A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.
Identifieur interne : 000053 ( PubMed/Checkpoint ); précédent : 000052; suivant : 000054A new generation of JASPAR, the open-access repository for transcription factor binding site profiles.
Auteurs : Dominique Vlieghe [Belgique] ; Albin Sandelin ; Pieter J. De Bleser ; Kris Vleminckx ; Wyeth W. Wasserman ; Frans Van Roy ; Boris LenhardSource :
- Nucleic acids research [ 1362-4962 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : DNA.
- chemical , metabolism : DNA, Transcription Factors.
- Animals, Binding Sites, Computational Biology, Conserved Sequence, Databases, Nucleic Acid, Genomics, Internet, Regulatory Sequences, Nucleic Acid, User-Computer Interface.
Abstract
JASPAR is the most complete open-access collection of transcription factor binding site (TFBS) matrices. In this new release, JASPAR grows into a meta-database of collections of TFBS models derived by diverse approaches. We present JASPAR CORE--an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JASPAR FAM--a collection of familial TFBS models and JASPAR phyloFACTS--a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes. JASPAR phyloFACTS serves as a non-redundant extension to JASPAR CORE, enhancing the overall breadth of JASPAR for promoter sequence analysis. The new release of JASPAR is available at http://jaspar.genereg.net.
DOI: 10.1093/nar/gkj115
PubMed: 16381983
Affiliations:
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pubmed:16381983Le document en format XML
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<term>DNA (metabolism)</term>
<term>Databases, Nucleic Acid</term>
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<term>Internet</term>
<term>Regulatory Sequences, Nucleic Acid</term>
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<front><div type="abstract" xml:lang="en">JASPAR is the most complete open-access collection of transcription factor binding site (TFBS) matrices. In this new release, JASPAR grows into a meta-database of collections of TFBS models derived by diverse approaches. We present JASPAR CORE--an expanded version of the original, non-redundant collection of annotated, high-quality matrix-based transcription factor binding profiles, JASPAR FAM--a collection of familial TFBS models and JASPAR phyloFACTS--a set of matrices computationally derived from statistically overrepresented, evolutionarily conserved regulatory region motifs from mammalian genomes. JASPAR phyloFACTS serves as a non-redundant extension to JASPAR CORE, enhancing the overall breadth of JASPAR for promoter sequence analysis. The new release of JASPAR is available at http://jaspar.genereg.net.</div>
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