Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals.
Identifieur interne : 000026 ( PubMed/Curation ); précédent : 000025; suivant : 000027Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals.
Auteurs : Mika Kivim Ki [Finlande] ; Markus Jokela [Finlande] ; Solja T. Nyberg [Finlande] ; Archana Singh-Manoux [France] ; Eleonor I. Fransson [Suède] ; Lars Alfredsson [Suède] ; Jakob B. Bjorner [Danemark] ; Marianne Borritz [Danemark] ; Hermann Burr [Allemagne] ; Annalisa Casini [Belgique] ; Els Clays [Belgique] ; Dirk De Bacquer [Belgique] ; Nico Dragano [Allemagne] ; Raimund Erbel [Allemagne] ; Goedele A. Geuskens [Pays-Bas] ; Mark Hamer [Royaume-Uni] ; Wendela E. Hooftman [Pays-Bas] ; Irene L. Houtman [Pays-Bas] ; Karl-Heinz Jöckel [Allemagne] ; France Kittel [Belgique] ; Anders Knutsson [Suède] ; Markku Koskenvuo [Finlande] ; Thorsten Lunau [Allemagne] ; Ida E H. Madsen [Danemark] ; Martin L. Nielsen [Danemark] ; Maria Nordin [Suède] ; Tuula Oksanen [Finlande] ; Jan H. Pejtersen [Danemark] ; Jaana Pentti [Finlande] ; Reiner Rugulies [Danemark] ; Paula Salo [Finlande] ; Martin J. Shipley [Royaume-Uni] ; Johannes Siegrist [Allemagne] ; Andrew Steptoe [Royaume-Uni] ; Sakari B. Suominen [Suède] ; Töres Theorell [Suède] ; Jussi Vahtera [Finlande] ; Peter J M. Westerholm [Suède] ; Hugo Westerlund [Suède] ; Dermot O'Reilly [Royaume-Uni] ; Meena Kumari [Royaume-Uni] ; G David Batty [Royaume-Uni] ; Jane E. Ferrie [Royaume-Uni] ; Marianna Virtanen [Finlande]Source :
- Lancet (London, England) [ 1474-547X ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Coronary Disease, Stroke.
- etiology : Coronary Disease, Stroke.
- Age Factors, Female, Humans, Male, Middle Aged, Risk, Risk Factors, Sex Factors, Socioeconomic Factors, Work Schedule Tolerance.
Abstract
Long working hours might increase the risk of cardiovascular disease, but prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We aimed to assess long working hours as a risk factor for incident coronary heart disease and stroke.
DOI: 10.1016/S0140-6736(15)60295-1
PubMed: 26298822
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Electronic address: m.kivimaki@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Faculty of Medicine, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioral Sciences, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Nyberg, Solja T" sort="Nyberg, Solja T" uniqKey="Nyberg S" first="Solja T" last="Nyberg">Solja T. 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Bjorner</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Research Centre for the Working Environment, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Borritz, Marianne" sort="Borritz, Marianne" uniqKey="Borritz M" first="Marianne" last="Borritz">Marianne Borritz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Medicine, Koege Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Occupational Medicine, Koege Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Burr, Hermann" sort="Burr, Hermann" uniqKey="Burr H" first="Hermann" last="Burr">Hermann Burr</name><affiliation wicri:level="1"><nlm:affiliation>Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Institute for Occupational Safety and Health (BAuA), Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Casini, Annalisa" sort="Casini, Annalisa" uniqKey="Casini A" first="Annalisa" last="Casini">Annalisa Casini</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Université libre de Bruxelles (ULB), Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>School of Public Health, Université libre de Bruxelles (ULB), Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Clays, Els" sort="Clays, Els" uniqKey="Clays E" first="Els" last="Clays">Els Clays</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="De Bacquer, Dirk" sort="De Bacquer, Dirk" uniqKey="De Bacquer D" first="Dirk" last="De Bacquer">Dirk De Bacquer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Dragano, Nico" sort="Dragano, Nico" uniqKey="Dragano N" first="Nico" last="Dragano">Nico Dragano</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Geuskens, Goedele A" sort="Geuskens, Goedele A" uniqKey="Geuskens G" first="Goedele A" last="Geuskens">Goedele A. Geuskens</name><affiliation wicri:level="1"><nlm:affiliation>TNO, Hoofddorp, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>TNO, Hoofddorp</wicri:regionArea></affiliation></author><author><name sortKey="Hamer, Mark" sort="Hamer, Mark" uniqKey="Hamer M" first="Mark" last="Hamer">Mark Hamer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Hooftman, Wendela E" sort="Hooftman, Wendela E" uniqKey="Hooftman W" first="Wendela E" last="Hooftman">Wendela E. Hooftman</name><affiliation wicri:level="1"><nlm:affiliation>TNO, Hoofddorp, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>TNO, Hoofddorp</wicri:regionArea></affiliation></author><author><name sortKey="Houtman, Irene L" sort="Houtman, Irene L" uniqKey="Houtman I" first="Irene L" last="Houtman">Irene L. Houtman</name><affiliation wicri:level="1"><nlm:affiliation>TNO, Hoofddorp, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>TNO, Hoofddorp</wicri:regionArea></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Kittel, France" sort="Kittel, France" uniqKey="Kittel F" first="France" last="Kittel">France Kittel</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Université libre de Bruxelles (ULB), Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>School of Public Health, Université libre de Bruxelles (ULB), Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Knutsson, Anders" sort="Knutsson, Anders" uniqKey="Knutsson A" first="Anders" last="Knutsson">Anders Knutsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Health Sciences, Mid Sweden University, Sundsvall</wicri:regionArea></affiliation></author><author><name sortKey="Koskenvuo, Markku" sort="Koskenvuo, Markku" uniqKey="Koskenvuo M" first="Markku" last="Koskenvuo">Markku Koskenvuo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Lunau, Thorsten" sort="Lunau, Thorsten" uniqKey="Lunau T" first="Thorsten" last="Lunau">Thorsten Lunau</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Madsen, Ida E H" sort="Madsen, Ida E H" uniqKey="Madsen I" first="Ida E H" last="Madsen">Ida E H. Madsen</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Research Centre for the Working Environment, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Martin L" sort="Nielsen, Martin L" uniqKey="Nielsen M" first="Martin L" last="Nielsen">Martin L. Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nordin, Maria" sort="Nordin, Maria" uniqKey="Nordin M" first="Maria" last="Nordin">Maria Nordin</name><affiliation wicri:level="1"><nlm:affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden; Department of Psychology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stress Research Institute, Stockholm University, Stockholm, Sweden; Department of Psychology, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Oksanen, Tuula" sort="Oksanen, Tuula" uniqKey="Oksanen T" first="Tuula" last="Oksanen">Tuula Oksanen</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author><author><name sortKey="Pejtersen, Jan H" sort="Pejtersen, Jan H" uniqKey="Pejtersen J" first="Jan H" last="Pejtersen">Jan H. Pejtersen</name><affiliation wicri:level="1"><nlm:affiliation>The Danish National Centre for Social Research, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish National Centre for Social Research, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Pentti, Jaana" sort="Pentti, Jaana" uniqKey="Pentti J" first="Jaana" last="Pentti">Jaana Pentti</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author><author><name sortKey="Rugulies, Reiner" sort="Rugulies, Reiner" uniqKey="Rugulies R" first="Reiner" last="Rugulies">Reiner Rugulies</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Salo, Paula" sort="Salo, Paula" uniqKey="Salo P" first="Paula" last="Salo">Paula Salo</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Psychology, University of Turku, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Psychology, University of Turku, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Shipley, Martin J" sort="Shipley, Martin J" uniqKey="Shipley M" first="Martin J" last="Shipley">Martin J. Shipley</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Siegrist, Johannes" sort="Siegrist, Johannes" uniqKey="Siegrist J" first="Johannes" last="Siegrist">Johannes Siegrist</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Suominen, Sakari B" sort="Suominen, Sakari B" uniqKey="Suominen S" first="Sakari B" last="Suominen">Sakari B. Suominen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; University of Skövde, Skövde, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; University of Skövde, Skövde</wicri:regionArea></affiliation></author><author><name sortKey="Theorell, Tores" sort="Theorell, Tores" uniqKey="Theorell T" first="Töres" last="Theorell">Töres Theorell</name><affiliation wicri:level="1"><nlm:affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stress Research Institute, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Vahtera, Jussi" sort="Vahtera, Jussi" uniqKey="Vahtera J" first="Jussi" last="Vahtera">Jussi Vahtera</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Public Health, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Public Health, University of Turku, Turku, Finland; Turku University Hospital, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Westerholm, Peter J M" sort="Westerholm, Peter J M" uniqKey="Westerholm P" first="Peter J M" last="Westerholm">Peter J M. Westerholm</name><affiliation wicri:level="1"><nlm:affiliation>Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Occupational and Environmental Medicine, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Westerlund, Hugo" sort="Westerlund, Hugo" uniqKey="Westerlund H" first="Hugo" last="Westerlund">Hugo Westerlund</name><affiliation wicri:level="1"><nlm:affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stress Research Institute, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="O Reilly, Dermot" sort="O Reilly, Dermot" uniqKey="O Reilly D" first="Dermot" last="O'Reilly">Dermot O'Reilly</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Public Health, Queen's University Belfast, Belfast, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Public Health, Queen's University Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester</wicri:regionArea></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G David" last="Batty">G David Batty</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology and Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology and Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Ferrie, Jane E" sort="Ferrie, Jane E" uniqKey="Ferrie J" first="Jane E" last="Ferrie">Jane E. Ferrie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; School of Community and Social Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; School of Community and Social Medicine, University of Bristol, Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Virtanen, Marianna" sort="Virtanen, Marianna" uniqKey="Virtanen M" first="Marianna" last="Virtanen">Marianna Virtanen</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26298822</idno><idno type="pmid">26298822</idno><idno type="doi">10.1016/S0140-6736(15)60295-1</idno><idno type="wicri:Area/PubMed/Corpus">000026</idno><idno type="wicri:Area/PubMed/Curation">000026</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals.</title><author><name sortKey="Kivim Ki, Mika" sort="Kivim Ki, Mika" uniqKey="Kivim Ki M" first="Mika" last="Kivim Ki">Mika Kivim Ki</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address: m.kivimaki@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Faculty of Medicine, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Jokela, Markus" sort="Jokela, Markus" uniqKey="Jokela M" first="Markus" last="Jokela">Markus Jokela</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Behavioral Sciences, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Nyberg, Solja T" sort="Nyberg, Solja T" uniqKey="Nyberg S" first="Solja T" last="Nyberg">Solja T. Nyberg</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author><author><name sortKey="Singh Manoux, Archana" sort="Singh Manoux, Archana" uniqKey="Singh Manoux A" first="Archana" last="Singh-Manoux">Archana Singh-Manoux</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Fransson, Eleonor I" sort="Fransson, Eleonor I" uniqKey="Fransson E" first="Eleonor I" last="Fransson">Eleonor I. Fransson</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; School of Health Sciences, Jönköping University, Jönköping, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; School of Health Sciences, Jönköping University, Jönköping, Sweden; Stress Research Institute, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Alfredsson, Lars" sort="Alfredsson, Lars" uniqKey="Alfredsson L" first="Lars" last="Alfredsson">Lars Alfredsson</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Bjorner, Jakob B" sort="Bjorner, Jakob B" uniqKey="Bjorner J" first="Jakob B" last="Bjorner">Jakob B. Bjorner</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Research Centre for the Working Environment, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Borritz, Marianne" sort="Borritz, Marianne" uniqKey="Borritz M" first="Marianne" last="Borritz">Marianne Borritz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Occupational Medicine, Koege Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Department of Occupational Medicine, Koege Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Burr, Hermann" sort="Burr, Hermann" uniqKey="Burr H" first="Hermann" last="Burr">Hermann Burr</name><affiliation wicri:level="1"><nlm:affiliation>Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Institute for Occupational Safety and Health (BAuA), Berlin</wicri:regionArea></affiliation></author><author><name sortKey="Casini, Annalisa" sort="Casini, Annalisa" uniqKey="Casini A" first="Annalisa" last="Casini">Annalisa Casini</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Université libre de Bruxelles (ULB), Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>School of Public Health, Université libre de Bruxelles (ULB), Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Clays, Els" sort="Clays, Els" uniqKey="Clays E" first="Els" last="Clays">Els Clays</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="De Bacquer, Dirk" sort="De Bacquer, Dirk" uniqKey="De Bacquer D" first="Dirk" last="De Bacquer">Dirk De Bacquer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, Ghent University, Ghent, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Public Health, Ghent University, Ghent</wicri:regionArea></affiliation></author><author><name sortKey="Dragano, Nico" sort="Dragano, Nico" uniqKey="Dragano N" first="Nico" last="Dragano">Nico Dragano</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Erbel, Raimund" sort="Erbel, Raimund" uniqKey="Erbel R" first="Raimund" last="Erbel">Raimund Erbel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Geuskens, Goedele A" sort="Geuskens, Goedele A" uniqKey="Geuskens G" first="Goedele A" last="Geuskens">Goedele A. Geuskens</name><affiliation wicri:level="1"><nlm:affiliation>TNO, Hoofddorp, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>TNO, Hoofddorp</wicri:regionArea></affiliation></author><author><name sortKey="Hamer, Mark" sort="Hamer, Mark" uniqKey="Hamer M" first="Mark" last="Hamer">Mark Hamer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Hooftman, Wendela E" sort="Hooftman, Wendela E" uniqKey="Hooftman W" first="Wendela E" last="Hooftman">Wendela E. Hooftman</name><affiliation wicri:level="1"><nlm:affiliation>TNO, Hoofddorp, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>TNO, Hoofddorp</wicri:regionArea></affiliation></author><author><name sortKey="Houtman, Irene L" sort="Houtman, Irene L" uniqKey="Houtman I" first="Irene L" last="Houtman">Irene L. Houtman</name><affiliation wicri:level="1"><nlm:affiliation>TNO, Hoofddorp, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>TNO, Hoofddorp</wicri:regionArea></affiliation></author><author><name sortKey="Jockel, Karl Heinz" sort="Jockel, Karl Heinz" uniqKey="Jockel K" first="Karl-Heinz" last="Jöckel">Karl-Heinz Jöckel</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen</wicri:regionArea></affiliation></author><author><name sortKey="Kittel, France" sort="Kittel, France" uniqKey="Kittel F" first="France" last="Kittel">France Kittel</name><affiliation wicri:level="1"><nlm:affiliation>School of Public Health, Université libre de Bruxelles (ULB), Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>School of Public Health, Université libre de Bruxelles (ULB), Brussels</wicri:regionArea></affiliation></author><author><name sortKey="Knutsson, Anders" sort="Knutsson, Anders" uniqKey="Knutsson A" first="Anders" last="Knutsson">Anders Knutsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Health Sciences, Mid Sweden University, Sundsvall</wicri:regionArea></affiliation></author><author><name sortKey="Koskenvuo, Markku" sort="Koskenvuo, Markku" uniqKey="Koskenvuo M" first="Markku" last="Koskenvuo">Markku Koskenvuo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Helsinki, Helsinki, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Public Health, University of Helsinki, Helsinki</wicri:regionArea></affiliation></author><author><name sortKey="Lunau, Thorsten" sort="Lunau, Thorsten" uniqKey="Lunau T" first="Thorsten" last="Lunau">Thorsten Lunau</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Madsen, Ida E H" sort="Madsen, Ida E H" uniqKey="Madsen I" first="Ida E H" last="Madsen">Ida E H. Madsen</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Research Centre for the Working Environment, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nielsen, Martin L" sort="Nielsen, Martin L" uniqKey="Nielsen M" first="Martin L" last="Nielsen">Martin L. Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Nordin, Maria" sort="Nordin, Maria" uniqKey="Nordin M" first="Maria" last="Nordin">Maria Nordin</name><affiliation wicri:level="1"><nlm:affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden; Department of Psychology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stress Research Institute, Stockholm University, Stockholm, Sweden; Department of Psychology, Umeå University, Umeå</wicri:regionArea></affiliation></author><author><name sortKey="Oksanen, Tuula" sort="Oksanen, Tuula" uniqKey="Oksanen T" first="Tuula" last="Oksanen">Tuula Oksanen</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author><author><name sortKey="Pejtersen, Jan H" sort="Pejtersen, Jan H" uniqKey="Pejtersen J" first="Jan H" last="Pejtersen">Jan H. Pejtersen</name><affiliation wicri:level="1"><nlm:affiliation>The Danish National Centre for Social Research, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>The Danish National Centre for Social Research, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Pentti, Jaana" sort="Pentti, Jaana" uniqKey="Pentti J" first="Jaana" last="Pentti">Jaana Pentti</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author><author><name sortKey="Rugulies, Reiner" sort="Rugulies, Reiner" uniqKey="Rugulies R" first="Reiner" last="Rugulies">Reiner Rugulies</name><affiliation wicri:level="1"><nlm:affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen</wicri:regionArea></affiliation></author><author><name sortKey="Salo, Paula" sort="Salo, Paula" uniqKey="Salo P" first="Paula" last="Salo">Paula Salo</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Psychology, University of Turku, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Psychology, University of Turku, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Shipley, Martin J" sort="Shipley, Martin J" uniqKey="Shipley M" first="Martin J" last="Shipley">Martin J. Shipley</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Siegrist, Johannes" sort="Siegrist, Johannes" uniqKey="Siegrist J" first="Johannes" last="Siegrist">Johannes Siegrist</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf</wicri:regionArea></affiliation></author><author><name sortKey="Steptoe, Andrew" sort="Steptoe, Andrew" uniqKey="Steptoe A" first="Andrew" last="Steptoe">Andrew Steptoe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Suominen, Sakari B" sort="Suominen, Sakari B" uniqKey="Suominen S" first="Sakari B" last="Suominen">Sakari B. Suominen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; University of Skövde, Skövde, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; University of Skövde, Skövde</wicri:regionArea></affiliation></author><author><name sortKey="Theorell, Tores" sort="Theorell, Tores" uniqKey="Theorell T" first="Töres" last="Theorell">Töres Theorell</name><affiliation wicri:level="1"><nlm:affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stress Research Institute, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="Vahtera, Jussi" sort="Vahtera, Jussi" uniqKey="Vahtera J" first="Jussi" last="Vahtera">Jussi Vahtera</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Public Health, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Public Health, University of Turku, Turku, Finland; Turku University Hospital, Turku</wicri:regionArea></affiliation></author><author><name sortKey="Westerholm, Peter J M" sort="Westerholm, Peter J M" uniqKey="Westerholm P" first="Peter J M" last="Westerholm">Peter J M. Westerholm</name><affiliation wicri:level="1"><nlm:affiliation>Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Occupational and Environmental Medicine, Uppsala University, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Westerlund, Hugo" sort="Westerlund, Hugo" uniqKey="Westerlund H" first="Hugo" last="Westerlund">Hugo Westerlund</name><affiliation wicri:level="1"><nlm:affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Stress Research Institute, Stockholm University, Stockholm</wicri:regionArea></affiliation></author><author><name sortKey="O Reilly, Dermot" sort="O Reilly, Dermot" uniqKey="O Reilly D" first="Dermot" last="O'Reilly">Dermot O'Reilly</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Public Health, Queen's University Belfast, Belfast, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centre for Public Health, Queen's University Belfast, Belfast</wicri:regionArea></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester</wicri:regionArea></affiliation></author><author><name sortKey="Batty, G David" sort="Batty, G David" uniqKey="Batty G" first="G David" last="Batty">G David Batty</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology and Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology and Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh</wicri:regionArea></affiliation></author><author><name sortKey="Ferrie, Jane E" sort="Ferrie, Jane E" uniqKey="Ferrie J" first="Jane E" last="Ferrie">Jane E. Ferrie</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology and Public Health, University College London, London, UK; School of Community and Social Medicine, University of Bristol, Bristol, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Public Health, University College London, London, UK; School of Community and Social Medicine, University of Bristol, Bristol</wicri:regionArea></affiliation></author><author><name sortKey="Virtanen, Marianna" sort="Virtanen, Marianna" uniqKey="Virtanen M" first="Marianna" last="Virtanen">Marianna Virtanen</name><affiliation wicri:level="1"><nlm:affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Coronary Disease (epidemiology)</term><term>Coronary Disease (etiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk</term><term>Risk Factors</term><term>Sex Factors</term><term>Socioeconomic Factors</term><term>Stroke (epidemiology)</term><term>Stroke (etiology)</term><term>Work Schedule Tolerance</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronary Disease</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Coronary Disease</term><term>Stroke</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk</term><term>Risk Factors</term><term>Sex Factors</term><term>Socioeconomic Factors</term><term>Work Schedule Tolerance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Long working hours might increase the risk of cardiovascular disease, but prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We aimed to assess long working hours as a risk factor for incident coronary heart disease and stroke.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26298822</PMID><DateCreated><Year>2015</Year><Month>11</Month><Day>7</Day></DateCreated><DateCompleted><Year>2015</Year><Month>11</Month><Day>20</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>7</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>386</Volume><Issue>10005</Issue><PubDate><Year>2015</Year><Month>Oct</Month><Day>31</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603,838 individuals.</ArticleTitle><Pagination><MedlinePgn>1739-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(15)60295-1</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(15)60295-1</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Long working hours might increase the risk of cardiovascular disease, but prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We aimed to assess long working hours as a risk factor for incident coronary heart disease and stroke.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We identified published studies through a systematic review of PubMed and Embase from inception to Aug 20, 2014. We obtained unpublished data for 20 cohort studies from the Individual-Participant-Data Meta-analysis in Working Populations (IPD-Work) Consortium and open-access data archives. We used cumulative random-effects meta-analysis to combine effect estimates from published and unpublished data.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">We included 25 studies from 24 cohorts in Europe, the USA, and Australia. The meta-analysis of coronary heart disease comprised data for 603,838 men and women who were free from coronary heart disease at baseline; the meta-analysis of stroke comprised data for 528,908 men and women who were free from stroke at baseline. Follow-up for coronary heart disease was 5·1 million person-years (mean 8·5 years), in which 4768 events were recorded, and for stroke was 3·8 million person-years (mean 7·2 years), in which 1722 events were recorded. In cumulative meta-analysis adjusted for age, sex, and socioeconomic status, compared with standard hours (35-40 h per week), working long hours (≥55 h per week) was associated with an increase in risk of incident coronary heart disease (relative risk [RR] 1·13, 95% CI 1·02-1·26; p=0·02) and incident stroke (1·33, 1·11-1·61; p=0·002). The excess risk of stroke remained unchanged in analyses that addressed reverse causation, multivariable adjustments for other risk factors, and different methods of stroke ascertainment (range of RR estimates 1·30-1·42). We recorded a dose-response association for stroke, with RR estimates of 1·10 (95% CI 0·94-1·28; p=0·24) for 41-48 working hours, 1·27 (1·03-1·56; p=0·03) for 49-54 working hours, and 1·33 (1·11-1·61; p=0·002) for 55 working hours or more per week compared with standard working hours (ptrend<0·0001).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Employees who work long hours have a higher risk of stroke than those working standard hours; the association with coronary heart disease is weaker. These findings suggest that more attention should be paid to the management of vascular risk factors in individuals who work long hours.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Medical Research Council, Economic and Social Research Council, European Union New and Emerging Risks in Occupational Safety and Health research programme, Finnish Work Environment Fund, Swedish Research Council for Working Life and Social Research, German Social Accident Insurance, Danish National Research Centre for the Working Environment, Academy of Finland, Ministry of Social Affairs and Employment (Netherlands), US National Institutes of Health, British Heart Foundation.</AbstractText><CopyrightInformation>Copyright © 2015 Kivimäki et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kivimäki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address: m.kivimaki@ucl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jokela</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nyberg</LastName><ForeName>Solja T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh-Manoux</LastName><ForeName>Archana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fransson</LastName><ForeName>Eleonor I</ForeName><Initials>EI</Initials><AffiliationInfo><Affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; School of Health Sciences, Jönköping University, Jönköping, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alfredsson</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bjorner</LastName><ForeName>Jakob B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borritz</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Occupational Medicine, Koege Hospital, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burr</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casini</LastName><ForeName>Annalisa</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Public Health, Université libre de Bruxelles (ULB), Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clays</LastName><ForeName>Els</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Public Health, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Bacquer</LastName><ForeName>Dirk</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Public Health, Ghent University, Ghent, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dragano</LastName><ForeName>Nico</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erbel</LastName><ForeName>Raimund</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geuskens</LastName><ForeName>Goedele A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>TNO, Hoofddorp, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamer</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hooftman</LastName><ForeName>Wendela E</ForeName><Initials>WE</Initials><AffiliationInfo><Affiliation>TNO, Hoofddorp, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houtman</LastName><ForeName>Irene L</ForeName><Initials>IL</Initials><AffiliationInfo><Affiliation>TNO, Hoofddorp, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jöckel</LastName><ForeName>Karl-Heinz</ForeName><Initials>KH</Initials><AffiliationInfo><Affiliation>Institute for Medical Informatics, Biometry, and Epidemiology, Faculty of Medicine, University Duisburg-Essen, Essen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kittel</LastName><ForeName>France</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>School of Public Health, Université libre de Bruxelles (ULB), Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knutsson</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koskenvuo</LastName><ForeName>Markku</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lunau</LastName><ForeName>Thorsten</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madsen</LastName><ForeName>Ida E H</ForeName><Initials>IE</Initials><AffiliationInfo><Affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nielsen</LastName><ForeName>Martin L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Unit of Social Medicine, Frederiksberg University Hospital, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nordin</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden; Department of Psychology, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oksanen</LastName><ForeName>Tuula</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pejtersen</LastName><ForeName>Jan H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>The Danish National Centre for Social Research, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pentti</LastName><ForeName>Jaana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rugulies</LastName><ForeName>Reiner</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salo</LastName><ForeName>Paula</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Psychology, University of Turku, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shipley</LastName><ForeName>Martin J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siegrist</LastName><ForeName>Johannes</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Medical Sociology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steptoe</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suominen</LastName><ForeName>Sakari B</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Turku, Turku, Finland; Folkhälsan Research Center, Helsinki, Finland; University of Skövde, Skövde, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Theorell</LastName><ForeName>Töres</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vahtera</LastName><ForeName>Jussi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland; Department of Public Health, University of Turku, Turku, Finland; Turku University Hospital, Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westerholm</LastName><ForeName>Peter J M</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westerlund</LastName><ForeName>Hugo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Stress Research Institute, Stockholm University, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Reilly</LastName><ForeName>Dermot</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Centre for Public Health, Queen's University Belfast, Belfast, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Meena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Institute for Social and Economic Research, University of Essex, Colchester, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Batty</LastName><ForeName>G David</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK; Centre for Cognitive Ageing and Cognitive Epidemiology and Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrie</LastName><ForeName>Jane E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, University College London, London, UK; School of Community and Social Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Virtanen</LastName><ForeName>Marianna</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Finnish Institute of Occupational Health, Helsinki, Tampere and Turku, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>IPD-Work Consortium</CollectiveName></Author></AuthorList><Language>ENG</Language><GrantList CompleteYN="Y"><Grant><GrantID>MRC_MR/K013351/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>BHF_RG/13/2/30098</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>K013351</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01AG034454</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL036310</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>Aug</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2015 Oct 31;386(10005):1710-1</RefSource><PMID Version="1">26298821</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003327" MajorTopicYN="N">Coronary Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020521" MajorTopicYN="N">Stroke</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014940" MajorTopicYN="Y">Work Schedule Tolerance</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>8</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>8</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26298822</ArticleId><ArticleId IdType="pii">S0140-6736(15)60295-1</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(15)60295-1</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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