Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis - Specific Immunity in Young Children.
Identifieur interne : 000005 ( PubMed/Corpus ); précédent : 000004; suivant : 000006Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis - Specific Immunity in Young Children.
Auteurs : Synne Jenum ; Sivmakumaran Dhanasekaran ; Christian Ritz ; Ragini Macaden ; T Mark Doherty ; Harleen M S. GrewalSource :
- The Pediatric infectious disease journal [ 1532-0987 ] ; 2016.
Abstract
We have explored the added value of IFNγ-inducible protein 10 as a read-out of Mycobacterium tuberculosis specific immunity in young Indian children where the sensitivity of the IGRA for tuberculosis (TB) is poor. Reduced frequency of indeterminate results and an increased sensitivity for TB, suggest a potential for fewer missed cases with a combined IFNγ/IP-10 read-out in a 4 generation IGRA.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
DOI: 10.1097/INF.0000000000001328
PubMed: 27642776
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<affiliation><nlm:affiliation>1Department of Global Public Health and Primary Care, University of Bergen,N-5021, and Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway. 2Department of Clinical Science, Faculty of Medicine and Dentistry, University of Bergen, N-5021, Norway. 3Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. 4Division of Infectious Diseases, St. John's Research Institute, Koramangala, Bangalore - 560 034, India. 5GlaxoSmithKline Vaccines Wavre, Belgium. 6TB Trials Study Group: Doherty M, Grewal HMS, Hesseling AC, Jacob A, Jahnsen F, D' Souza G, Kurpad AV, Lau E, Lindtjorn B, Macaden R, Vaz M.</nlm:affiliation>
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<front><div type="abstract" xml:lang="en">We have explored the added value of IFNγ-inducible protein 10 as a read-out of Mycobacterium tuberculosis specific immunity in young Indian children where the sensitivity of the IGRA for tuberculosis (TB) is poor. Reduced frequency of indeterminate results and an increased sensitivity for TB, suggest a potential for fewer missed cases with a combined IFNγ/IP-10 read-out in a 4 generation IGRA.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.</div>
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