A Quantitative Method to Monitor Reactive Oxygen Species Production by Electron Paramagnetic Resonance in Physiological and Pathological Conditions
Identifieur interne : 000356 ( Main/Exploration ); précédent : 000355; suivant : 000357A Quantitative Method to Monitor Reactive Oxygen Species Production by Electron Paramagnetic Resonance in Physiological and Pathological Conditions
Auteurs : Simona Mrakic-Sposta [Italie] ; Maristella Gussoni [Italie] ; Michela Montorsi [Italie] ; Simone Porcelli [Italie] ; Alessandra Vezzoli [Italie]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Espèces réactives de l'oxygène.
- métabolisme : Espèces réactives de l'oxygène.
- physiologie : Stress oxydatif.
- Adulte, Adulte d'âge moyen, Analyse chimique du sang, Femelle, Humains, Jeune adulte, Mâle, Oxydoréduction, Spectroscopie de résonance de spin électronique, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Reactive Oxygen Species.
- chemical , metabolism : Reactive Oxygen Species.
- methods : Blood Chemical Analysis, Electron Spin Resonance Spectroscopy.
- physiology : Oxidative Stress.
- Adult, Aged, Female, Humans, Male, Middle Aged, Oxidation-Reduction, Young Adult.
Abstract
The growing interest in the role of Reactive Oxygen Species (ROS) and in the assessment of oxidative stress in health and disease clashes with the lack of consensus on reliable quantitative noninvasive methods applicable. The study aimed at demonstrating that a recently developed Electron Paramagnetic Resonance microinvasive method provides direct evidence of the “instantaneous” presence of ROS returning absolute concentration levels that correlate with “a posteriori” assays of ROS-induced damage by means of biomarkers. The reliability of the choice to measure ROS production rate in human capillary blood rather than in plasma was tested (step I). A significant (
Url:
DOI: 10.1155/2014/306179
PubMed: 25374651
PubMed Central: 4211297
Affiliations:
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Le document en format XML
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level="a" type="main">A Quantitative Method to Monitor Reactive Oxygen Species Production by Electron Paramagnetic Resonance in Physiological and Pathological Conditions</title><author><name sortKey="Mrakic Sposta, Simona" sort="Mrakic Sposta, Simona" uniqKey="Mrakic Sposta S" first="Simona" last="Mrakic-Sposta">Simona Mrakic-Sposta</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto di Bioimmagini e di Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Fratelli Cervi 93, 20090 Segrate, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Bioimmagini e di Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Fratelli Cervi 93, 20090 Segrate</wicri:regionArea><wicri:noRegion>20090 Segrate</wicri:noRegion></affiliation></author><author><name sortKey="Gussoni, Maristella" sort="Gussoni, Maristella" uniqKey="Gussoni M" first="Maristella" last="Gussoni">Maristella Gussoni</name><affiliation wicri:level="1"><nlm:aff id="I2">Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università di Milano, Via Fratelli Cervi 93, 20090 Segrate, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università di Milano, Via Fratelli Cervi 93, 20090 Segrate</wicri:regionArea><wicri:noRegion>20090 Segrate</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I3">Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Via Bassini 15, 20133 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Via Bassini 15, 20133 Milano</wicri:regionArea><wicri:noRegion>20133 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Montorsi, Michela" sort="Montorsi, Michela" uniqKey="Montorsi M" first="Michela" last="Montorsi">Michela Montorsi</name><affiliation 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Raffaele Roma, Via F. Daverio 7, 20122 Milano, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Università Telematica S. Raffaele Roma, Via F. Daverio 7, 20122 Milano</wicri:regionArea><wicri:noRegion>20122 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Porcelli, Simone" sort="Porcelli, Simone" uniqKey="Porcelli S" first="Simone" last="Porcelli">Simone Porcelli</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto di Bioimmagini e di Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Fratelli Cervi 93, 20090 Segrate, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Bioimmagini e di Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Fratelli Cervi 93, 20090 Segrate</wicri:regionArea><wicri:noRegion>20090 Segrate</wicri:noRegion></affiliation></author><author><name sortKey="Vezzoli, Alessandra" sort="Vezzoli, Alessandra" uniqKey="Vezzoli A" first="Alessandra" last="Vezzoli">Alessandra Vezzoli</name><affiliation wicri:level="1"><nlm:aff id="I1">Istituto di Bioimmagini e di Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Fratelli Cervi 93, 20090 Segrate, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Bioimmagini e di Fisiologia Molecolare, Consiglio Nazionale delle Ricerche, Via Fratelli Cervi 93, 20090 Segrate</wicri:regionArea><wicri:noRegion>20090 Segrate</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Blood Chemical Analysis (methods)</term><term>Electron Spin Resonance Spectroscopy (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oxidation-Reduction</term><term>Oxidative Stress (physiology)</term><term>Reactive Oxygen Species (analysis)</term><term>Reactive Oxygen Species (metabolism)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse chimique du sang ()</term><term>Espèces réactives de l'oxygène (analyse)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Oxydoréduction</term><term>Spectroscopie de résonance de spin électronique ()</term><term>Stress oxydatif (physiologie)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Espèces réactives de l'oxygène</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Blood Chemical Analysis</term><term>Electron Spin Resonance Spectroscopy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espèces réactives de l'oxygène</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Stress oxydatif</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Oxidation-Reduction</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse chimique du sang</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Oxydoréduction</term><term>Spectroscopie de résonance de spin électronique</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The growing interest in the role of Reactive Oxygen Species (ROS) and in the assessment of oxidative stress in health and disease clashes with the lack of consensus on reliable quantitative noninvasive methods applicable. The study aimed at demonstrating that a recently developed Electron Paramagnetic Resonance microinvasive method provides direct evidence of the “instantaneous” presence of ROS returning absolute concentration levels that correlate with “a posteriori” assays of ROS-induced damage by means of biomarkers. The reliability of the choice to measure ROS production rate in human capillary blood rather than in plasma was tested (step I). A significant (<italic>P</italic> < 0.01) linear relationship between EPR data collected on capillary blood versus venous blood (<italic>R</italic><sup>2</sup> = 0.95), plasma (<italic>R</italic><sup>2</sup> = 0.82), and erythrocytes (<italic>R</italic><sup>2</sup> = 0.73) was found. Then (step II) ROS production changes of various subjects' categories, young versus old and healthy versus pathological at rest condition, were found significantly different (range 0.0001–0.05 <italic>P</italic> level). The comparison of the results with antioxidant capacity and oxidative damage biomarkers concentrations showed that all changes indicating increased oxidative stress are directly related to ROS production increase. Therefore, the adopted method may be an automated technique for a lot of routine in clinical trials.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Droge, W" uniqKey="Droge W">W Dröge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tappel, Al" uniqKey="Tappel A">AL Tappel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stadtman, Er" uniqKey="Stadtman E">ER Stadtman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Floyd, Ra" uniqKey="Floyd R">RA Floyd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reuter, S" uniqKey="Reuter S">S Reuter</name></author><author><name sortKey="Gupta, Sc" uniqKey="Gupta S">SC Gupta</name></author><author><name sortKey="Chaturvedi, Mm" uniqKey="Chaturvedi M">MM Chaturvedi</name></author><author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB 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Perry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perry, G" uniqKey="Perry G">G Perry</name></author><author><name sortKey="Nunomura, A" uniqKey="Nunomura A">A Nunomura</name></author><author><name sortKey="Hirai, K" uniqKey="Hirai K">K Hirai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pellegrino, Ma" uniqKey="Pellegrino M">MA Pellegrino</name></author><author><name sortKey="Desaphy, J F" uniqKey="Desaphy J">J-F Desaphy</name></author><author><name sortKey="Brocca, L" uniqKey="Brocca L">L Brocca</name></author><author><name sortKey="Pierno, S" uniqKey="Pierno S">S Pierno</name></author><author><name sortKey="Camerino, Dc" uniqKey="Camerino D">DC Camerino</name></author><author><name sortKey="Bottinelli, R" uniqKey="Bottinelli R">R Bottinelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goswami, A" uniqKey="Goswami A">A Goswami</name></author><author><name sortKey="Dikshit, P" uniqKey="Dikshit P">P Dikshit</name></author><author><name sortKey="Mishra, A" uniqKey="Mishra A">A Mishra</name></author><author><name sortKey="Mulherkar, S" uniqKey="Mulherkar S">S Mulherkar</name></author><author><name sortKey="Nukina, N" uniqKey="Nukina N">N Nukina</name></author><author><name sortKey="Jana, Nr" uniqKey="Jana N">NR Jana</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Mrakic Sposta, Simona" sort="Mrakic Sposta, Simona" uniqKey="Mrakic Sposta S" first="Simona" last="Mrakic-Sposta">Simona Mrakic-Sposta</name></noRegion><name sortKey="Gussoni, Maristella" sort="Gussoni, Maristella" uniqKey="Gussoni M" first="Maristella" last="Gussoni">Maristella Gussoni</name><name sortKey="Gussoni, Maristella" sort="Gussoni, Maristella" uniqKey="Gussoni M" first="Maristella" last="Gussoni">Maristella Gussoni</name><name sortKey="Montorsi, Michela" sort="Montorsi, Michela" uniqKey="Montorsi M" first="Michela" last="Montorsi">Michela Montorsi</name><name sortKey="Montorsi, Michela" sort="Montorsi, Michela" uniqKey="Montorsi M" first="Michela" last="Montorsi">Michela Montorsi</name><name sortKey="Porcelli, Simone" sort="Porcelli, Simone" uniqKey="Porcelli S" first="Simone" last="Porcelli">Simone Porcelli</name><name sortKey="Vezzoli, Alessandra" sort="Vezzoli, Alessandra" uniqKey="Vezzoli A" first="Alessandra" last="Vezzoli">Alessandra Vezzoli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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