A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs
Identifieur interne : 000352 ( Main/Exploration ); précédent : 000351; suivant : 000353A knowledge base for the discovery of function, diagnostic potential and drug effects on cellular and extracellular miRNAs
Auteurs : Francesco Russo [Italie] ; Sebastiano Di Bella [Italie] ; Vincenzo Bonnici [Italie] ; Alessandro Laganà [États-Unis] ; Giuseppe Rainaldi [Italie] ; Marco Pellegrini [Italie] ; Alfredo Pulvirenti [Italie] ; Rosalba Giugno [Italie] ; Alfredo Ferro [Italie]Source :
- BMC Genomics [ 1471-2164 ] ; 2014.
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers.
We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed.
This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs.
Url:
DOI: 10.1186/1471-2164-15-S3-S4
PubMed: 25077952
PubMed Central: 4083404
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream Ncbi, to step Curation: 000A47
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Le document en format XML
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University of Catania, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Molecular Biomedicine - University of Catania</wicri:regionArea></affiliation></author><author><name sortKey="Di Bella, Sebastiano" sort="Di Bella, Sebastiano" uniqKey="Di Bella S" first="Sebastiano" last="Di Bella">Sebastiano Di Bella</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Clinical and Molecular Biomedicine - University of Catania, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Molecular Biomedicine - University of Catania</wicri:regionArea></affiliation></author><author><name sortKey="Bonnici, Vincenzo" sort="Bonnici, Vincenzo" uniqKey="Bonnici V" first="Vincenzo" last="Bonnici">Vincenzo Bonnici</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Computer Science - University of Verona, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Computer Science - University of Verona</wicri:regionArea></affiliation></author><author><name sortKey="Lagana, Alessandro" sort="Lagana, Alessandro" uniqKey="Lagana A" first="Alessandro" last="Laganà">Alessandro Laganà</name><affiliation wicri:level="2"><nlm:aff id="I3">Department of Molecular Virology, Immunology and Medical Genetics Comprehensive Cancer Center - The Ohio State University, OH</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Molecular Virology, Immunology and Medical Genetics Comprehensive Cancer Center - The Ohio State University</wicri:cityArea></affiliation></author><author><name sortKey="Rainaldi, Giuseppe" sort="Rainaldi, Giuseppe" uniqKey="Rainaldi G" first="Giuseppe" last="Rainaldi">Giuseppe Rainaldi</name><affiliation wicri:level="3"><nlm:aff id="I1">Laboratory of Integrative System Medicine, Institute of Informatics and Telematics and Institute of Clinical Physiology, National Research Council, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Integrative System Medicine, Institute of Informatics and Telematics and Institute of Clinical Physiology, National Research Council, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Pellegrini, Marco" sort="Pellegrini, Marco" uniqKey="Pellegrini M" first="Marco" last="Pellegrini">Marco Pellegrini</name><affiliation wicri:level="3"><nlm:aff id="I1">Laboratory of Integrative System Medicine, Institute of Informatics and Telematics and Institute of Clinical Physiology, National Research Council, Pisa, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Laboratory of Integrative System Medicine, Institute of Informatics and Telematics and Institute of Clinical Physiology, National Research Council, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName></affiliation></author><author><name sortKey="Pulvirenti, Alfredo" sort="Pulvirenti, Alfredo" uniqKey="Pulvirenti A" first="Alfredo" last="Pulvirenti">Alfredo Pulvirenti</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Clinical and Molecular Biomedicine - University of Catania, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Molecular Biomedicine - University of Catania</wicri:regionArea></affiliation></author><author><name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Clinical and Molecular Biomedicine - University of Catania, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Molecular Biomedicine - University of Catania</wicri:regionArea></affiliation></author><author><name sortKey="Ferro, Alfredo" sort="Ferro, Alfredo" uniqKey="Ferro A" first="Alfredo" last="Ferro">Alfredo Ferro</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Clinical and Molecular Biomedicine - University of Catania, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Clinical and Molecular Biomedicine - University of Catania</wicri:regionArea></affiliation></author></analytic><series><title level="j">BMC Genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in the regulation of various biological processes through their interaction with cellular mRNAs. A significant amount of miRNAs has been found in extracellular human body fluids (e.g. plasma and serum) and some circulating miRNAs in the blood have been successfully revealed as biomarkers for diseases including cardiovascular diseases and cancer. Released miRNAs do not necessarily reflect the abundance of miRNAs in the cell of origin. It is claimed that release of miRNAs from cells into blood and ductal fluids is selective and that the selection of released miRNAs may correlate with malignancy. Moreover, miRNAs play a significant role in pharmacogenomics by down-regulating genes that are important for drug function. In particular, the use of drugs should be taken into consideration while analyzing plasma miRNA levels as drug treatment. This may impair their employment as biomarkers.</p></sec><sec><title>Description</title><p>We enriched our manually curated extracellular/circulating microRNAs database, miRandola, by providing (i) a systematic comparison of expression profiles of cellular and extracellular miRNAs, (ii) a miRNA targets enrichment analysis procedure, (iii) information on drugs and their effect on miRNA expression, obtained by applying a natural language processing algorithm to abstracts obtained from PubMed.</p></sec><sec><title>Conclusions</title><p>This allows users to improve the knowledge about the function, diagnostic potential, and the drug effects on cellular and circulating miRNAs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bartel, D" uniqKey="Bartel D">D Bartel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cortez, M" uniqKey="Cortez M">M Cortez</name></author><author><name sortKey="Bueso 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Ferro</name><name sortKey="Giugno, Rosalba" sort="Giugno, Rosalba" uniqKey="Giugno R" first="Rosalba" last="Giugno">Rosalba Giugno</name><name sortKey="Pellegrini, Marco" sort="Pellegrini, Marco" uniqKey="Pellegrini M" first="Marco" last="Pellegrini">Marco Pellegrini</name><name sortKey="Pulvirenti, Alfredo" sort="Pulvirenti, Alfredo" uniqKey="Pulvirenti A" first="Alfredo" last="Pulvirenti">Alfredo Pulvirenti</name><name sortKey="Rainaldi, Giuseppe" sort="Rainaldi, Giuseppe" uniqKey="Rainaldi G" first="Giuseppe" last="Rainaldi">Giuseppe Rainaldi</name><name sortKey="Russo, Francesco" sort="Russo, Francesco" uniqKey="Russo F" first="Francesco" last="Russo">Francesco Russo</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Lagana, Alessandro" sort="Lagana, Alessandro" uniqKey="Lagana A" first="Alessandro" last="Laganà">Alessandro Laganà</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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