Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial
Identifieur interne : 000318 ( Pmc/Curation ); précédent : 000317; suivant : 000319Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial
Auteurs : H K Genant [États-Unis] ; C G Peterfy [États-Unis] ; R. Westhovens [Belgique] ; J-C Becker [États-Unis] ; R. Aranda [États-Unis] ; G. Vratsanos [États-Unis] ; J. Teng [États-Unis] ; J M Kremer [États-Unis]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2007.
Abstract
Assess the effect of abatacept on progression of structural damage over 2 years in patients with rheumatoid arthritis who had an inadequate response to methotrexate.
539 patients entered an open-label extension of the AIM (
In patients treated with abatacept for 2 years, greater reduction in progression of structural damage was observed in year 2 than in year 1. The mean change in total Genant-modified Sharp scores was reduced from 1.07 units in year 1 to 0.46 units in year 2. Similar reductions were observed in erosion and joint space narrowing scores. Following 2 years of treatment with abatacept, 50% of patients had no progression of structural damage as defined by a change in the total score of ⩽0 compared with baseline. 56% of patients treated with abatacept had no progression during the first year compared with 45% of patients treated with placebo. In their second year of treatment with abatacept, more patients had no progression than in the first year (66% vs 56%).
Abatacept has a sustained effect that inhibits progression of structural damage. Furthermore, the mean change in radiographic progression in patients treated with abatacept for 2 years was significantly lower in year 2 versus year 1, suggesting that abatacept may have an increasing disease-modifying effect on structural damage over time.
Url:
DOI: 10.1136/ard.2007.085084
PubMed: 18086727
PubMed Central: 2569144
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<author><name sortKey="Peterfy, C G" sort="Peterfy, C G" uniqKey="Peterfy C" first="C G" last="Peterfy">C G Peterfy</name>
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<series><title level="j">Annals of the Rheumatic Diseases</title>
<idno type="ISSN">0003-4967</idno>
<idno type="eISSN">1468-2060</idno>
<imprint><date when="2007">2007</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Objective:</title>
<p>Assess the effect of abatacept on progression of structural damage over 2 years in patients with rheumatoid arthritis who had an inadequate response to methotrexate.</p>
</sec>
<sec><title>Methods:</title>
<p>539 patients entered an open-label extension of the AIM (<underline>A</underline>
batacept in <underline>I</underline>
nadequate responders to <underline>M</underline>
ethotrexate) trial and received abatacept. Radiographic assessment of the hands and feet was performed at baseline, year 1 and year 2. At year 2, each patient’s radiographs were scored for progression blinded to sequence and treatment allocation.</p>
</sec>
<sec><title>Results:</title>
<p>In patients treated with abatacept for 2 years, greater reduction in progression of structural damage was observed in year 2 than in year 1. The mean change in total Genant-modified Sharp scores was reduced from 1.07 units in year 1 to 0.46 units in year 2. Similar reductions were observed in erosion and joint space narrowing scores. Following 2 years of treatment with abatacept, 50% of patients had no progression of structural damage as defined by a change in the total score of ⩽0 compared with baseline. 56% of patients treated with abatacept had no progression during the first year compared with 45% of patients treated with placebo. In their second year of treatment with abatacept, more patients had no progression than in the first year (66% vs 56%).</p>
</sec>
<sec><title>Conclusions:</title>
<p>Abatacept has a sustained effect that inhibits progression of structural damage. Furthermore, the mean change in radiographic progression in patients treated with abatacept for 2 years was significantly lower in year 2 versus year 1, suggesting that abatacept may have an increasing disease-modifying effect on structural damage over time.</p>
</sec>
</div>
</front>
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<author><name sortKey="Malaise, M" uniqKey="Malaise M">M Malaise</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cohen, Sb" uniqKey="Cohen S">SB Cohen</name>
</author>
<author><name sortKey="Emery, P" uniqKey="Emery P">P Emery</name>
</author>
<author><name sortKey="Greenwald, Mw" uniqKey="Greenwald M">MW Greenwald</name>
</author>
<author><name sortKey="Dougados, M" uniqKey="Dougados M">M Dougados</name>
</author>
<author><name sortKey="Furie, Ra" uniqKey="Furie R">RA Furie</name>
</author>
<author><name sortKey="Genovese, Mc" uniqKey="Genovese M">MC Genovese</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Genant, Hk" uniqKey="Genant H">HK Genant</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id>
<journal-id journal-id-type="publisher-id">ard</journal-id>
<journal-title-group><journal-title>Annals of the Rheumatic Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">0003-4967</issn>
<issn pub-type="epub">1468-2060</issn>
<publisher><publisher-name>BMJ Publishing Group</publisher-name>
<publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">18086727</article-id>
<article-id pub-id-type="pmc">2569144</article-id>
<article-id pub-id-type="publisher-id">ar85084</article-id>
<article-id pub-id-type="doi">10.1136/ard.2007.085084</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Extended Reports</subject>
</subj-group>
</article-categories>
<title-group><article-title>Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial</article-title>
<alt-title alt-title-type="running-head">Extended report</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Genant</surname>
<given-names>H K</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peterfy</surname>
<given-names>C G</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Westhovens</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Becker</surname>
<given-names>J-C</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aranda</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vratsanos</surname>
<given-names>G</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Teng</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kremer</surname>
<given-names>J M</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>University of California, San Francisco, San Francisco, California, USA</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Synarc, Inc., San Francisco, California, USA</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>UZ Gasthuisberg, Leuven, Belgium</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>Global Clinical Research, Immunology, Bristol-Myers Squibb, Princeton, New Jersey, USA</addr-line>
</aff>
<aff id="aff5"><label>5</label>
<addr-line>Albany Medical College and The Center for Rheumatology, Albany, New York, USA</addr-line>
</aff>
<author-notes><corresp>Correspondence to: Harry K Genant, University of California, San Francisco, San Francisco, CA, USA; <email>harry.genant@ucsf.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2008</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2008</year>
</pub-date>
<pub-date pub-type="epub"><day>17</day>
<month>11</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>17</day>
<month>11</month>
<year>2007</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>67</volume>
<issue>8</issue>
<fpage>1084</fpage>
<lpage>1089</lpage>
<history><date date-type="accepted"><day>17</day>
<month>11</month>
<year>2007</year>
</date>
</history>
<permissions><copyright-statement>© Genant et al 2008</copyright-statement>
<copyright-year>2008</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec><title>Objective:</title>
<p>Assess the effect of abatacept on progression of structural damage over 2 years in patients with rheumatoid arthritis who had an inadequate response to methotrexate.</p>
</sec>
<sec><title>Methods:</title>
<p>539 patients entered an open-label extension of the AIM (<underline>A</underline>
batacept in <underline>I</underline>
nadequate responders to <underline>M</underline>
ethotrexate) trial and received abatacept. Radiographic assessment of the hands and feet was performed at baseline, year 1 and year 2. At year 2, each patient’s radiographs were scored for progression blinded to sequence and treatment allocation.</p>
</sec>
<sec><title>Results:</title>
<p>In patients treated with abatacept for 2 years, greater reduction in progression of structural damage was observed in year 2 than in year 1. The mean change in total Genant-modified Sharp scores was reduced from 1.07 units in year 1 to 0.46 units in year 2. Similar reductions were observed in erosion and joint space narrowing scores. Following 2 years of treatment with abatacept, 50% of patients had no progression of structural damage as defined by a change in the total score of ⩽0 compared with baseline. 56% of patients treated with abatacept had no progression during the first year compared with 45% of patients treated with placebo. In their second year of treatment with abatacept, more patients had no progression than in the first year (66% vs 56%).</p>
</sec>
<sec><title>Conclusions:</title>
<p>Abatacept has a sustained effect that inhibits progression of structural damage. Furthermore, the mean change in radiographic progression in patients treated with abatacept for 2 years was significantly lower in year 2 versus year 1, suggesting that abatacept may have an increasing disease-modifying effect on structural damage over time.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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