Transdisciplinary unifying implications of circadian findings in the 1950s
Identifieur interne : 000243 ( Pmc/Curation ); précédent : 000242; suivant : 000244Transdisciplinary unifying implications of circadian findings in the 1950s
Auteurs : Franz Halberg [États-Unis] ; Germaine Cornélissen [États-Unis] ; George Katinas [États-Unis] ; Elena V. Syutkina [Russie] ; Robert B. Sothern [États-Unis] ; Rina Zaslavskaya [Russie] ; Francine Halberg [États-Unis] ; Yoshihiko Watanabe [Japon] ; Othild Schwartzkopff [États-Unis] ; Kuniaki Otsuka [Japon] ; Roberto Tarquini [Italie] ; Perfetto Frederico [Italie] ; Jarmila Siggelova [République tchèque]Source :
- Journal of Circadian Rhythms [ 1740-3391 ] ; 2003.
Abstract
A few puzzles relating to a small fraction of my endeavors in the 1950s are summarized herein, with answers to a few questions of the Editor-in-Chief, to suggest that the rules of variability in time complement the rules of genetics as a biological variability in space. I advocate to replace truisms such as a relative constancy or homeostasis, that have served bioscience very well for very long. They were never intended, however, to lower a curtain of ignorance over everyday physiology. In raising these curtains, we unveil a range of dynamics, resolvable in the data collection and as-one-goes analysis by computers built into smaller and smaller devices, for a continued self-surveillance of the normal and for an individualized detection of the abnormal. The current medical art based on spotchecks interpreted by reference to a time-unqualified normal range can become a science of time series with tests relating to the individual in inferential statistical terms. This is already doable for the case of blood pressure, but eventually should become possible for many other variables interpreted today only based on the quicksand of clinical trials on groups. These ignore individual differences and hence the individual's needs. Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology to focus on the normal as well as on the grossly abnormal.
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DOI: 10.1186/1740-3391-1-2
PubMed: 14728726
PubMed Central: 317388
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<series><title level="j">Journal of Circadian Rhythms</title>
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<front><div type="abstract" xml:lang="en"><p>A few puzzles relating to a small fraction of my endeavors in the 1950s are summarized herein, with answers to a few questions of the Editor-in-Chief, to suggest that the rules of variability in time complement the rules of genetics as a biological variability in space. I advocate to replace truisms such as a relative constancy or homeostasis, that have served bioscience very well for very long. They were never intended, however, to lower a curtain of ignorance over everyday physiology. In raising these curtains, we unveil a range of dynamics, resolvable in the data collection and as-one-goes analysis by computers built into smaller and smaller devices, for a continued self-surveillance of the normal and for an individualized detection of the abnormal. The current medical art based on spotchecks interpreted by reference to a time-unqualified normal range can become a science of time series with tests relating to the individual in inferential statistical terms. This is already doable for the case of blood pressure, but eventually should become possible for many other variables interpreted today only based on the quicksand of clinical trials on groups. These ignore individual differences and hence the individual's needs. Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology to focus on the normal as well as on the grossly abnormal.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Circadian Rhythms</journal-id>
<journal-title>Journal of Circadian Rhythms</journal-title>
<issn pub-type="epub">1740-3391</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">14728726</article-id>
<article-id pub-id-type="pmc">317388</article-id>
<article-id pub-id-type="publisher-id">1740-3391-1-2</article-id>
<article-id pub-id-type="doi">10.1186/1740-3391-1-2</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Transdisciplinary unifying implications of circadian findings in the 1950s</article-title>
</title-group>
<contrib-group><contrib id="A1" corresp="yes" contrib-type="author"><name><surname>Halberg</surname>
<given-names>Franz</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>halbe001@umn.edu</email>
</contrib>
<contrib id="A2" contrib-type="author"><name><surname>Cornélissen</surname>
<given-names>Germaine</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>corne001@umn.edu</email>
</contrib>
<contrib id="A3" contrib-type="author"><name><surname>Katinas</surname>
<given-names>George</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>katin001@umn.edu</email>
</contrib>
<contrib id="A4" contrib-type="author"><name><surname>Syutkina</surname>
<given-names>Elena V</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>masalov@sci.lebedev.ru</email>
</contrib>
<contrib id="A5" contrib-type="author"><name><surname>Sothern</surname>
<given-names>Robert B</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>sothe001@umn.edu</email>
</contrib>
<contrib id="A6" contrib-type="author"><name><surname>Zaslavskaya</surname>
<given-names>Rina</given-names>
</name>
<xref ref-type="aff" rid="I3">3</xref>
<email>rinazas1@yandex.ru</email>
</contrib>
<contrib id="A7" contrib-type="author"><name><surname>Halberg</surname>
<given-names>Francine</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>fehalberg@yahoo.com</email>
</contrib>
<contrib id="A8" contrib-type="author"><name><surname>Watanabe</surname>
<given-names>Yoshihiko</given-names>
</name>
<xref ref-type="aff" rid="I4">4</xref>
<email>yoshi-w@jd5.so-net.ne.jp</email>
</contrib>
<contrib id="A9" contrib-type="author"><name><surname>Schwartzkopff</surname>
<given-names>Othild</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>schwa115@umn.edu</email>
</contrib>
<contrib id="A10" contrib-type="author"><name><surname>Otsuka</surname>
<given-names>Kuniaki</given-names>
</name>
<xref ref-type="aff" rid="I5">5</xref>
<email>frtotk99@baz.so_net.ne.jp</email>
</contrib>
<contrib id="A11" contrib-type="author"><name><surname>Tarquini</surname>
<given-names>Roberto</given-names>
</name>
<xref ref-type="aff" rid="I6">6</xref>
<email>rtarquini@cestit1.unifi.it</email>
</contrib>
<contrib id="A12" contrib-type="author"><name><surname>Frederico</surname>
<given-names>Perfetto</given-names>
</name>
<xref ref-type="aff" rid="I6">6</xref>
<email>perfetto@unifi.it</email>
</contrib>
<contrib id="A13" contrib-type="author"><name><surname>Siggelova</surname>
<given-names>Jarmila</given-names>
</name>
<xref ref-type="aff" rid="I7">7</xref>
<email>Jarmila.siegelova@fnusa.cz</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA</aff>
<aff id="I2"><label>2</label>
Institute of Pediatrics, Scientific Center for Children's Health, Academy of Medical Sciences, Moscow, Russia</aff>
<aff id="I3"><label>3</label>
Department of Cardiology, Hospital #60, Moscow, Russia</aff>
<aff id="I4"><label>4</label>
Tokyo Women's Medical University, Daini Hospital, Tokyo, Japan</aff>
<aff id="I5"><label>5</label>
Tokyo Women Medical University, School of Medicine, Daini Hospital, Division of Neurocardiology and Chronoecology, Nishiogu 2-1-10, Arakawa-ku, Tokyo 116-856, Japan</aff>
<aff id="I6"><label>6</label>
Department of Internal Medicine, University of Florence, Italy</aff>
<aff id="I7"><label>7</label>
Clinic of Functional Diagnostics and Rehabilitation, St. Anna Faculty Hospital and Masaryk University of Brno, Pekaská 53, 656 91, Brno, Czech Republic</aff>
<pub-date pub-type="collection"><year>2003</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>10</month>
<year>2003</year>
</pub-date>
<volume>1</volume>
<fpage>2</fpage>
<lpage>2</lpage>
<ext-link ext-link-type="uri" xlink:href="http://www.JCircadianRhythms.com/content/1/1/2"></ext-link>
<history><date date-type="received"><day>24</day>
<month>9</month>
<year>2003</year>
</date>
<date date-type="accepted"><day>29</day>
<month>10</month>
<year>2003</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2003 Halberg et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</copyright-statement>
<copyright-year>2003</copyright-year>
<copyright-holder>Halberg et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</copyright-holder>
</permissions>
<abstract><p>A few puzzles relating to a small fraction of my endeavors in the 1950s are summarized herein, with answers to a few questions of the Editor-in-Chief, to suggest that the rules of variability in time complement the rules of genetics as a biological variability in space. I advocate to replace truisms such as a relative constancy or homeostasis, that have served bioscience very well for very long. They were never intended, however, to lower a curtain of ignorance over everyday physiology. In raising these curtains, we unveil a range of dynamics, resolvable in the data collection and as-one-goes analysis by computers built into smaller and smaller devices, for a continued self-surveillance of the normal and for an individualized detection of the abnormal. The current medical art based on spotchecks interpreted by reference to a time-unqualified normal range can become a science of time series with tests relating to the individual in inferential statistical terms. This is already doable for the case of blood pressure, but eventually should become possible for many other variables interpreted today only based on the quicksand of clinical trials on groups. These ignore individual differences and hence the individual's needs. Chronomics (mapping time structures) with the major aim of quantifying normalcy by dynamic reference values for detecting earliest risk elevation, also yields the dividend of allowing molecular biology to focus on the normal as well as on the grossly abnormal.</p>
</abstract>
</article-meta>
</front>
</pmc>
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