Anaerobic biosynthesis of the lower ligand of vitamin B12
Identifieur interne : 000145 ( Main/Merge ); précédent : 000144; suivant : 000146Anaerobic biosynthesis of the lower ligand of vitamin B12
Auteurs : Amrita B. Hazra ; Andrew W. Han ; Angad P. Mehta ; Kenny C. Mok ; Vadim Osadchiy ; Tadhg P. Begley ; Michiko E. TagaSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.
Abstract
Vitamin B12 is required by humans and a variety of other organisms for diverse metabolic processes, but is produced only by a subset of microorganisms. The anaerobic biosynthesis of the “lower ligand” of B12, 5,6-dimethylbenzimidazole (DMB), is the only unknown component of the B12 biosynthetic pathway. We report the identification of the
Url:
DOI: 10.1073/pnas.1509132112
PubMed: 26246619
PubMed Central: 4553811
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PMC:4553811Le document en format XML
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<author><name sortKey="Begley, Tadhg P" sort="Begley, Tadhg P" uniqKey="Begley T" first="Tadhg P." last="Begley">Tadhg P. Begley</name>
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<author><name sortKey="Mehta, Angad P" sort="Mehta, Angad P" uniqKey="Mehta A" first="Angad P." last="Mehta">Angad P. Mehta</name>
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,<addr-line>CA</addr-line>
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<author><name sortKey="Osadchiy, Vadim" sort="Osadchiy, Vadim" uniqKey="Osadchiy V" first="Vadim" last="Osadchiy">Vadim Osadchiy</name>
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,<addr-line>CA</addr-line>
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, College Station,<addr-line>TX</addr-line>
77843</nlm:aff>
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<author><name sortKey="Taga, Michiko E" sort="Taga, Michiko E" uniqKey="Taga M" first="Michiko E." last="Taga">Michiko E. Taga</name>
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,<addr-line>CA</addr-line>
94720;</nlm:aff>
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Vitamin B<sub>12</sub>
is required by humans and a variety of other organisms for diverse metabolic processes, but is produced only by a subset of microorganisms. The anaerobic biosynthesis of the “lower ligand” of B<sub>12</sub>
, 5,6-dimethylbenzimidazole (DMB), is the only unknown component of the B<sub>12</sub>
biosynthetic pathway. We report the identification of the <italic>bzaABCDE</italic>
genes that are necessary and sufficient for the anaerobic biosynthesis of DMB. We have characterized the role of each of the <italic>bza</italic>
genes and identified three intermediates in the pathway. This finding not only completes the B<sub>12</sub>
biosynthesis pathway but also enables the sequence-based prediction of cobamides synthesized by anaerobic microorganisms.</p>
</div>
</front>
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