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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Study protocol for a randomised controlled trial of internet-based cognitive-behavioural therapy for obsessive-compulsive disorder</title>
<author><name sortKey="Kyrios, Michael" sort="Kyrios, Michael" uniqKey="Kyrios M" first="Michael" last="Kyrios">Michael Kyrios</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nedeljkovic, Maja" sort="Nedeljkovic, Maja" uniqKey="Nedeljkovic M" first="Maja" last="Nedeljkovic">Maja Nedeljkovic</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Moulding, Richard" sort="Moulding, Richard" uniqKey="Moulding R" first="Richard" last="Moulding">Richard Moulding</name>
<affiliation><nlm:aff id="Aff78">Centre for Mental Health and Wellbeing Research, Deakin University, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klein, Britt" sort="Klein, Britt" uniqKey="Klein B" first="Britt" last="Klein">Britt Klein</name>
<affiliation><nlm:aff id="Aff79">DVC-R Portfolio, School of Health Sciences, and the Collaborative Research Network, Federation University, Ballarat, VIC Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff80">Centre for Mental Health Research, The Australian National University, Canberra, ACT Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Austin, David" sort="Austin, David" uniqKey="Austin D" first="David" last="Austin">David Austin</name>
<affiliation><nlm:aff id="Aff78">Centre for Mental Health and Wellbeing Research, Deakin University, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meyer, Denny" sort="Meyer, Denny" uniqKey="Meyer D" first="Denny" last="Meyer">Denny Meyer</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ahern, Claire" sort="Ahern, Claire" uniqKey="Ahern C" first="Claire" last="Ahern">Claire Ahern</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25062747</idno>
<idno type="pmc">4222668</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222668</idno>
<idno type="RBID">PMC:4222668</idno>
<idno type="doi">10.1186/1471-244X-14-209</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000115</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Study protocol for a randomised controlled trial of internet-based cognitive-behavioural therapy for obsessive-compulsive disorder</title>
<author><name sortKey="Kyrios, Michael" sort="Kyrios, Michael" uniqKey="Kyrios M" first="Michael" last="Kyrios">Michael Kyrios</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nedeljkovic, Maja" sort="Nedeljkovic, Maja" uniqKey="Nedeljkovic M" first="Maja" last="Nedeljkovic">Maja Nedeljkovic</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Moulding, Richard" sort="Moulding, Richard" uniqKey="Moulding R" first="Richard" last="Moulding">Richard Moulding</name>
<affiliation><nlm:aff id="Aff78">Centre for Mental Health and Wellbeing Research, Deakin University, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klein, Britt" sort="Klein, Britt" uniqKey="Klein B" first="Britt" last="Klein">Britt Klein</name>
<affiliation><nlm:aff id="Aff79">DVC-R Portfolio, School of Health Sciences, and the Collaborative Research Network, Federation University, Ballarat, VIC Australia</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="Aff80">Centre for Mental Health Research, The Australian National University, Canberra, ACT Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Austin, David" sort="Austin, David" uniqKey="Austin D" first="David" last="Austin">David Austin</name>
<affiliation><nlm:aff id="Aff78">Centre for Mental Health and Wellbeing Research, Deakin University, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meyer, Denny" sort="Meyer, Denny" uniqKey="Meyer D" first="Denny" last="Meyer">Denny Meyer</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ahern, Claire" sort="Ahern, Claire" uniqKey="Ahern C" first="Claire" last="Ahern">Claire Ahern</name>
<affiliation><nlm:aff id="Aff77">Swinburne University of Technology, Melbourne, VIC Australia</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Psychiatry</title>
<idno type="eISSN">1471-244X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Obsessive-Compulsive Disorder (OCD) is a common chronic psychiatric disorder that constitutes a leading cause of disability. Although Cognitive-Behaviour Therapy (CBT) has been shown to be an effective treatment for OCD, this specialised treatment is unavailable to many due to access issues and the social stigma associated with seeing a mental health specialist. Internet-based psychological treatments have shown to provide effective, accessible and affordable treatment for a range of anxiety disorders, and two Randomised Controlled Trials (RCTs) have demonstrated the efficacy and acceptability of internet-based CBT (iCBT) for OCD, as compared to waitlist or supportive therapy. Although these initial findings are promising, they do not isolate the specific effect of iCBT. This paper details the study protocol for the first randomised control trial evaluating the efficacy of therapist-assisted iCBT for OCD, as compared to a matched control intervention; internet-based therapist-assisted progressive relaxation training (iPRT). It will aim to examine whether therapist-assisted iCBT is an acceptable and efficacious treatment, and to examine how effectiveness is influenced by patient characteristics.</p>
</sec>
<sec><title>Method/design</title>
<p>A randomised controlled trial using repeated measures with two arms (intervention and matched control) will be used to evaluate the efficacy and acceptability of iCBT for OCD. The RCT will randomise 212 Australian adults with a primary diagnosis of OCD into either the active intervention or control condition, for 12 weeks duration. Outcomes for participants in both study arms will be assessed at baseline and post-intervention. Participants in iCBT will be further assessed at six month follow-up, while participants in the control condition will be crossed over to receive the iCBT intervention and reassessed at post-intervention and six month follow-up. The primary outcome will be clinically significant change in obsessive-compulsive symptom scores.</p>
</sec>
<sec><title>Discussion</title>
<p>This will be the first known therapist assisted internet-based trial of a comprehensive CBT treatment for OCD as compared to a matched control intervention. Demonstrating the efficacy of an internet-based treatment for OCD will allow the development of models of care for broad-based access to an evidence-based but complex treatment.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Psychiatry</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Psychiatry</journal-id>
<journal-title-group><journal-title>BMC Psychiatry</journal-title>
</journal-title-group>
<issn pub-type="epub">1471-244X</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25062747</article-id>
<article-id pub-id-type="pmc">4222668</article-id>
<article-id pub-id-type="publisher-id">1720</article-id>
<article-id pub-id-type="doi">10.1186/1471-244X-14-209</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Study Protocol</subject>
</subj-group>
</article-categories>
<title-group><article-title>Study protocol for a randomised controlled trial of internet-based cognitive-behavioural therapy for obsessive-compulsive disorder</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kyrios</surname>
<given-names>Michael</given-names>
</name>
<address><email>mkyrios@swin.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff77"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nedeljkovic</surname>
<given-names>Maja</given-names>
</name>
<address><email>mnedeljkovic@swin.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff77"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Moulding</surname>
<given-names>Richard</given-names>
</name>
<address><email>richard.moulding@deakin.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff78"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klein</surname>
<given-names>Britt</given-names>
</name>
<address><email>b.klein@federation.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff79"></xref>
<xref ref-type="aff" rid="Aff80"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Austin</surname>
<given-names>David</given-names>
</name>
<address><email>david.austin@deakin.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff78"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Meyer</surname>
<given-names>Denny</given-names>
</name>
<address><email>dmeyer@swin.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff77"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ahern</surname>
<given-names>Claire</given-names>
</name>
<address><email>cahern@swin.edu.au</email>
</address>
<xref ref-type="aff" rid="Aff77"></xref>
</contrib>
<aff id="Aff77"><label></label>
Swinburne University of Technology, Melbourne, VIC Australia</aff>
<aff id="Aff78"><label></label>
Centre for Mental Health and Wellbeing Research, Deakin University, Melbourne, VIC Australia</aff>
<aff id="Aff79"><label></label>
DVC-R Portfolio, School of Health Sciences, and the Collaborative Research Network, Federation University, Ballarat, VIC Australia</aff>
<aff id="Aff80"><label></label>
Centre for Mental Health Research, The Australian National University, Canberra, ACT Australia</aff>
</contrib-group>
<pub-date pub-type="epub"><day>25</day>
<month>7</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<volume>14</volume>
<elocation-id>209</elocation-id>
<history><date date-type="received"><day>22</day>
<month>5</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>9</day>
<month>6</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© Kyrios et al.; licensee BioMed Central Ltd. 2014</copyright-statement>
<license license-type="open-access"><license-p>This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Obsessive-Compulsive Disorder (OCD) is a common chronic psychiatric disorder that constitutes a leading cause of disability. Although Cognitive-Behaviour Therapy (CBT) has been shown to be an effective treatment for OCD, this specialised treatment is unavailable to many due to access issues and the social stigma associated with seeing a mental health specialist. Internet-based psychological treatments have shown to provide effective, accessible and affordable treatment for a range of anxiety disorders, and two Randomised Controlled Trials (RCTs) have demonstrated the efficacy and acceptability of internet-based CBT (iCBT) for OCD, as compared to waitlist or supportive therapy. Although these initial findings are promising, they do not isolate the specific effect of iCBT. This paper details the study protocol for the first randomised control trial evaluating the efficacy of therapist-assisted iCBT for OCD, as compared to a matched control intervention; internet-based therapist-assisted progressive relaxation training (iPRT). It will aim to examine whether therapist-assisted iCBT is an acceptable and efficacious treatment, and to examine how effectiveness is influenced by patient characteristics.</p>
</sec>
<sec><title>Method/design</title>
<p>A randomised controlled trial using repeated measures with two arms (intervention and matched control) will be used to evaluate the efficacy and acceptability of iCBT for OCD. The RCT will randomise 212 Australian adults with a primary diagnosis of OCD into either the active intervention or control condition, for 12 weeks duration. Outcomes for participants in both study arms will be assessed at baseline and post-intervention. Participants in iCBT will be further assessed at six month follow-up, while participants in the control condition will be crossed over to receive the iCBT intervention and reassessed at post-intervention and six month follow-up. The primary outcome will be clinically significant change in obsessive-compulsive symptom scores.</p>
</sec>
<sec><title>Discussion</title>
<p>This will be the first known therapist assisted internet-based trial of a comprehensive CBT treatment for OCD as compared to a matched control intervention. Demonstrating the efficacy of an internet-based treatment for OCD will allow the development of models of care for broad-based access to an evidence-based but complex treatment.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Mental health</kwd>
<kwd>Online intervention</kwd>
<kwd>Obsessive-compulsive disorder</kwd>
<kwd>OCD</kwd>
<kwd>Cognitive-behaviour therapy</kwd>
<kwd>CBT</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2014</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
<body><sec id="Sec1"><title>Background</title>
<p>Obsessive-Compulsive Disorder (OCD) is a severe and incapacitating disorder associated with intense anxiety, high degrees of psychiatric comorbidity, and significant health and social costs [<xref ref-type="bibr" rid="CR1">1</xref>
]. The disorder is recognised as a leading cause of disability [<xref ref-type="bibr" rid="CR2">2</xref>
] with levels of impairment similar to that of patients with schizophrenia [<xref ref-type="bibr" rid="CR1">1</xref>
]. OCD is characterised by the presence of obsessions and/or compulsions [<xref ref-type="bibr" rid="CR3">3</xref>
]. Obsessions are unwanted ego-dystonic thoughts, images or urges that are recurrent, persistent and intrusive, and that lead to marked distress. Compulsions are repetitive, rigid intentional behaviours or mental acts performed to reduce distress that follows an obsession, or to avoid potential danger [<xref ref-type="bibr" rid="CR3">3</xref>
]. OCD is a highly complex and heterogenous disorder with differential treatment outcomes for its various presentations [<xref ref-type="bibr" rid="CR4">4</xref>
].</p>
<p>Cognitive models of OCD have prompted recent advances in its psychological treatment. Central to the model is the understanding that normal unwanted intrusions (i.e., thoughts, images, urges) form the basis of obsessions [<xref ref-type="bibr" rid="CR5">5</xref>
]. Unwanted intrusions are universal in the experiences of the general population, and normal intrusions are indistinguishable from clinical obsessions. However, misappraisals of intrusions as personally significant, meaningful or dangerous, lead to anxiety or discomfort, and provoke maladaptive responses (e.g., compulsions) to alleviate distress [<xref ref-type="bibr" rid="CR6">6</xref>
]. Although these compulsions reduce discomfort in the short term, they are negatively reinforced and ultimately serve to maintain the misappraisals. Attempts at neutralising the unwanted intrusions paradoxically increase the intrusion’s salience, difficulty of dismissal, and intensity. Misinterpretation and neutralisation or compulsive actions thus maintain the occurrence of obsessions and further strengthen maladaptive beliefs.</p>
<sec id="Sec2"><title>Cognitive behaviour therapy for OCD</title>
<p>In targeting such processes in cognitive-behaviour therapy (CBT), patients monitor thoughts, evaluate evidence for maladaptive beliefs and appraisals, and develop and practice more productive appraisals to counter cognitive biases. Behavioural experiments and other cognitive techniques that help test alternative interpretations of intrusions are a key strategy in the treatment of OCD [<xref ref-type="bibr" rid="CR7">7</xref>
], but these techniques are somewhat more specialised and less accessible than the more widely known exposure-based strategies [<xref ref-type="bibr" rid="CR8">8</xref>
]. Exposure and Response Prevention (ERP) is an evidence-based central behavioural technique requiring individuals to face situations that induce distress while refraining from engaging in compulsive rituals [<xref ref-type="bibr" rid="CR9">9</xref>
, <xref ref-type="bibr" rid="CR10">10</xref>
]. In doing so, ERP leads to the extinction of avoidance and anxiety responses. Anxiety management and coping strategies such as relaxation techniques also have some credibility and acceptability amongst patients as they are useful in decreasing anxiety; however, they are generally no longer centrally utilised in CBT programs as the evidence for their efficacy is inconsistent, although they may be useful when the person has extreme anxiety responses [<xref ref-type="bibr" rid="CR10">10</xref>
].</p>
<p>Current clinical guidelines recommend CBT as a first line treatment for OCD [<xref ref-type="bibr" rid="CR11">11</xref>
]. CBT programs are typically 12 – 24 hours duration, with drop-out rates of around 25% and recovery rates at post-treatment of 50% to 75% [<xref ref-type="bibr" rid="CR10">10</xref>
]. Systematic reviews and meta-analyses support that CBT programs are effective in reducing OCD symptoms, with effect sizes ranging from 0.8 to 1.24 from pre to post treatment [<xref ref-type="bibr" rid="CR10">10</xref>
–<xref ref-type="bibr" rid="CR15">15</xref>
]. Although effective treatments exist, only a small percentage (<10%) of individuals with OCD receive CBT [<xref ref-type="bibr" rid="CR16">16</xref>
–<xref ref-type="bibr" rid="CR18">18</xref>
]. The mean duration between onset of first OCD symptoms and presentation for treatment is around seven years [<xref ref-type="bibr" rid="CR19">19</xref>
, <xref ref-type="bibr" rid="CR20">20</xref>
]. Individuals may go undiagnosed and untreated for many years due to a failure of health professionals to recognise OCD [<xref ref-type="bibr" rid="CR21">21</xref>
] and to intense feelings of embarrassment and guilt motivating patients to not disclose their experiences [<xref ref-type="bibr" rid="CR16">16</xref>
, <xref ref-type="bibr" rid="CR22">22</xref>
]. For those that do present for help, access to evidence-based treatment is poor; a shortage of appropriately qualified professionals (especially in geographically remote areas), long waitlists, and individuals’ financial constraints mean that specialised evidence-based treatment is often unavailable [<xref ref-type="bibr" rid="CR8">8</xref>
].</p>
</sec>
<sec id="Sec3"><title>Use of internet in mental health treatment to increase accessibility</title>
<p>Internet access is increasing across the world [<xref ref-type="bibr" rid="CR23">23</xref>
]. In Australia, the proportion of households with Internet access at home in 2012–13 was 83%, an increase from 79% in 2010–11 [<xref ref-type="bibr" rid="CR24">24</xref>
]. It is not surprising that the majority of people (77%) seek out mental health information from the internet [<xref ref-type="bibr" rid="CR25">25</xref>
]. Hence, internet interventions represent a unique opportunity to deliver evidence-based mental health treatment to large segments of the population, who might otherwise be unable to access such treatment [<xref ref-type="bibr" rid="CR26">26</xref>
, <xref ref-type="bibr" rid="CR27">27</xref>
]. Internet-based therapy has distinct potential advantages. It allows dissemination of standardised yet personalised treatments, which may include contact with therapists over e-mail or other modes of remote communication (e.g., telephone, video-chat). This is particularly beneficial for patients in geographically isolated regions, who may not have access to specialised mental health professionals. In contrast to face-to-face services, internet-based treatments can be accessed 24 hours a day, 7 days a week, without affecting efficiency while increasing personal convenience and being generally a lower cost option than face-to-face equivalents [<xref ref-type="bibr" rid="CR28">28</xref>
]. A further advantage of internet-based treatments is that they can be easily utilised in conjunction with other treatments, inclusive of pharmacotherapy and face-to-face supports such as supportive psychotherapy, general practice review and other psychological interventions. Particularly important for OCD, internet-based therapies allow anonymity, and in some cohorts experiencing stigma, individuals feel more comfortable with using technology than discussing their concerns in person [<xref ref-type="bibr" rid="CR29">29</xref>
–<xref ref-type="bibr" rid="CR31">31</xref>
].</p>
<p>Internet-based mental health interventions have been established as an effective model for the provision of CBT, without the need for intensive therapist involvement, for a variety of disorders and/or symptoms, including depression [<xref ref-type="bibr" rid="CR32">32</xref>
], panic disorder [<xref ref-type="bibr" rid="CR26">26</xref>
, <xref ref-type="bibr" rid="CR33">33</xref>
, <xref ref-type="bibr" rid="CR34">34</xref>
], post-traumatic stress disorder [<xref ref-type="bibr" rid="CR35">35</xref>
], and specific phobias [<xref ref-type="bibr" rid="CR36">36</xref>
]. Reviews of randomised controlled trials (RCTs) of internet interventions with therapist assistance for depressive and anxiety disorders have found reductions in symptoms, relevant cognitions and improvement in patients’ mental health literacy [<xref ref-type="bibr" rid="CR37">37</xref>
–<xref ref-type="bibr" rid="CR39">39</xref>
]. Interventions with therapist-assistance generally show larger effect sizes and lower attrition rates than self-help programs [<xref ref-type="bibr" rid="CR38">38</xref>
], while the amount and nature of the therapists’ experience has not been found to greatly influence the clinical outcome of internet therapy [<xref ref-type="bibr" rid="CR40">40</xref>
].</p>
</sec>
<sec id="Sec4"><title>Internet-based interventions for OCD</title>
<p>Although a relatively new area of investigation, a few open trials have been reported [<xref ref-type="bibr" rid="CR41">41</xref>
, <xref ref-type="bibr" rid="CR42">42</xref>
], with only two RCTs demonstrating the efficacy and acceptability of internet-based CBT (iCBT) for OCD. The first and largest RCT to date by Andersson et al. [<xref ref-type="bibr" rid="CR43">43</xref>
] comprised 101 individuals with a primary diagnosis of OCD who were not currently receiving counseling, and had no recent history of CBT (2 years) or changes to medication (2 months). Eligible participants were randomly allocated to receive 10-week therapist guided iCBT or a 10-week control condition (online supportive therapy). The iCBT condition was associated with a significant reduction in OCD symptoms (<italic>d</italic>
= 1.55) as measured by the Yale Brown Obsessive Compulsive Scale (YBOCS; [<xref ref-type="bibr" rid="CR44">44</xref>
]), compared to a medium within-group effect size (<italic>d</italic>
= 0.47) for the Control Group. Additionally, there was a large between between-group effect size (<italic>d</italic>
= 1.12) on the YBOCS, and only 6% participants in the control condition met criteria for clinically significant change, compared with 60% in iCBT. The results of iCBT were maintained at 4-month follow up. Although therapist contact in the control group was significantly lower than iCBT (129 minutes versus 17 minutes for iCBT and control, respectively), the between groups difference remained significant after therapist contact was statistically controlled. Nevertheless the specific effect of iCBT is unclear, as the control condition did not provide intervention elements that were experienced as similar to the active treatment (e.g., online self-help information, downloadable audio files, worksheets and homework).</p>
<p>Similar results were found in a smaller RCT by Wootton et al. [<xref ref-type="bibr" rid="CR45">45</xref>
] which involved 56 individuals with OCD who were not currently receiving CBT and had not had any changes to medication within the previous month. The authors found that 8-week therapist guided iCBT (N = 17) and therapist guided bibliotherapy (bCBT; N = 20) were effective compared to a waitlist control condition (N = 19; between-group effect sizes of <italic>d</italic>
= 1.57 and 1.40, respectively). The experimental groups were associated with a 47% (bCBT) and 39% (iCBT) reduction in OCD symptoms scores, which were maintained at 3-month follow-up, with a mean total therapist time of approximately 103 minutes for bCBT and 89 minutes for iCBT. The within group effect sizes for the experimental groups were larger than those obtained by self-help versions of the same program [<xref ref-type="bibr" rid="CR41">41</xref>
], suggesting that therapist assisted iCBT had stronger treatment effects. The same research group demonstrated similar efficacy in an earlier open trial of therapist-guided iCBT [<xref ref-type="bibr" rid="CR46">46</xref>
], which was rated as highly acceptable by participants despite their receiving an average of only 86 minutes of therapist contact.</p>
<p>These studies demonstrate that large effect sizes, which were comparable to those obtained in face-to-face therapy [<xref ref-type="bibr" rid="CR47">47</xref>
, <xref ref-type="bibr" rid="CR48">48</xref>
], can be obtained with minimal therapist contact, although follow-up periods have been relatively shorter than in other outcome studies for OCD that usually report 6-to-12 month follow-up data. Given that a standard course of face-to-face CBT would be around 6–12 sessions of one hour, online therapies for OCD are shown to be not only efficacious, but also cost effective. These economic, acceptability and efficacy considerations make it imperative that there is further examination into the utility of online therapy for OCD. In particular, RCTs that compare iCBT to a matched control are required to help isolate whether therapeutic outcomes are due to CBT and are independent of other intervention elements such as treatment credibility, therapist attention, therapeutic alliance, time, and use of an online modality and associated therapeutic tools (e.g., downloadable audiovisual components, homework tasks, etc.). Given the complexity and heterogeneity in presentations of OCD, therapist-assisted programs are best suited to help tailor intervention programs to individual client needs, and to promote treatment engagement and adherence.</p>
</sec>
<sec id="Sec5"><title>The current study</title>
<p>This paper details the study protocol for an RCT evaluating the efficacy of therapist-assisted iCBT for OCD. The primary aim is to examine whether therapist-assisted iCBT is an acceptable and efficacious treatment, as compared to an analogous active control, for patients who can choose to continue with their usual treatment. Treatment as usual is particularly well-suited to answer the practical question of whether introducing the new treatment could improve outcomes over and above the current state of practice. A further aim is to examine how effectiveness is influenced by patient and other characteristics.</p>
</sec>
<sec id="Sec6"><title>Primary outcome</title>
<p>The primary outcomes will be clinically significant change in obsessive-compulsive symptom scores and diagnostic status. Our primary hypothesis is that individuals in the iCBT and matched control groups will experience reduction in the proportion of diagnosable OCD and significant alleviation of OCD symptoms from pre to post-intervention, with significantly greater improvements in iCBT. It is further anticipated that iCBT outcomes would be maintained at 6-to-12 month follow-up.</p>
</sec>
<sec id="Sec7"><title>Secondary outcome</title>
<p>Secondary outcomes will be general mental health (depression and anxiety), psychological variables (cognitions related to OCD, self-efficacy), and psychosocial variables (quality of life, functional impairment). We expect that individuals randomised to receive iCBT, compared to matched controls, will demonstrate significantly greater improvements in secondary outcome measures from pre- to post-intervention. We also expect iCBT to be associated with lower service utilisation than the matched control condition.</p>
<p>Demographic and clinical variables, treatment credibility and expectations of treatment, treatment acceptability, working alliance between patient and therapist, and attitudes towards homework tasks will also be assessed. We expect that: a) participants will rate iCBT as more credible and acceptable than the matched control group, but that there will be no differences between groups on working alliance and attitudes towards homework; and b) outcomes will be positively associated with homework completion, but other predictors (e.g. education, gender, age, degree to which other treatments were undertaken) are not expected to contribute to outcomes. Finally, the present study proposes to explore how individual patient characteristics may influence therapeutic outcomes (e.g., demographic variables, functional impairment, treatment readiness, personality, diagnostic/symptom severity, specific symptom presentation, levels of comorbidity, expectancies of treatment credibility).</p>
</sec>
</sec>
<sec id="Sec8"><title>Methods/design</title>
<p>The study will evaluate the acceptability and efficacy of iCBT compared to a matched control condition. The RCT will randomise 212 individuals who fulfil inclusion criteria into either the active treatment or control condition, for 12 weeks duration (Figure <xref rid="Fig1" ref-type="fig">1</xref>
). Outcomes for participants in both groups will be assessed at baseline (Time = 0) and post-intervention (Time = 12 weeks). Participants in iCBT will be further assessed at follow-up (Time = 6-to-12 months), while participants in the control will be crossed over to receive the intervention and assessed at post-intervention (Time = 24 weeks) and follow-up (Time = 9 months).<fig id="Fig1"><label>Figure 1</label>
<caption><p><bold>CONSORT flowchart.</bold>
</p>
</caption>
<graphic xlink:href="12888_2014_1720_Fig1_HTML" id="d30e587"></graphic>
</fig>
</p>
<sec id="Sec9"><title>Ethics approval</title>
<p>The present study proposal has been subject to peer review and approval by the National Health and Medical Research Council (Project Grant Application 620506). Ethics approval has been obtained from the Human Research Ethics Committees from Swinburne University of Technology (No. 2010/104).</p>
</sec>
<sec id="Sec10"><title>Participants</title>
<p>Recruitment will occur in all states and territories of Australia, and will be open to all Australian residents aged 18 years and over. Two hundred and twelve individuals with a primary diagnosis of OCD, as indicated by structured clinical interview, will be recruited through widespread media coverage, internet advertising (e.g., Facebook), web search engines (e.g., Google) and referrals from other online treatment services (e.g., Anxiety Online, Mental Health Online; [<xref ref-type="bibr" rid="CR49">49</xref>
]). Consumer organisations and mental health services/professionals (e.g., university psychology clinics, divisions of general practice, psychiatric facilities, private psychologists and psychiatrists) will be approached to promote the program and invited to make referrals.</p>
</sec>
<sec id="Sec11"><title>Eligibility criteria</title>
<p>All interested participants will be required to complete a telephone interview and fulfil Diagnostic and Statistical Manual for Mental Disorders (DSM-IV) criteria for OCD on the Structured Clinical Interview for DSM-IV (SCID) [<xref ref-type="bibr" rid="CR50">50</xref>
]. All participants will be required to have sufficient English to complete treatment and assessments without translation, provide multiple contact details, be able and willing to access internet and email, and consent to follow up assessments. Comorbid diagnosis of other disorders will be permitted where OCD is the primary diagnosis, and the non-OCD diagnosis is not in the extremely severe range. Exclusion criteria include meeting criteria for current psychosis, substance abuse, head injury or neurological disorder, and active suicidal ideation. Checks with participants about other treatments received will be maintained during the study.</p>
</sec>
<sec id="Sec12"><title>Sample size calculation</title>
<p>Given previous research showing large effects for online CBT for OCD [<xref ref-type="bibr" rid="CR43">43</xref>
, <xref ref-type="bibr" rid="CR45">45</xref>
], we expect a large effect for iCBT (i.e., 33% achieving clinically significant change in YBOCS scores; Cohen’s d of approximately 1.0). Progressive relaxation training (PRT) will be the active attention control [<xref ref-type="bibr" rid="CR51">51</xref>
]. PRT has demonstrated inconsistent effectiveness in treating OCD with studies indicating low [<xref ref-type="bibr" rid="CR52">52</xref>
] and high efficacy [<xref ref-type="bibr" rid="CR53">53</xref>
]. Given this, we anticipate a moderate effect size for this group (i.e., 15% achieving clinically significant change in YBOCS scores; Cohen’s d approximately 0.5). Therefore, 88 individuals per intervention group will be sufficient to detect a difference in effects between iCBT and control at post-intervention, assuming significance is set at 5% (α = 0.05) power at 80% and a standard deviation of 5 for the distribution of mean change. We include an additional 20% (N = 18 per group) to allow for attrition and potential effects of various extraneous influences, such as protocol adherence; 106 participants per group will be required (total = 212).</p>
</sec>
<sec id="Sec13"><title>Participant recruitment procedure</title>
<p>Participants will make initial contact via email or telephone. Those who express an interest will be emailed a Participant Information and Consent Form. Consenting participants will be asked to provide contact details to arrange the telephone interview (to assess eligibility and collect baseline measures). At the telephone interview, those participants not meeting criteria will be given information about alternative treatment and relevant local services and internet sites. If participation criteria are met, consent will be sought for further baseline assessment, treatment and follow-up.</p>
</sec>
<sec id="Sec14"><title>Randomisation procedure</title>
<p>In accordance with CONSORT guidelines [<xref ref-type="bibr" rid="CR54">54</xref>
], randomisation will occur after participants have completed their baseline measures. Although there is a generally equal gender prevalence of OCD in adults, there are inconsistent reports of gender differences in service utilization rates [<xref ref-type="bibr" rid="CR55">55</xref>
]. Therefore, stratified randomisation will be used in order to minimize the differences in gender distributions across and within groups. This will be done via computer software and entered by an independent researcher. Participants will be allocated to a therapist and given immediate access to their online condition (intervention or control), and participants in the control condition given access to the intervention after completing the post-intervention assessment. The CONSORT diagram of the study design is shown in Figure <xref rid="Fig1" ref-type="fig">1</xref>
.</p>
</sec>
<sec id="Sec15"><title>Study arms</title>
<p>Throughout the course of the study, participants from both the intervention and control groups will continue to receive treatment as usual (TAU). Structured checks with participants about other treatments will be maintained at all assessment points with assessors blind to condition. Both groups receive an online program consisting of 12 modules over 12-weeks. Participants will be encouraged to complete one module per week for the duration of treatment. Both groups will receive online information, weekly homework tasks, downloadable worksheets and audio files. All participants will receive weekly email support from a remote therapist who will monitor progress, review homework, provide support and encouragement, and give assistance in tailoring the treatment to the participant’s individual problem, in line with the online content of their allocated condition. The communication will be restricted to one therapist email per week, although users will be able to email their therapists as often as they wish. Treatment will be via automated programs. Assessors and therapists will be licenced psychologists, or supervised students enrolled in a Masters or Professional Doctorate in Clinical Psychology. Therapy provision and assessment will be conducted with independent assessors. All therapists will be trained and supervised on a fortnightly review basis by a Clinical Psychologist experienced in the treatment of OCD. Email therapy sessions will be saved and rated by independent assessors to assess treatment fidelity, and interrater reliability assessments will be conducted to confirm diagnosis.</p>
</sec>
<sec id="Sec16"><title>Intervention: Therapist-assisted internet-based cognitive behavioural therapy (iCBT)</title>
<p>The intervention is a 12-week internet-based cognitive behavioural therapy. Modules 1–3 provide information about OCD, anxiety, and an introduction to CBT, along with anxiety and depression management strategies (e.g., relaxation, activity scheduling). In Modules 4–6, Exposure and Response Prevention (ERP) strategies are introduced through the construction of fear hierarchies. These teach the participant to plan and implement an ERP program suited to their individual needs. Due to the heterogeneity of the disorder, participants are provided with a range of examples to correspond to various presentations. Modules 7–9 include cognitive therapy techniques (e.g., cognitive restructuring) targeting OCD specific cognitive styles (such as inflated responsibility/overestimation of threat, importance/control of thoughts). As part of this, cognitive misappraisals are identified and alternatives developed and practiced; and more advanced ERP, integrating cognitive strategies is undertaken. Modules 10–12 include relapse preventions strategies (e.g., problem solving, risk identification, contingency management, and mindfulness techniques). The importance of daily practice is emphasised and discussions focus on enablers of, and barriers to, maintenance of CBT.</p>
</sec>
<sec id="Sec17"><title>Control: Therapist-assisted internet-based progressive relaxation training (iPRT)</title>
<p>The matched control condition is an internet-based treatment for anxiety adapted from Bernstein et al. [<xref ref-type="bibr" rid="CR56">56</xref>
]. Participants initially receive basic information about OCD, the relationship of OCD to anxiety, and the use of relaxation to manage anxiety. Individuals are then taught to relax specific muscle groups while paying attention to the feelings associated with both the tensed and relaxed stages. The program teaches the individual to achieve a state of deep relaxation in increasingly shorter periods and to control excess tension in stress-inducing situations. Participants work through the sequential tensing and releasing of 16 muscle groups (Modules 1 to 3). These groups are reduced to seven (Modules 4 and 5) and to four (Modules 6 to 7). The tension component is then withdrawn (Modules 8 to 11) in what is called “relaxation through recall”, and the final stage (Module 12) consists of a mental summary of the previously learned techniques. Participants will have access to downloadable audiovisual and written material to guide their progressive relaxation training. Although relaxation training has previously not been considered effective for OCD [<xref ref-type="bibr" rid="CR52">52</xref>
], recent research supports that progressive relaxation can be effective [<xref ref-type="bibr" rid="CR53">53</xref>
]. Considering that the program requires more than attention and engagement, the term ‘matched control’ was deemed a more appropriate descriptor than ‘active attention placebo’.</p>
</sec>
<sec id="Sec18"><title>Measures</title>
<p>Outcomes will be assessed via clinician-rated telephone interview at baseline, post-intervention and follow-up. Throughout the intervention and control, participants will self-report secondary outcomes through an online questionnaire embedded within Modules 1, 5, 9 and 12 of each condition. Instruments used to collect data from participants, including primary and secondary outcomes, are listed in Table <xref rid="Tab1" ref-type="table">1</xref>
.<table-wrap id="Tab1"><label>Table 1</label>
<caption><p><bold>Instruments used for data collection</bold>
</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" colspan="2">Measurement tools/questions</th>
<th colspan="4">Time point</th>
</tr>
<tr><th colspan="2">Clinician administered (telephone)</th>
<th>Baseline</th>
<th colspan="2">Post-treat</th>
<th>Follow-up</th>
</tr>
</thead>
<tbody><tr><td>Demographics</td>
<td>Age, gender, postcode, family characteristics, religion, education, general medical history</td>
<td align="center">x</td>
<td align="center" colspan="2"></td>
<td align="center"></td>
</tr>
<tr><td>Current treatment</td>
<td>Current physiological & psychological treatment</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">x</td>
</tr>
<tr><td>Diagnosis</td>
<td>Structured Clinical Interview for DSM-IV Axis I Disorders - Clinician Version (SCID-IV) [<xref ref-type="bibr" rid="CR50">50</xref>
]</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">x</td>
</tr>
<tr><td>OCD severity</td>
<td>Yale-Brown Obsessive-Compulsive Scale (YBOCS) [<xref ref-type="bibr" rid="CR44">44</xref>
]</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Obsessive-Compulsive Inventory (OCI) [<xref ref-type="bibr" rid="CR57">57</xref>
]</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Clinical Global Improvement Scale (CGI) [<xref ref-type="bibr" rid="CR58">58</xref>
]</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">x</td>
</tr>
<tr><td>Mental health</td>
<td>Hamilton Rating Scale for Depression (HRSD) [<xref ref-type="bibr" rid="CR59">59</xref>
]</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">X</td>
</tr>
<tr><td align="center"></td>
<td>Hamilton Rating Scale for Anxiety (HRSA) [<xref ref-type="bibr" rid="CR60">60</xref>
]</td>
<td align="center">x</td>
<td align="center" colspan="2">x</td>
<td align="center">x</td>
</tr>
<tr><td colspan="2"></td>
<td align="center" colspan="4"><bold>Modules</bold>
</td>
</tr>
<tr><td colspan="2"><bold>Self-report (online)</bold>
</td>
<td align="center"><bold>1</bold>
</td>
<td align="center"><bold>5</bold>
</td>
<td align="center"><bold>9</bold>
</td>
<td align="center"><bold>12</bold>
</td>
</tr>
<tr><td>OCD measures</td>
<td>Yale-Brown Obsessive-Compulsive Scale (YBOCS) [<xref ref-type="bibr" rid="CR44">44</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Obsessive Compulsive Inventory (OCI) [<xref ref-type="bibr" rid="CR61">61</xref>
]</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Revised Obsessional Beliefs Questionnaire (OBQ) [<xref ref-type="bibr" rid="CR62">62</xref>
]</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
</tr>
<tr><td>Psychosocial</td>
<td>Depression, Anxiety, Stress Scale (DASS) [<xref ref-type="bibr" rid="CR63">63</xref>
]</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Centre for Epidemiologic Studies Depression Scale (CES-D) [<xref ref-type="bibr" rid="CR64">64</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
</tr>
<tr><td></td>
<td>General Self-Efficacy Scale (GSES) [<xref ref-type="bibr" rid="CR65">65</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
</tr>
<tr><td></td>
<td>Australian Quality of Life Scale (AQoLS) [<xref ref-type="bibr" rid="CR66">66</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Brief Disability Questionnaire (BDQ) [<xref ref-type="bibr" rid="CR67">67</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Service Utilisation & Loss of Role Questionnaire (SULRQ) [<xref ref-type="bibr" rid="CR68">68</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td>Treatment measures</td>
<td>Credibility/Expectancy Questionnaire (CEQ) [<xref ref-type="bibr" rid="CR69">69</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td></td>
</tr>
<tr><td></td>
<td>Current Treatments Measure [<xref ref-type="bibr" rid="CR70">70</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Treatment Evaluation Inventory (TEI) [<xref ref-type="bibr" rid="CR71">71</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Working Alliance Questionnaire (WAQ) [<xref ref-type="bibr" rid="CR72">72</xref>
]</td>
<td align="center">x</td>
<td align="center"></td>
<td align="center"></td>
<td align="center">x</td>
</tr>
<tr><td></td>
<td>Homework Rating Scale (HSR-II) [<xref ref-type="bibr" rid="CR73">73</xref>
]</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
<td align="center">x</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
</sec>
<sec id="Sec19"><title>Data analysis</title>
<p>Exploratory and confirmatory factor analysis will be used to check the psychometric properties of the various scales. Where appropriate, scales will be adjusted and further validation performed to ensure that the resulting scales have internal validity and reliability. The primary analyses will utilise a within and between groups design with two time points (baseline and post-intervention) and two groups (iCBT versus control). Repeated measures analyses will be conducted on follow-up outcomes for the group initially assigned to the iCBT condition. <italic>Clinically significant change</italic>
will be based on a combination of reliable reduction in YBOCS scores and post-treatment YBOCS outside the clinical range [<xref ref-type="bibr" rid="CR74">74</xref>
].</p>
<p>Despite randomisation, there are advantages in accounting for potential biases in assignment to treatments [<xref ref-type="bibr" rid="CR32">32</xref>
]. Similarity of baseline characteristics of intervention and control participants will be assessed using appropriate summary statistics and use of multi-level modeling will allow comparison of the iCBT and control conditions in terms of pre-/post changes in primary and secondary outcomes, while controlling for relevant confounds. An intention to treat and completer analyses, and then a longitudinal hierarchical linear model analyses, will be conducted to avoid the need to impute missing data, and baseline data will be examined to analyse probability of attrition bias.</p>
</sec>
<sec id="Sec20"><title>Trial status</title>
<p>The trial is currently in the data collection phase. Recruitment to the study commenced in 2010. To date, from over 1300 referrals that expressed interest in the study either online or via telephone, 197 participants have provided consent and completed the pre-intervention interview via telephone. Applicants who met inclusion criteria (n = 179) completed baseline assessments and were randomised into the intervention (n = 91) and control (n = 88) conditions. It is anticipated that full post-intervention and follow up data will be completed by December, 2014.</p>
</sec>
</sec>
<sec id="Sec21" sec-type="discussion"><title>Discussion</title>
<p>Internet access is increasingly available, and reliance on the internet for healthcare information and treatments will increase with improved infrastructure. This paper provides a comprehensive description of the methodology used to implement, disseminate and evaluate an online cognitive-behavioural therapy program for OCD. Although other treatments exist and RCTs have been conducted [<xref ref-type="bibr" rid="CR51">51</xref>
, <xref ref-type="bibr" rid="CR75">75</xref>
], evaluations using study designs controlling for expectancy/attention-placebo effects are still required. This will be the first known therapist assisted internet-based trial of a comprehensive CBT treatment (iCBT) for OCD as compared to a matched control (iPRT) for patients who have a choice of undertaking other concurrent treatment. The added advantage of this design is that it encompasses a more representative cohort of patients undertaking internet-based psychological treatment for OCD by not excluding those undertaking other concurrent treatments or those with a wide range of comorbidity. The iCBT program will provide necessary assistance by remote contact with a suitably qualified mental health professional, providing greater access to a specialised OCD service, particularly for those from rural and remote areas, whilst also encouraging active patient self-management. Hence, this project serves as a contemporary model for greater access to flexible, innovative, affordable and evidence-based psychological treatment for OCD. Demonstrating the efficacy of such a program will facilitate its integration into clinical practice and the development of models of care for the management of OCD.</p>
</sec>
</body>
<back><glossary><title>Abbreviations</title>
<def-list><def-list><def-item><term>NHMRC</term>
<def><p>National Health and Medical Research Council</p>
</def>
</def-item>
<def-item><term>OCD</term>
<def><p>Obsessive-compulsive disorder</p>
</def>
</def-item>
<def-item><term>CBT</term>
<def><p>Cognitive-behaviour therapy</p>
</def>
</def-item>
<def-item><term>RCT</term>
<def><p>Randomised controlled trial</p>
</def>
</def-item>
<def-item><term>iCBT</term>
<def><p>Internet-based cognitive-behaviour therapy</p>
</def>
</def-item>
<def-item><term>iPRT</term>
<def><p>Internet-based progressive relaxation training</p>
</def>
</def-item>
<def-item><term>ANZCTR</term>
<def><p>Australian New Zealand Clinical Trials Registry</p>
</def>
</def-item>
<def-item><term>ERP</term>
<def><p>Exposure and response prevention</p>
</def>
</def-item>
<def-item><term>bCBT</term>
<def><p>Bibliotherapy cognitive-behavioural therapy</p>
</def>
</def-item>
<def-item><term>DSM-IV</term>
<def><p>Diagnostic and statistical manual for mental disorders</p>
</def>
</def-item>
<def-item><term>PRT</term>
<def><p>Progressive Relaxation Training.</p>
</def>
</def-item>
</def-list>
</def-list>
</glossary>
<fn-group><fn><p><bold>Competing interests</bold>
</p>
<p>The authors declare that they have no competing interests.</p>
</fn>
<fn><p><bold>Authors’ contributions</bold>
</p>
<p>MK led study conception, research design, methodology, intervention, and study implementation. MN participated in the study conception, design and intervention development. RM participated in the study conception, design and intervention development. BK established the programming platform and user interface for the intervention, participated in the study conception, research design, methodology and intervention development. DA established the programming platform and user interface for the intervention, contributed to conceptualisation of the study, the research design, methodology and intervention. DM established randomisation of participants and statistics design. CA drafted the manuscript and was responsible for study recruitment and implementation. All authors read and edited drafts of the manuscript and approved the final manuscript.</p>
</fn>
</fn-group>
<ack><title>Acknowledgements</title>
<p>Research funded by the NHMRC (Project Grant 620506) awarded to Kyrios, M., Nedeljkovic, M., Moulding, R., Klein, B. & Austin, D. The development of the OCD intervention program was supported by a small grant in 2007 from The Telematics Trust awarded to Kyrios, M., Williams, B. & Jones, B.</p>
</ack>
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