Comprehensive Reconstruction and Visualization of Non-Coding Regulatory Networks in Human
Identifieur interne : 000323 ( Main/Exploration ); précédent : 000322; suivant : 000324Comprehensive Reconstruction and Visualization of Non-Coding Regulatory Networks in Human
Auteurs : Vincenzo Bonnici [Italie] ; Francesco Russo [Italie] ; Nicola Bombieri [Italie] ; Alfredo Pulvirenti [Italie] ; Rosalba Giugno [Italie]Source :
- Frontiers in Bioengineering and Biotechnology [ 2296-4185 ] ; 2014.
Abstract
Research attention has been powered to understand the functional roles of non-coding RNAs (ncRNAs). Many studies have demonstrated their deregulation in cancer and other human disorders. ncRNAs are also present in extracellular human body fluids such as serum and plasma, giving them a great potential as non-invasive biomarkers. However, non-coding RNAs have been relatively recently discovered and a comprehensive database including all of them is still missing. Reconstructing and visualizing the network of ncRNAs interactions are important steps to understand their regulatory mechanism in complex systems. This work presents
Url:
DOI: 10.3389/fbioe.2014.00069
PubMed: 25540777
PubMed Central: 4261811
Affiliations:
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sortKey="Pulvirenti, Alfredo" sort="Pulvirenti, Alfredo" uniqKey="Pulvirenti A" first="Alfredo" last="Pulvirenti">Alfredo Pulvirenti</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical and Experimental Medicine, University of Catania</institution>,<addr-line>Catania</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical and Experimental Medicine, University of Catania</institution>,<addr-line>Catania</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno 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wicri:step="Curation">000139</idno><idno type="wicri:Area/PubMed/Checkpoint">000139</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000139</idno><idno type="wicri:Area/Ncbi/Merge">000B06</idno><idno type="wicri:Area/Ncbi/Curation">000B06</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B06</idno><idno type="wicri:Area/Main/Merge">000323</idno><idno type="wicri:Area/Main/Curation">000323</idno><idno type="wicri:Area/Main/Exploration">000323</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comprehensive Reconstruction and Visualization of Non-Coding Regulatory Networks in Human</title><author><name sortKey="Bonnici, Vincenzo" sort="Bonnici, Vincenzo" uniqKey="Bonnici V" first="Vincenzo" last="Bonnici">Vincenzo Bonnici</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Computer Science, University of Verona</institution>,<addr-line>Verona</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Laboratory of Integrative Systems Medicine (LISM), Institute of Informatics and Telematics (IIT) and Institute of Clinical Physiology (IFC), National Research Council (CNR)</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Computer Science, University of Pisa</institution>,<addr-line>Pisa</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bombieri, Nicola" sort="Bombieri, Nicola" uniqKey="Bombieri N" first="Nicola" last="Bombieri">Nicola Bombieri</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Computer Science, University of Verona</institution>,<addr-line>Verona</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pulvirenti, Alfredo" sort="Pulvirenti, Alfredo" uniqKey="Pulvirenti A" first="Alfredo" last="Pulvirenti">Alfredo Pulvirenti</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical and Experimental Medicine, University of Catania</institution>,<addr-line>Catania</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Clinical and Experimental Medicine, University of Catania</institution>,<addr-line>Catania</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Bioengineering and Biotechnology</title><idno type="eISSN">2296-4185</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Research attention has been powered to understand the functional roles of non-coding RNAs (ncRNAs). Many studies have demonstrated their deregulation in cancer and other human disorders. ncRNAs are also present in extracellular human body fluids such as serum and plasma, giving them a great potential as non-invasive biomarkers. However, non-coding RNAs have been relatively recently discovered and a comprehensive database including all of them is still missing. Reconstructing and visualizing the network of ncRNAs interactions are important steps to understand their regulatory mechanism in complex systems. This work presents <italic>ncRNA-DB</italic>, a NoSQL database that integrates ncRNAs data interactions from a large number of well established on-line repositories. The interactions involve RNA, DNA, proteins, and diseases. ncRNA-DB is available at <uri xlink:type="simple" xlink:href="http://ncrnadb.scienze.univr.it/ncrnadb/">http://ncrnadb.scienze.univr.it/ncrnadb/</uri>. It is equipped with three interfaces: web based, command-line, and a Cytoscape app called ncINetView. 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Zhu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Bonnici, Vincenzo" sort="Bonnici, Vincenzo" uniqKey="Bonnici V" first="Vincenzo" last="Bonnici">Vincenzo Bonnici</name></noRegion><name sortKey="Bombieri, Nicola" sort="Bombieri, Nicola" uniqKey="Bombieri N" first="Nicola" last="Bombieri">Nicola Bombieri</name><name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name><name sortKey="Pulvirenti, Alfredo" sort="Pulvirenti, Alfredo" uniqKey="Pulvirenti A" first="Alfredo" last="Pulvirenti">Alfredo Pulvirenti</name><name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name><name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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