Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection
Identifieur interne : 000074 ( Main/Merge ); précédent : 000073; suivant : 000075Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to Helicobacter pylori Infection
Auteurs : Maksudul Alam [États-Unis] ; Xinwei Deng [États-Unis] ; Casandra Philipson [États-Unis] ; Josep Bassaganya-Riera [États-Unis] ; Keith Bisset [États-Unis] ; Adria Carbo [États-Unis] ; Stephen Eubank [États-Unis] ; Raquel Hontecillas [États-Unis] ; Stefan Hoops [États-Unis] ; Yongguo Mei [États-Unis] ; Vida Abedi [États-Unis] ; Madhav Marathe [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
Agent-based models (ABM) are widely used to study immune systems, providing a procedural and interactive view of the underlying system. The interaction of components and the behavior of individual objects is described procedurally as a function of the internal states and the local interactions, which are often stochastic in nature. Such models typically have complex structures and consist of a large number of modeling parameters. Determining the key modeling parameters which govern the outcomes of the system is very challenging. Sensitivity analysis plays a vital role in quantifying the impact of modeling parameters in massively interacting systems, including large complex ABM. The high computational cost of executing simulations impedes running experiments with exhaustive parameter settings. Existing techniques of analyzing such a complex system typically focus on local sensitivity analysis, i.e. one parameter at a time, or a close “neighborhood” of particular parameter settings. However, such methods are not adequate to measure the uncertainty and sensitivity of parameters accurately because they overlook the global impacts of parameters on the system. In this article, we develop novel experimental design and analysis techniques to perform both global and local sensitivity analysis of large-scale ABMs. The proposed method can efficiently identify the most significant parameters and quantify their contributions to outcomes of the system. We demonstrate the proposed methodology for ENteric Immune SImulator (ENISI), a large-scale ABM environment, using a computational model of immune responses to
Url:
DOI: 10.1371/journal.pone.0136139
PubMed: 26327290
PubMed Central: 4556515
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PMC:4556515Le document en format XML
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<author><name sortKey="Marathe, Madhav" sort="Marathe, Madhav" uniqKey="Marathe M" first="Madhav" last="Marathe">Madhav Marathe</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sensitivity Analysis of an ENteric Immunity SImulator (ENISI)-Based Model of Immune Responses to <italic>Helicobacter pylori</italic>
Infection</title>
<author><name sortKey="Alam, Maksudul" sort="Alam, Maksudul" uniqKey="Alam M" first="Maksudul" last="Alam">Maksudul Alam</name>
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<author><name sortKey="Philipson, Casandra" sort="Philipson, Casandra" uniqKey="Philipson C" first="Casandra" last="Philipson">Casandra Philipson</name>
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<author><name sortKey="Bassaganya Riera, Josep" sort="Bassaganya Riera, Josep" uniqKey="Bassaganya Riera J" first="Josep" last="Bassaganya-Riera">Josep Bassaganya-Riera</name>
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<placeName><region type="state">Virginie</region>
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</nlm:aff>
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<placeName><region type="state">Virginie</region>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Virginie</region>
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<author><name sortKey="Bisset, Keith" sort="Bisset, Keith" uniqKey="Bisset K" first="Keith" last="Bisset">Keith Bisset</name>
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</nlm:aff>
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<author><name sortKey="Carbo, Adria" sort="Carbo, Adria" uniqKey="Carbo A" first="Adria" last="Carbo">Adria Carbo</name>
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<author><name sortKey="Eubank, Stephen" sort="Eubank, Stephen" uniqKey="Eubank S" first="Stephen" last="Eubank">Stephen Eubank</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Virginie</region>
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<placeName><region type="state">Virginie</region>
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</author>
<author><name sortKey="Hontecillas, Raquel" sort="Hontecillas, Raquel" uniqKey="Hontecillas R" first="Raquel" last="Hontecillas">Raquel Hontecillas</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
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<author><name sortKey="Hoops, Stefan" sort="Hoops, Stefan" uniqKey="Hoops S" first="Stefan" last="Hoops">Stefan Hoops</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Virginie</region>
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</nlm:aff>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Mei, Yongguo" sort="Mei, Yongguo" uniqKey="Mei Y" first="Yongguo" last="Mei">Yongguo Mei</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Virginie</region>
</placeName>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Abedi, Vida" sort="Abedi, Vida" uniqKey="Abedi V" first="Vida" last="Abedi">Vida Abedi</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
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<affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marathe, Madhav" sort="Marathe, Madhav" uniqKey="Marathe M" first="Madhav" last="Marathe">Madhav Marathe</name>
<affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Department of Computer Science, Virginia Tech, Blacksburg, Virginia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Computer Science, Virginia Tech, Blacksburg, Virginia</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
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</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>Agent-based models (ABM) are widely used to study immune systems, providing a procedural and interactive view of the underlying system. The interaction of components and the behavior of individual objects is described procedurally as a function of the internal states and the local interactions, which are often stochastic in nature. Such models typically have complex structures and consist of a large number of modeling parameters. Determining the key modeling parameters which govern the outcomes of the system is very challenging. Sensitivity analysis plays a vital role in quantifying the impact of modeling parameters in massively interacting systems, including large complex ABM. The high computational cost of executing simulations impedes running experiments with exhaustive parameter settings. Existing techniques of analyzing such a complex system typically focus on local sensitivity analysis, i.e. one parameter at a time, or a close “neighborhood” of particular parameter settings. However, such methods are not adequate to measure the uncertainty and sensitivity of parameters accurately because they overlook the global impacts of parameters on the system. In this article, we develop novel experimental design and analysis techniques to perform both global and local sensitivity analysis of large-scale ABMs. The proposed method can efficiently identify the most significant parameters and quantify their contributions to outcomes of the system. We demonstrate the proposed methodology for ENteric Immune SImulator (ENISI), a large-scale ABM environment, using a computational model of immune responses to <italic>Helicobacter pylori</italic>
colonization of the gastric mucosa.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Saltelli, A" uniqKey="Saltelli A">A Saltelli</name>
</author>
<author><name sortKey="Annoni, P" uniqKey="Annoni P">P Annoni</name>
</author>
<author><name sortKey="Azzini, I" uniqKey="Azzini I">I Azzini</name>
</author>
<author><name sortKey="Campolongo, F" uniqKey="Campolongo F">F Campolongo</name>
</author>
<author><name sortKey="Ratto, M" uniqKey="Ratto M">M Ratto</name>
</author>
<author><name sortKey="Tarantola, S" uniqKey="Tarantola S">S Tarantola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Helton, Jc" uniqKey="Helton J">JC Helton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cacuci, Dg" uniqKey="Cacuci D">DG Cacuci</name>
</author>
<author><name sortKey="Ionescu Bujor, M" uniqKey="Ionescu Bujor M">M Ionescu-Bujor</name>
</author>
<author><name sortKey="Navon, Im" uniqKey="Navon I">IM Navon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brooks, Rj" uniqKey="Brooks R">RJ Brooks</name>
</author>
<author><name sortKey="Semenov, Ma" uniqKey="Semenov M">MA Semenov</name>
</author>
<author><name sortKey="Jamieson, Pd" uniqKey="Jamieson P">PD Jamieson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sher, Aa" uniqKey="Sher A">AA Sher</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
</author>
<author><name sortKey="Wathen, A" uniqKey="Wathen A">A Wathen</name>
</author>
<author><name sortKey="Maybank, Pj" uniqKey="Maybank P">PJ Maybank</name>
</author>
<author><name sortKey="Mirams, Gr" uniqKey="Mirams G">GR Mirams</name>
</author>
<author><name sortKey="Abramson, D" uniqKey="Abramson D">D Abramson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frey, Hc" uniqKey="Frey H">HC Frey</name>
</author>
<author><name sortKey="Patil, Sr" uniqKey="Patil S">SR Patil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamby, Dm" uniqKey="Hamby D">DM Hamby</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saltelli, A" uniqKey="Saltelli A">A Saltelli</name>
</author>
<author><name sortKey="Tarantola, S" uniqKey="Tarantola S">S Tarantola</name>
</author>
<author><name sortKey="Campolongo, F" uniqKey="Campolongo F">F Campolongo</name>
</author>
<author><name sortKey="Ratto, M" uniqKey="Ratto M">M Ratto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arwade, Sr" uniqKey="Arwade S">SR Arwade</name>
</author>
<author><name sortKey="Moradi, M" uniqKey="Moradi M">M Moradi</name>
</author>
<author><name sortKey="Louhghalam, A" uniqKey="Louhghalam A">A Louhghalam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bauer, Kw" uniqKey="Bauer K">KW Bauer</name>
</author>
<author><name sortKey="Parnell, Gs" uniqKey="Parnell G">GS Parnell</name>
</author>
<author><name sortKey="Meyers, Da" uniqKey="Meyers D">DA Meyers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lim, Jt" uniqKey="Lim J">JT Lim</name>
</author>
<author><name sortKey="Gold, Hj" uniqKey="Gold H">HJ Gold</name>
</author>
<author><name sortKey="Wilkerson, Gg" uniqKey="Wilkerson G">GG Wilkerson</name>
</author>
<author><name sortKey="Raper, Jcd" uniqKey="Raper J">JCD Raper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Helton, Jc" uniqKey="Helton J">JC Helton</name>
</author>
<author><name sortKey="Johnson, Jd" uniqKey="Johnson J">JD Johnson</name>
</author>
<author><name sortKey="Sallaberry, Cj" uniqKey="Sallaberry C">CJ Sallaberry</name>
</author>
<author><name sortKey="Storlie, Cb" uniqKey="Storlie C">CB Storlie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bonabeau, E" uniqKey="Bonabeau E">E Bonabeau</name>
</author>
<author><name sortKey="Dorigo, M" uniqKey="Dorigo M">M Dorigo</name>
</author>
<author><name sortKey="Theraulaz, G" uniqKey="Theraulaz G">G Theraulaz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, X" uniqKey="Dong X">X Dong</name>
</author>
<author><name sortKey="Foteinou, Pt" uniqKey="Foteinou P">PT Foteinou</name>
</author>
<author><name sortKey="Calvano, Se" uniqKey="Calvano S">SE Calvano</name>
</author>
<author><name sortKey="Lowry, Sf" uniqKey="Lowry S">SF Lowry</name>
</author>
<author><name sortKey="Androulakis, Ip" uniqKey="Androulakis I">IP Androulakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forrest, S" uniqKey="Forrest S">S Forrest</name>
</author>
<author><name sortKey="Beauchemin, C" uniqKey="Beauchemin C">C Beauchemin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neugebauer, Ea" uniqKey="Neugebauer E">EA Neugebauer</name>
</author>
<author><name sortKey="Willy, C" uniqKey="Willy C">C Willy</name>
</author>
<author><name sortKey="Sauerland, S" uniqKey="Sauerland S">S Sauerland</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="An, G" uniqKey="An G">G An</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lowry, Sf" uniqKey="Lowry S">SF Lowry</name>
</author>
<author><name sortKey="Calvano, Se" uniqKey="Calvano S">SE Calvano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seely, Aj" uniqKey="Seely A">AJ Seely</name>
</author>
<author><name sortKey="Christou, Nv" uniqKey="Christou N">NV Christou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="An, G" uniqKey="An G">G An</name>
</author>
<author><name sortKey="Faeder, J" uniqKey="Faeder J">J Faeder</name>
</author>
<author><name sortKey="Vodovotz, Y" uniqKey="Vodovotz Y">Y Vodovotz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vodovotz, Y" uniqKey="Vodovotz Y">Y Vodovotz</name>
</author>
<author><name sortKey="Chow, Cc" uniqKey="Chow C">CC Chow</name>
</author>
<author><name sortKey="Bartels, J" uniqKey="Bartels J">J Bartels</name>
</author>
<author><name sortKey="Lagoa, C" uniqKey="Lagoa C">C Lagoa</name>
</author>
<author><name sortKey="Prince, Jm" uniqKey="Prince J">JM Prince</name>
</author>
<author><name sortKey="Levy, Rm" uniqKey="Levy R">RM Levy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baldazzi, V" uniqKey="Baldazzi V">V Baldazzi</name>
</author>
<author><name sortKey="Castiglione, F" uniqKey="Castiglione F">F Castiglione</name>
</author>
<author><name sortKey="Bernaschi, M" uniqKey="Bernaschi M">M Bernaschi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mi, Q" uniqKey="Mi Q">Q Mi</name>
</author>
<author><name sortKey="Riviere, B" uniqKey="Riviere B">B Rivière</name>
</author>
<author><name sortKey="Clermont, G" uniqKey="Clermont G">G Clermont</name>
</author>
<author><name sortKey="Steed, Dl" uniqKey="Steed D">DL Steed</name>
</author>
<author><name sortKey="Vodovotz, Y" uniqKey="Vodovotz Y">Y Vodovotz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="An, G" uniqKey="An G">G An</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="An, G" uniqKey="An G">G An</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shapiro, M" uniqKey="Shapiro M">M Shapiro</name>
</author>
<author><name sortKey="Duca, Ka" uniqKey="Duca K">KA Duca</name>
</author>
<author><name sortKey="Lee, K" uniqKey="Lee K">K Lee</name>
</author>
<author><name sortKey="Delgado Eckert, E" uniqKey="Delgado Eckert E">E Delgado-Eckert</name>
</author>
<author><name sortKey="Hawkins, J" uniqKey="Hawkins J">J Hawkins</name>
</author>
<author><name sortKey="Jarrah, As" uniqKey="Jarrah A">AS Jarrah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duca, Ka" uniqKey="Duca K">KA Duca</name>
</author>
<author><name sortKey="Shapiro, M" uniqKey="Shapiro M">M Shapiro</name>
</author>
<author><name sortKey="Delgado Eckert, E" uniqKey="Delgado Eckert E">E Delgado-Eckert</name>
</author>
<author><name sortKey="Hadinoto, V" uniqKey="Hadinoto V">V Hadinoto</name>
</author>
<author><name sortKey="Jarrah, As" uniqKey="Jarrah A">AS Jarrah</name>
</author>
<author><name sortKey="Laubenbacher, R" uniqKey="Laubenbacher R">R Laubenbacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bauer, Al" uniqKey="Bauer A">AL Bauer</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
<author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Barrett, Cl" uniqKey="Barrett C">CL Barrett</name>
</author>
<author><name sortKey="Bisset, K" uniqKey="Bisset K">K Bisset</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J Chen</name>
</author>
<author><name sortKey="Eubank, S" uniqKey="Eubank S">S Eubank</name>
</author>
<author><name sortKey="Lewis, B" uniqKey="Lewis B">B Lewis</name>
</author>
<author><name sortKey="Kumar, Vsa" uniqKey="Kumar V">VSA Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eubank, S" uniqKey="Eubank S">S Eubank</name>
</author>
<author><name sortKey="Guclu, H" uniqKey="Guclu H">H Guclu</name>
</author>
<author><name sortKey="Kumar, Vsa" uniqKey="Kumar V">VSA Kumar</name>
</author>
<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
</author>
<author><name sortKey="Srinivasan, A" uniqKey="Srinivasan A">A Srinivasan</name>
</author>
<author><name sortKey="Toroczkai, Z" uniqKey="Toroczkai Z">Z Toroczkai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrett, C" uniqKey="Barrett C">C Barrett</name>
</author>
<author><name sortKey="Beckman, R" uniqKey="Beckman R">R Beckman</name>
</author>
<author><name sortKey="Berkbigler, K" uniqKey="Berkbigler K">K Berkbigler</name>
</author>
<author><name sortKey="Bisset, K" uniqKey="Bisset K">K Bisset</name>
</author>
<author><name sortKey="Bush, B" uniqKey="Bush B">B Bush</name>
</author>
<author><name sortKey="Campbell, K" uniqKey="Campbell K">K Campbell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barrett, E" uniqKey="Barrett E">E Barrett</name>
</author>
<author><name sortKey="Ross, Rp" uniqKey="Ross R">RP Ross</name>
</author>
<author><name sortKey="Fitzgerald, Gf" uniqKey="Fitzgerald G">GF Fitzgerald</name>
</author>
<author><name sortKey="Stanton, C" uniqKey="Stanton C">C Stanton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karaoz, U" uniqKey="Karaoz U">U Karaoz</name>
</author>
<author><name sortKey="Murali, Tm" uniqKey="Murali T">TM Murali</name>
</author>
<author><name sortKey="Letovsky, S" uniqKey="Letovsky S">S Letovsky</name>
</author>
<author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name>
</author>
<author><name sortKey="Ding, C" uniqKey="Ding C">C Ding</name>
</author>
<author><name sortKey="Cantor, Cr" uniqKey="Cantor C">CR Cantor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wendelsdorf, Kv" uniqKey="Wendelsdorf K">KV Wendelsdorf</name>
</author>
<author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
<author><name sortKey="Bisset, K" uniqKey="Bisset K">K Bisset</name>
</author>
<author><name sortKey="Eubank, S" uniqKey="Eubank S">S Eubank</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Wendelsdorf, Kv" uniqKey="Wendelsdorf K">KV Wendelsdorf</name>
</author>
<author><name sortKey="Alam, M" uniqKey="Alam M">M Alam</name>
</author>
<author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
<author><name sortKey="Bisset, K" uniqKey="Bisset K">K Bisset</name>
</author>
<author><name sortKey="Eubank, S" uniqKey="Eubank S">S Eubank</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Mei, Y" uniqKey="Mei Y">Y Mei</name>
</author>
<author><name sortKey="Abedi, V" uniqKey="Abedi V">V Abedi</name>
</author>
<author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name>
</author>
<author><name sortKey="Philipson, C" uniqKey="Philipson C">C Philipson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kelly, D" uniqKey="Kelly D">D Kelly</name>
</author>
<author><name sortKey="Campbell, Ji" uniqKey="Campbell J">JI Campbell</name>
</author>
<author><name sortKey="King, Tp" uniqKey="King T">TP King</name>
</author>
<author><name sortKey="Grant, G" uniqKey="Grant G">G Grant</name>
</author>
<author><name sortKey="Jansson, Ea" uniqKey="Jansson E">EA Jansson</name>
</author>
<author><name sortKey="Coutts, Ag" uniqKey="Coutts A">AG Coutts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marzo, Al" uniqKey="Marzo A">AL Marzo</name>
</author>
<author><name sortKey="Klonowski, Kd" uniqKey="Klonowski K">KD Klonowski</name>
</author>
<author><name sortKey="Bon, Al" uniqKey="Bon A">AL Bon</name>
</author>
<author><name sortKey="Borrow, P" uniqKey="Borrow P">P Borrow</name>
</author>
<author><name sortKey="Tough, Df" uniqKey="Tough D">DF Tough</name>
</author>
<author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L Lefrancois</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name>
</author>
<author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F Sallusto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sallusto, F" uniqKey="Sallusto F">F Sallusto</name>
</author>
<author><name sortKey="Geginat, J" uniqKey="Geginat J">J Geginat</name>
</author>
<author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kaech, Sm" uniqKey="Kaech S">SM Kaech</name>
</author>
<author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naresh, R" uniqKey="Naresh R">R Naresh</name>
</author>
<author><name sortKey="Song, Y" uniqKey="Song Y">Y Song</name>
</author>
<author><name sortKey="Hampson, Dj" uniqKey="Hampson D">DJ Hampson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
<author><name sortKey="Kronsteiner, B" uniqKey="Kronsteiner B">B Kronsteiner</name>
</author>
<author><name sortKey="Viladomiu, M" uniqKey="Viladomiu M">M Viladomiu</name>
</author>
<author><name sortKey="Pedragosa, M" uniqKey="Pedragosa M">M Pedragosa</name>
</author>
<author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
<author><name sortKey="Andrew, T" uniqKey="Andrew T">T Andrew</name>
</author>
<author><name sortKey="Eden, K" uniqKey="Eden K">K Eden</name>
</author>
<author><name sortKey="Mei, Y" uniqKey="Mei Y">Y Mei</name>
</author>
<author><name sortKey="Hoops, S" uniqKey="Hoops S">S Hoops</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Olivares Villagomez, D" uniqKey="Olivares Villagomez D">D Olivares-Villagomez</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
<author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
<author><name sortKey="Chaturvedi, R" uniqKey="Chaturvedi R">R Chaturvedi</name>
</author>
<author><name sortKey="Piazuelo, Mb" uniqKey="Piazuelo M">MB Piazuelo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
<author><name sortKey="Viladomiu, M" uniqKey="Viladomiu M">M Viladomiu</name>
</author>
<author><name sortKey="Leber, A" uniqKey="Leber A">A Leber</name>
</author>
<author><name sortKey="Hoops, S" uniqKey="Hoops S">S Hoops</name>
</author>
<author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leber, A" uniqKey="Leber A">A Leber</name>
</author>
<author><name sortKey="Viladomiu, M" uniqKey="Viladomiu M">M Viladomiu</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
<author><name sortKey="Abedi, V" uniqKey="Abedi V">V Abedi</name>
</author>
<author><name sortKey="Philipson, C" uniqKey="Philipson C">C Philipson</name>
</author>
<author><name sortKey="Hoops, S" uniqKey="Hoops S">S Hoops</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sumner, T" uniqKey="Sumner T">T Sumner</name>
</author>
<author><name sortKey="Hetherington, J" uniqKey="Hetherington J">J Hetherington</name>
</author>
<author><name sortKey="Seymour, Rm" uniqKey="Seymour R">RM Seymour</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Rey, Mv" uniqKey="Rey M">MV Rey</name>
</author>
<author><name sortKey="Yamaji, S" uniqKey="Yamaji S">S Yamaji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sumner, T" uniqKey="Sumner T">T Sumner</name>
</author>
<author><name sortKey="Shephard, E" uniqKey="Shephard E">E Shephard</name>
</author>
<author><name sortKey="Bogle, Id" uniqKey="Bogle I">ID Bogle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sumner, T" uniqKey="Sumner T">T Sumner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Broeke, Gat" uniqKey="Broeke G">GAT Broeke</name>
</author>
<author><name sortKey="Voorn, Gakv" uniqKey="Voorn G">GAKv Voorn</name>
</author>
<author><name sortKey="Ligtenberg, A" uniqKey="Ligtenberg A">A Ligtenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schouten, M" uniqKey="Schouten M">M Schouten</name>
</author>
<author><name sortKey="Verwaart, T" uniqKey="Verwaart T">T Verwaart</name>
</author>
<author><name sortKey="Heijman, W" uniqKey="Heijman W">W Heijman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ligmann Zielinska, A" uniqKey="Ligmann Zielinska A">A Ligmann-Zielinska</name>
</author>
<author><name sortKey="Kramer, Db" uniqKey="Kramer D">DB Kramer</name>
</author>
<author><name sortKey="Cheruvelil, Ks" uniqKey="Cheruvelil K">KS Cheruvelil</name>
</author>
<author><name sortKey="Soranno, Pa" uniqKey="Soranno P">PA Soranno</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parry, Hr" uniqKey="Parry H">HR Parry</name>
</author>
<author><name sortKey="Topping, Cj" uniqKey="Topping C">CJ Topping</name>
</author>
<author><name sortKey="Kennedy, Mc" uniqKey="Kennedy M">MC Kennedy</name>
</author>
<author><name sortKey="Boatman, Nd" uniqKey="Boatman N">ND Boatman</name>
</author>
<author><name sortKey="Murray, Awa" uniqKey="Murray A">AWA Murray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fonoberova, M" uniqKey="Fonoberova M">M Fonoberova</name>
</author>
<author><name sortKey="Fonoberov, Va" uniqKey="Fonoberov V">VA Fonoberov</name>
</author>
<author><name sortKey="Mezi, I" uniqKey="Mezi I">I Mezić</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kandulski, A" uniqKey="Kandulski A">A Kandulski</name>
</author>
<author><name sortKey="Malfertheiner, P" uniqKey="Malfertheiner P">P Malfertheiner</name>
</author>
<author><name sortKey="Wex, T" uniqKey="Wex T">T Wex</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramarao, N" uniqKey="Ramarao N">N Ramarao</name>
</author>
<author><name sortKey="Meyer, Tf" uniqKey="Meyer T">TF Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
<author><name sortKey="Pedragosa, M" uniqKey="Pedragosa M">M Pedragosa</name>
</author>
<author><name sortKey="Viladomiu, M" uniqKey="Viladomiu M">M Viladomiu</name>
</author>
<author><name sortKey="Marathe, M" uniqKey="Marathe M">M Marathe</name>
</author>
<author><name sortKey="Eubank, S" uniqKey="Eubank S">S Eubank</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Cj" uniqKey="Wu C">CJ Wu</name>
</author>
<author><name sortKey="Hamada, Ms" uniqKey="Hamada M">MS Hamada</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez Fernandez, M" uniqKey="Rodriguez Fernandez M">M Rodriguez-Fernandez</name>
</author>
<author><name sortKey="Banga, Jr" uniqKey="Banga J">JR Banga</name>
</author>
<author><name sortKey="Doyle, Fj" uniqKey="Doyle F">FJ Doyle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Box, Ge" uniqKey="Box G">GE Box</name>
</author>
<author><name sortKey="Hunter, Js" uniqKey="Hunter J">JS Hunter</name>
</author>
<author><name sortKey="Hunter, Wg" uniqKey="Hunter W">WG Hunter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kleijnen, Jpc" uniqKey="Kleijnen J">JPC Kleijnen</name>
</author>
<author><name sortKey="Groenendaal, Wv" uniqKey="Groenendaal W">Wv Groenendaal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Law, Am" uniqKey="Law A">AM Law</name>
</author>
<author><name sortKey="Kelton, Dm" uniqKey="Kelton D">DM Kelton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Noordegraaf, Av" uniqKey="Noordegraaf A">AV Noordegraaf</name>
</author>
<author><name sortKey="Nielen, M" uniqKey="Nielen M">M Nielen</name>
</author>
<author><name sortKey="Kleijnen, Jpc" uniqKey="Kleijnen J">JPC Kleijnen</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Montgomery, Dc" uniqKey="Montgomery D">DC Montgomery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hedayat, As" uniqKey="Hedayat A">AS Hedayat</name>
</author>
<author><name sortKey="Sloane, Nja" uniqKey="Sloane N">NJA Sloane</name>
</author>
<author><name sortKey="Stufken, J" uniqKey="Stufken J">J Stufken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morris, Md" uniqKey="Morris M">MD Morris</name>
</author>
<author><name sortKey="Moore, Lm" uniqKey="Moore L">LM Moore</name>
</author>
<author><name sortKey="Mckay, Md" uniqKey="Mckay M">MD McKay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scheffe, H" uniqKey="Scheffe H">H Scheffé</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seber, Gaf" uniqKey="Seber G">GAF Seber</name>
</author>
<author><name sortKey="Lee, Aj" uniqKey="Lee A">AJ Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
<author><name sortKey="Dominguez Bello, Mg" uniqKey="Dominguez Bello M">MG Dominguez-Bello</name>
</author>
<author><name sortKey="Kronsteiner, B" uniqKey="Kronsteiner B">B Kronsteiner</name>
</author>
<author><name sortKey="Carbo, A" uniqKey="Carbo A">A Carbo</name>
</author>
<author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name>
</author>
<author><name sortKey="Viladomiu, M" uniqKey="Viladomiu M">M Viladomiu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schumacher, Ma" uniqKey="Schumacher M">MA Schumacher</name>
</author>
<author><name sortKey="Donnelly, Jm" uniqKey="Donnelly J">JM Donnelly</name>
</author>
<author><name sortKey="Engevik, Ac" uniqKey="Engevik A">AC Engevik</name>
</author>
<author><name sortKey="Xiao, C" uniqKey="Xiao C">C Xiao</name>
</author>
<author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name>
</author>
<author><name sortKey="Kenny, S" uniqKey="Kenny S">S Kenny</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kronsteiner, B" uniqKey="Kronsteiner B">B Kronsteiner</name>
</author>
<author><name sortKey="Bassaganya Riera, J" uniqKey="Bassaganya Riera J">J Bassaganya-Riera</name>
</author>
<author><name sortKey="Philipson, N" uniqKey="Philipson N">N Philipson</name>
</author>
<author><name sortKey="Hontecillas, R" uniqKey="Hontecillas R">R Hontecillas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sigal, M" uniqKey="Sigal M">M Sigal</name>
</author>
<author><name sortKey="Rothenberg, Me" uniqKey="Rothenberg M">ME Rothenberg</name>
</author>
<author><name sortKey="Logan, Cy" uniqKey="Logan C">CY Logan</name>
</author>
<author><name sortKey="Lee, Jy" uniqKey="Lee J">JY Lee</name>
</author>
<author><name sortKey="Honaker, Rw" uniqKey="Honaker R">RW Honaker</name>
</author>
<author><name sortKey="Cooper, Rl" uniqKey="Cooper R">RL Cooper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sacks, J" uniqKey="Sacks J">J Sacks</name>
</author>
<author><name sortKey="Welch, Wj" uniqKey="Welch W">WJ Welch</name>
</author>
<author><name sortKey="Mitchell, Tj" uniqKey="Mitchell T">TJ Mitchell</name>
</author>
<author><name sortKey="Wynn, Hp" uniqKey="Wynn H">HP Wynn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Santner, Tj" uniqKey="Santner T">TJ Santner</name>
</author>
<author><name sortKey="Williams, Bj" uniqKey="Williams B">BJ Williams</name>
</author>
<author><name sortKey="Notz, W" uniqKey="Notz W">W Notz</name>
</author>
</analytic>
</biblStruct>
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