MalarImDB: an open-access literature-based malaria immunology database.
Identifieur interne : 000040 ( PubMed/Curation ); précédent : 000039; suivant : 000041MalarImDB: an open-access literature-based malaria immunology database.
Auteurs : Katrien Deroost [Belgique] ; Ghislain Opdenakker [Belgique] ; Philippe E. Van Den Steen [Belgique]Source :
- Trends in parasitology [ 1471-5007 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- standards : Databases, Factual.
- trends : Databases, Factual.
- Access to Information, Allergy and Immunology, Animals, Humans, Literature, Malaria, Transcriptome.
Abstract
The Malaria Immunology Database (MalarImDB, www.malarimdb.org) is a novel literature-based database of host mediators in blood-stage malaria. We designed this open-access online tool because intensive malaria research has resulted in a dazzling complexity of host mediators with pathogenic or protective functions. MalarImDB allows comparisons between expression levels in humans, expression levels in murine models, and functional data from experimental treatments in mice. The database is equipped with multiple search engines to retrieve information from many published studies. The search output is visualized schematically in tables, thereby revealing similarities and disparities. Thus, the primary aim of this database is to present a clear overview of the currently available data about malaria and to simplify literature searches.
DOI: 10.1016/j.pt.2014.04.006
PubMed: 24794510
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Van Den Steen</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: Philippe.vandensteen@rega.kuleuven.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven</wicri:regionArea></affiliation></author></analytic><series><title level="j">Trends in parasitology</title><idno type="eISSN">1471-5007</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Access to Information</term><term>Allergy and Immunology</term><term>Animals</term><term>Databases, Factual (standards)</term><term>Databases, Factual (trends)</term><term>Humans</term><term>Literature</term><term>Malaria</term><term>Transcriptome</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Databases, Factual</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Access to Information</term><term>Allergy and Immunology</term><term>Animals</term><term>Humans</term><term>Literature</term><term>Malaria</term><term>Transcriptome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Malaria Immunology Database (MalarImDB, www.malarimdb.org) is a novel literature-based database of host mediators in blood-stage malaria. We designed this open-access online tool because intensive malaria research has resulted in a dazzling complexity of host mediators with pathogenic or protective functions. MalarImDB allows comparisons between expression levels in humans, expression levels in murine models, and functional data from experimental treatments in mice. The database is equipped with multiple search engines to retrieve information from many published studies. The search output is visualized schematically in tables, thereby revealing similarities and disparities. 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We designed this open-access online tool because intensive malaria research has resulted in a dazzling complexity of host mediators with pathogenic or protective functions. MalarImDB allows comparisons between expression levels in humans, expression levels in murine models, and functional data from experimental treatments in mice. The database is equipped with multiple search engines to retrieve information from many published studies. The search output is visualized schematically in tables, thereby revealing similarities and disparities. Thus, the primary aim of this database is to present a clear overview of the currently available data about malaria and to simplify literature searches.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deroost</LastName><ForeName>Katrien</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Opdenakker</LastName><ForeName>Ghislain</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van den Steen</LastName><ForeName>Philippe E</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven - University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium. 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