Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates*
Identifieur interne : 000078 ( Main/Merge ); précédent : 000077; suivant : 000079Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates*
Auteurs : Feng Gao ; Alicia D. Kight [États-Unis] ; Rory Henderson ; Srinivas Jayanthi ; Parth Patel ; Marissa Murchison ; Priyanka Sharma [États-Unis] ; Robyn L. Goforth [États-Unis] ; Thallapuranam Krishnaswamy Suresh Kumar ; Ralph L. Henry [États-Unis] ; Colin D. HeyesSource :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2015.
Abstract
Url:
DOI: 10.1074/jbc.M114.624346
PubMed: 25918165
PubMed Central: 4505461
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<author><name sortKey="Jayanthi, Srinivas" sort="Jayanthi, Srinivas" uniqKey="Jayanthi S" first="Srinivas" last="Jayanthi">Srinivas Jayanthi</name>
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<author><name sortKey="Heyes, Colin D" sort="Heyes, Colin D" uniqKey="Heyes C" first="Colin D." last="Heyes">Colin D. Heyes</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
Targeting of proteins requires a signal recognition particle (SRP) and multiple protein interactions.</p>
<p><bold>Results:</bold>
We observed a decrease in the structural dynamics of cpSRP43 and an increase in substrate affinity upon its binding to cpSRP54.</p>
<p><bold>Conclusion:</bold>
Changes in domain dynamics induced by cpSRP subunit interactions mediate substrate affinity.</p>
<p><bold>Significance:</bold>
Relating structure and dynamics of SRP proteins allows for a better understanding of vectorial targeting within cells.</p>
</div>
</front>
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