Graded Porous β-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation
Identifieur interne : 000043 ( Pmc/Curation ); précédent : 000042; suivant : 000044Graded Porous β-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation
Auteurs : Jingwen Yang ; Yunqing Kang ; Christopher Browne ; Ting Jiang ; Yunzhi YangSource :
- The Journal of Craniofacial Surgery [ 1049-2275 ] ; 2015.
Abstract
Bone augmentation requires scaffold to promote forming of natural bone structure. Currently, most of the reported bone scaffolds are porous solids with uniform pores. The aim of the currentstudy is to evaluate the effect of a graded porous β-tricalcium phosphate scaffolds on alveolar bone augmentation. Three groups of scaffolds were fabricated by a template-casting method: (1) graded porous scaffolds with large pores in the center and small pores at theperiphery, (2) scaffolds with large uniform pores, and (3) scaffolds with small uniform pores. Bone augmentation on rabbit mandible wasinvestigated by microcomputed tomography, sequential fluorescentlabeling, and histologic examination 3 months after implantation.The result presents that all the scaffold groups maintain their augmented bone height after 3-month observation, whereas the autograftinggroup presents an obvious bone resorption. Microcomputed tomography reveals that the graded porous group has significantly greater volume of new bone (
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DOI: 10.1097/SCS.0000000000001383
PubMed: 25675019
PubMed Central: 4357553
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Jingwen Yang<affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Graded Porous β-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation</title><author><name sortKey="Yang, Jingwen" sort="Yang, Jingwen" uniqKey="Yang J" first="Jingwen" last="Yang">Jingwen Yang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Kang, Yunqing" sort="Kang, Yunqing" uniqKey="Kang Y" first="Yunqing" last="Kang">Yunqing Kang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Browne, Christopher" sort="Browne, Christopher" uniqKey="Browne C" first="Christopher" last="Browne">Christopher Browne</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Ting" sort="Jiang, Ting" uniqKey="Jiang T" first="Ting" last="Jiang">Ting Jiang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25675019</idno><idno type="pmc">4357553</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357553</idno><idno type="RBID">PMC:4357553</idno><idno type="doi">10.1097/SCS.0000000000001383</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000043</idno><idno type="wicri:Area/Pmc/Curation">000043</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Graded Porous β-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation</title><author><name sortKey="Yang, Jingwen" sort="Yang, Jingwen" uniqKey="Yang J" first="Jingwen" last="Yang">Jingwen Yang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Kang, Yunqing" sort="Kang, Yunqing" uniqKey="Kang Y" first="Yunqing" last="Kang">Yunqing Kang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Browne, Christopher" sort="Browne, Christopher" uniqKey="Browne C" first="Christopher" last="Browne">Christopher Browne</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Jiang, Ting" sort="Jiang, Ting" uniqKey="Jiang T" first="Ting" last="Jiang">Ting Jiang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Yunzhi" sort="Yang, Yunzhi" uniqKey="Yang Y" first="Yunzhi" last="Yang">Yunzhi Yang</name><affiliation><nlm:aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Journal of Craniofacial Surgery</title><idno type="ISSN">1049-2275</idno><idno type="eISSN">1536-3732</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Bone augmentation requires scaffold to promote forming of natural bone structure. Currently, most of the reported bone scaffolds are porous solids with uniform pores. The aim of the currentstudy is to evaluate the effect of a graded porous β-tricalcium phosphate scaffolds on alveolar bone augmentation. Three groups of scaffolds were fabricated by a template-casting method: (1) graded porous scaffolds with large pores in the center and small pores at theperiphery, (2) scaffolds with large uniform pores, and (3) scaffolds with small uniform pores. Bone augmentation on rabbit mandible wasinvestigated by microcomputed tomography, sequential fluorescentlabeling, and histologic examination 3 months after implantation.The result presents that all the scaffold groups maintain their augmented bone height after 3-month observation, whereas the autograftinggroup presents an obvious bone resorption. Microcomputed tomography reveals that the graded porous group has significantly greater volume of new bone (<italic>P</italic> < 0.05) and similar bone density compared with the uniform pores groups. Bone substance distributes unevenly in all the 3 experimental groups. Greater bone volume can be observed in the area closer to the bone bed. The sequential fluorescentlabeling observation reveals robust bone regeneration in the first month and faster bone growth in the graded porous scaffold group than that in the large porous scaffold group. Histologic examinationsconfirm bone structure in the aspect of distribution, activity, and maturity. We conclude that graded porous designed biodegradableβ-tricalcium phosphate scaffolds are beneficial to promote bone augmentation in the aspect of bone volume.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shimono, K" uniqKey="Shimono K">K Shimono</name></author><author><name sortKey="Oshima, M" uniqKey="Oshima M">M Oshima</name></author><author><name sortKey="Arakawa, H" uniqKey="Arakawa H">H Arakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davo, R" uniqKey="Davo R">R Davo</name></author><author><name sortKey="Malevez, C" uniqKey="Malevez C">C Malevez</name></author><author><name sortKey="Rojas, J" uniqKey="Rojas J">J Rojas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cawood, Ji" uniqKey="Cawood J">JI Cawood</name></author><author><name sortKey="Howell, Ra" uniqKey="Howell R">RA 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Craniofac Surg</journal-id><journal-id journal-id-type="iso-abbrev">J Craniofac Surg</journal-id><journal-id journal-id-type="publisher-id">SCS</journal-id><journal-title-group><journal-title>The Journal of Craniofacial Surgery</journal-title></journal-title-group><issn pub-type="ppub">1049-2275</issn><issn pub-type="epub">1536-3732</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25675019</article-id><article-id pub-id-type="pmc">4357553</article-id><article-id pub-id-type="publisher-id">SCS41082</article-id><article-id pub-id-type="doi">10.1097/SCS.0000000000001383</article-id><article-id pub-id-type="art-access-id">00109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Clinical Studies</subject></subj-group></article-categories><title-group><article-title>Graded Porous β-Tricalcium Phosphate Scaffolds Enhance Bone Regeneration in Mandible Augmentation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Jingwen</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Kang</surname><given-names>Yunqing</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">†</xref></contrib><contrib contrib-type="author"><name><surname>Browne</surname><given-names>Christopher</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1">†</xref></contrib><contrib contrib-type="author"><name><surname>Jiang</surname><given-names>Ting</given-names></name><degrees>DDS, PhD</degrees><xref ref-type="aff" rid="aff1">*</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Yunzhi</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1">†‡</xref></contrib></contrib-group><aff id="aff1">From the *Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, China; †Department of Orthopedic Surgery, Stanford University, Stanford, California; and ‡Department of Materials Science and Engineering, Stanford University, Stanford, California.</aff><author-notes><corresp id="cor1">Address correspondence and reprint requests to Ting Jiang, DDS, PhD, Department of Prosthodontics, School and Hospital of Stomatology, Peking University, 22 South Ave Zhongguancun, Haidian, Beijing 100081, China; E-mail: <email>tingright@gmail.com</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>12</day><month>5</month><year>2015</year></pub-date><volume>26</volume><issue>2</issue><fpage>e148</fpage><lpage>e153</lpage><history><date date-type="received"><day>18</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>9</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2015 by Mutaz B. Habal, MD</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Lippincott Williams & Wilkins</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.</license-p></license></permissions><self-uri xlink:type="simple" xlink:href="scs-26-e148.pdf"></self-uri><abstract><title>Abstract</title><p>Bone augmentation requires scaffold to promote forming of natural bone structure. Currently, most of the reported bone scaffolds are porous solids with uniform pores. The aim of the currentstudy is to evaluate the effect of a graded porous β-tricalcium phosphate scaffolds on alveolar bone augmentation. Three groups of scaffolds were fabricated by a template-casting method: (1) graded porous scaffolds with large pores in the center and small pores at theperiphery, (2) scaffolds with large uniform pores, and (3) scaffolds with small uniform pores. Bone augmentation on rabbit mandible wasinvestigated by microcomputed tomography, sequential fluorescentlabeling, and histologic examination 3 months after implantation.The result presents that all the scaffold groups maintain their augmented bone height after 3-month observation, whereas the autograftinggroup presents an obvious bone resorption. Microcomputed tomography reveals that the graded porous group has significantly greater volume of new bone (<italic>P</italic> < 0.05) and similar bone density compared with the uniform pores groups. Bone substance distributes unevenly in all the 3 experimental groups. Greater bone volume can be observed in the area closer to the bone bed. The sequential fluorescentlabeling observation reveals robust bone regeneration in the first month and faster bone growth in the graded porous scaffold group than that in the large porous scaffold group. Histologic examinationsconfirm bone structure in the aspect of distribution, activity, and maturity. We conclude that graded porous designed biodegradableβ-tricalcium phosphate scaffolds are beneficial to promote bone augmentation in the aspect of bone volume.</p></abstract><kwd-group><title>Key Words</title><kwd>Bone regeneration</kwd><kwd>graded pore size</kwd><kwd>β-TCP</kwd><kwd>bone augmentation</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta><custom-meta><meta-name>STATUS</meta-name><meta-value>ONLINE-ONLY</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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