Heterotopic Bone Formation Around Vessels: Pilot Study of a New Animal Model
Identifieur interne : 000335 ( Pmc/Curation ); précédent : 000334; suivant : 000336Heterotopic Bone Formation Around Vessels: Pilot Study of a New Animal Model
Auteurs : Wei-Xin Cai ; Li-Wu Zheng ; Franz E. Weber ; Chun-Lei Li ; Li Ma ; Martin Ehrbar ; Roger A. ZwahlenSource :
- BioResearch Open Access [ 2164-7844 ] ; 2013.
Abstract
To achieve an easily established, safe, and reproducible animal model for the study of heterotopic bone formation around vessels, a small animal series using New Zealand White rabbits was performed. Three different dosages of recombinant human bone morphogenic protein (rhBMP-2) carried by fibrin matrix were tested. A guided tissue regeneration (GTR) membrane sheet was formed into a tube and allowed to harden; it served both to maintain the space around the vessel bundle and to separate the fibrin matrix with rhBMP-2 from skeletal muscle. Wrapped around the femoral vessel bundle and fixed in place, the tube was filled with the fibrin matrix containing rhBMP-2. The surgical site was closed in layers, and the postoperative healing was uneventful. All animals resumed their full preoperative daily activities 3–4 days after the operation. No adverse events such as wound dehiscence or infection occurred, and all animals could be sacrified at the scheduled date. Micro–computed tomography and histological investigations showed heterotopic bone formation around the vessel bundle in the medium- and high-dosage rhBMP-2 groups. An easy, safe, and reproducible animal model that allows the study of heterotopic bone formation around vessels was successfully established.
Url:
DOI: 10.1089/biores.2013.0025
PubMed: 23914333
PubMed Central: 3731688
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Weber</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Li, Chun Lei" sort="Li, Chun Lei" uniqKey="Li C" first="Chun-Lei" last="Li">Chun-Lei Li</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Ma, Li" sort="Ma, Li" uniqKey="Ma L" first="Li" last="Ma">Li Ma</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Ehrbar, Martin" sort="Ehrbar, Martin" uniqKey="Ehrbar M" first="Martin" last="Ehrbar">Martin Ehrbar</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Zwahlen, Roger A" sort="Zwahlen, Roger A" uniqKey="Zwahlen R" first="Roger A." last="Zwahlen">Roger A. Zwahlen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23914333</idno><idno type="pmc">3731688</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731688</idno><idno type="RBID">PMC:3731688</idno><idno type="doi">10.1089/biores.2013.0025</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000335</idno><idno type="wicri:Area/Pmc/Curation">000335</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Heterotopic Bone Formation Around Vessels: Pilot Study of a New Animal Model</title><author><name sortKey="Cai, Wei Xin" sort="Cai, Wei Xin" uniqKey="Cai W" first="Wei-Xin" last="Cai">Wei-Xin Cai</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Zheng, Li Wu" sort="Zheng, Li Wu" uniqKey="Zheng L" first="Li-Wu" last="Zheng">Li-Wu Zheng</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Weber, Franz E" sort="Weber, Franz E" uniqKey="Weber F" first="Franz E." last="Weber">Franz E. Weber</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Li, Chun Lei" sort="Li, Chun Lei" uniqKey="Li C" first="Chun-Lei" last="Li">Chun-Lei Li</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Ma, Li" sort="Ma, Li" uniqKey="Ma L" first="Li" last="Ma">Li Ma</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Ehrbar, Martin" sort="Ehrbar, Martin" uniqKey="Ehrbar M" first="Martin" last="Ehrbar">Martin Ehrbar</name><affiliation><nlm:aff id="aff5"></nlm:aff></affiliation></author><author><name sortKey="Zwahlen, Roger A" sort="Zwahlen, Roger A" uniqKey="Zwahlen R" first="Roger A." last="Zwahlen">Roger A. Zwahlen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">BioResearch Open Access</title><idno type="ISSN">2164-7844</idno><idno type="eISSN">2164-7860</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>To achieve an easily established, safe, and reproducible animal model for the study of heterotopic bone formation around vessels, a small animal series using New Zealand White rabbits was performed. Three different dosages of recombinant human bone morphogenic protein (rhBMP-2) carried by fibrin matrix were tested. A guided tissue regeneration (GTR) membrane sheet was formed into a tube and allowed to harden; it served both to maintain the space around the vessel bundle and to separate the fibrin matrix with rhBMP-2 from skeletal muscle. Wrapped around the femoral vessel bundle and fixed in place, the tube was filled with the fibrin matrix containing rhBMP-2. The surgical site was closed in layers, and the postoperative healing was uneventful. All animals resumed their full preoperative daily activities 3–4 days after the operation. No adverse events such as wound dehiscence or infection occurred, and all animals could be sacrified at the scheduled date. Micro–computed tomography and histological investigations showed heterotopic bone formation around the vessel bundle in the medium- and high-dosage rhBMP-2 groups. An easy, safe, and reproducible animal model that allows the study of heterotopic bone formation around vessels was successfully established.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Warnke, Ph" uniqKey="Warnke P">PH Warnke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warnke, Ph" uniqKey="Warnke P">PH Warnke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Lw" uniqKey="Zheng L">LW Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herford, As" uniqKey="Herford A">AS Herford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, Re" uniqKey="Jung R">RE Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmoekel, H" uniqKey="Schmoekel H">H Schmoekel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmoekel, Hg" uniqKey="Schmoekel H">HG Schmoekel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmoekel, Hg" uniqKey="Schmoekel H">HG Schmoekel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmoekel, H" uniqKey="Schmoekel H">H Schmoekel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Fe" uniqKey="Weber F">FE Weber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jung, R" uniqKey="Jung R">R Jung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wingerd, Bd" uniqKey="Wingerd B">BD Wingerd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pirhonen, E" uniqKey="Pirhonen E">E Pirhonen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lounev, Vy" uniqKey="Lounev V">VY Lounev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miguel, B" uniqKey="Miguel B">B Miguel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maes, C" uniqKey="Maes C">C Maes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerber, Hp" uniqKey="Gerber H">HP Gerber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zelzer, E" uniqKey="Zelzer E">E Zelzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maes, C" uniqKey="Maes C">C Maes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, H" uniqKey="Peng H">H Peng</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biores Open Access</journal-id><journal-id journal-id-type="iso-abbrev">Biores Open Access</journal-id><journal-id journal-id-type="publisher-id">biores</journal-id><journal-title-group><journal-title>BioResearch Open Access</journal-title></journal-title-group><issn pub-type="ppub">2164-7844</issn><issn pub-type="epub">2164-7860</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23914333</article-id><article-id pub-id-type="pmc">3731688</article-id><article-id pub-id-type="publisher-id">10.1089/biores.2013.0025</article-id><article-id pub-id-type="doi">10.1089/biores.2013.0025</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research Articles</subject></subj-group></article-categories><title-group><article-title>Heterotopic Bone Formation Around Vessels: Pilot Study of a New Animal Model</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cai</surname><given-names>Wei-Xin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Li-Wu</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Franz E.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Chun-Lei</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ma</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ehrbar</surname><given-names>Martin</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Zwahlen</surname><given-names>Roger A.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Discipline of Oral & Maxillofacial Surgery, Faculty of Dentistry,<institution>The University of Hong Kong</institution>, Hong Kong,<country>China</country>.</aff><aff id="aff2"><label><sup>2</sup></label>Discipline of Oral Diagnosis & Polyclinics, Faculty of Dentistry,<institution>The University of Hong Kong</institution>, Hong Kong,<country>China</country>.</aff><aff id="aff3"><label><sup>3</sup></label>Oral Biotechnology and Bioengineering Unit, Division of Cranio-Maxillofacial and Oral Surgery,<institution>University Hospital Zurich</institution>, Zurich,<country>Switzerland</country>.</aff><aff id="aff4"><label><sup>4</sup></label>Discipline of Oral Rehabilitation, Faculty of Dentistry,<institution>The University of Hong Kong</institution>, Hong Kong,<country>China</country>.</aff><aff id="aff5"><label><sup>5</sup></label>Department of Obstetrics,<institution>University Hospital Zurich</institution>, Zurich,<country>Switzerland</country>.</aff></contrib-group><author-notes><corresp>Address correspondence to: <italic>Roger A. Zwahlen, MD, DMD, Professor, Oral & Maxillofacial Surgery, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Rd., Hong Kong, China. E-mail:</italic><email xlink:href="mailto:zwahlen@hku.hk">zwahlen@hku.hk</email></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2013</year><pmc-comment>string-date: August 2013</pmc-comment>
</pub-date><pub-date pub-type="pmc-release"><month>8</month><year>2013</year><pmc-comment>string-date: August 2013</pmc-comment>
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<volume>2</volume><issue>4</issue><fpage>266</fpage><lpage>272</lpage><permissions><copyright-statement>Copyright 2013, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri xlink:type="simple" xlink:href="biores.2013.0025.pdf"></self-uri><abstract><title>Abstract</title><p>To achieve an easily established, safe, and reproducible animal model for the study of heterotopic bone formation around vessels, a small animal series using New Zealand White rabbits was performed. Three different dosages of recombinant human bone morphogenic protein (rhBMP-2) carried by fibrin matrix were tested. A guided tissue regeneration (GTR) membrane sheet was formed into a tube and allowed to harden; it served both to maintain the space around the vessel bundle and to separate the fibrin matrix with rhBMP-2 from skeletal muscle. Wrapped around the femoral vessel bundle and fixed in place, the tube was filled with the fibrin matrix containing rhBMP-2. The surgical site was closed in layers, and the postoperative healing was uneventful. All animals resumed their full preoperative daily activities 3–4 days after the operation. No adverse events such as wound dehiscence or infection occurred, and all animals could be sacrified at the scheduled date. Micro–computed tomography and histological investigations showed heterotopic bone formation around the vessel bundle in the medium- and high-dosage rhBMP-2 groups. An easy, safe, and reproducible animal model that allows the study of heterotopic bone formation around vessels was successfully established.</p></abstract><kwd-group kwd-group-type="author"><title>Key words</title><kwd>biomaterials</kwd><kwd>growth factor</kwd><kwd>tissue engineering</kwd></kwd-group><counts><fig-count count="10"></fig-count><ref-count count="20"></ref-count><page-count count="7"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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