Control of bacterial exoelectrogenesis by c-AMP-GMP
Identifieur interne : 000133 ( Main/Merge ); précédent : 000132; suivant : 000134Control of bacterial exoelectrogenesis by c-AMP-GMP
Auteurs : James W. Nelson ; Narasimhan Sudarsan ; Grace E. Phillips ; Shira Stav ; Christina E. Lünse ; Phillip J. Mccown ; Ronald R. BreakerSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2015.
Abstract
The cyclic dinucleotides c-di-GMP and c-di-AMP are responsible for controlling broad changes in cell phenotypes during the life cycles of many bacterial species. To date, riboswitches that sense c-di-GMP and c-di-AMP have been discovered. The genomic locations of riboswitches reveal numerous genes that are controlled by these signaling compounds and thereby reveal the biological processes that are regulated. Herein, we report that a subset of conserved noncoding RNA domains previously annotated as c-di-GMP-I riboswitches in fact bind the newly discovered second messenger c-AMP-GMP. These riboswitches control many genes involved in the utilization of extracellular iron(III) oxide as an electron sink by various
Url:
DOI: 10.1073/pnas.1419264112
PubMed: 25848023
PubMed Central: 4418907
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PMC:4418907Le document en format XML
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<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>The cyclic dinucleotides c-di-GMP and c-di-AMP are responsible for controlling broad changes in cell phenotypes during the life cycles of many bacterial species. To date, riboswitches that sense c-di-GMP and c-di-AMP have been discovered. The genomic locations of riboswitches reveal numerous genes that are controlled by these signaling compounds and thereby reveal the biological processes that are regulated. Herein, we report that a subset of conserved noncoding RNA domains previously annotated as c-di-GMP-I riboswitches in fact bind the newly discovered second messenger c-AMP-GMP. These riboswitches control many genes involved in the utilization of extracellular iron(III) oxide as an electron sink by various <italic>Geobacter</italic>
species. Our findings reveal additional roles for this recently discovered signaling molecule.</p>
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