An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies
Identifieur interne : 000377 ( Istex/Curation ); précédent : 000376; suivant : 000378An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies
Auteurs : Toralf Kirsten [Allemagne] ; Jörg Lange [Allemagne] ; Erhard Rahm [Allemagne]Source :
- Lecture Notes in Computer Science [ 0302-9743 ] ; 2006.
Abstract
Abstract: To investigate molecular-biological causes and effects of diseases and their therapies it becomes increasingly important to combine data from clinical trials with high volumes of experimental genetic data and annotations. We present our approach to integrate such data for two large collaborative cancer research studies in Germany. Our platform interconnects a commercial study management system (eRN) with a data warehouse-based gene expression analysis system (GeWare). We utilize a generic approach to import different anonymized pathological and patient-related annotations into the warehouse. The platform also integrates different forms of experimental data and public molecular-biological annotation data and thus supports a wide range of genetic analyses for both clinical and non-clinical parameters.
Url:
DOI: 10.1007/11896548_31
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Toralf Kirsten<affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: tkirsten@izbi.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: lange@izbi.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation><mods:affiliation>Dept. of Computer Science, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: rahm@informatik.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation><affiliation><mods:affiliation>Dept. of Computer Science, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: rahm@informatik.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies</title><author><name sortKey="Kirsten, Toralf" sort="Kirsten, Toralf" uniqKey="Kirsten T" first="Toralf" last="Kirsten">Toralf Kirsten</name><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: tkirsten@izbi.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Lange, Jorg" sort="Lange, Jorg" uniqKey="Lange J" first="Jörg" last="Lange">Jörg Lange</name><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: lange@izbi.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Rahm, Erhard" sort="Rahm, Erhard" uniqKey="Rahm E" first="Erhard" last="Rahm">Erhard Rahm</name><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation><mods:affiliation>Dept. of Computer Science, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: rahm@informatik.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3995AE32FCFE0785DDCB71A9ADFF99961CE8F2E7</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1007/11896548_31</idno><idno type="url">https://api.istex.fr/document/3995AE32FCFE0785DDCB71A9ADFF99961CE8F2E7/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000377</idno><idno type="wicri:Area/Istex/Curation">000377</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies</title><author><name sortKey="Kirsten, Toralf" sort="Kirsten, Toralf" uniqKey="Kirsten T" first="Toralf" last="Kirsten">Toralf Kirsten</name><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: tkirsten@izbi.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Lange, Jorg" sort="Lange, Jorg" uniqKey="Lange J" first="Jörg" last="Lange">Jörg Lange</name><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: lange@izbi.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Rahm, Erhard" sort="Rahm, Erhard" uniqKey="Rahm E" first="Erhard" last="Rahm">Erhard Rahm</name><affiliation><mods:affiliation>Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation><mods:affiliation>Dept. of Computer Science, University of Leipzig</mods:affiliation><wicri:noCountry code="subField">Leipzig</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: rahm@informatik.uni-leipzig.de</mods:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author></analytic><monogr></monogr><series><title level="s">Lecture Notes in Computer Science</title><imprint><date>2006</date></imprint><idno type="ISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><idno type="ISSN">0302-9743</idno></series><idno type="istex">3995AE32FCFE0785DDCB71A9ADFF99961CE8F2E7</idno><idno type="DOI">10.1007/11896548_31</idno><idno type="ChapterID">31</idno><idno type="ChapterID">Chap31</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-9743</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: To investigate molecular-biological causes and effects of diseases and their therapies it becomes increasingly important to combine data from clinical trials with high volumes of experimental genetic data and annotations. We present our approach to integrate such data for two large collaborative cancer research studies in Germany. Our platform interconnects a commercial study management system (eRN) with a data warehouse-based gene expression analysis system (GeWare). We utilize a generic approach to import different anonymized pathological and patient-related annotations into the warehouse. The platform also integrates different forms of experimental data and public molecular-biological annotation data and thus supports a wide range of genetic analyses for both clinical and non-clinical parameters.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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