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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The impact of the intensity of fear on patient’s delay regarding health care seeking behavior: a systematic review</title><author><name sortKey="Dubayova, Tatiana" sort="Dubayova, Tatiana" uniqKey="Dubayova T" first="Tatiana" last="Dubayova">Tatiana Dubayova</name><affiliation><nlm:aff id="Aff1">Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Van Dijk, Jitse P" sort="Van Dijk, Jitse P" uniqKey="Van Dijk J" first="Jitse P." last="Van Dijk">Jitse P. Van Dijk</name><affiliation><nlm:aff id="Aff2">Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Nagyova, Iveta" sort="Nagyova, Iveta" uniqKey="Nagyova I" first="Iveta" last="Nagyova">Iveta Nagyova</name><affiliation><nlm:aff id="Aff3">Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Rosenberger, Jaroslav" sort="Rosenberger, Jaroslav" uniqKey="Rosenberger J" first="Jaroslav" last="Rosenberger">Jaroslav Rosenberger</name><affiliation><nlm:aff id="Aff3">Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Havlikova, Eva" sort="Havlikova, Eva" uniqKey="Havlikova E" first="Eva" last="Havlikova">Eva Havlikova</name><affiliation><nlm:aff id="Aff1">Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Gdovinova, Zuzana" sort="Gdovinova, Zuzana" uniqKey="Gdovinova Z" first="Zuzana" last="Gdovinova">Zuzana Gdovinova</name><affiliation><nlm:aff id="Aff1">Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Middel, Berrie" sort="Middel, Berrie" uniqKey="Middel B" first="Berrie" last="Middel">Berrie Middel</name><affiliation><nlm:aff id="Aff2">Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Groothoff, Johan W" sort="Groothoff, Johan W" uniqKey="Groothoff J" first="Johan W." last="Groothoff">Johan W. Groothoff</name><affiliation><nlm:aff id="Aff2">Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20467882</idno><idno type="pmc">2941081</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941081</idno><idno type="RBID">PMC:2941081</idno><idno type="doi">10.1007/s00038-010-0149-0</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000204</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The impact of the intensity of fear on patient’s delay regarding health care seeking behavior: a systematic review</title><author><name sortKey="Dubayova, Tatiana" sort="Dubayova, Tatiana" uniqKey="Dubayova T" first="Tatiana" last="Dubayova">Tatiana Dubayova</name><affiliation><nlm:aff id="Aff1">Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Van Dijk, Jitse P" sort="Van Dijk, Jitse P" uniqKey="Van Dijk J" first="Jitse P." last="Van Dijk">Jitse P. Van Dijk</name><affiliation><nlm:aff id="Aff2">Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff3">Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Nagyova, Iveta" sort="Nagyova, Iveta" uniqKey="Nagyova I" first="Iveta" last="Nagyova">Iveta Nagyova</name><affiliation><nlm:aff id="Aff3">Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Rosenberger, Jaroslav" sort="Rosenberger, Jaroslav" uniqKey="Rosenberger J" first="Jaroslav" last="Rosenberger">Jaroslav Rosenberger</name><affiliation><nlm:aff id="Aff3">Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Havlikova, Eva" sort="Havlikova, Eva" uniqKey="Havlikova E" first="Eva" last="Havlikova">Eva Havlikova</name><affiliation><nlm:aff id="Aff1">Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Gdovinova, Zuzana" sort="Gdovinova, Zuzana" uniqKey="Gdovinova Z" first="Zuzana" last="Gdovinova">Zuzana Gdovinova</name><affiliation><nlm:aff id="Aff1">Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Middel, Berrie" sort="Middel, Berrie" uniqKey="Middel B" first="Berrie" last="Middel">Berrie Middel</name><affiliation><nlm:aff id="Aff2">Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author><author><name sortKey="Groothoff, Johan W" sort="Groothoff, Johan W" uniqKey="Groothoff J" first="Johan W." last="Groothoff">Johan W. Groothoff</name><affiliation><nlm:aff id="Aff2">Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff></affiliation><affiliation><nlm:aff id="Aff4">Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Public Health</title><idno type="ISSN">1661-8556</idno><idno type="eISSN">1661-8564</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>This systematic review focuses on the role of the intensity of fear in patient’s delay in cancer and in myocardial infarction.</p></sec><sec><title>Methods</title><p>In a search of literature published between 1990 and June 2009, 161 articles were found. After the use of inclusion and exclusion criteria, 11 articles in cancer and 4 articles in myocardial infarction remained.</p></sec><sec><title>Results</title><p>High levels of fear are associated with earlier help-seeking in both diseases; for low levels of fear, the picture is unclear.</p></sec><sec><title>Conclusion</title><p>The level of fear is an important factor, which should be taken into account when facilitating help-seeking by patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Andersen, Bl" uniqKey="Andersen B">BL Andersen</name></author><author><name sortKey="Cacioppo, J" uniqKey="Cacioppo J">J Cacioppo</name></author><author><name sortKey="Roberts, Dc" uniqKey="Roberts D">DC Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arndt, V" uniqKey="Arndt V">V Arndt</name></author><author><name sortKey="Sturmer, T" uniqKey="Sturmer T">T 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Public Health</journal-id><journal-title-group><journal-title>International Journal of Public Health</journal-title></journal-title-group><issn pub-type="ppub">1661-8556</issn><issn pub-type="epub">1661-8564</issn><publisher><publisher-name>SP Birkhäuser Verlag Basel</publisher-name><publisher-loc>Basel</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20467882</article-id><article-id pub-id-type="pmc">2941081</article-id><article-id pub-id-type="publisher-id">149</article-id><article-id pub-id-type="doi">10.1007/s00038-010-0149-0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>The impact of the intensity of fear on patient’s delay regarding health care seeking behavior: a systematic review</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Dubayova</surname><given-names>Tatiana</given-names></name><address><phone>+421-51-7470572</phone><fax>+421-51-7470551</fax><email>dubayovat@unipo.sk</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>van Dijk</surname><given-names>Jitse P.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Nagyova</surname><given-names>Iveta</given-names></name><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Rosenberger</surname><given-names>Jaroslav</given-names></name><xref ref-type="aff" rid="Aff3">3</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Havlikova</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Gdovinova</surname><given-names>Zuzana</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Middel</surname><given-names>Berrie</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Groothoff</surname><given-names>Johan W.</given-names></name><xref ref-type="aff" rid="Aff2">2</xref><xref ref-type="aff" rid="Aff4">4</xref></contrib><aff id="Aff1"><label>1</label>Department of Special Education, Faculty of Pedagogy, University of Presov, Ul 17. novembra 1, 080 01 Presov, Slovakia</aff><aff id="Aff2"><label>2</label>Department of Social Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</aff><aff id="Aff3"><label>3</label>Department of Educational Psychology and Health Psychology, Faculty of Arts, Kosice Institute for Society and Health, University of PJ Safarik, Kosice, Slovakia</aff><aff id="Aff4"><label>4</label>Department of Neurology, Faculty of Medicine, University of PJ Safarik, Kosice, Slovakia</aff></contrib-group><pub-date pub-type="epub"><day>14</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>5</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2010</year></pub-date><volume>55</volume><issue>5</issue><fpage>459</fpage><lpage>468</lpage><history><date date-type="received"><day>12</day><month>11</month><year>2008</year></date><date date-type="rev-recd"><day>1</day><month>11</month><year>2009</year></date><date date-type="accepted"><day>8</day><month>1</month><year>2010</year></date></history><permissions><copyright-statement>© The Author(s) 2010</copyright-statement></permissions><abstract><sec><title>Objectives</title><p>This systematic review focuses on the role of the intensity of fear in patient’s delay in cancer and in myocardial infarction.</p></sec><sec><title>Methods</title><p>In a search of literature published between 1990 and June 2009, 161 articles were found. After the use of inclusion and exclusion criteria, 11 articles in cancer and 4 articles in myocardial infarction remained.</p></sec><sec><title>Results</title><p>High levels of fear are associated with earlier help-seeking in both diseases; for low levels of fear, the picture is unclear.</p></sec><sec><title>Conclusion</title><p>The level of fear is an important factor, which should be taken into account when facilitating help-seeking by patients.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Patient’s delay</kwd><kwd>Help-seeking behavior</kwd><kwd>Fear</kwd><kwd>Anxiety</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Swiss School of Public Health 2010</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec id="Sec1"><title>Introduction</title><p>An early visit to the physician is sometimes a matter of life or death. The question is, what is late and what is ‘in time’ in health care? Early help-seeking has an impact on the success of treatment related to the moment of intervention for a particular disease. For example, the prognosis for breast cancer and melanomas is better for patients if the problem is diagnosed within 3 months (Arndt et al. <xref ref-type="bibr" rid="CR2">2002</xref>). Thrombolytic treatment for heart attack is more effective when given within 2 h (Davalos <xref ref-type="bibr" rid="CR12">2005</xref>), though it works best in the first 60 min (Warnes et al. <xref ref-type="bibr" rid="CR51">2008</xref>). To achieve a reduction in mortality from the most prevalent diseases among people of working age [men and women from 15 to 64 years of age (Eurostat <xref ref-type="bibr" rid="CR20">2008</xref>)] in European countries [acute myocardial infarction (AMI) and cancer], a better understanding of the reasons for late and delayed diagnosis and consequent treatment in patients with potential symptoms of these diseases is required (Caplan and Helzlsouer <xref ref-type="bibr" rid="CR11">1992</xref>; Moser et al. <xref ref-type="bibr" rid="CR37">2007</xref>).</p><p>Patient’s delay is most frequently described as the “length of delay between the onset/discovery/recognition of signs and symptoms and a patient’s first visit to a health care/medical provider” (Demissie et al. <xref ref-type="bibr" rid="CR15">2002</xref>; Thongsuksai et al. <xref ref-type="bibr" rid="CR49">2000</xref>), but more simple descriptions like “time to first presentation of signs or symptoms to a physician” can be found as well (Andersen et al. <xref ref-type="bibr" rid="CR1">1995</xref>; Young et al. <xref ref-type="bibr" rid="CR52">2000</xref>). In addition, the terms ‘help-seeking delay’ or ‘help-seeking behavior’ are frequently used in the literature as a synonym for ‘patient’s delay’.</p><p>In many studies, patient’s delay is associated mainly with sociodemographic factors, such as gender, age, socioeconomic status (SES) or marital status, though the findings are equivocal. The strongest evidence exists for longer patient’s delay being associated with age and SES (without regard to diagnosis). Older people (Arndt et al. <xref ref-type="bibr" rid="CR2">2002</xref>; Facione et al. <xref ref-type="bibr" rid="CR21">2002</xref>; Montella et al. <xref ref-type="bibr" rid="CR33">2001a</xref>; Ottesen et al. <xref ref-type="bibr" rid="CR40">1996</xref>) and people from low SES groups (Caplan and Helzlsouer <xref ref-type="bibr" rid="CR11">1992</xref>; Dracup and Moser <xref ref-type="bibr" rid="CR18">1997</xref>; Facione et al. <xref ref-type="bibr" rid="CR21">2002</xref>; Schmidt and Borsch <xref ref-type="bibr" rid="CR45">1990</xref>) had a tendency to hesitate in consulting an expert. The relationship between gender and patient’s delay is not so strong and varies from ‘women had a higher tendency to delay’ (in cases of AMI and cases of melanoma) (Betti et al. <xref ref-type="bibr" rid="CR3">2003</xref>; Dracup and Moser <xref ref-type="bibr" rid="CR17">1991</xref>; Lefler and Bondy <xref ref-type="bibr" rid="CR26">2004</xref>; Ottesen et al. <xref ref-type="bibr" rid="CR40">1996</xref>; Schmidt and Borsch <xref ref-type="bibr" rid="CR45">1990</xref>) to “there is no correlation between patient’s delay and gender” (in cases of AMI) (Maynard et al. <xref ref-type="bibr" rid="CR30">1989</xref>; Schroeder et al. <xref ref-type="bibr" rid="CR46">1978</xref>). The same holds true for education; several studies confirmed the association between a lower level of education and a greater tendency to hesitate in seeking help (Caplan and Helzlsouer <xref ref-type="bibr" rid="CR11">1992</xref>; Lefler and Bondy <xref ref-type="bibr" rid="CR26">2004</xref>; Montella et al. <xref ref-type="bibr" rid="CR33">2001a</xref>, <xref ref-type="bibr" rid="CR34">2001b</xref>), but approximately the same number of studies refuted this association (Bleeker et al. <xref ref-type="bibr" rid="CR5">1995</xref>; Burgess et al. <xref ref-type="bibr" rid="CR7">1998</xref>; Demissie et al. <xref ref-type="bibr" rid="CR15">2002</xref>; Yu et al. <xref ref-type="bibr" rid="CR53">2002</xref>).</p><p>Not only sociodemographic factors influence patient’s delay, but clinical variables also appear to be important for making a decision on accessing health care. In many cases, <italic>previous medical history</italic> has an opposite effect on an early visit to surgery or emergency center. Women with a personal history of benign forms of breast cancer delayed longer in comparison with women without a history of a benign disease (Caplan and Helzlsouer <xref ref-type="bibr" rid="CR11">1992</xref>; Dracup et al. <xref ref-type="bibr" rid="CR19">1995</xref>). It was also found that patients with <italic>typical symptoms</italic> of a certain disease seek help sooner. Persons who identified symptoms correctly as originating from the heart received help 1 h earlier compared to those who attributed their pain to other parts of the body (Dracup and Moser <xref ref-type="bibr" rid="CR17">1991</xref>; Lefler and Bondy <xref ref-type="bibr" rid="CR26">2004</xref>). Results from breast cancer studies also confirm this association between typical symptoms of the disease and earlier consulting with an expert. Women delayed longer when initial breast symptoms did not include a lump (Burgess et al. <xref ref-type="bibr" rid="CR7">1998</xref>) compared to women who detected a breast lump, the latter group waiting significantly less time (Meechan et al. <xref ref-type="bibr" rid="CR32">2003</xref>). An important factor for decision-making is <italic>knowledge</italic>. Patients who came earlier to the emergency room had more knowledge about the cardiovascular system and cardiac symptoms, more appropriate behavior and fewer risk factors when compared with the group of patients who delayed for more than 1.5 h (Bleeker et al. <xref ref-type="bibr" rid="CR5">1995</xref>). This was confirmed by the finding that knowledge is a stimulating factor in the decision-making process about having a disease (Moser et al. <xref ref-type="bibr" rid="CR36">2005</xref>; de Nooijer et al. <xref ref-type="bibr" rid="CR13">2001a</xref>).</p><p>Apart from sociodemographic and clinical variables, psychological factors may also play a role in patient’s delay. Several clinical studies mentioned fear as an important psychological factor associated with motivation for treatment or patient’s delay (Bish et al. <xref ref-type="bibr" rid="CR4">2005</xref>; George et al. <xref ref-type="bibr" rid="CR22">2007</xref>; Leeuw et al. <xref ref-type="bibr" rid="CR25">2006</xref>). According to the definition, fear is the emotional reaction to a specific, identifiable and immediate threat such as a dangerous animal or an injury, and it has a protective function associated with the fight or flight response (Rachman <xref ref-type="bibr" rid="CR42">1989</xref>). Clinically, the terms fear and anxiety are frequently used interchangeably (Leeuw et al. <xref ref-type="bibr" rid="CR25">2006</xref>). However, there are differences between these variables from a psychological point of view. Anxiety is a form of negative emotions closely related to fear and is defined as unspecified fear with no clear focus (Hartl and Hartlova <xref ref-type="bibr" rid="CR23">2004</xref>). Whereas fear motivates an individual to engage in defensive behaviors, anxiety is associated with preventive behaviors, including avoidance, and may have higher intensity than actual fear. For these reasons, ‘being anxious’ was defined for the purposes of this paper as having a higher intensity than ‘having fear’.</p><p>The connection of fear with patient’s delay was well described in the Leicester review, where the authors identified two types of fear (fear of embarrassment and fear of cancer) in a review of studies in different types of cancer (Smith et al. <xref ref-type="bibr" rid="CR47">2005</xref>). In order to complete the variances of fear, fear of pain may also be included a fact relevant mainly for diseases associated with muscular injuries or delay in the rehabilitation process (George et al. <xref ref-type="bibr" rid="CR22">2007</xref>). Feelings, such as worry, fear and anxiety, can be elicited by symptom-induced pain or discomfort, presumed diagnosis and anticipated consequences of treatment, as well as by coping failures and reinterpretations of the illness condition (Cameron et al. <xref ref-type="bibr" rid="CR10">1993</xref>). Fear appears to be an important psychological factor in delay, and its intensity may have an influence on early arrival to a health care professional. Studies analyzing the association between patient’s delay and fear in patients with cancer and AMI were selected for the review, because these two diseases are the two main causes of death in European countries (Mackenbach et al. <xref ref-type="bibr" rid="CR28">2008</xref>). The aim of this paper is to explore the role of the intensity of the perception of fear and anxiety in the help-seeking process in patients with a slow, progressive disease and in those with an acute disease.</p></sec><sec id="Sec2" sec-type="methods"><title>Methods</title><p>In June 2009, the electronic databases MEDLINE and PsychINFO were searched for articles meeting the following inclusion criteria: (1) original papers on cancer or AMI, (2) written in English, (3) from the search period 1990 until June 2009 and (4) containing the key words ‘patient’s delay’ or ‘help-seeking behavior’ or ‘treatment-seeking behavior’ or ‘treatment seeking delay’ or ‘patient acceptance of health care’ and ‘fear’ or ‘anxiety’.</p><p>Two reviewers (TD and JPvD) independently assessed the studies that were identified during the screening based on information obtained from the title and the abstract of the publications from the first search strategy. When discrepancies appeared, the papers were independently assessed by a third reviewer (JWG). After the first search, both reviewers read the full text of the selected 15 articles.</p><p>For this systematic review, we adopted and modified criteria from existing quality assessment lists (van der Mei et al. <xref ref-type="bibr" rid="CR50">2006</xref>; den Oudsten et al. <xref ref-type="bibr" rid="CR16">2007</xref>). Two reviewers (TD and JPvD) assessed the quality of the publications as positive (+), negative (−) or unknown (?) based on the information provided in the article. Disagreements between reviewers were discussed during a consensus meeting. The following four quality criteria were chosen for evaluating the publications:<list list-type="order"><list-item><p>definition and operationalization of patient’s delay—patient’s delay was defined exactly using a disease-specific cutoff point which divided the sample into delayers and non-delayers (+), or patient’s delay was defined as a continuous variable (−),</p></list-item><list-item><p>definition and operationalization of fear or anxiety—fear and anxiety were operationalized and defined (+), or they were not clearly defined (−),</p></list-item><list-item><p>reliability of measurements of fear or anxiety—using validated measurements for fear and anxiety (e.g. HADS, STAI-T, SCID, LEDS, etc.) (+), qualitative study (+), assessing fear or anxiety only from self-reporting of patients or non-validated scales (−),</p></list-item><list-item><p>sample size—adequate sample size for the statistical method used (+), inadequate sample size for the statistical method used (−)</p></list-item><list-item><p>statistical analyses—using <italic>t</italic>-tests, chi-square, correlations, regression analyses etc. for (+) or using descriptive statistical methods (means and percentages) (−) for assessment of the relationships between patient’s delay and intensity of fear.</p></list-item></list></p><p>For each study, a quality score was calculated. The paper was rated as <italic>‘strong evidence’</italic> when it had an adequate sample size, used validated measurements and reported statistically significant differences in relation to the patient’s delay or fear or used appropriate analytic techniques (qualitative studies). Papers which had an adequate sample size and used a rigorous methodology to ascertain data but used only descriptive statistical methods were rated as having a <italic>‘moderate’</italic> level of evidence. Papers which used inappropriate methods of collecting relevant data about patient’s delay or fear and used insufficient analysis were considered as <italic>‘insufficient’</italic>.</p></sec><sec id="Sec3"><title>Results</title><p>Using the first search strategy, 158 articles were found. Additional screening based on authors detected another 16 articles, which were not included in the MEDLINE or the PsychINFO database. Three of the 19 authors consulted also mailed a reference to 3 other articles related to the topic of patient’s delay. Thus, the total number of articles found was 177.</p><p>From these 177 articles, 162 were excluded because: they contained irrelevant content; involved studies of children and adolescents; were case reports; were books or book chapters; and because they:<list list-type="bullet"><list-item><p>focused only on the association between patient’s delay and progression of disease or the effectiveness of treatment;</p></list-item><list-item><p>reported on the effectiveness of educational programs for reducing patient’s delay;</p></list-item><list-item><p>concentrated only on the association of patient’s delay with sociodemographic factors (e.g. age, gender, educational level, occupation);</p></list-item><list-item><p>focused only on measuring the time from first signs until first contact with a medical doctor without any further explanation.</p></list-item></list></p><p>The process of applying these criteria is shown in Fig. <xref rid="Fig1" ref-type="fig">1</xref>; 15 articles remained for review.<fig id="Fig1"><label>Fig. 1</label><caption><p>Flow diagram of the selection process</p></caption><graphic xlink:href="38_2010_149_Fig1_HTML" id="MO1"></graphic></fig></p><p>Disagreement occurred mainly because of reading errors and differences in the interpretation of the list of criteria, but after the consensus meeting no disagreements persisted. The third reviewer was not asked for a final decision.</p><sec id="Sec4"><title>Quality assessment</title><p>Only one of the 15 selected studies was rated as ‘insufficient’. Eleven were considered as having a ‘moderate’ level of evidence and three were rated as studies with a ‘strong level of evidence’ (Table <xref rid="Tab1" ref-type="table">1</xref>).<table-wrap id="Tab1"><label>Table 1</label><caption><p>The ratings of the 15 studies</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left">Study, reference</th><th align="left">Disease</th><th align="left">I</th><th align="left">II</th><th align="left">III</th><th align="left">IV</th><th align="left">V</th><th align="left" colspan="2">Evaluation of the study</th></tr></thead><tbody><tr><td align="left">Mor et al. (<xref ref-type="bibr" rid="CR35">1990</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">−</td><td align="left">2/5</td><td align="left">M</td></tr><tr><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR7">1998</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">?</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">3/5</td><td align="left">M</td></tr><tr><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR8">2000</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">5/5</td><td align="left">S</td></tr><tr><td align="left">Nosarti et al. (<xref ref-type="bibr" rid="CR39">2000</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">−</td><td align="left">2/5</td><td align="left">M</td></tr><tr><td align="left">Brochez et al. (<xref ref-type="bibr" rid="CR6">2001</xref>)</td><td align="left">Cancer</td><td align="left">−</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">2/5</td><td align="left">M</td></tr><tr><td align="left">de Nooijer et al. (<xref ref-type="bibr" rid="CR13">2001a</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">−</td><td align="left">−</td><td align="left">3/5</td><td align="left">M</td></tr><tr><td align="left">de Nooijer et al. (<xref ref-type="bibr" rid="CR14">2001b</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">−</td><td align="left">−</td><td align="left">3/5</td><td align="left">M</td></tr><tr><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR9">2001</xref>)</td><td align="left">Cancer</td><td align="left">+</td><td align="left">+</td><td align="left">−</td><td align="left">+</td><td align="left">−</td><td align="left">3/5</td><td align="left">M</td></tr><tr><td align="left">Meechan et al. (<xref ref-type="bibr" rid="CR32">2003</xref>)</td><td align="left">Cancer</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">4/5</td><td align="left">S</td></tr><tr><td align="left">Rozniatowski et al. (<xref ref-type="bibr" rid="CR44">2005</xref>)</td><td align="left">Cancer</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">+</td><td align="left">4/5</td><td align="left">S</td></tr><tr><td align="left">Rozniatowski et al. (<xref ref-type="bibr" rid="CR44">2005</xref>)</td><td align="left">Cancer</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">−</td><td align="left">+</td><td align="left">3/5</td><td align="left">M</td></tr><tr><td align="left">Dracup et al. (1997)</td><td align="left">AMI</td><td align="left">+</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">3/5</td><td align="left">M</td></tr><tr><td align="left">McKinley et al. (<xref ref-type="bibr" rid="CR31">2000</xref>)</td><td align="left">AMI</td><td align="left">−</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">−</td><td align="left">1/5</td><td align="left">I</td></tr><tr><td align="left">Kentsch et al. (<xref ref-type="bibr" rid="CR24">2002</xref>)</td><td align="left">AMI</td><td align="left">+</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">−</td><td align="left">2/5</td><td align="left">M</td></tr><tr><td align="left">Moser et al. (<xref ref-type="bibr" rid="CR36">2005</xref>)</td><td align="left">AMI</td><td align="left">−</td><td align="left">−</td><td align="left">−</td><td align="left">+</td><td align="left">+</td><td align="left">2/5</td><td align="left">M</td></tr></tbody></table><table-wrap-foot><p><italic>S</italic> Strong level of evidence, <italic>M</italic> Moderate level of evidence, <bold><italic>I</italic></bold> Insufficient level of evidence; Quality criteria: <italic>I</italic> definition and operationalization of patient’s delay—patient’s delay was defined exactly using disease specific cut-off point which divided sample on delayers and non-delayers (+), or patient’s delay was defined as continuous variable (−); <italic>II</italic> definition and operationalization of fear or anxiety—fear and anxiety were operationalized and defined (+), or they were not clearly defined (−); <italic>III</italic> reliability of measurements of fear or anxiety—using validated measurements for fear and anxiety (e.g. HADS, STAI-T, SCID, LEDS etc.) (+), qualitative study (+), assessing fear or anxiety only from self-reporting of a patients or non-validated scales (−); <italic>IV</italic> sample size—adequate sample size to the used statistic method (+), inadequate sample size to the used statistic method (−); <italic>V</italic> statistical analyses—using<italic> t</italic> tests, chi-square, correlations, regression analyses etc. for (+) or using descriptive statistic methods (means and percentages) (−) for assessment of the relationships between patient’s delay and intensity of fear</p></table-wrap-foot></table-wrap></p></sec><sec id="Sec5"><title>Study characteristics</title><p>The characteristics of the studies are presented in Table <xref rid="Tab2" ref-type="table">2</xref>. Twelve of the 15 selected studies addressed some form of carcinoma (5 on breast cancer, 1 on cutaneous melanomas, 3 on patients with various types of carcinoma, 1 on rectal cancer and 1 on head and neck cancer) and 4 looked at acute myocardial infarction.<table-wrap id="Tab2"><label>Table 2</label><caption><p>Summary of reviewed studies divided in studies of cancer and AMI</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left">Reference/country</th><th align="left">Type of study</th><th align="left">Study population</th><th align="left">Disease</th><th align="left">Quality of the study</th><th align="left">Overall assessment and strength of evidence</th></tr></thead><tbody><tr><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR7">1998</xref>), UK</td><td align="left">Cross-sectional</td><td align="left">135 women with cancer 53 control study</td><td align="left">Breast cancer</td><td align="left">M</td><td align="left">Delayers reported less fear on discovering symptoms (<italic>P</italic> = 0.05)</td></tr><tr><td align="left" rowspan="2">Burgess et al. (<xref ref-type="bibr" rid="CR8">2000</xref>), UK</td><td align="left" rowspan="2">Cross-sectional</td><td align="left" rowspan="2">158 women</td><td align="left" rowspan="2">Breast cancer</td><td align="left" rowspan="2">S</td><td align="left">No difference between delayers and non-delayers in prevalence of full-case depression (<italic>P</italic> = 0.7), borderline anxiety (<italic>P</italic> = 0.6), or full-case anxiety (<italic>P</italic> = 0.3)</td></tr><tr><td align="left">The study found no evidence that being clinically anxious or depressed before or around the time of symptom discovery increases the risk of delaying</td></tr><tr><td align="left" rowspan="2">Nosarti et al. (<xref ref-type="bibr" rid="CR39">2000</xref>), UK</td><td align="left" rowspan="2">Cross-sectional</td><td align="left" rowspan="2">692 women</td><td align="left" rowspan="2">Breast cancer</td><td align="left" rowspan="2">M</td><td align="left">Women who delayed because they feared a cancer diagnosis had the highest median delay</td></tr><tr><td align="left">Long delayers were characterized by poor health awareness about hypothetical breast symptoms and by fear and high levels of psychological morbidity</td></tr><tr><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR9">2001</xref>), UK</td><td align="left">Cross-sectional</td><td align="left">46 women</td><td align="left">Breast cancer</td><td align="left">M</td><td align="left">Delayers expressed more fear about the consequences of diagnosis and treatment of breast cancer</td></tr><tr><td align="left" rowspan="2">Meechan et al. (<xref ref-type="bibr" rid="CR32">2003</xref>), New Zealand</td><td align="left" rowspan="2">Cross-sectional</td><td align="left" rowspan="2">85 women</td><td align="left" rowspan="2">Breast cancer</td><td align="left" rowspan="2">S</td><td align="left">A significant correlation was found between patient’s delay and emotional response to symptom discovery—high levels of emotional response were associated with shorter delay (<italic>P</italic> = 0.01)</td></tr><tr><td align="left">There were no association between delay time and fear of cancer treatment</td></tr><tr><td align="left">Mor et al. (<xref ref-type="bibr" rid="CR35">1990</xref>),<break></break>US</td><td align="left">Cross-sectional</td><td align="left">121 patients with lung cancer<break></break>214 patients with breast cancer<break></break>290 patients with colorectal cancer</td><td align="left">Lung cancer<break></break>Breast cancer<break></break>Colorectal cancer</td><td align="left">M</td><td align="left">17% of delayers reported fear of discovering the cause of their symptoms as a reason of delaying</td></tr><tr><td align="left" rowspan="2">de Nooijer et al. (<xref ref-type="bibr" rid="CR13">2001a</xref>), The Netherlands</td><td align="left" rowspan="2">Cross-sectional</td><td align="left" rowspan="2">23 patients</td><td align="left" rowspan="2">Cancer</td><td align="left" rowspan="2">M</td><td align="left">Panic shortened appraisal delay</td></tr><tr><td align="left">Shame or embarrassment and lack of worry about the nature of the symptom increased patient’s delay</td></tr><tr><td align="left" rowspan="2">de Nooijer et al. (<xref ref-type="bibr" rid="CR14">2001b</xref>), The Netherlands</td><td align="left" rowspan="2">Cross-sectional</td><td align="left" rowspan="2">23 patients</td><td align="left" rowspan="2">Cancer</td><td align="left" rowspan="2">M</td><td align="left">Panic and being anxious stimulated patients to consult with GP within few hours</td></tr><tr><td align="left">Lack of worry was an impeding factor</td></tr><tr><td align="left" rowspan="2">Brochez et al. (<xref ref-type="bibr" rid="CR6">2001</xref>), Belgium</td><td align="left" rowspan="2">Cross-sectional</td><td align="left" rowspan="2">130 patients (89 women, 41 men)</td><td align="left" rowspan="2">Melanoma</td><td align="left" rowspan="2">M</td><td align="left">Worried patients tended to have a longer patient’s delay, although the difference was not statistically significant</td></tr><tr><td align="left">Patients who were worried about their lesion more frequently consulted a dermatologist than those who were not anxious (χ<sup>2</sup> = 4.95, <italic>P</italic> = 0.03)</td></tr><tr><td align="left">Rozniatowski et al. (<xref ref-type="bibr" rid="CR44">2005</xref>), France</td><td align="left">Cross-sectional</td><td align="left">100 patients</td><td align="left">Head and neck cancer</td><td align="left">S</td><td align="left">In delayers a lack of anxiety and depressive symptoms was observed; non-delayers presented a high level of anxiety (<italic>P</italic> < 0.0001)</td></tr><tr><td align="left">Ristvedt and Trinkaus (<xref ref-type="bibr" rid="CR43">2005</xref>), USA</td><td align="left">Cross-sectional</td><td align="left">69 patients</td><td align="left">Rectal cancer</td><td align="left">M</td><td align="left">Low scores in anxiety in STAI-T were associated with more favorable judgments of overall prior health (<italic>P</italic> = 0.025) and with fewer doctor visits (<italic>P</italic> = 0.041), but were not associated with cancer screening.</td></tr><tr><td align="left">Dracup et al. (1997), North America</td><td align="left">Cross-sectional</td><td align="left">Patients enrolled to the GUSTO trial <italic>N</italic> = 277</td><td align="left">AMI</td><td align="left">M</td><td align="left">Delayers reported being worried about troubling others with a request for assistance (<italic>P</italic> = 0.001) and feared of consequences of seeking help (<italic>P</italic> = 0.02)</td></tr><tr><td align="left">McKinley et al. (<xref ref-type="bibr" rid="CR31">2000</xref>) Australia</td><td align="left">Cross-sectional</td><td align="left">277 North Americans 147 Australians</td><td align="left">AMI</td><td align="left">I</td><td align="left">Fearing the financial consequences of seeking help were associated with longer delay in North American patients, but not in Australian</td></tr><tr><td align="left">Kentsch et al. (<xref ref-type="bibr" rid="CR24">2002</xref>) Germany</td><td align="left"></td><td align="left">739 patients</td><td align="left">AMI</td><td align="left">M</td><td align="left">Short decision time (< 1 h) was associated with death anxiety and with being scared of immediate hospitalization</td></tr><tr><td align="left">Moser et al. (<xref ref-type="bibr" rid="CR36">2005</xref>)</td><td align="left">Cross-sectional</td><td align="left">194 patients</td><td align="left">AMI</td><td align="left">M</td><td align="left">Patients whose symptoms were perceived as serious (<italic>P</italic> = 0.004) and felt anxious about them (<italic>P</italic> = 0.04) delayed less than patients who did not view their symptoms as serious or experienced anxiety about them</td></tr></tbody></table></table-wrap></p><p>In the selected papers, information about patient’s delay was obtained from structured or semi-structured interviews with patients or from medical records. The questionnaires contained parts in which the patients were asked about delay and the reasons for delay (Brochez et al. <xref ref-type="bibr" rid="CR6">2001</xref>; Burgess et al. <xref ref-type="bibr" rid="CR7">1998</xref>; Mor et al. <xref ref-type="bibr" rid="CR35">1990</xref>), or the data about delay was obtained from medical records (Dracup and Moser <xref ref-type="bibr" rid="CR18">1997</xref>; McKinley et al. <xref ref-type="bibr" rid="CR31">2000</xref>; Meechan et al. <xref ref-type="bibr" rid="CR32">2003</xref>; Moser et al. <xref ref-type="bibr" rid="CR36">2005</xref>). Measuring the concept of fear varied in the selected articles from spontaneous sentences from patients about their fear to standardized measures, where fear was expressed in numbers. Although reliable, validated and standardized measures to assess fear or anxiety are widely used in diagnosis and research [such as the Hospital Anxiety and Depression Scale (HADS), State-Trait Anxiety Inventory—Trait scale (STAI-T), the Structured Clinical Interview (SCID), the Response to Symptoms Questionnaire and the Bedford College Life Events and Difficulties Schedule (LEDS)], such measures were used in only six of the studies (Burgess et al. <xref ref-type="bibr" rid="CR8">2000</xref>; Dracup and Moser <xref ref-type="bibr" rid="CR18">1997</xref>; Moser et al. <xref ref-type="bibr" rid="CR36">2005</xref>; Ristvedt and Trinkaus <xref ref-type="bibr" rid="CR43">2005</xref>; Rozniatowski et al. <xref ref-type="bibr" rid="CR44">2005</xref>). In 11 of the 15 analyzed studies, expressions of patients were investigated using a few items from a larger, non-standardized questionnaire or a semi-structured interview. In addition to standardized questionnaires, several authors also used qualitative measures covering many aspects of various domains of the patient’s life. They offer a place for spontaneous expressions from the patient’s point of view.</p></sec><sec id="Sec6"><title>How does the intensity of fear influence patient’s delay?</title><p>Words which described the intensity of fear varied in the reviewed studies from ‘being worried’ to ‘have a fear’, ‘be anxious’, ‘in panic’ or ‘feel death anxiety’. This sequence reflects the intensity of the emotion of fear.</p></sec><sec id="Sec7"><title>Cancer</title><p>Being only ‘worried’ by the first signs of disease is not enough stimulus for seeking help in patients with cancer. It appears that patients who were worried tended to have longer patient’s delay than those who were not worried, although the difference were not statistically significant (<italic>P</italic> = 0.07) (Brochez et al. <xref ref-type="bibr" rid="CR6">2001</xref>). But the same authors also found that patients who were worried about their lesion more frequently consulted a dermatologist than those who were not anxious at all (<italic>P</italic> = 0.03). It can be hypothesized that being worried has no impact on the decision-making process to visit a specialist for the first time, but that it does have an impact on the patient’s wish to be treated.</p><p>Results of the studies on ‘having fear’ are contradictory. In patients with different types of carcinoma, 17% of the delayers reported fear of discovering the cause of their symptoms as the reason for delaying. Delayers with breast cancer mentioned this reason more often than patients with lung or colorectal carcinoma (20.7% vs. 10.5 and 16%) (Mor et al. <xref ref-type="bibr" rid="CR35">1990</xref>). It was also found that women who expressed more fear about the consequences of diagnosis and the treatment of the disease delayed longer (Burgess et al. <xref ref-type="bibr" rid="CR9">2001</xref>). In a different study, those who delayed were those who reported less fear after discovering the first symptoms of disease (<italic>P</italic> = 0.05); but in contrast, in the same sample more psychological distress (as expressed by the GHQ-12 scores) was associated with longer delay, especially in those who did indeed turn out to have breast cancer (Burgess et al. <xref ref-type="bibr" rid="CR7">1998</xref>; Nosarti et al. <xref ref-type="bibr" rid="CR39">2000</xref>). In a later analysis, it was found that the influence of fear on decision making is related to various aspects of treatment, the seriousness of the disease, dying or leaving relatives behind (de Nooijer et al. <xref ref-type="bibr" rid="CR14">2001b</xref>).</p><p>‘Being anxious’ appears to be a factor which stimulates decision-making in women with breast cancer (Nosarti et al. <xref ref-type="bibr" rid="CR39">2000</xref>). This finding was confirmed in a study which shows that there was a lack of anxiety and depression symptoms in patients with large tumor lesions who delayed consultation, whereas patients with smaller lesions with a short delay presented high levels of anxiety (<italic>P</italic> = 0.00001) (Rozniatowski et al. <xref ref-type="bibr" rid="CR44">2005</xref>). Using a regression model, not having a breast lump (<italic>β</italic> = −0.35, <italic>t</italic> = −3.30, <italic>P</italic> = 0.0001) and lower initial symptom distress (<italic>β</italic> = −0.32, <italic>t</italic> = −3.03, <italic>P</italic> = 0.001) were found to be the factors most predictive of patient’s delay (Meechan et al. <xref ref-type="bibr" rid="CR32">2003</xref>). However, in other studies, different results were found. It was not confirmed that being clinically anxious or depressed before or around the time of symptom discovery increases the risk of a woman with symptoms delaying her presentation for medical attention (Burgess et al. <xref ref-type="bibr" rid="CR8">2000</xref>). Similar results were reported in a study by Ristvedt and Trinkaus (<xref ref-type="bibr" rid="CR43">2005</xref>), in which anxiety was measured with a standardized STAI-T questionnaire. Lower scores on STAI-T were associated with fewer doctor visits, so it can be hypothesized that the level of anxiety has a positive correlation with patient’s delay (Ristvedt and Trinkaus <xref ref-type="bibr" rid="CR43">2005</xref>). However, in the same article, the authors found that people characterized as fearful, shy, tense, and worried had a significantly shorter delay time (Ristvedt and Trinkaus <xref ref-type="bibr" rid="CR43">2005</xref>).</p><p>Patients who reacted to first symptoms with ‘panic’ or were ‘extremely alarmed’ or ‘anxious’ sought medical help or visited the EMS within a few hours (de Nooijer et al. <xref ref-type="bibr" rid="CR14">2001b</xref>). The study showed that panic stimulated patients into inferring illness from the symptoms and shortening appraisal delay as a result.</p></sec><sec id="Sec8"><title>Acute myocardial infarction</title><p>Studies about worries regarding AMI itself were absent, but several studies confirmed that patients with AMI who delayed seeking assistance reported being worried about troubling others with a request for assistance (<italic>P</italic> = 0.001) and feared the financial consequences of seeking help (<italic>P</italic> = 0.02) (Dracup and Moser <xref ref-type="bibr" rid="CR18">1997</xref>; McKinley et al. <xref ref-type="bibr" rid="CR31">2000</xref>). In patients with AMI ‘having fear’ is associated with hesitation in seeking help and therefore with longer patient’s delay (Burgess et al. <xref ref-type="bibr" rid="CR9">2001</xref>). Those patients with AMI who were least anxious about their symptoms delayed seeking medical attention (Moser et al. <xref ref-type="bibr" rid="CR36">2005</xref>). Short decision time (<1 h) was associated in the case of AMI with evaluating symptoms as threatening or dangerous and causing a feeling of ‘panic’ and ‘death anxiety’ (Kentsch et al. <xref ref-type="bibr" rid="CR24">2002</xref>).</p><p>A summary of the findings is presented in Table <xref rid="Tab3" ref-type="table">3</xref>.<table-wrap id="Tab3"><label>Table 3</label><caption><p>Patient’s delay and stages of fear</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left"></th><th align="left">Results</th><th align="left">Cancer</th><th align="left">AMI</th></tr></thead><tbody><tr><td align="left">Worry</td><td align="left">Worry has no impact on patient’s delay</td><td align="left">Brochez et al. (<xref ref-type="bibr" rid="CR6">2001</xref>)</td><td align="left"></td></tr><tr><td align="left" rowspan="2">Fear</td><td align="left">Fear shortened time of patient’s delay</td><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR7">1998</xref>), Nosarti et al. (<xref ref-type="bibr" rid="CR39">2000</xref>)</td><td align="left"></td></tr><tr><td align="left">Fear prolonged time of patient’s delay</td><td align="left">Mor et al. (<xref ref-type="bibr" rid="CR35">1990</xref>), Burgess et al. (<xref ref-type="bibr" rid="CR9">2001</xref>)</td><td align="left">Dracup and Moser (<xref ref-type="bibr" rid="CR18">1997</xref>), McKinley et al. (<xref ref-type="bibr" rid="CR31">2000</xref>)</td></tr><tr><td align="left" rowspan="2">Anxiety</td><td align="left">Anxiety shortened time of patient’s delay</td><td align="left">Nosarti et al. (<xref ref-type="bibr" rid="CR39">2000</xref>) Rozniatowski et al. (<xref ref-type="bibr" rid="CR44">2005</xref>) Meechan et al. (<xref ref-type="bibr" rid="CR32">2003</xref>) Ristvedt and Trinkaus (<xref ref-type="bibr" rid="CR43">2005</xref>)</td><td align="left">Moser et al. (<xref ref-type="bibr" rid="CR36">2005</xref>)</td></tr><tr><td align="left">Anxiety prolonged time of patient’s delay</td><td align="left">Burgess et al. (<xref ref-type="bibr" rid="CR8">2000</xref>) Ristvedt and Trinkaus (<xref ref-type="bibr" rid="CR43">2005</xref>)</td><td align="left"></td></tr><tr><td align="left">Panic/Death anxiety</td><td align="left">Panic or death anxiety shortened time of patient’s delay</td><td align="left">De Nooijer et al. (2001)</td><td align="left">Kentsch et al. (<xref ref-type="bibr" rid="CR24">2002</xref>)</td></tr></tbody></table></table-wrap></p></sec></sec><sec id="Sec9"><title>Discussion</title><sec id="Sec10"><title>Summary of the main findings</title><p>This paper presents the results of 15 studies which investigated patient’s delay with the intensity of fear. Levels of intensity of fear were constructed after a detailed reading of the studies. These stages of fear were: ‘being worried’, ‘having fear’, ‘being anxious’, ‘being in panic’ and ‘feeling death anxiety’. Differences in fear between cancer and AMI patients were expected. ‘Being worried’, ‘having fear’, and ‘being anxious’ were mainly present in cancer patients. ‘Being worried’ is not enough for seeking help with cancer, but it starts the process of internal thinking about the possibility of being treated. The emotion ‘fear’ seems to be a factor for longer delay, but the decision process in patients experiencing fear was also influenced by other factors, such as embarrassment, pressure from a patient’s relatives or fear of financial consequences. ‘Being anxious’ had a direct impact on shortening patient’s delay. These emotions were not present in the case of AMI, but the feeling of ‘panic’ or ‘death anxiety’ present in cancer and AMI was associated with seeking help within a few hours of the appearance of the first symptoms of illness; the impact of this type of fear on the patient’s delay was similar in both diagnoses.</p></sec><sec id="Sec11"><title>Meaning of the results</title><p>The emotion of fear could lead to either help-seeking behavior or to delay, depending on the cause of the fear and the way people cope with it. The intensity of negative feelings seems to be an important predictor of a patient’s help-seeking behavior. Of the defined levels of fear (‘being worried’, ‘having fear’, ‘being anxious’, ‘in panic’ and ‘feeling death anxiety’), the latter two have a significantly positive effect on decision-making in help-seeking behavior. Either the first two have no influence on patient’s delay (worry) or their impact is ambivalent (fear). Although there are differences in the onset of both diseases, the emotional reaction upon first signs or symptoms were similar. ‘Having fear’ from treatment, from the consequences of diagnose or from bothering others with bad feelings slowed help-seeking behavior in cancer and in AMI. On the other hand, when patients feel anxiety or panic, according to the results of our review, they seek help sooner in both cases. On this basis, it can be expected that people who are more frightened will have a greater chance of getting medical help earlier than those without such a strong emotional response like in a slow progressive disease—cancer and sometimes also in the case of acute myocardial infarction.</p><p>The results of this review also show that minimizing the seriousness of symptoms was negatively correlated with the intensity of fear, making seeking treatment less urgent and producing longer delay. Some authors call this phenomenon health-related ‘defensive bias’ (Caplan and Helzlsouer <xref ref-type="bibr" rid="CR11">1992</xref>), ‘optimistic bias’ (Andersen et al. <xref ref-type="bibr" rid="CR1">1995</xref>) or ‘denial’ (Moyer and Levine <xref ref-type="bibr" rid="CR38">1999</xref>), which leads to longer patient’s delay. On the other hand, these behavioral variables were found to be associated with the degree of patient’s understanding of the treatment, which is why some authors suggest speaking about ‘indecision’ rather than about ‘denial’ (Leslie et al. <xref ref-type="bibr" rid="CR27">2000</xref>; Temoshok et al. <xref ref-type="bibr" rid="CR48">1984</xref>).</p><p>Another explanation for the connection between fear and patient’s delay is that people also differ in their perception of symptoms. Some people simply have more symptoms than others, or they differ in the sensation they experience from the same symptom (de Nooijer et al. <xref ref-type="bibr" rid="CR14">2001b</xref>). It was observed that some people focus on bodily symptoms more intensely than other people, leading to increased reports of symptoms (Pennebaker <xref ref-type="bibr" rid="CR41">1982</xref>). Recognizing pain symptoms has a positive effect on rising anxiety and thus on decision-making in patients with acute myocardial infarction and breast cancer (Caplan and Helzlsouer <xref ref-type="bibr" rid="CR11">1992</xref>; Dracup and Moser <xref ref-type="bibr" rid="CR17">1991</xref>), but this was not proven in all of the studies (Cameron et al. <xref ref-type="bibr" rid="CR10">1993</xref>). The considerable difference between acute pain in cases of acute myocardial infarction and chronic pain in breast cancer occurring in later stages of the disease also has to be taken into account. In the variables of patient’s delay between patients with acute myocardial infarction experiencing pain and those without pain, no significant correlations were found (Dracup and Moser <xref ref-type="bibr" rid="CR18">1997</xref>). Similar results were found in women with breast cancer (Meechan et al. <xref ref-type="bibr" rid="CR32">2003</xref>).</p></sec><sec id="Sec12"><title>Strengths and limitations</title><p>This study is the first which systematically summarizes the influence of the intensity of fear in patient’s delay in both a slow, progressive disease and in an acute disease. A limitation of this study was that the analyzed studies did not use the same instruments for measuring fear or anxiety. They varied from standardized instruments like STAI-T, HADS or LEDS to information from semi-structured interviews or self-created questionnaires. Measurement of fear was not the primary aim in several analyzed studies; therefore, the authors did not pay such detailed attention to analyzing the connection of fear or anxiety with patient’s delay. Another limitation of the analyses of fear is that, like in all studies examining the relationship between level of fear/anxiety and delay, all patients were assessed retrospectively after they had been admitted to the hospital. The generalizability of the results may be limited by a potential publication bias towards positive findings.</p><p>The qualitative evaluation of studies may be also interpreted. Only six of the 15 selected articles use validated measurements of fear or anxiety. In the remaining cases, fear was not the main aim of the study, but it was one of the possible reasons for patient’s delay. In six cases, the authors used the patient’s delay as continuous variable in the analyses, a fact viewed as a negative factor in this paper. Patient’s delay should be interpreted from a disease-specific point of view, which is why it is preferable to speak about patient’s delay only in cases when a patient comes to a health professional after a certain moment which is related to the diagnose. A lack of operationalization of fear or anxiety was observed especially in studies where the author did not used validated measurements. Patients in these studies just reported fear for various reasons, but its intensity or specification is missing. The results of the evaluation of the studies reviewed in this paper should inspire us to be more focused primarily on the association between patient’s delay and fear and anxiety.</p></sec></sec><sec id="Sec13"><title>Conclusion</title><p>There are two ways of coping with fear—fight or flight. The avoidance behavior associated with reduction of fear and anxiety seems to be helpful in the short term because of the reduction of negative feelings, but it may be counterproductive in the long run (Leeuw et al. <xref ref-type="bibr" rid="CR25">2006</xref>). Our data explored the possible reasons for patient’s delay. The lack of emotional response on symptom discovery can lead to patient’s delay in both AMI and cancer. The level of fear evidently influences the decision-making process in patients on help-seeking and hence, this important factor should be taken into account when facilitating help-seeking by patients, and especially in cases of low level of fear, encouraging them to seek out medical care. Results of the study suggest that fear might not be disease specific and might have a similar impact on the decision making process in acute as well as slow progressive diagnoses. Unfortunately, the results needed to clarify this point regarding other diseases are missing.</p><p>Knowledge about factors associated with patient’s delay also could be used in preparing educational programs. Studies suggest that psychological rather than demographic factors are the main predictors of delay time (Nosarti et al. <xref ref-type="bibr" rid="CR39">2000</xref>). Therefore, information about clinical variables could be included in the content of such programs, though knowledge about psychological phenomena such as fear and worry can be a more meaningful factor affecting their efficiency. It was observed that health education about cancer mostly tells people how to identify cancer symptoms but provides little about the consequences of a cancer diagnosis (Burgess et al. <xref ref-type="bibr" rid="CR9">2001</xref>). Moreover, it was shown that when patients are prepared to anticipate an aversive situation, they are more likely to cope effectively (Dracup and Moser <xref ref-type="bibr" rid="CR18">1997</xref>). Further successful cooperation after a patient’s first visit to the medical doctor is conditioned by the doctor’s communicative skills and his/her proper counseling (Matejic et al. <xref ref-type="bibr" rid="CR29">2008</xref>). Health programs for early help-seeking in case of the appearance of the first symptoms of cancer which are oriented only on information about the disease and not on the positive aspects of early diagnosis may increase the fear of a certain diagnosis, which may lead to two types of behavior: denying the initial symptoms or being hypersensitive to any type of small discomforts in the body. Both reactions are strategies with low efficacy for coping with the disease process and may lead to difficulties in help-seeking behavior, a delay which in turn does not contribute to the reduction in mortality aimed for by health policy in most countries.</p></sec></body><back><ack><p>This work was supported by the Slovak Research and Development Agency under contract No. APVV-20-038305.</p><p><bold>Open Access</bold> This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.</p></ack><ref-list id="Bib1"><title>References</title><ref id="CR1"><mixed-citation publication-type="journal"><person-group 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