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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>ACC2</italic> gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat</title><author><name sortKey="Phillips, Catherine M" sort="Phillips, Catherine M" uniqKey="Phillips C" first="Catherine M." last="Phillips">Catherine M. Phillips</name><affiliation><nlm:aff id="aff1">Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Goumidi, Louisa" sort="Goumidi, Louisa" uniqKey="Goumidi L" first="Louisa" last="Goumidi">Louisa Goumidi</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bertrais, Sandrine" sort="Bertrais, Sandrine" uniqKey="Bertrais S" first="Sandrine" last="Bertrais">Sandrine Bertrais</name><affiliation><nlm:aff id="aff3">INSERM U557/INRA/CNAM,<institution>Université Paris</institution>, Bobigny,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Field, Martyn R" sort="Field, Martyn R" uniqKey="Field M" first="Martyn R." last="Field">Martyn R. Field</name><affiliation><nlm:aff id="aff4"><institution>Hitachi Dublin Laboratory</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="aff5"><institution>Boston University School of Public Health</institution>, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Ordovas, Jose M" sort="Ordovas, Jose M" uniqKey="Ordovas J" first="Jose M." last="Ordovas">Jose M. Ordovas</name><affiliation><nlm:aff id="aff6">Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging,<institution>Tufts University</institution>, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Mcmonagle, Jolene" sort="Mcmonagle, Jolene" uniqKey="Mcmonagle J" first="Jolene" last="Mcmonagle">Jolene Mcmonagle</name><affiliation><nlm:aff id="aff1">Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Defoort, Catherine" sort="Defoort, Catherine" uniqKey="Defoort C" first="Catherine" last="Defoort">Catherine Defoort</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lovegrove, Julie A" sort="Lovegrove, Julie A" uniqKey="Lovegrove J" first="Julie A." last="Lovegrove">Julie A. Lovegrove</name><affiliation><nlm:aff id="aff7">Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, Institute for Cardiovascular and Metabolic Research,<institution>University of Reading</institution>, Reading,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Drevon, Christian A" sort="Drevon, Christian A" uniqKey="Drevon C" first="Christian A." last="Drevon">Christian A. Drevon</name><affiliation><nlm:aff id="aff8">Department of Nutrition, Institute of Basic Medical Sciences,<institution>University of Oslo</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Blaak, Ellen E" sort="Blaak, Ellen E" uniqKey="Blaak E" first="Ellen E." last="Blaak">Ellen E. Blaak</name><affiliation><nlm:aff id="aff9">Department of Human Biology,<institution>Nutrition and Toxicology Research Institute Maastricht (NUTRIM)</institution>, Maastricht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Kiec Wilk, Beata" sort="Kiec Wilk, Beata" uniqKey="Kiec Wilk B" first="Beata" last="Kiec-Wilk">Beata Kiec-Wilk</name><affiliation><nlm:aff id="aff10">Department of Clinical Biochemistry,<institution>Jagiellonian University Medical College</institution>, Krakow,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Riserus">Ulf Riserus</name><affiliation><nlm:aff id="aff11">Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism,<institution>Uppsala University</institution>, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lopez Miranda, Jose" sort="Lopez Miranda, Jose" uniqKey="Lopez Miranda J" first="Jose" last="Lopez-Miranda">Jose Lopez-Miranda</name><affiliation><nlm:aff id="aff12">Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN),<institution>Instituto de Salud Carlos III (ISCIII)</institution>, Spain</nlm:aff></affiliation></author><author><name sortKey="Mcmanus, Ross" sort="Mcmanus, Ross" uniqKey="Mcmanus R" first="Ross" last="Mcmanus">Ross Mcmanus</name><affiliation><nlm:aff id="aff13">Institute of Molecular Medicine,<institution>Trinity College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="aff3">INSERM U557/INRA/CNAM,<institution>Université Paris</institution>, Bobigny,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lairon, Denis" sort="Lairon, Denis" uniqKey="Lairon D" first="Denis" last="Lairon">Denis Lairon</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Planells, Richard" sort="Planells, Richard" uniqKey="Planells R" first="Richard" last="Planells">Richard Planells</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Roche, Helen M" sort="Roche, Helen M" uniqKey="Roche H" first="Helen M." last="Roche">Helen M. Roche</name><affiliation><nlm:aff id="aff1">Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20855566</idno><idno type="pmc">2975722</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975722</idno><idno type="RBID">PMC:2975722</idno><idno type="doi">10.1194/jlr.M008474</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000390</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>ACC2</italic> gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat</title><author><name sortKey="Phillips, Catherine M" sort="Phillips, Catherine M" uniqKey="Phillips C" first="Catherine M." last="Phillips">Catherine M. Phillips</name><affiliation><nlm:aff id="aff1">Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Goumidi, Louisa" sort="Goumidi, Louisa" uniqKey="Goumidi L" first="Louisa" last="Goumidi">Louisa Goumidi</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Bertrais, Sandrine" sort="Bertrais, Sandrine" uniqKey="Bertrais S" first="Sandrine" last="Bertrais">Sandrine Bertrais</name><affiliation><nlm:aff id="aff3">INSERM U557/INRA/CNAM,<institution>Université Paris</institution>, Bobigny,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Field, Martyn R" sort="Field, Martyn R" uniqKey="Field M" first="Martyn R." last="Field">Martyn R. Field</name><affiliation><nlm:aff id="aff4"><institution>Hitachi Dublin Laboratory</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Cupples, L Adrienne" sort="Cupples, L Adrienne" uniqKey="Cupples L" first="L. Adrienne" last="Cupples">L. Adrienne Cupples</name><affiliation><nlm:aff id="aff5"><institution>Boston University School of Public Health</institution>, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Ordovas, Jose M" sort="Ordovas, Jose M" uniqKey="Ordovas J" first="Jose M." last="Ordovas">Jose M. Ordovas</name><affiliation><nlm:aff id="aff6">Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging,<institution>Tufts University</institution>, Boston, MA</nlm:aff></affiliation></author><author><name sortKey="Mcmonagle, Jolene" sort="Mcmonagle, Jolene" uniqKey="Mcmonagle J" first="Jolene" last="Mcmonagle">Jolene Mcmonagle</name><affiliation><nlm:aff id="aff1">Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Defoort, Catherine" sort="Defoort, Catherine" uniqKey="Defoort C" first="Catherine" last="Defoort">Catherine Defoort</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lovegrove, Julie A" sort="Lovegrove, Julie A" uniqKey="Lovegrove J" first="Julie A." last="Lovegrove">Julie A. Lovegrove</name><affiliation><nlm:aff id="aff7">Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, Institute for Cardiovascular and Metabolic Research,<institution>University of Reading</institution>, Reading,<country>UK</country></nlm:aff></affiliation></author><author><name sortKey="Drevon, Christian A" sort="Drevon, Christian A" uniqKey="Drevon C" first="Christian A." last="Drevon">Christian A. Drevon</name><affiliation><nlm:aff id="aff8">Department of Nutrition, Institute of Basic Medical Sciences,<institution>University of Oslo</institution>, Oslo,<country>Norway</country></nlm:aff></affiliation></author><author><name sortKey="Blaak, Ellen E" sort="Blaak, Ellen E" uniqKey="Blaak E" first="Ellen E." last="Blaak">Ellen E. Blaak</name><affiliation><nlm:aff id="aff9">Department of Human Biology,<institution>Nutrition and Toxicology Research Institute Maastricht (NUTRIM)</institution>, Maastricht,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Kiec Wilk, Beata" sort="Kiec Wilk, Beata" uniqKey="Kiec Wilk B" first="Beata" last="Kiec-Wilk">Beata Kiec-Wilk</name><affiliation><nlm:aff id="aff10">Department of Clinical Biochemistry,<institution>Jagiellonian University Medical College</institution>, Krakow,<country>Poland</country></nlm:aff></affiliation></author><author><name sortKey="Riserus, Ulf" sort="Riserus, Ulf" uniqKey="Riserus U" first="Ulf" last="Riserus">Ulf Riserus</name><affiliation><nlm:aff id="aff11">Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism,<institution>Uppsala University</institution>, Uppsala, Sweden</nlm:aff></affiliation></author><author><name sortKey="Lopez Miranda, Jose" sort="Lopez Miranda, Jose" uniqKey="Lopez Miranda J" first="Jose" last="Lopez-Miranda">Jose Lopez-Miranda</name><affiliation><nlm:aff id="aff12">Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN),<institution>Instituto de Salud Carlos III (ISCIII)</institution>, Spain</nlm:aff></affiliation></author><author><name sortKey="Mcmanus, Ross" sort="Mcmanus, Ross" uniqKey="Mcmanus R" first="Ross" last="Mcmanus">Ross Mcmanus</name><affiliation><nlm:aff id="aff13">Institute of Molecular Medicine,<institution>Trinity College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:aff id="aff3">INSERM U557/INRA/CNAM,<institution>Université Paris</institution>, Bobigny,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Lairon, Denis" sort="Lairon, Denis" uniqKey="Lairon D" first="Denis" last="Lairon">Denis Lairon</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Planells, Richard" sort="Planells, Richard" uniqKey="Planells R" first="Richard" last="Planells">Richard Planells</name><affiliation><nlm:aff id="aff2">INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></nlm:aff></affiliation></author><author><name sortKey="Roche, Helen M" sort="Roche, Helen M" uniqKey="Roche H" first="Helen M." last="Roche">Helen M. Roche</name><affiliation><nlm:aff id="aff1">Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Lipid Research</title><idno type="ISSN">0022-2275</idno><idno type="eISSN">1539-7262</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Acetyl-CoA carboxylase β (ACC2) plays a key role in fatty acid synthesis and oxidation pathways. Disturbance of these pathways is associated with impaired insulin responsiveness and metabolic syndrome (MetS). Gene-nutrient interactions may affect MetS risk. This study determined the relationship between <italic>ACC2</italic> polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). Minor A allele carriers of rs4766587 had increased MetS risk (OR 1.29 [CI 1.08, 1.58], <italic>P</italic> = 0.0064) compared with the GG homozygotes, which may in part be explained by their increased body mass index (BMI), abdominal obesity, and impaired insulin sensitivity (<italic>P</italic> < 0.05). MetS risk was modulated by dietary fat intake (<italic>P</italic> = 0.04 for gene-nutrient interaction), where risk conferred by the A allele was exacerbated among individuals with a high-fat intake (>35% energy) (OR 1.62 [CI 1.05, 2.50], <italic>P</italic> = 0.027), particularly a high intake (>5.5% energy) of n-6 polyunsaturated fat (PUFA) (OR 1.82 [CI 1.14, 2.94], <italic>P</italic> = 0.01; <italic>P</italic> = 0.05 for gene-nutrient interaction). Saturated and monounsaturated fat intake did not modulate MetS risk. Importantly, we replicated some of these findings in an independent cohort. In conclusion, the <italic>ACC2</italic> rs4766587 polymorphism influences MetS risk, which was modulated by dietary fat, suggesting novel gene-nutrient interactions.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Lipid Res</journal-id><journal-id journal-id-type="publisher-id">jlr</journal-id><journal-title-group><journal-title>Journal of Lipid Research</journal-title></journal-title-group><issn pub-type="ppub">0022-2275</issn><issn pub-type="epub">1539-7262</issn><publisher><publisher-name>The American Society for Biochemistry and Molecular Biology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20855566</article-id><article-id pub-id-type="pmc">2975722</article-id><article-id pub-id-type="publisher-id">m008474</article-id><article-id pub-id-type="doi">10.1194/jlr.M008474</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group></article-categories><title-group><article-title><italic>ACC2</italic> gene polymorphisms, metabolic syndrome, and gene-nutrient interactions with dietary fat</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Phillips</surname><given-names>Catherine M.</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Goumidi</surname><given-names>Louisa</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Bertrais</surname><given-names>Sandrine</given-names></name><xref ref-type="aff" rid="aff3">§</xref></contrib><contrib contrib-type="author"><name><surname>Field</surname><given-names>Martyn R.</given-names></name><xref ref-type="aff" rid="aff4">**</xref></contrib><contrib contrib-type="author"><name><surname>Cupples</surname><given-names>L. Adrienne</given-names></name><xref ref-type="aff" rid="aff5">††</xref></contrib><contrib contrib-type="author"><name><surname>Ordovas</surname><given-names>Jose M.</given-names></name><xref ref-type="aff" rid="aff6">§§</xref></contrib><contrib contrib-type="author"><name><surname>McMonagle</surname><given-names>Jolene</given-names></name><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Defoort</surname><given-names>Catherine</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Lovegrove</surname><given-names>Julie A.</given-names></name><xref ref-type="aff" rid="aff7">***</xref></contrib><contrib contrib-type="author"><name><surname>Drevon</surname><given-names>Christian A.</given-names></name><xref ref-type="aff" rid="aff8">†††</xref></contrib><contrib contrib-type="author"><name><surname>Blaak</surname><given-names>Ellen E.</given-names></name><xref ref-type="aff" rid="aff9">§§§</xref></contrib><contrib contrib-type="author"><name><surname>Kiec-Wilk</surname><given-names>Beata</given-names></name><xref ref-type="aff" rid="aff10">****</xref></contrib><contrib contrib-type="author"><name><surname>Riserus</surname><given-names>Ulf</given-names></name><xref ref-type="aff" rid="aff11">††††</xref></contrib><contrib contrib-type="author"><name><surname>Lopez-Miranda</surname><given-names>Jose</given-names></name><xref ref-type="aff" rid="aff12">§§§§</xref></contrib><contrib contrib-type="author"><name><surname>McManus</surname><given-names>Ross</given-names></name><xref ref-type="aff" rid="aff13">*****</xref></contrib><contrib contrib-type="author"><name><surname>Hercberg</surname><given-names>Serge</given-names></name><xref ref-type="aff" rid="aff3">§</xref></contrib><contrib contrib-type="author"><name><surname>Lairon</surname><given-names>Denis</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Planells</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff2">†</xref></contrib><contrib contrib-type="author"><name><surname>Roche</surname><given-names>Helen M.</given-names></name><xref ref-type="corresp" rid="cor1">1</xref><xref ref-type="aff" rid="aff1">*</xref></contrib></contrib-group><aff id="aff1"><label>*</label>Nutrigenomics Research Group, UCD School of Public Health and Population Science, UCD Conway Institute,<institution>University College Dublin</institution>, Dublin,<country>Ireland</country></aff><aff id="aff2"><label>†</label>INSERM 476/INRA 1260,<institution>Université de la Méditerranée</institution>, Faculté de Médecine, Marseille,<country>France</country></aff><aff id="aff3"><label>§</label>INSERM U557/INRA/CNAM,<institution>Université Paris</institution>, Bobigny,<country>France</country></aff><aff id="aff4"><label>**</label><institution>Hitachi Dublin Laboratory</institution>, Dublin,<country>Ireland</country></aff><aff id="aff5"><label>††</label><institution>Boston University School of Public Health</institution>, Boston, MA</aff><aff id="aff6"><label>§§</label>Nutrition and Genomics Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging,<institution>Tufts University</institution>, Boston, MA</aff><aff id="aff7"><label>***</label>Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, Institute for Cardiovascular and Metabolic Research,<institution>University of Reading</institution>, Reading,<country>UK</country></aff><aff id="aff8"><label>†††</label>Department of Nutrition, Institute of Basic Medical Sciences,<institution>University of Oslo</institution>, Oslo,<country>Norway</country></aff><aff id="aff9"><label>§§§</label>Department of Human Biology,<institution>Nutrition and Toxicology Research Institute Maastricht (NUTRIM)</institution>, Maastricht,<country>The Netherlands</country></aff><aff id="aff10"><label>****</label>Department of Clinical Biochemistry,<institution>Jagiellonian University Medical College</institution>, Krakow,<country>Poland</country></aff><aff id="aff11"><label>††††</label>Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism,<institution>Uppsala University</institution>, Uppsala, Sweden</aff><aff id="aff12"><label>§§§§</label>Lipids and Atherosclerosis Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC)/Hospital Universitario Reina Sofía/Universidad de Córdoba and CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN),<institution>Instituto de Salud Carlos III (ISCIII)</institution>, Spain</aff><aff id="aff13"><label>*****</label>Institute of Molecular Medicine,<institution>Trinity College Dublin</institution>, Dublin,<country>Ireland</country></aff><author-notes><corresp id="cor1"><label>1</label>To whom correspondence should be addressed. e-mail: <email>helen.roche@ucd.ie</email></corresp></author-notes><pub-date pub-type="epub-ppub"><month>12</month><year>2010</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2010</year></pub-date><volume>51</volume><issue>12</issue><fpage>3500</fpage><lpage>3507</lpage><history><date date-type="received"><day>17</day><month>5</month><year>2010</year></date><date date-type="rev-recd"><day>27</day><month>8</month><year>2010</year></date></history><abstract><p>Acetyl-CoA carboxylase β (ACC2) plays a key role in fatty acid synthesis and oxidation pathways. Disturbance of these pathways is associated with impaired insulin responsiveness and metabolic syndrome (MetS). Gene-nutrient interactions may affect MetS risk. This study determined the relationship between <italic>ACC2</italic> polymorphisms (rs2075263, rs2268387, rs2284685, rs2284689, rs2300453, rs3742023, rs3742026, rs4766587, and rs6606697) and MetS risk, and whether dietary fatty acids modulate this in the LIPGENE-SU.VI.MAX study of MetS cases and matched controls (n = 1754). Minor A allele carriers of rs4766587 had increased MetS risk (OR 1.29 [CI 1.08, 1.58], <italic>P</italic> = 0.0064) compared with the GG homozygotes, which may in part be explained by their increased body mass index (BMI), abdominal obesity, and impaired insulin sensitivity (<italic>P</italic> < 0.05). MetS risk was modulated by dietary fat intake (<italic>P</italic> = 0.04 for gene-nutrient interaction), where risk conferred by the A allele was exacerbated among individuals with a high-fat intake (>35% energy) (OR 1.62 [CI 1.05, 2.50], <italic>P</italic> = 0.027), particularly a high intake (>5.5% energy) of n-6 polyunsaturated fat (PUFA) (OR 1.82 [CI 1.14, 2.94], <italic>P</italic> = 0.01; <italic>P</italic> = 0.05 for gene-nutrient interaction). Saturated and monounsaturated fat intake did not modulate MetS risk. Importantly, we replicated some of these findings in an independent cohort. In conclusion, the <italic>ACC2</italic> rs4766587 polymorphism influences MetS risk, which was modulated by dietary fat, suggesting novel gene-nutrient interactions.</p></abstract><kwd-group><kwd>genetic polymorphisms</kwd><kwd>insulin resistance</kwd><kwd>fatty acid metabolism</kwd><kwd>polyunsaturated fatty acids</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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| This area was generated with Dilib version V0.6.31. |  |