author><author><name sortKey="Wolynes, Peter G" sort="Wolynes, Peter G" uniqKey="Wolynes P" first="Peter G." last="Wolynes">Peter G. Wolynes</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff wicri:cut=", and" id="aff2">Physics and Astronomy</nlm:aff></affiliation><affiliation><nlm:aff id="aff3">Center for Theoretical Biological Physics,<institution>Rice University</institution>, Houston,<addr-line>TX</addr-line> 77005</nlm:aff></affiliation></author></analytic><series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title><idno type="ISSN">0027-8424</idno><idno type="eISSN">1091-6490</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Significance</title><p>This study leverages a predictive protein-folding simulation model to study the free energy landscapes of fused oligomeric constructs to quantify the conditions under which these constructs spontaneously misfold. Constructs of this type have been used to probe the early stages of aggregation in the laboratory. Oligomeric species may be the toxic agents in misfolding-related diseases. The critical structures that initiate aggregation are shown to depend on specific sequence signals and thermodynamic conditions. Our results also suggest that branching due to the presence of multiple amyloidogenic segments may determine the morphology of protein aggregates.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/CyberinfraV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000350 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000350 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Ticri/CIDE
|area= CyberinfraV1
|flux= Main
|étape= Merge
|type= RBID
|clé= PMC:3870682
|texte= Free energy landscapes for initiation and branching of protein aggregation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Merge/RBID.i -Sk "pubmed:24284165" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Merge/biblio.hfd \
| NlmPubMed2Wicri -a CyberinfraV1
| This area was generated with Dilib version V0.6.25. |  |