Capsule shell material impacts the in vitro disintegration and dissolution behaviour of a green tea extract☆
Identifieur interne : 000427 ( Pmc/Curation ); précédent : 000426; suivant : 000428Capsule shell material impacts the in vitro disintegration and dissolution behaviour of a green tea extract☆
Auteurs : Natalie Glube ; Lea Von Moos ; Guus DuchateauSource :
- Results in Pharma Sciences [ 2211-2863 ] ; 2013.
Abstract
A green tea extract was formulated into simple powder-in-capsule formulations of which the capsule shell material was either of gelatin or HPMC origin. The disintegration times were determined together with the dissolution profiles in compendial and biorelevant media.
All formulations disintegrated within 30 min, meeting the USP criteria for botanical formulations. An immediate release dissolution profile was achieved for gelatin capsules in all media but not for the specified HPMC formulations. Dissolution release was especially impaired for HPMCgell at pH 1.2 and for both HPMC formulations in FeSSIF media suggesting the potential for food interactions.
The delayed release from studied HPMC capsule materials is likely attributed to an interaction between the catechins, the major constituents of the green tea extract, and the capsule shell material. An assessment of
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DOI: 10.1016/j.rinphs.2013.08.002
PubMed: 25755998
PubMed Central: 3940125
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Capsule shell material impacts the <italic>in vitro</italic> disintegration and dissolution behaviour of a green tea extract<sup><xref ref-type="fn" rid="d32e448">☆</xref></sup></title><author><name sortKey="Glube, Natalie" sort="Glube, Natalie" uniqKey="Glube N" first="Natalie" last="Glube">Natalie Glube</name></author><author><name sortKey="Moos, Lea Von" sort="Moos, Lea Von" uniqKey="Moos L" first="Lea Von" last="Moos">Lea Von Moos</name></author><author><name sortKey="Duchateau, Guus" sort="Duchateau, Guus" uniqKey="Duchateau G" first="Guus" last="Duchateau">Guus Duchateau</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25755998</idno><idno type="pmc">3940125</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940125</idno><idno type="RBID">PMC:3940125</idno><idno type="doi">10.1016/j.rinphs.2013.08.002</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000427</idno><idno type="wicri:Area/Pmc/Curation">000427</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Capsule shell material impacts the <italic>in vitro</italic> disintegration and dissolution behaviour of a green tea extract<sup><xref ref-type="fn" rid="d32e448">☆</xref></sup></title><author><name sortKey="Glube, Natalie" sort="Glube, Natalie" uniqKey="Glube N" first="Natalie" last="Glube">Natalie Glube</name></author><author><name sortKey="Moos, Lea Von" sort="Moos, Lea Von" uniqKey="Moos L" first="Lea Von" last="Moos">Lea Von Moos</name></author><author><name sortKey="Duchateau, Guus" sort="Duchateau, Guus" uniqKey="Duchateau G" first="Guus" last="Duchateau">Guus Duchateau</name></author></analytic><series><title level="j">Results in Pharma Sciences</title><idno type="eISSN">2211-2863</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p><italic>In vitro</italic> disintegration and dissolution are routine methods used to assess the performance and quality of oral dosage forms. The purpose of the current work was to determine the potential for interaction between capsule shell material and a green tea extract and the impact it can have on the release.</p></sec><sec><title>Methods</title><p>A green tea extract was formulated into simple powder-in-capsule formulations of which the capsule shell material was either of gelatin or HPMC origin. The disintegration times were determined together with the dissolution profiles in compendial and biorelevant media.</p></sec><sec><title>Results</title><p>All formulations disintegrated within 30 min, meeting the USP criteria for botanical formulations. An immediate release dissolution profile was achieved for gelatin capsules in all media but not for the specified HPMC formulations. Dissolution release was especially impaired for HPMC<sub>gell</sub> at pH 1.2 and for both HPMC formulations in FeSSIF media suggesting the potential for food interactions.</p></sec><sec><title>Conclusions</title><p>The delayed release from studied HPMC capsule materials is likely attributed to an interaction between the catechins, the major constituents of the green tea extract, and the capsule shell material. An assessment of <italic>in vitro</italic> dissolution is recommended prior to the release of a dietary supplement or clinical trial investigational product to ensure efficacy.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Deka, A" uniqKey="Deka A">A Deka</name></author><author><name sortKey="Vita, Ja" uniqKey="Vita J">JA Vita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeukendrup, Ae" uniqKey="Jeukendrup A">AE Jeukendrup</name></author><author><name sortKey="Randell, R" uniqKey="Randell R">R Randell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Jm" uniqKey="Yuan J">JM Yuan</name></author><author><name sortKey="Sun, C" uniqKey="Sun C">C Sun</name></author><author><name sortKey="Butler, Lm" uniqKey="Butler L">LM Butler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cabrera, C" uniqKey="Cabrera C">C Cabrera</name></author><author><name sortKey="Artacho, R" uniqKey="Artacho R">R Artacho</name></author><author><name sortKey="Gimenez, R" uniqKey="Gimenez R">R Giménez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allen, Lv" uniqKey="Allen L">LV Allen</name></author><author><name sortKey="Popovich, Ng" uniqKey="Popovich N">NG Popovich</name></author><author><name sortKey="Ansel, Hc" uniqKey="Ansel H">HC Ansel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Podczek, F" uniqKey="Podczek F">F Podczek</name></author><author><name sortKey="Jones, Be" uniqKey="Jones B">BE Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Cs" uniqKey="Yang C">CS Yang</name></author><author><name sortKey="Sang, S" uniqKey="Sang S">S Sang</name></author><author><name sortKey="Lambert, Jd" uniqKey="Lambert J">JD Lambert</name></author><author><name sortKey="Lee, Mj" uniqKey="Lee M">MJ Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quideau, S" uniqKey="Quideau S">S Quideau</name></author><author><name sortKey="Deffieux, D" uniqKey="Deffieux D">D Deffieux</name></author><author><name sortKey="Douat Casassus, C" uniqKey="Douat Casassus C">C Douat-Casassus</name></author><author><name sortKey="Pouysegu, L" uniqKey="Pouysegu L">L Pouységu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chow, Hh" uniqKey="Chow H">HH Chow</name></author><author><name sortKey="Hakim, Ia" uniqKey="Hakim I">IA Hakim</name></author><author><name sortKey="Vining, Dr" uniqKey="Vining D">DR Vining</name></author><author><name sortKey="Crowell, Ja" uniqKey="Crowell J">JA Crowell</name></author><author><name sortKey="Ranger Moore, J" uniqKey="Ranger Moore J">J Ranger-Moore</name></author><author><name sortKey="Chew, Wm" uniqKey="Chew W">WM Chew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siebert, Kj" uniqKey="Siebert K">KJ Siebert</name></author><author><name sortKey="Troukhanova, Nv" uniqKey="Troukhanova N">NV Troukhanova</name></author><author><name sortKey="Lynn, Py" uniqKey="Lynn P">PY Lynn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galia, E" uniqKey="Galia E">E Galia</name></author><author><name sortKey="Nicolaides, E" uniqKey="Nicolaides E">E Nicolaides</name></author><author><name sortKey="Horter, D" uniqKey="Horter D">D Horter</name></author><author><name sortKey="Lobenberg, R" uniqKey="Lobenberg R">R Löbenberg</name></author><author><name sortKey="Reppas, C" uniqKey="Reppas C">C Reppas</name></author><author><name sortKey="Dressman, Jb" uniqKey="Dressman J">JB Dressman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Wen, Y" uniqKey="Wen Y">Y Wen</name></author><author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name></author><author><name sortKey="Yan, X" uniqKey="Yan X">X Yan</name></author><author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name></author><author><name sortKey="Rycroft, Ja" uniqKey="Rycroft J">JA Rycroft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiwele, I" uniqKey="Chiwele I">I Chiwele</name></author><author><name sortKey="Jones, Be" uniqKey="Jones B">BE Jones</name></author><author><name sortKey="Podczeck, F" uniqKey="Podczeck F">F Podczeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Malah, Y" uniqKey="El Malah Y">Y El-Malah</name></author><author><name sortKey="Nazzal, S" uniqKey="Nazzal S">S Nazzal</name></author><author><name sortKey="Bottom, Cb" uniqKey="Bottom C">CB Bottom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vardakou, M" uniqKey="Vardakou M">M Vardakou</name></author><author><name sortKey="Mercuri, A" uniqKey="Mercuri A">A Mercuri</name></author><author><name sortKey="Naylor, Ta" uniqKey="Naylor T">TA Naylor</name></author><author><name sortKey="Rizzo, D" uniqKey="Rizzo D">D Rizzo</name></author><author><name sortKey="Butler, Jm" uniqKey="Butler J">JM Butler</name></author><author><name sortKey="Connolly, Pc" uniqKey="Connolly P">PC Connolly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ku, Ms" uniqKey="Ku M">MS Ku</name></author><author><name sortKey="Lu, Q" uniqKey="Lu Q">Q Lu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, Be" uniqKey="Jones B">BE Jones</name></author><author><name sortKey="Podczeck, F" uniqKey="Podczeck F">F Podczeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cole, Et" uniqKey="Cole E">ET Cole</name></author><author><name sortKey="Scott, Ra" uniqKey="Scott R">RA Scott</name></author><author><name sortKey="Cade, D" uniqKey="Cade D">D Cade</name></author><author><name sortKey="Connor, Al" uniqKey="Connor A">AL Connor</name></author><author><name sortKey="Wilding, Ir" uniqKey="Wilding I">IR Wilding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuleu, C" uniqKey="Tuleu C">C Tuleu</name></author><author><name sortKey="Khela, Mk" uniqKey="Khela M">MK Khela</name></author><author><name sortKey="Evans, Df" uniqKey="Evans D">DF Evans</name></author><author><name sortKey="Jones, Be" uniqKey="Jones B">BE Jones</name></author><author><name sortKey="Nagata, S" uniqKey="Nagata S">S Nagata</name></author><author><name sortKey="Basit, Aw" uniqKey="Basit A">AW Basit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donauer, N" uniqKey="Donauer N">N Donauer</name></author><author><name sortKey="Lobenberg, R" uniqKey="Lobenberg R">R Löbenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Groshens, E" uniqKey="Groshens E">E. Groshens</name></author><author><name sortKey="He, X" uniqKey="He X">X He</name></author><author><name sortKey="Cade, D" uniqKey="Cade D">D Cade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, K" uniqKey="Yi K">K Yi</name></author><author><name sortKey="Cheng, G" uniqKey="Cheng G">G Cheng</name></author><author><name sortKey="Xing, F" uniqKey="Xing F">F Xing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, Jk" uniqKey="Jackson J">JK Jackson</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Wong, W" uniqKey="Wong W">W Wong</name></author><author><name sortKey="Burt, Hm" uniqKey="Burt H">HM Burt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, Ar" uniqKey="Patel A">AR Patel</name></author><author><name sortKey="Nijsse, J" uniqKey="Nijsse J">J Nijsse</name></author><author><name sortKey="Velikov, Kp" uniqKey="Velikov K">KP Velikov</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Results Pharma Sci</journal-id><journal-id journal-id-type="iso-abbrev">Results Pharma Sci</journal-id><journal-title-group><journal-title>Results in Pharma Sciences</journal-title></journal-title-group><issn pub-type="epub">2211-2863</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25755998</article-id><article-id pub-id-type="pmc">3940125</article-id><article-id pub-id-type="publisher-id">S2211-2863(13)00003-1</article-id><article-id pub-id-type="doi">10.1016/j.rinphs.2013.08.002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Capsule shell material impacts the <italic>in vitro</italic> disintegration and dissolution behaviour of a green tea extract<sup><xref ref-type="fn" rid="d32e448">☆</xref></sup></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Glube</surname><given-names>Natalie</given-names></name><xref rid="fn1" ref-type="fn">1</xref></contrib><contrib contrib-type="author"><name><surname>Moos</surname><given-names>Lea von</given-names></name><xref rid="fn2" ref-type="fn">2</xref></contrib><contrib contrib-type="author"><name><surname>Duchateau</surname><given-names>Guus</given-names></name><email>guus.duchateau@unilever.com</email><xref rid="cor0001" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff0001">Unilever Research & Development, Vlaardingen, The Netherlands</aff><author-notes><corresp id="cor0001"><label>*</label>Correspondence to: Unilever Research & Development, Nutrition & Health Department, Olivier van Noortlaan 120, 3133 AT Vlaardingen, The Netherlands. Tel.: +31 10 460 6470; fax: +31 10 460 5993. <email>guus.duchateau@unilever.com</email></corresp><fn id="fn1"><label>1</label><p>Current address: BASF SE, Human Nutrition Europe, 68623 Lampertheim, Germany.</p></fn><fn id="fn2"><label>2</label><p>Current address: Institute of Food, Nutrition and Health, Zürich, Switzerland.</p></fn></author-notes><pub-date pub-type="pmc-release"><day>13</day><month>9</month><year>2013</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>13</day><month>9</month><year>2013</year></pub-date><pub-date pub-type="collection"><year>2013</year></pub-date><volume>3</volume><fpage>1</fpage><lpage>6</lpage><history><date date-type="received"><day>9</day><month>8</month><year>2013</year></date><date date-type="accepted"><day>15</day><month>8</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 The Authors</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p><italic>In vitro</italic> disintegration and dissolution are routine methods used to assess the performance and quality of oral dosage forms. The purpose of the current work was to determine the potential for interaction between capsule shell material and a green tea extract and the impact it can have on the release.</p></sec><sec><title>Methods</title><p>A green tea extract was formulated into simple powder-in-capsule formulations of which the capsule shell material was either of gelatin or HPMC origin. The disintegration times were determined together with the dissolution profiles in compendial and biorelevant media.</p></sec><sec><title>Results</title><p>All formulations disintegrated within 30 min, meeting the USP criteria for botanical formulations. An immediate release dissolution profile was achieved for gelatin capsules in all media but not for the specified HPMC formulations. Dissolution release was especially impaired for HPMC<sub>gell</sub> at pH 1.2 and for both HPMC formulations in FeSSIF media suggesting the potential for food interactions.</p></sec><sec><title>Conclusions</title><p>The delayed release from studied HPMC capsule materials is likely attributed to an interaction between the catechins, the major constituents of the green tea extract, and the capsule shell material. An assessment of <italic>in vitro</italic> dissolution is recommended prior to the release of a dietary supplement or clinical trial investigational product to ensure efficacy.</p></sec></abstract><abstract abstract-type="graphical"><title>Graphical Abstract</title><fig id="fig0008" position="anchor"><graphic xlink:href="fx1"></graphic></fig></abstract><kwd-group><title>Keywords</title><kwd>Formulation</kwd><kwd><italic>In vitro</italic> dissolution</kwd><kwd>Disintegration</kwd><kwd>Green tea extract</kwd><kwd>Hard shell capsule</kwd></kwd-group><kwd-group><title>Abbreviations</title><kwd>BA, bioavailability</kwd><kwd>BCS, biopharmaceutical classification system</kwd><kwd>C, catechin</kwd><kwd>DS, dietary supplement</kwd><kwd>EC, epicatechin</kwd><kwd>ECG, epicatechin gallate</kwd><kwd>EGCG, epigallocatechin gallate</kwd><kwd>EGC, epigallocatechin</kwd><kwd>FaSSIF, fasted state simulated intestinal fluid</kwd><kwd>FeSSIF, fed state simulated intestinal fluid</kwd><kwd>GA, gallic acid</kwd><kwd>GTE, green tea extract</kwd><kwd>HPMC, hydroxypropyl methylcellulose</kwd><kwd>HPMC<sub>carr</sub>, hydroxypropyl methylcellulose containing carrageenan</kwd><kwd>HPMC<sub>gell</sub>, hydroxypropyl methylcellulose containing gellan gum</kwd><kwd>IR, immediate release</kwd><kwd>PIC, powder-in-capsule</kwd><kwd>SIF, simulated intestinal fluid</kwd><kwd>USP, United States Pharmacopeia</kwd></kwd-group></article-meta></front><floats-group><fig id="fig0001"><label>Fig. 1</label><caption><p>Disintegration test: HPMC<sub>gell</sub> and HPMC capsules filled with green tea extract, in acetate buffer after 30 min, (A) HPMC<sub>gell</sub> and (B) HPMC</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="fig0002"><label>Fig. 2</label><caption><p>Capsule disintegration times for gelatin, HPMC<sub>gell</sub> and HPMC capsules filled with green tea extract in acetate buffer (pH 4.5) and de-mineralized water. Bars represent SD, <italic>n</italic> = 6.</p></caption><graphic xlink:href="gr2"></graphic></fig><fig id="fig0003"><label>Fig. 3</label><caption><p>Dissolution profiles showing the mean percentage of green tea extract (GTE) released from gelatin, HPMC<sub>gell</sub> and HPMC capsules in 0.1 M HCl buffer at pH 1.2, 37 °C, 75 rpm, 2 h. Bars represent SD, <italic>n</italic> = 6.</p></caption><graphic xlink:href="gr3"></graphic></fig><fig id="fig0004"><label>Fig. 4</label><caption><p>Dissolution profiles showing the mean percentage of green tea extract (GTE) released from 437 gelatin, HPMC<sub>gell</sub> and HPMC capsules in acetate buffer at pH 4.5, 37 °C, 75 rpm, 2 h. Bars represent 438 SD, <italic>n</italic> = 6.</p></caption><graphic xlink:href="gr4"></graphic></fig><fig id="fig0005"><label>Fig. 5</label><caption><p>Dissolution profiles showing the mean percentage of green tea extract (GTE) released from gelatin, HPMC<sub>gell</sub> and HPMC capsules in phosphate buffer at pH 6.8, 37 °C, 75 rpm, 2 h. Bars represent SD, <italic>n</italic> = 6.</p></caption><graphic xlink:href="gr5"></graphic></fig><fig id="fig0006"><label>Fig. 6</label><caption><p>Dissolution profiles showing the mean percentage of green tea extract (GTE) released from HPMC<sub>gell</sub> and HPMC capsules in FaSSIF, pH 6.5, 37 °C, 75 rpm, 2 h. Bars represent SD, <italic>n</italic> = 3.</p></caption><graphic xlink:href="gr6"></graphic></fig><fig id="fig0007"><label>Fig. 7</label><caption><p>Dissolution profiles showing the mean percentage of green tea extract (GTE) released from HPMC<sub>gell</sub> and HPMC capsules in FeSSIF, pH 5, 37 °C, 75 rpm, 2 h. Bars represent SD, <italic>n</italic> = 3.</p></caption><graphic xlink:href="gr7"></graphic></fig><table-wrap id="tbl0001" position="float"><label>Table 1</label><caption><p>Composition of the green tea extract as determined by HPLC. GA = gallic acid, EGC = epigallocatechin, C = catechin, EC = epicatechin, EGCG = epigallocatechin gallate, GCG = gallocatechin gallate, ECG = epicatechin gallate.</p></caption><table frame="hsides" rules="groups"><thead><tr><th>Component</th><th>mg/g Green tea extract</th></tr></thead><tbody><tr><td>GA</td><td>1.5</td></tr><tr><td>EGC</td><td>2.5</td></tr><tr><td>C</td><td>7.8</td></tr><tr><td>Caffeine</td><td>8.1</td></tr><tr><td>EC</td><td>59.8</td></tr><tr><td>EGCG</td><td>523.9</td></tr><tr><td>GCG</td><td>15.8</td></tr><tr><td>ECG</td><td>164.9</td></tr><tr><td>Total catechins</td><td>784.3</td></tr></tbody></table></table-wrap><table-wrap id="tbl0002" position="float"><label>Table 2</label><caption><p>Dissolution of green tea extract from gelatin, HPMC<sub>gell</sub> and HPMC capsules at pH 1.2, 4.5, 6.8, FaSSIF and FeSSIF; dissolution conditions: 37 °C, 75 rpm, sampling time points from 5 to 120 min (average % dissolved ± SD, <italic>n</italic> = 6).</p></caption><table frame="hsides" rules="groups"><thead><tr><th rowspan="2">Min</th><th colspan="3" align="center">Gelatin<hr></hr></th><th colspan="5" align="center">HPMC<sub>gell</sub><hr></hr></th><th colspan="5" align="center">HPMC<hr></hr></th></tr><tr><th>pH 1.2</th><th>pH 4.5</th><th>pH 6.8</th><th>pH 1.2</th><th>pH 4.5</th><th>pH 6.8</th><th>FaSSIF</th><th>FeSSIF</th><th>pH 1.2</th><th>pH 4.5</th><th>pH 6.8</th><th>FaSSIF</th><th>FeSSIF</th></tr></thead><tbody><tr><td>5</td><td>39 ± 7</td><td>2 ± 2</td><td>1 ± 1</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>10</td><td>91 ± 3</td><td>32 ± 16</td><td>14 ± 4</td><td>0</td><td>1</td><td>0</td><td>0</td><td>0</td><td>1</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>20</td><td>94 ± 7</td><td>85 ± 4</td><td>83 ± 14</td><td>0</td><td>7 ± 10</td><td>3 ± 2</td><td>0</td><td>0</td><td>10 ± 7</td><td>10 ± 11</td><td>46</td><td>22</td><td>1 ± 1</td></tr><tr><td>30</td><td>95 ± 6</td><td>90 ± 2</td><td>96 ± 11</td><td>0</td><td>18 ± 14</td><td>7 ± 6</td><td>6 ± 4</td><td>2 ± 2</td><td>18 ± 11</td><td>32 ± 18</td><td>15 ± 15</td><td>15 ± 8</td><td>8 ± 4</td></tr><tr><td>45</td><td>95 ± 3</td><td>92 ± 2</td><td>96 ± 12</td><td>0</td><td>25 ± 17</td><td>13 ± 7</td><td>12 ± 13</td><td>4 ± 6</td><td>30 ± 19</td><td>47 ± 21</td><td>25 ± 12</td><td>41 ± 12</td><td>16 ± 9</td></tr><tr><td>60</td><td>95 ± 5</td><td>92 ± 2</td><td>99 ± 10</td><td>2 ± 1</td><td>41 ± 22</td><td>17 ± 8</td><td>22 ± 23</td><td>12 ± 12</td><td>49 ± 20</td><td>59 ± 11</td><td>38 ± 11</td><td>54 ± 13</td><td>27 ± 18</td></tr><tr><td>120</td><td>95 ± 4</td><td>94 ± 3</td><td>101 ± 9</td><td>35 ± 13</td><td>58 ± 11</td><td>25 ± 10</td><td>33 ± 29</td><td>64 ± 10</td><td>69 ± 17</td><td>80 ± 10</td><td>52 ± 11</td><td>61 ± 12</td><td>54 ± 5</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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