Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine – a review
Identifieur interne : 000202 ( Pmc/Curation ); précédent : 000201; suivant : 000203Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine – a review
Auteurs : Uta Eberlein [Allemagne] ; Jörn Hendrik Bröer [Allemagne] ; Charlot Vandevoorde [Belgique] ; Paula Santos [France] ; Manuel Bardiès [France] ; Klaus Bacher [Belgique] ; Dietmar Nosske [Allemagne] ; Michael Lassmann [Allemagne]Source :
- European Journal of Nuclear Medicine and Molecular Imaging [ 1619-7070 ] ; 2011.
Abstract
The impact on patients’ health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE.NET (
A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (
Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago.
It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.
The online version of this article (doi:10.1007/s00259-011-1904-z) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1007/s00259-011-1904-z
PubMed: 21877166
PubMed Central: 3218267
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<series><title level="j">European Journal of Nuclear Medicine and Molecular Imaging</title>
<idno type="ISSN">1619-7070</idno>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>The impact on patients’ health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE.NET (<ext-link ext-link-type="uri" xlink:href="http://www.peddose.net">www.peddose.net</ext-link>
), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals.</p>
</sec>
<sec><title>Methods</title>
<p>A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed">www.ncbi.nlm.nih.gov/pubmed</ext-link>
). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting.</p>
</sec>
<sec><title>Results</title>
<p>Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago.</p>
</sec>
<sec><title>Conclusion</title>
<p>It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1007/s00259-011-1904-z) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur J Nucl Med Mol Imaging</journal-id>
<journal-title-group><journal-title>European Journal of Nuclear Medicine and Molecular Imaging</journal-title>
</journal-title-group>
<issn pub-type="ppub">1619-7070</issn>
<issn pub-type="epub">1619-7089</issn>
<publisher><publisher-name>Springer-Verlag</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21877166</article-id>
<article-id pub-id-type="pmc">3218267</article-id>
<article-id pub-id-type="publisher-id">1904</article-id>
<article-id pub-id-type="doi">10.1007/s00259-011-1904-z</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine – a review</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Eberlein</surname>
<given-names>Uta</given-names>
</name>
<address><phone>+49-931-20135500</phone>
<fax>+49-931-20161803</fax>
<email>eberlein_u@klinik.uni-wuerzburg.de</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bröer</surname>
<given-names>Jörn Hendrik</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vandevoorde</surname>
<given-names>Charlot</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Santos</surname>
<given-names>Paula</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bardiès</surname>
<given-names>Manuel</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bacher</surname>
<given-names>Klaus</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nosske</surname>
<given-names>Dietmar</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lassmann</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Department of Nuclear Medicine, University of Würzburg, Oberdürrbacher Str. 6, 97080 Würzburg, Germany</aff>
<aff id="Aff2"><label>2</label>
Department of Radiation Protection and Health, Federal Office for Radiation Protection, Oberschleißheim, Germany</aff>
<aff id="Aff3"><label>3</label>
Department of Basic Medical Sciences, Division of Medical Physics, Ghent University, Ghent, Belgium</aff>
<aff id="Aff4"><label>4</label>
INSERM UMR892, Nantes, France</aff>
</contrib-group>
<pub-date pub-type="epub"><day>30</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>30</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
</pub-date>
<volume>38</volume>
<issue>12</issue>
<fpage>2269</fpage>
<lpage>2281</lpage>
<history><date date-type="received"><day>10</day>
<month>6</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>2</day>
<month>8</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2011</copyright-statement>
</permissions>
<abstract id="Abs1"><sec><title>Purpose</title>
<p>The impact on patients’ health of radiopharmaceuticals in nuclear medicine diagnostics has not until now been evaluated systematically in a European context. Therefore, as part of the EU-funded Project PEDDOSE.NET (<ext-link ext-link-type="uri" xlink:href="http://www.peddose.net">www.peddose.net</ext-link>
), we review and summarize the current knowledge on biokinetics and dosimetry of commonly used diagnostic radiopharmaceuticals.</p>
</sec>
<sec><title>Methods</title>
<p>A detailed literature search on published biokinetic and dosimetric data was performed mostly via PubMed (<ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/pubmed">www.ncbi.nlm.nih.gov/pubmed</ext-link>
). In principle the criteria for inclusion of data followed the EANM Dosimetry Committee guidance document on good clinical reporting.</p>
</sec>
<sec><title>Results</title>
<p>Data on dosimetry and biokinetics can be difficult to find, are scattered in various journals and, especially in paediatric nuclear medicine, are very scarce. The data collection and calculation methods vary with respect to the time-points, bladder voiding, dose assessment after the last data point and the way the effective dose was calculated. In many studies the number of subjects included for obtaining biokinetic and dosimetry data was fewer than ten, and some of the biokinetic data were acquired more than 20 years ago.</p>
</sec>
<sec><title>Conclusion</title>
<p>It would be of interest to generate new data on biokinetics and dosimetry in diagnostic nuclear medicine using state-of-the-art equipment and more uniform dosimetry protocols. For easier public access to dosimetry data for diagnostic radiopharmaceuticals, a database containing these data should be created and maintained.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1007/s00259-011-1904-z) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Dosimetry</kwd>
<kwd>Biokinetics</kwd>
<kwd>Diagnostic radiopharmaceuticals</kwd>
<kwd>Effective dose</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer-Verlag 2011</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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