Comprehensive Reconstruction and Visualization of Non-Coding Regulatory Networks in Human
Identifieur interne : 000323 ( Main/Exploration ); précédent : 000322; suivant : 000324Comprehensive Reconstruction and Visualization of Non-Coding Regulatory Networks in Human
Auteurs : Vincenzo Bonnici [Italie] ; Francesco Russo [Italie] ; Nicola Bombieri [Italie] ; Alfredo Pulvirenti [Italie] ; Rosalba Giugno [Italie]Source :
- Frontiers in Bioengineering and Biotechnology [ 2296-4185 ] ; 2014.
Abstract
Research attention has been powered to understand the functional roles of non-coding RNAs (ncRNAs). Many studies have demonstrated their deregulation in cancer and other human disorders. ncRNAs are also present in extracellular human body fluids such as serum and plasma, giving them a great potential as non-invasive biomarkers. However, non-coding RNAs have been relatively recently discovered and a comprehensive database including all of them is still missing. Reconstructing and visualizing the network of ncRNAs interactions are important steps to understand their regulatory mechanism in complex systems. This work presents
Url:
DOI: 10.3389/fbioe.2014.00069
PubMed: 25540777
PubMed Central: 4261811
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Research attention has been powered to understand the functional roles of non-coding RNAs (ncRNAs). Many studies have demonstrated their deregulation in cancer and other human disorders. ncRNAs are also present in extracellular human body fluids such as serum and plasma, giving them a great potential as non-invasive biomarkers. However, non-coding RNAs have been relatively recently discovered and a comprehensive database including all of them is still missing. Reconstructing and visualizing the network of ncRNAs interactions are important steps to understand their regulatory mechanism in complex systems. This work presents <italic>ncRNA-DB</italic>
, a NoSQL database that integrates ncRNAs data interactions from a large number of well established on-line repositories. The interactions involve RNA, DNA, proteins, and diseases. ncRNA-DB is available at <uri xlink:type="simple" xlink:href="http://ncrnadb.scienze.univr.it/ncrnadb/">http://ncrnadb.scienze.univr.it/ncrnadb/</uri>
. It is equipped with three interfaces: web based, command-line, and a Cytoscape app called ncINetView. By accessing only one resource, users can search for ncRNAs and their interactions, build a network annotated with all known ncRNAs and associated diseases, and use all visual and mining features available in Cytoscape.</p>
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</back>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
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<tree><country name="Italie"><noRegion><name sortKey="Bonnici, Vincenzo" sort="Bonnici, Vincenzo" uniqKey="Bonnici V" first="Vincenzo" last="Bonnici">Vincenzo Bonnici</name>
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<name sortKey="Bombieri, Nicola" sort="Bombieri, Nicola" uniqKey="Bombieri N" first="Nicola" last="Bombieri">Nicola Bombieri</name>
<name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name>
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<name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name>
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</record>
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