Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays
Identifieur interne : 000153 ( Pmc/Curation ); précédent : 000152; suivant : 000154Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays
Auteurs : Marcel Van Der Heijden [Belgique, Pays-Bas] ; Dries H. G. Louage [Belgique] ; Philip X. Joris [Belgique]Source :
- JARO: Journal of the Association for Research in Otolaryngology [ 1525-3961 ] ; 2011.
Abstract
The quality of temporal coding of sound waveforms in the monaural afferents that converge on binaural neurons in the brainstem limits the sensitivity to temporal differences at the two ears. The anteroventral cochlear nucleus (AVCN) houses the cells that project to the binaural nuclei, which are known to have enhanced temporal coding of low-frequency sounds relative to auditory nerve (AN) fibers. We applied a coincidence analysis within the framework of detection theory to investigate the extent to which AVCN processing affects interaural time delay (ITD) sensitivity. Using monaural spike trains to a 1-s broadband or narrowband noise token, we emulated the binaural task of ITD discrimination and calculated just noticeable differences (jnds). The ITD jnds derived from AVCN neurons were lower than those derived from AN fibers, showing that the enhanced temporal coding in the AVCN improves binaural sensitivity to ITDs. AVCN processing also increased the dynamic range of ITD sensitivity and changed the shape of the frequency dependence of ITD sensitivity. Bandwidth dependence of ITD jnds from AN as well as AVCN fibers agreed with psychophysical data. These findings demonstrate that monaural preprocessing in the AVCN improves the temporal code in a way that is beneficial for binaural processing and may be crucial in achieving the exquisite sensitivity to ITDs observed in binaural pathways.
Url:
DOI: 10.1007/s10162-011-0268-1
PubMed: 21567250
PubMed Central: 3123442
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays</title><author><name sortKey="Van Der Heijden, Marcel" sort="Van Der Heijden, Marcel" uniqKey="Van Der Heijden M" first="Marcel" last="Van Der Heijden">Marcel Van Der Heijden</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Neuroscience, Erasmus MC, 3015 Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neuroscience, Erasmus MC, 3015 Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Louage, Dries H G" sort="Louage, Dries H G" uniqKey="Louage D" first="Dries H. G." last="Louage">Dries H. G. Louage</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Joris, Philip X" sort="Joris, Philip X" uniqKey="Joris P" first="Philip X." last="Joris">Philip X. Joris</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21567250</idno><idno type="pmc">3123442</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123442</idno><idno type="RBID">PMC:3123442</idno><idno type="doi">10.1007/s10162-011-0268-1</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000153</idno><idno type="wicri:Area/Pmc/Curation">000153</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays</title><author><name sortKey="Van Der Heijden, Marcel" sort="Van Der Heijden, Marcel" uniqKey="Van Der Heijden M" first="Marcel" last="Van Der Heijden">Marcel Van Der Heijden</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Neuroscience, Erasmus MC, 3015 Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neuroscience, Erasmus MC, 3015 Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Louage, Dries H G" sort="Louage, Dries H G" uniqKey="Louage D" first="Dries H. G." last="Louage">Dries H. G. Louage</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven</wicri:regionArea></affiliation></author><author><name sortKey="Joris, Philip X" sort="Joris, Philip X" uniqKey="Joris P" first="Philip X." last="Joris">Philip X. Joris</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven</wicri:regionArea></affiliation></author></analytic><series><title level="j">JARO: Journal of the Association for Research in Otolaryngology</title><idno type="ISSN">1525-3961</idno><idno type="eISSN">1438-7573</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The quality of temporal coding of sound waveforms in the monaural afferents that converge on binaural neurons in the brainstem limits the sensitivity to temporal differences at the two ears. The anteroventral cochlear nucleus (AVCN) houses the cells that project to the binaural nuclei, which are known to have enhanced temporal coding of low-frequency sounds relative to auditory nerve (AN) fibers. We applied a coincidence analysis within the framework of detection theory to investigate the extent to which AVCN processing affects interaural time delay (ITD) sensitivity. Using monaural spike trains to a 1-s broadband or narrowband noise token, we emulated the binaural task of ITD discrimination and calculated just noticeable differences (jnds). The ITD jnds derived from AVCN neurons were lower than those derived from AN fibers, showing that the enhanced temporal coding in the AVCN improves binaural sensitivity to ITDs. AVCN processing also increased the dynamic range of ITD sensitivity and changed the shape of the frequency dependence of ITD sensitivity. Bandwidth dependence of ITD jnds from AN as well as AVCN fibers agreed with psychophysical data. These findings demonstrate that monaural preprocessing in the AVCN improves the temporal code in a way that is beneficial for binaural processing and may be crucial in achieving the exquisite sensitivity to ITDs observed in binaural pathways.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Batra, R" uniqKey="Batra R">R Batra</name></author><author><name sortKey="Kuwada, S" uniqKey="Kuwada S">S Kuwada</name></author><author><name sortKey="Fitzpatrick, Dc" uniqKey="Fitzpatrick D">DC Fitzpatrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernstein, Lr" uniqKey="Bernstein L">LR Bernstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bernstein, Lr" uniqKey="Bernstein L">LR Bernstein</name></author><author><name sortKey="Trahiotis, C" uniqKey="Trahiotis C">C Trahiotis</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Assoc Res Otolaryngol</journal-id><journal-title-group><journal-title>JARO: Journal of the Association for Research in Otolaryngology</journal-title></journal-title-group><issn pub-type="ppub">1525-3961</issn><issn pub-type="epub">1438-7573</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21567250</article-id><article-id pub-id-type="pmc">3123442</article-id><article-id pub-id-type="publisher-id">268</article-id><article-id pub-id-type="doi">10.1007/s10162-011-0268-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Responses of Auditory Nerve and Anteroventral Cochlear Nucleus Fibers to Broadband and Narrowband Noise: Implications for the Sensitivity to Interaural Delays</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>van der Heijden</surname><given-names>Marcel</given-names></name><address><phone>+31-10-7043567</phone><email>m.vanderheyden@erasmusmc.nl</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Louage</surname><given-names>Dries H. G.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Joris</surname><given-names>Philip X.</given-names></name><address><phone>+32-16-345741</phone><fax>+32-16-345993</fax><email>Philip.Joris@med.kuleuven.be</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label>Laboratory of Auditory Neurophysiology, Medical School, University of Leuven, 3000 Leuven, Belgium</aff><aff id="Aff2"><label>2</label>Department of Neuroscience, Erasmus MC, 3015 Rotterdam, the Netherlands</aff></contrib-group><pub-date pub-type="epub"><day>13</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>5</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2011</year></pub-date><volume>12</volume><issue>4</issue><fpage>485</fpage><lpage>502</lpage><history><date date-type="received"><day>1</day><month>7</month><year>2010</year></date><date date-type="accepted"><day>11</day><month>4</month><year>2011</year></date></history><permissions><copyright-statement>© The Author(s) 2011</copyright-statement></permissions><abstract id="Abs1"><p>The quality of temporal coding of sound waveforms in the monaural afferents that converge on binaural neurons in the brainstem limits the sensitivity to temporal differences at the two ears. The anteroventral cochlear nucleus (AVCN) houses the cells that project to the binaural nuclei, which are known to have enhanced temporal coding of low-frequency sounds relative to auditory nerve (AN) fibers. We applied a coincidence analysis within the framework of detection theory to investigate the extent to which AVCN processing affects interaural time delay (ITD) sensitivity. Using monaural spike trains to a 1-s broadband or narrowband noise token, we emulated the binaural task of ITD discrimination and calculated just noticeable differences (jnds). The ITD jnds derived from AVCN neurons were lower than those derived from AN fibers, showing that the enhanced temporal coding in the AVCN improves binaural sensitivity to ITDs. AVCN processing also increased the dynamic range of ITD sensitivity and changed the shape of the frequency dependence of ITD sensitivity. Bandwidth dependence of ITD jnds from AN as well as AVCN fibers agreed with psychophysical data. These findings demonstrate that monaural preprocessing in the AVCN improves the temporal code in a way that is beneficial for binaural processing and may be crucial in achieving the exquisite sensitivity to ITDs observed in binaural pathways.</p></abstract><kwd-group><title>Keywords</title><kwd>coincidence detection</kwd><kwd>interaural time difference</kwd><kwd>discrimination</kwd><kwd>binaural</kwd><kwd>sound localization</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Association for Research in Otolaryngology 2011</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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