A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs
Identifieur interne : 000352 ( Main/Exploration ); précédent : 000351; suivant : 000353A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs
Auteurs : Francesco Russo [Italie] ; Sebastiano Di Bella [Italie] ; Vincenzo Bonnici [Italie] ; Alessandro Laganà [États-Unis] ; Giuseppe Rainaldi [Italie] ; Marco Pellegrini [Italie] ; Alfredo Pulvirenti [Italie] ; Rosalba Giugno [Italie] ; Alfredo Ferro [Italie]Source :
- BMC Genomics [ 1471-2164 ] ; 2014.
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers.
We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed.
This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs.
Url:
DOI: 10.1186/1471-2164-15-S3-S4
PubMed: 25077952
PubMed Central: 4083404
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Pmc, to step Checkpoint: 000197
- to stream Ncbi, to step Merge: 000A47
- to stream Ncbi, to step Curation: 000A47
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers.</p>
</sec>
<sec><title>Description</title>
<p>We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed.</p>
</sec>
<sec><title>Conclusions</title>
<p>This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs.</p>
</sec>
</div>
</front>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cortez, M" uniqKey="Cortez M">M Cortez</name>
</author>
<author><name sortKey="Bueso Ramos, C" uniqKey="Bueso Ramos C">C Bueso-Ramos</name>
</author>
<author><name sortKey="Ferdin, J" uniqKey="Ferdin J">J Ferdin</name>
</author>
<author><name sortKey="Lopez Berestein, G" uniqKey="Lopez Berestein G">G Lopez-Berestein</name>
</author>
<author><name sortKey="Sood, A" uniqKey="Sood A">A Sood</name>
</author>
<author><name sortKey="Calin, G" uniqKey="Calin G">G Calin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kunej, T" uniqKey="Kunej T">T Kunej</name>
</author>
<author><name sortKey="Godnic, I" uniqKey="Godnic I">I Godnic</name>
</author>
<author><name sortKey="Ferdin, J" uniqKey="Ferdin J">J Ferdin</name>
</author>
<author><name sortKey="Horvat, S" uniqKey="Horvat S">S Horvat</name>
</author>
<author><name sortKey="Dovc, P" uniqKey="Dovc P">P Dovc</name>
</author>
<author><name sortKey="Calin, G" uniqKey="Calin G">G Calin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitchell, P" uniqKey="Mitchell P">P Mitchell</name>
</author>
<author><name sortKey="Parkin, R" uniqKey="Parkin R">R Parkin</name>
</author>
<author><name sortKey="Kroh, E" uniqKey="Kroh E">E Kroh</name>
</author>
<author><name sortKey="Fritz, B" uniqKey="Fritz B">B Fritz</name>
</author>
<author><name sortKey="Wyman, S" uniqKey="Wyman S">S Wyman</name>
</author>
<author><name sortKey="Pogosova Agadjanyan, E" uniqKey="Pogosova Agadjanyan E">E Pogosova-Agadjanyan</name>
</author>
<author><name sortKey="Peterson, A" uniqKey="Peterson A">A Peterson</name>
</author>
<author><name sortKey="Noteboom, J" uniqKey="Noteboom J">J Noteboom</name>
</author>
<author><name sortKey="O Briant, K" uniqKey="O Briant K">K O'Briant</name>
</author>
<author><name sortKey="Allen, A" uniqKey="Allen A">A Allen</name>
</author>
<author><name sortKey="Lin, D" uniqKey="Lin D">D Lin</name>
</author>
<author><name sortKey="Urban, N" uniqKey="Urban N">N Urban</name>
</author>
<author><name sortKey="Drescher, C" uniqKey="Drescher C">C Drescher</name>
</author>
<author><name sortKey="Knudsen, B" uniqKey="Knudsen B">B Knudsen</name>
</author>
<author><name sortKey="Stirewalt, D" uniqKey="Stirewalt D">D Stirewalt</name>
</author>
<author><name sortKey="Gentleman, R" uniqKey="Gentleman R">R Gentleman</name>
</author>
<author><name sortKey="Vessella, R" uniqKey="Vessella R">R Vessella</name>
</author>
<author><name sortKey="Nelson, P" uniqKey="Nelson P">P Nelson</name>
</author>
<author><name sortKey="Martin, D" uniqKey="Martin D">D Martin</name>
</author>
<author><name sortKey="Tewari, M" uniqKey="Tewari M">M Tewari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanke, M" uniqKey="Hanke M">M Hanke</name>
</author>
<author><name sortKey="Hoefig, K" uniqKey="Hoefig K">K Hoefig</name>
</author>
<author><name sortKey="Merz, H" uniqKey="Merz H">H Merz</name>
</author>
<author><name sortKey="Feller, A" uniqKey="Feller A">A Feller</name>
</author>
<author><name sortKey="Kausch, I" uniqKey="Kausch I">I Kausch</name>
</author>
<author><name sortKey="Jocham, D" uniqKey="Jocham D">D Jocham</name>
</author>
<author><name sortKey="Warnecke, J" uniqKey="Warnecke J">J Warnecke</name>
</author>
<author><name sortKey="Sczakiel, G" uniqKey="Sczakiel G">G Sczakiel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name>
</author>
<author><name sortKey="Bang, C" uniqKey="Bang C">C Bang</name>
</author>
<author><name sortKey="Thum, T" uniqKey="Thum T">T Thum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tomimaru, Y" uniqKey="Tomimaru Y">Y Tomimaru</name>
</author>
<author><name sortKey="Eguchi, H" uniqKey="Eguchi H">H Eguchi</name>
</author>
<author><name sortKey="Nagano, H" uniqKey="Nagano H">H Nagano</name>
</author>
<author><name sortKey="Wada, H" uniqKey="Wada H">H Wada</name>
</author>
<author><name sortKey="Kobayashi, S" uniqKey="Kobayashi S">S Kobayashi</name>
</author>
<author><name sortKey="Marubashi, S" uniqKey="Marubashi S">S Marubashi</name>
</author>
<author><name sortKey="Tanemura, M" uniqKey="Tanemura M">M Tanemura</name>
</author>
<author><name sortKey="Tomokuni, A" uniqKey="Tomokuni A">A Tomokuni</name>
</author>
<author><name sortKey="Take Masa, I" uniqKey="Take Masa I">I Take-masa</name>
</author>
<author><name sortKey="Umeshita, K" uniqKey="Umeshita K">K Umeshita</name>
</author>
<author><name sortKey="Kanto, T" uniqKey="Kanto T">T Kanto</name>
</author>
<author><name sortKey="Doki, Y" uniqKey="Doki Y">Y Doki</name>
</author>
<author><name sortKey="Mori, M" uniqKey="Mori M">M Mori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Russo, F" uniqKey="Russo F">F Russo</name>
</author>
<author><name sortKey="Di Bella, S" uniqKey="Di Bella S">S Di Bella</name>
</author>
<author><name sortKey="Nigita, G" uniqKey="Nigita G">G Nigita</name>
</author>
<author><name sortKey="Macca, V" uniqKey="Macca V">V Macca</name>
</author>
<author><name sortKey="Lagana, A" uniqKey="Lagana A">A Lagana</name>
</author>
<author><name sortKey="Giugno, R" uniqKey="Giugno R">R Giugno</name>
</author>
<author><name sortKey="Pulvirenti, A" uniqKey="Pulvirenti A">A Pulvirenti</name>
</author>
<author><name sortKey="Ferro, A" uniqKey="Ferro A">A Ferro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Turchinovich, A" uniqKey="Turchinovich A">A Turchinovich</name>
</author>
<author><name sortKey="Weiz, L" uniqKey="Weiz L">L Weiz</name>
</author>
<author><name sortKey="Langheinz, A" uniqKey="Langheinz A">A Langheinz</name>
</author>
<author><name sortKey="Burwinkel, B" uniqKey="Burwinkel B">B Burwinkel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Arroyo, J" uniqKey="Arroyo J">J Arroyo</name>
</author>
<author><name sortKey="Chevillet, J" uniqKey="Chevillet J">J Chevillet</name>
</author>
<author><name sortKey="Kroh, E" uniqKey="Kroh E">E Kroh</name>
</author>
<author><name sortKey="Ruf, I" uniqKey="Ruf I">I Ruf</name>
</author>
<author><name sortKey="Pritchard, C" uniqKey="Pritchard C">C Pritchard</name>
</author>
<author><name sortKey="Gibson, D" uniqKey="Gibson D">D Gibson</name>
</author>
<author><name sortKey="Mitchell, P" uniqKey="Mitchell P">P Mitchell</name>
</author>
<author><name sortKey="Bennett, C" uniqKey="Bennett C">C Bennett</name>
</author>
<author><name sortKey="Pogosova Agadjanyan, E" uniqKey="Pogosova Agadjanyan E">E Pogosova-Agadjanyan</name>
</author>
<author><name sortKey="Stirewalt, D" uniqKey="Stirewalt D">D Stirewalt</name>
</author>
<author><name sortKey="Tait, J" uniqKey="Tait J">J Tait</name>
</author>
<author><name sortKey="M, T" uniqKey="M T">T M</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Valadi, H" uniqKey="Valadi H">H Valadi</name>
</author>
<author><name sortKey="Ekstrom, K" uniqKey="Ekstrom K">K Ekstrom</name>
</author>
<author><name sortKey="Bossios, A" uniqKey="Bossios A">A Bossios</name>
</author>
<author><name sortKey="Sjostrand, M" uniqKey="Sjostrand M">M Sjostrand</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name>
</author>
<author><name sortKey="Lotvall, J" uniqKey="Lotvall J">J Lotvall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vickers, K" uniqKey="Vickers K">K Vickers</name>
</author>
<author><name sortKey="Palmisano, B" uniqKey="Palmisano B">B Palmisano</name>
</author>
<author><name sortKey="Shoucri, B" uniqKey="Shoucri B">B Shoucri</name>
</author>
<author><name sortKey="Shamburek, R" uniqKey="Shamburek R">R Shamburek</name>
</author>
<author><name sortKey="Remaley, A" uniqKey="Remaley A">A Remaley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fevrier, B" uniqKey="Fevrier B">B Fevrier</name>
</author>
<author><name sortKey="Raposo, G" uniqKey="Raposo G">G Raposo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, J" uniqKey="Song J">J Song</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
</author>
<author><name sortKey="Tolia, N" uniqKey="Tolia N">N Tolia</name>
</author>
<author><name sortKey="Schneiderman, J" uniqKey="Schneiderman J">J Schneiderman</name>
</author>
<author><name sortKey="Smith, S" uniqKey="Smith S">S Smith</name>
</author>
<author><name sortKey="Martienssen, R" uniqKey="Martienssen R">R Martienssen</name>
</author>
<author><name sortKey="Hannon, G" uniqKey="Hannon G">G Hannon</name>
</author>
<author><name sortKey="Joshua Tor, L" uniqKey="Joshua Tor L">L Joshua-Tor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name>
</author>
<author><name sortKey="Ye, K" uniqKey="Ye K">K Ye</name>
</author>
<author><name sortKey="Patel, D" uniqKey="Patel D">D Patel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mathivanan, S" uniqKey="Mathivanan S">S Mathivanan</name>
</author>
<author><name sortKey="Fahner, C" uniqKey="Fahner C">C Fahner</name>
</author>
<author><name sortKey="Reid, G" uniqKey="Reid G">G Reid</name>
</author>
<author><name sortKey="Simpson, R" uniqKey="Simpson R">R Simpson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruepp, A" uniqKey="Ruepp A">A Ruepp</name>
</author>
<author><name sortKey="Kowarsch, A" uniqKey="Kowarsch A">A Kowarsch</name>
</author>
<author><name sortKey="Schmidl, D" uniqKey="Schmidl D">D Schmidl</name>
</author>
<author><name sortKey="Buggenthin, F" uniqKey="Buggenthin F">F Buggenthin</name>
</author>
<author><name sortKey="Brauner, B" uniqKey="Brauner B">B Brauner</name>
</author>
<author><name sortKey="Dunger, I" uniqKey="Dunger I">I Dunger</name>
</author>
<author><name sortKey="Fobo, G" uniqKey="Fobo G">G Fobo</name>
</author>
<author><name sortKey="Frishman, G" uniqKey="Frishman G">G Frishman</name>
</author>
<author><name sortKey="Montrone, C" uniqKey="Montrone C">C Montrone</name>
</author>
<author><name sortKey="Theis, F" uniqKey="Theis F">F Theis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Griffiths Jones, S" uniqKey="Griffiths Jones S">S Griffiths-Jones</name>
</author>
<author><name sortKey="Grocock, R" uniqKey="Grocock R">R Grocock</name>
</author>
<author><name sortKey="Van Dongen, S" uniqKey="Van Dongen S">S Van Dongen</name>
</author>
<author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name>
</author>
<author><name sortKey="Enright, A" uniqKey="Enright A">A Enright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knox, C" uniqKey="Knox C">C Knox</name>
</author>
<author><name sortKey="Law, V" uniqKey="Law V">V Law</name>
</author>
<author><name sortKey="Jewison, T" uniqKey="Jewison T">T Jewison</name>
</author>
<author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name>
</author>
<author><name sortKey="Ly, S" uniqKey="Ly S">S Ly</name>
</author>
<author><name sortKey="Frolkis, A" uniqKey="Frolkis A">A Frolkis</name>
</author>
<author><name sortKey="Pon, A" uniqKey="Pon A">A Pon</name>
</author>
<author><name sortKey="Banco, K" uniqKey="Banco K">K Banco</name>
</author>
<author><name sortKey="Mak, C" uniqKey="Mak C">C Mak</name>
</author>
<author><name sortKey="Neveu, V" uniqKey="Neveu V">V Neveu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sayers, E" uniqKey="Sayers E">E Sayers</name>
</author>
<author><name sortKey="Wheeler, D" uniqKey="Wheeler D">D Wheeler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stanford, N" uniqKey="Stanford N">N Stanford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baldridge, J" uniqKey="Baldridge J">J Baldridge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name>
</author>
<author><name sortKey="Swaminathan, R" uniqKey="Swaminathan R">R Swaminathan</name>
</author>
<author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fader, A" uniqKey="Fader A">A Fader</name>
</author>
<author><name sortKey="Soderland, S" uniqKey="Soderland S">S Soderland</name>
</author>
<author><name sortKey="Etzioni, O" uniqKey="Etzioni O">O Etzioni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Meng, F" uniqKey="Meng F">F Meng</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Dai, E" uniqKey="Dai E">E Dai</name>
</author>
<author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, D" uniqKey="Huang D">D Huang</name>
</author>
<author><name sortKey="Sherman, B" uniqKey="Sherman B">B Sherman</name>
</author>
<author><name sortKey="Lempicki, R" uniqKey="Lempicki R">R Lempicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiao, X" uniqKey="Jiao X">X Jiao</name>
</author>
<author><name sortKey="Sherman, B" uniqKey="Sherman B">B Sherman</name>
</author>
<author><name sortKey="Huang Da, W" uniqKey="Huang Da W">W Huang da</name>
</author>
<author><name sortKey="Stephens, R" uniqKey="Stephens R">R Stephens</name>
</author>
<author><name sortKey="Baseler, M" uniqKey="Baseler M">M Baseler</name>
</author>
<author><name sortKey="Lane, H" uniqKey="Lane H">H Lane</name>
</author>
<author><name sortKey="Lempicki, R" uniqKey="Lempicki R">R Lempicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hosack, D" uniqKey="Hosack D">D Hosack</name>
</author>
<author><name sortKey="Dennis, Gj" uniqKey="Dennis G">GJ Dennis</name>
</author>
<author><name sortKey="Sherman, B" uniqKey="Sherman B">B Sherman</name>
</author>
<author><name sortKey="Lane, H" uniqKey="Lane H">H Lane</name>
</author>
<author><name sortKey="Lempicki, R" uniqKey="Lempicki R">R Lempicki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Boer, H" uniqKey="De Boer H">H de Boer</name>
</author>
<author><name sortKey="Van Solingen, C" uniqKey="Van Solingen C">C van Solingen</name>
</author>
<author><name sortKey="Prins, J" uniqKey="Prins J">J Prins</name>
</author>
<author><name sortKey="Duijs, J" uniqKey="Duijs J">J Duijs</name>
</author>
<author><name sortKey="Mv, H" uniqKey="Mv H">H MV</name>
</author>
<author><name sortKey="Rabelink, T" uniqKey="Rabelink T">T Rabelink</name>
</author>
<author><name sortKey="Van Zonneveld, A" uniqKey="Van Zonneveld A">A van Zonneveld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Starkey Lewis, P" uniqKey="Starkey Lewis P">P Starkey Lewis</name>
</author>
<author><name sortKey="Dear, J" uniqKey="Dear J">J Dear</name>
</author>
<author><name sortKey="Platt, V" uniqKey="Platt V">V Platt</name>
</author>
<author><name sortKey="Simpson, K" uniqKey="Simpson K">K Simpson</name>
</author>
<author><name sortKey="Craig, D" uniqKey="Craig D">D Craig</name>
</author>
<author><name sortKey="Antoine, D" uniqKey="Antoine D">D Antoine</name>
</author>
<author><name sortKey="French, N" uniqKey="French N">N French</name>
</author>
<author><name sortKey="Dhaun, N" uniqKey="Dhaun N">N Dhaun</name>
</author>
<author><name sortKey="Webb, D" uniqKey="Webb D">D Webb</name>
</author>
<author><name sortKey="Costello, E" uniqKey="Costello E">E Costello</name>
</author>
<author><name sortKey="Neoptolemos, J" uniqKey="Neoptolemos J">J Neoptolemos</name>
</author>
<author><name sortKey="Moggs, J" uniqKey="Moggs J">J Moggs</name>
</author>
<author><name sortKey="Goldring, C" uniqKey="Goldring C">C Goldring</name>
</author>
<author><name sortKey="Park, B" uniqKey="Park B">B Park</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pigati, L" uniqKey="Pigati L">L Pigati</name>
</author>
<author><name sortKey="Yaddanapudi, S" uniqKey="Yaddanapudi S">S Yaddanapudi</name>
</author>
<author><name sortKey="Iyengar, R" uniqKey="Iyengar R">R Iyengar</name>
</author>
<author><name sortKey="Kim, D" uniqKey="Kim D">D Kim</name>
</author>
<author><name sortKey="Hearn, S" uniqKey="Hearn S">S Hearn</name>
</author>
<author><name sortKey="Danforth, D" uniqKey="Danforth D">D Danforth</name>
</author>
<author><name sortKey="Hastings, M" uniqKey="Hastings M">M Hastings</name>
</author>
<author><name sortKey="Duelli, D" uniqKey="Duelli D">D Duelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bryant, R" uniqKey="Bryant R">R Bryant</name>
</author>
<author><name sortKey="Pawlowski, T" uniqKey="Pawlowski T">T Pawlowski</name>
</author>
<author><name sortKey="Catto, J" uniqKey="Catto J">J Catto</name>
</author>
<author><name sortKey="Marsden, G" uniqKey="Marsden G">G Marsden</name>
</author>
<author><name sortKey="Vessella, R" uniqKey="Vessella R">R Vessella</name>
</author>
<author><name sortKey="Rhees, B" uniqKey="Rhees B">B Rhees</name>
</author>
<author><name sortKey="Kuslich, C" uniqKey="Kuslich C">C Kuslich</name>
</author>
<author><name sortKey="Visakorpi, T" uniqKey="Visakorpi T">T Visakorpi</name>
</author>
<author><name sortKey="Hamdy, F" uniqKey="Hamdy F">F Hamdy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Porkka, K" uniqKey="Porkka K">K Porkka</name>
</author>
<author><name sortKey="Pfeiffer, M" uniqKey="Pfeiffer M">M Pfeiffer</name>
</author>
<author><name sortKey="Waltering, K" uniqKey="Waltering K">K Waltering</name>
</author>
<author><name sortKey="Vessella, R" uniqKey="Vessella R">R Vessella</name>
</author>
<author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name>
</author>
<author><name sortKey="Visakorpi, T" uniqKey="Visakorpi T">T Visakorpi</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Italie</li>
<li>États-Unis</li>
</country>
<region><li>Ohio</li>
<li>Toscane</li>
</region>
<settlement><li>Pise</li>
</settlement>
</list>
<tree><country name="Italie"><region name="Toscane"><name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name>
</region>
<name sortKey="Bonnici, Vincenzo" sort="Bonnici, Vincenzo" uniqKey="Bonnici V" first="Vincenzo" last="Bonnici">Vincenzo Bonnici</name>
<name sortKey="Di Bella, Sebastiano" sort="Di Bella, Sebastiano" uniqKey="Di Bella S" first="Sebastiano" last="Di Bella">Sebastiano Di Bella</name>
<name sortKey="Ferro, Alfredo" sort="Ferro, Alfredo" uniqKey="Ferro A" first="Alfredo" last="Ferro">Alfredo Ferro</name>
<name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name>
<name sortKey="Pellegrini, Marco" sort="Pellegrini, Marco" uniqKey="Pellegrini M" first="Marco" last="Pellegrini">Marco Pellegrini</name>
<name sortKey="Pulvirenti, Alfredo" sort="Pulvirenti, Alfredo" uniqKey="Pulvirenti A" first="Alfredo" last="Pulvirenti">Alfredo Pulvirenti</name>
<name sortKey="Rainaldi, Giuseppe" sort="Rainaldi, Giuseppe" uniqKey="Rainaldi G" first="Giuseppe" last="Rainaldi">Giuseppe Rainaldi</name>
<name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name>
</country>
<country name="États-Unis"><region name="Ohio"><name sortKey="Lagana, Alessandro" sort="Lagana, Alessandro" uniqKey="Lagana A" first="Alessandro" last="Laganà">Alessandro Laganà</name>
</region>
</country>
</tree>
</affiliations>
</record>
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