CyberinfraV1, Main, Merge, bibRecord, 000133

Control of bacterial exoelectrogenesis by c-AMP-GMP

Identifieur interne : 000133 ( Main/Merge ); précédent : 000132; suivant : 000134

Control of bacterial exoelectrogenesis by c-AMP-GMP

Auteurs : James W. Nelson ; Narasimhan Sudarsan ; Grace E. Phillips ; Shira Stav ; Christina E. Lünse ; Phillip J. Mccown ; Ronald R. Breaker

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.

RBID : PMC:4418907

Abstract

Significance

The cyclic dinucleotides c-di-GMP and c-di-AMP are responsible for controlling broad changes in cell phenotypes during the life cycles of many bacterial species. To date, riboswitches that sense c-di-GMP and c-di-AMP have been discovered. The genomic locations of riboswitches reveal numerous genes that are controlled by these signaling compounds and thereby reveal the biological processes that are regulated. Herein, we report that a subset of conserved noncoding RNA domains previously annotated as c-di-GMP-I riboswitches in fact bind the newly discovered second messenger c-AMP-GMP. These riboswitches control many genes involved in the utilization of extracellular iron(III) oxide as an electron sink by various Geobacter species. Our findings reveal additional roles for this recently discovered signaling molecule.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418907

DOI: 10.1073/pnas.1419264112
PubMed: 25848023
PubMed Central: 4418907

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PMC:4418907

Le document en format XML

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 06520</nlm:aff>
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>The cyclic dinucleotides c-di-GMP and c-di-AMP are responsible for controlling broad changes in cell phenotypes during the life cycles of many bacterial species. To date, riboswitches that sense c-di-GMP and c-di-AMP have been discovered. The genomic locations of riboswitches reveal numerous genes that are controlled by these signaling compounds and thereby reveal the biological processes that are regulated. Herein, we report that a subset of conserved noncoding RNA domains previously annotated as c-di-GMP-I riboswitches in fact bind the newly discovered second messenger c-AMP-GMP. These riboswitches control many genes involved in the utilization of extracellular iron(III) oxide as an electron sink by various <italic>Geobacter</italic>
 species. Our findings reveal additional roles for this recently discovered signaling molecule.</p>
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Control of bacterial exoelectrogenesis by c-AMP-GMP

Control of bacterial exoelectrogenesis by c-AMP-GMP

Source :

Abstract

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