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Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates*

Identifieur interne : 000078 ( Main/Merge ); précédent : 000077; suivant : 000079

Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates*

Auteurs : Feng Gao ; Alicia D. Kight [États-Unis] ; Rory Henderson ; Srinivas Jayanthi ; Parth Patel ; Marissa Murchison ; Priyanka Sharma [États-Unis] ; Robyn L. Goforth [États-Unis] ; Thallapuranam Krishnaswamy Suresh Kumar ; Ralph L. Henry [États-Unis] ; Colin D. Heyes

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2015.

RBID : PMC:4505461

Abstract

Background: Targeting of proteins requires a signal recognition particle (SRP) and multiple protein interactions.

Results: We observed a decrease in the structural dynamics of cpSRP43 and an increase in substrate affinity upon its binding to cpSRP54.

Conclusion: Changes in domain dynamics induced by cpSRP subunit interactions mediate substrate affinity.

Significance: Relating structure and dynamics of SRP proteins allows for a better understanding of vectorial targeting within cells.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505461

DOI: 10.1074/jbc.M114.624346
PubMed: 25918165
PubMed Central: 4505461

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PMC:4505461

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Targeting of proteins requires a signal recognition particle (SRP) and multiple protein interactions.</p>
<p><bold>Results:</bold>
 We observed a decrease in the structural dynamics of cpSRP43 and an increase in substrate affinity upon its binding to cpSRP54.</p>
<p><bold>Conclusion:</bold>
 Changes in domain dynamics induced by cpSRP subunit interactions mediate substrate affinity.</p>
<p><bold>Significance:</bold>
 Relating structure and dynamics of SRP proteins allows for a better understanding of vectorial targeting within cells.</p>
</div>
</front>
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Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates*

Regulation of Structural Dynamics within a Signal Recognition Particle Promotes Binding of Protein Targeting Substrates*

Source :

Abstract

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