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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">How many people are living with undiagnosed HIV infection? An estimate for Italy, based on surveillance data</title><author><name sortKey="Mammone, Alessia" sort="Mammone, Alessia" uniqKey="Mammone A" first="Alessia" last="Mammone">Alessia Mammone</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author><author><name sortKey="Pezzotti, Patrizio" sort="Pezzotti, Patrizio" uniqKey="Pezzotti P" first="Patrizio" last="Pezzotti">Patrizio Pezzotti</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Regine, Vincenza" sort="Regine, Vincenza" uniqKey="Regine V" first="Vincenza" last="Regine">Vincenza Regine</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Camoni, Laura" sort="Camoni, Laura" uniqKey="Camoni L" first="Laura" last="Camoni">Laura Camoni</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Puro, Vincenzo" sort="Puro, Vincenzo" uniqKey="Puro V" first="Vincenzo" last="Puro">Vincenzo Puro</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author><author><name sortKey="Suligoi, Barbara" sort="Suligoi, Barbara" uniqKey="Suligoi B" first="Barbara" last="Suligoi">Barbara Suligoi</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Girardi, Enrico" sort="Girardi, Enrico" uniqKey="Girardi E" first="Enrico" last="Girardi">Enrico Girardi</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26807973</idno><idno type="pmc">4819953</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819953</idno><idno type="RBID">PMC:4819953</idno><idno type="doi">10.1097/QAD.0000000000001034</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000077</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">How many people are living with undiagnosed HIV infection? An estimate for Italy, based on surveillance data</title><author><name sortKey="Mammone, Alessia" sort="Mammone, Alessia" uniqKey="Mammone A" first="Alessia" last="Mammone">Alessia Mammone</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author><author><name sortKey="Pezzotti, Patrizio" sort="Pezzotti, Patrizio" uniqKey="Pezzotti P" first="Patrizio" last="Pezzotti">Patrizio Pezzotti</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Regine, Vincenza" sort="Regine, Vincenza" uniqKey="Regine V" first="Vincenza" last="Regine">Vincenza Regine</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Camoni, Laura" sort="Camoni, Laura" uniqKey="Camoni L" first="Laura" last="Camoni">Laura Camoni</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Puro, Vincenzo" sort="Puro, Vincenzo" uniqKey="Puro V" first="Vincenzo" last="Puro">Vincenzo Puro</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author><author><name sortKey="Ippolito, Giuseppe" sort="Ippolito, Giuseppe" uniqKey="Ippolito G" first="Giuseppe" last="Ippolito">Giuseppe Ippolito</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author><author><name sortKey="Suligoi, Barbara" sort="Suligoi, Barbara" uniqKey="Suligoi B" first="Barbara" last="Suligoi">Barbara Suligoi</name><affiliation><nlm:aff id="aff2">Istituto Superiore di Sanità, Rome, Italy.</nlm:aff></affiliation></author><author><name sortKey="Girardi, Enrico" sort="Girardi, Enrico" uniqKey="Girardi E" first="Enrico" last="Girardi">Enrico Girardi</name><affiliation><nlm:aff id="aff1">‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</nlm:aff></affiliation></author></analytic><series><title level="j">AIDS (London, England)</title><idno type="ISSN">0269-9370</idno><idno type="eISSN">1473-5571</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To estimate the size and characteristics of the undiagnosed HIV population in Italy in 2012 applying a method that does not require surveillance data from the beginning of the HIV epidemic.</p></sec><sec sec-type="methods"><title>Methods:</title><p>We adapted the method known as ‘London method 2’; the undiagnosed population is estimated as the ratio between the estimated annual number of simultaneous HIV/clinical AIDS diagnoses and the expected annual progression rate to clinical AIDS in the undiagnosed HIV population; the latter is estimated using the CD4<sup>+</sup> cell count distribution of asymptomatic patients reported to surveillance. Under-reporting/ascertainment of new diagnoses was also considered. Also, the total number of people living with HIV was estimated.</p></sec><sec sec-type="results"><title>Results:</title><p>The undiagnosed HIV population in 2012 was 13 729 (95% confidence interval: 12 152–15 592), 15 102 (13 366–17 151) and 16 475 (14 581–18 710), assuming no under-reporting/ascertainment, 10 and 20% of under-reporting/ascertainment, respectively. The percentage of undiagnosed cases was higher among HIV people aged below 25 years (25–28%), MSM (16–19%) and people born abroad (16–19%), whereas it was small among injection drug users (3%).</p></sec><sec sec-type="conclusion"><title>Conclusion:</title><p>The estimate of people in Italy with undiagnosed HIV in 2012 was in a plausible range of 12 000–18 000 cases, corresponding to 11–13% of the overall prevalence. The method is straightforward to implement only requiring annual information from the HIV surveillance system about CD4<sup>+</sup> cell count and clinical stage at HIV diagnosis. Thus, it could be used to monitor if a certain prevention initiative lead to the reduction of the undiagnosed HIV population over time. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">AIDS</journal-id><journal-id journal-id-type="iso-abbrev">AIDS</journal-id><journal-id journal-id-type="publisher-id">AIDS</journal-id><journal-title-group><journal-title>AIDS (London, England)</journal-title></journal-title-group><issn pub-type="ppub">0269-9370</issn><issn pub-type="epub">1473-5571</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26807973</article-id><article-id pub-id-type="pmc">4819953</article-id><article-id pub-id-type="doi">10.1097/QAD.0000000000001034</article-id><article-categories><subj-group subj-group-type="heading"><subject>Epidemiology and Social: CONCISE COMMUNICATION</subject></subj-group></article-categories><title-group><article-title>How many people are living with undiagnosed HIV infection? An estimate for Italy, based on surveillance data</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mammone</surname><given-names>Alessia</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pezzotti</surname><given-names>Patrizio</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Regine</surname><given-names>Vincenza</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Camoni</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Puro</surname><given-names>Vincenzo</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ippolito</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Suligoi</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Girardi</surname><given-names>Enrico</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib></contrib-group><aff id="aff1"><label>a</label>‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS</aff><aff id="aff2"><label>b</label>Istituto Superiore di Sanità, Rome, Italy.</aff><author-notes><corresp>Correspondence to Alessia Mammone, PhD, ’L. Spallanzani’ National Institute for Infectious Diseases, IRCCS, Via Portuense, 292, 00149 Rome, Italy.Tel: +39 06 55170919; fax: +39 06 5582825; e-mail: <email>alessia.mammone@inmi.it</email></corresp></author-notes><pub-date pub-type="ppub"><day>24</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>3</month><year>2016</year></pub-date><volume>30</volume><issue>7</issue><fpage>1131</fpage><lpage>1136</lpage><history><date date-type="received"><day>12</day><month>6</month><year>2015</year></date><date date-type="rev-recd"><day>23</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>05</day><month>1</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0./"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0.">http://creativecommons.org/licenses/by-nc-nd/3.0.</ext-link></license-p></license></permissions><self-uri xlink:type="simple" xlink:href="aids-30-1131.pdf"></self-uri><abstract><sec><title>Objective:</title><p>To estimate the size and characteristics of the undiagnosed HIV population in Italy in 2012 applying a method that does not require surveillance data from the beginning of the HIV epidemic.</p></sec><sec sec-type="methods"><title>Methods:</title><p>We adapted the method known as ‘London method 2’; the undiagnosed population is estimated as the ratio between the estimated annual number of simultaneous HIV/clinical AIDS diagnoses and the expected annual progression rate to clinical AIDS in the undiagnosed HIV population; the latter is estimated using the CD4<sup>+</sup> cell count distribution of asymptomatic patients reported to surveillance. Under-reporting/ascertainment of new diagnoses was also considered. Also, the total number of people living with HIV was estimated.</p></sec><sec sec-type="results"><title>Results:</title><p>The undiagnosed HIV population in 2012 was 13 729 (95% confidence interval: 12 152–15 592), 15 102 (13 366–17 151) and 16 475 (14 581–18 710), assuming no under-reporting/ascertainment, 10 and 20% of under-reporting/ascertainment, respectively. The percentage of undiagnosed cases was higher among HIV people aged below 25 years (25–28%), MSM (16–19%) and people born abroad (16–19%), whereas it was small among injection drug users (3%).</p></sec><sec sec-type="conclusion"><title>Conclusion:</title><p>The estimate of people in Italy with undiagnosed HIV in 2012 was in a plausible range of 12 000–18 000 cases, corresponding to 11–13% of the overall prevalence. The method is straightforward to implement only requiring annual information from the HIV surveillance system about CD4<sup>+</sup> cell count and clinical stage at HIV diagnosis. Thus, it could be used to monitor if a certain prevention initiative lead to the reduction of the undiagnosed HIV population over time. It can also be easily implemented in other countries collecting the same basic information from the HIV surveillance system.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>back-calculation</kwd><kwd>CD4<sup>+</sup> cell count</kwd><kwd>HIV surveillance</kwd><kwd>HIV undiagnosed infections</kwd><kwd>prevalence</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>To control the HIV epidemic, it is necessary to develop, plan and implement innovative strategies to find undiagnosed persons and engage them in care and treatment. A preliminary step to reach this objective is to regularly monitor the size and characteristics of the undiagnosed population and properly address interventions, i.e. according to age, sex and sexual behavior.</p><p>Broadly, three approaches have been used to estimate the number of people with undiagnosed HIV: prevalence surveys [<xref rid="R1" ref-type="bibr">1</xref>], extended back-calculation on HIV and AIDS data [<xref rid="R2" ref-type="bibr">2</xref>,<xref rid="R3" ref-type="bibr">3</xref>], and other statistical models based on the synthesis of various data sources [<xref rid="R4" ref-type="bibr">4</xref>,<xref rid="R5" ref-type="bibr">5</xref>]. All methods are quite complex and demand surveillance systems that have been in place for a long time, along with population-based or community-based surveys.</p><p>In Italy, national surveillance of new HIV diagnoses was only established in 2008, and prevalence surveys are not routinely carried out; thus, given the available data, it is necessary to consider alternative methods to estimate the undiagnosed population.</p><p>The objective of this study was to provide an estimate of the undiagnosed HIV population in Italy in 2012, also stratified by sex, HIV exposure category, age group, and country of birth, using a simple approach of combining routine surveillance data with estimates of progression to AIDS before HAART introduction. An estimate of the overall prevalence of persons living with HIV in Italy in 2012 was also provided.</p></sec><sec sec-type="methods"><title>Methods</title><p>The method is a modification of the ‘London method 2’ [<xref rid="R6" ref-type="bibr">6</xref>–<xref rid="R8" ref-type="bibr">8</xref>] and it does not require surveillance data from the beginning of the HIV epidemic. Very briefly, the undiagnosed HIV population is estimated as the ratio between the estimated annual number of simultaneous HIV/clinical AIDS diagnoses and the expected annual progression rate to AIDS in the undiagnosed population. This progression rate was estimated considering the annual AIDS incidence by CD4<sup>+</sup> cell count in untreated patients before the introduction of HAART (as derived from by cohort studies, [<xref rid="R9" ref-type="bibr">9</xref>]) and the CD4<sup>+</sup> cell count distribution of newly diagnosed asymptomatic HIV reported to surveillance.</p><p>Thus, the annual number of cases with undiagnosed HIV, <italic>n</italic>, can be estimated by: <disp-formula id="MU1"><graphic xlink:href="aids-30-1131-g001.jpg" position="float"></graphic></disp-formula></p><p>where <italic>S</italic> is the estimate of simultaneous HIV/clinical AIDS diagnoses, <italic>p</italic><sub><italic>i</italic></sub> is the proportion of patients in CD4<sup>+</sup>-stratum <italic>i</italic> among asymptomatic, <italic>r</italic><sub><italic>i</italic></sub> is the annual AIDS rate in CD4<sup>+</sup>-stratum <italic>i</italic>, <italic>k</italic> is the number of CD4<sup>+</sup> cell count classes considered.</p><p>We considered new HIV diagnoses in 2012, reported by June 2014, to the Italian HIV surveillance system [<xref rid="R10" ref-type="bibr">10</xref>]. Available information were date of birth, sex, nationality, date of diagnosis, reasons for testing, HIV exposure category, CD4<sup>+</sup> cell count and clinical stage at HIV diagnosis (i.e. asymptomatic stage, symptomatic non-AIDS stage, AIDS stage).</p><p>Also, different scenarios about under-reporting/ascertainment of HIV/AIDS were considered to estimate the undiagnosed population.</p><p>We estimated the overall HIV prevalence in Italy in 2012 through several steps: the number of people diagnosed and in care in 2012 was retrieved from a national survey [<xref rid="R11" ref-type="bibr">11</xref>]. The total number of people diagnosed was obtained considering the estimated percentage of people not retained in care according to a survey performed in three Italian infectious disease clinics [<xref rid="R12" ref-type="bibr">12</xref>]. Finally, the number of people living with HIV was obtained by adding the estimates of undiagnosed HIV cases to the estimates of diagnosed.</p><p>Analyses were performed using R software 3.1.0 [<xref rid="R13" ref-type="bibr">13</xref>]; multiple imputation was implemented through mi R-package [<xref rid="R14" ref-type="bibr">14</xref>].</p></sec><sec sec-type="results"><title>Results</title><p>There were 4082 new HIV diagnoses in adults (≥15 years of age) reported to the Italian National Surveillance System by July 2014 with an HIV test date in the year 2012. In total 13.8% of the cases had an unknown HIV exposure category, 21.6 and 28.4% had a missing CD4<sup>+</sup> cell count and clinical stage respectively (Supplementary Table 1).</p><p>Table <xref ref-type="table" rid="T1">1</xref> shows the distribution of new HIV diagnosis by clinical stage and CD4<sup>+</sup> cell count at diagnosis and estimated annual rate to clinical AIDS in people with undiagnosed HIV (0.076 and 0.078 for raw and imputed data, respectively). This means that 7.6–7.8% of undiagnosed HIV positive cases would progress to AIDS, unless they were diagnosed with HIV before the end of the year.</p><p>Table <xref ref-type="table" rid="T2">2</xref> shows the estimates of simultaneous HIV/clinical AIDS diagnoses, the number expected to progress to AIDS in that year unless they were diagnosed before, and the number of undiagnosed HIV cases in Italy in 2012 considering three different scenarios about under-reporting. Estimates are stratified according to HIV exposure category, sex, nationality and age group.</p><p>The median estimates of the number of undiagnosed cases vary between 13 729 [95% confidence interval (CI): 12 152–15 592] and 16 475 (95%CI: 14 581–18 710) under the hypothesis of no under-reporting and under-reporting of 20%, respectively; estimates stratified by HIV exposure category evidenced that MSM had the highest estimate of undiagnosed cases whereas the injection drug users (IDU) was the category with the lowest estimate; regarding sex, estimates of undiagnosed HIV+ men were around 4.5 times more than those for women; three times higher for people born in Italy than for those born abroad; regarding age, the highest estimate of undiagnosed cases was for the 35–44 years old group.</p><p>Finally, we estimated that the undiagnosed HIV population in Italy was around 11–13% for an overall prevalence of about 125 000–130 000 cases; regarding the exposure category, it is of note that the estimated percentage of undiagnosed HIV among IDU was around 3% whereas the estimated percentage among MSM accounted for about 16–19%; regarding sex, the estimated percentage was about 7–8% in women compared with 13–15% in men; with respect to the country of birth, the estimated percentage of undiagnosed cases was higher in those born abroad (16–19%) than those born in Italy (10–12%); regarding age groups, the percentage of undiagnosed cases was particularly high among those aged below 25 years old (25–28%) whereas the lowest percentage was among those aged 50–59 years old (Supplementary Table 2).</p></sec><sec sec-type="discussion"><title>Discussion</title><p>The magnitude and characteristics of the undiagnosed HIV population is important for focusing intervention strategies and prevention initiatives. Reducing the prevalence of undiagnosed HIV infection and increasing the proportion of HIV-infected individuals who are aware of their status are important for HIV prevention, as the transmission rate from the unaware group was estimated to be 3.5 times higher than the aware group [<xref rid="R15" ref-type="bibr">15</xref>] and that persons who are undiagnosed accounted for almost one-third of transmissions [<xref rid="R16" ref-type="bibr">16</xref>]. Also, it was estimated that about eight transmissions would be averted per 100 persons newly aware of their infection [<xref rid="R17" ref-type="bibr">17</xref>].</p><p>Thus, increasing the number of HIV-infected persons who are diagnosed and linked with effective care and prevention programs may have the potential to significantly reduce new HIV infections over time. In addition, diagnosed persons can benefit from clinical treatments to prevent immune system damage and opportunistic infections.</p><p>Using routine surveillance data, we estimated that there were about 12 000–18 000 people in Italy with undiagnosed HIV, corresponding to 11–13% of the overall prevalent population with HIV. This estimate is lower than that obtained (19%) from routine HIV testing among persons attending clinics for sexually transmitted infections (STI), in 2013 [<xref rid="R18" ref-type="bibr">18</xref>]. This estimate could be over-biased because of possible nondisclosure of HIV status due to convenience and discomfort in disclosing risky sexual behavior to healthcare professionals [<xref rid="R19" ref-type="bibr">19</xref>,<xref rid="R20" ref-type="bibr">20</xref>].</p><p>The percentage of undiagnosed cases was lower for IDU (around 3.0%) and higher for MSM (16–19%); the low percentage among IDU is likely attributable to routine HIV testing for all people attending drug treatment services since the 1980s, and to the decreasing incidence of new HIV infections in this group [<xref rid="R21" ref-type="bibr">21</xref>]. Stratified estimates also evidenced a higher percentage of undiagnosed men compared with women, in people born abroad compared with those born in Italy, and in people below 25 years old compared with the other age groups.</p><p>The approach we used is simpler than other statistical methods requiring historical data about new HIV/AIDS diagnoses; in particular, only annual routine surveillance data for new HIV diagnoses such as CD4<sup>+</sup> cell count, presence/absence of HIV/AIDS-related symptoms are needed to implement the method. Thus, it could be used for example to evaluate if a particular strategy (e.g. expanded HIV testing in men older than 45, opt-out testing in specific health facilities, rapid-test testing among young people) leads to a reduction of the undiagnosed population from one year to another. A similar approach, (although with different assumptions) the so-called ‘London 1 method’, was recently proposed [<xref rid="R22" ref-type="bibr">22</xref>] to estimate the number of undiagnosed in the lower CD4<sup>+</sup> cell count range (i.e. <200 or <350 cells/μl).</p><p>The estimated overall prevalence of undiagnosed HIV-infected people in Italy are in line with those recently obtained in other countries using statistical/mathematical models: 16–18% in 2009–2010 in United States [<xref rid="R23" ref-type="bibr">23</xref>,<xref rid="R24" ref-type="bibr">24</xref>], 20% in 2010 in France [<xref rid="R25" ref-type="bibr">25</xref>], 17% in United Kingdom in 2014 [<xref rid="R26" ref-type="bibr">26</xref>], 9.4% in Australia in 2013 [<xref rid="R27" ref-type="bibr">27</xref>]. For MSM these percentage were 15% in 2011 in the Netherlands [<xref rid="R28" ref-type="bibr">28</xref>], 13% in Switzerland in 2010 [<xref rid="R29" ref-type="bibr">29</xref>], 22% in England and Wales in 2010 [<xref rid="R30" ref-type="bibr">30</xref>].</p><p>Some issues should be considered. The method mainly relies on the assumption that the CD4<sup>+</sup> cell count distribution in the undiagnosed population is similar to that of newly diagnosed asymptomatic people. This assumption cannot be verified, although the distribution of CD4<sup>+</sup> cell count in asymptomatic people we used was not particularly different from the CD4<sup>+</sup> cell count distribution estimated in undiagnosed [<xref rid="R26" ref-type="bibr">26</xref>,<xref rid="R28" ref-type="bibr">28</xref>], whereas it appeared to be different from that reported in [<xref rid="R30" ref-type="bibr">30</xref>] (Supplementary Table 3). To evaluate the impact of the assumption on the estimates we performed some simulations assuming that the undiagnosed HIV people had ± 5%, ± 10% and ± 15% CD4<sup>+</sup> cell counts, compared with the new asymptomatic HIV diagnoses; the estimates varied up to ± 2500 cases, corresponding up to ± 2% on the overall prevalence.</p><p>Another issue is also the possible under-reporting/ascertainment of both AIDS and HIV diagnoses. Assuming that under-reporting/diagnosis was not different by clinical stage, CD4<sup>+</sup> at diagnosis and the other characteristics considered, a 10% (20%) increase of under-reporting/diagnosis results in about 1% (2%) increase in prevalence of undiagnosed infections (Supplementary Table 2).</p><p>We assumed that the progression rates depend only on CD4<sup>+</sup> cell count and that the estimates before introduction of HAART could be similar to current AIDS progression rates among the undiagnosed. Our method did not consider age [<xref rid="R31" ref-type="bibr">31</xref>] as determinant of progression before introduction of HAART, although such a development could be incorporated to refine the estimates.</p><p>Finally, to estimate the overall prevalence of people living with HIV, we also considered the percentage of those not retained in care. This percentage was considered equal in all subgroups evaluated.</p><p>In conclusion, the estimated undiagnosed HIV population in Italy is in a plausible range of 12 000–18 000 cases, corresponding to 11–13% of the overall prevalence. The approach described can also be easily implemented in other countries where HIV surveillance systems have routinely been collecting data on CD4<sup>+</sup> cell count and clinical stage at diagnosis.</p></sec><sec><title>Acknowledgements</title><p>We thank Nicoletta Orchi, Assunta Navarra, Claudio Angeletti, (‘L. Spallanzani’ National Institute for Infectious Diseases, IRCCS, Rome, Italy), Mariangela Raimondo (Istituto Superiore di Sanità, Rome, Italy) who provided comments in the preliminary discussion about this work.</p><p>We thank also Matthias An der Heiden (Germany), Andre Sasse (Belgium), Zheng Yin (United Kingdom), Stephane Le Vu (France), Anastasia Pharris (ECDC), who provided the CD4<sup>+</sup> cell count distribution among newly diagnosed HIV-infected cases reported to the national surveillance system.</p><p>We are extremely grateful to Andrew Phillips and Rebecca Lodwick who provided their insight on the initial idea of the approach we used here; and Kholoud Porter who provided the AIDS rate by CD4<sup>+</sup> cell count from CASCADE Collaboration.</p><p>Source of funding: The Ministry of Health, Progetto di Ricerca RF-IMI-2009-1302855 – Conv.ne I.S.S. n 40H78. A.M. is also the recipient of an unrestricted grant from Gilead (2014 Fellowship Program).</p><p>A.M., P.P., and E.G. conceived the initial idea and the study design; A.M. and P.P. implemented the model and drafted the manuscript; V.R. and L.C. managed the database of National Surveillance System and extracted the data; B.S. coordinated the National Surveillance System and contributed to data interpretation; V.P. and G.I. contributed to data interpretation; A.M. and P.P. revised the manuscript. 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non-AIDS</td><td colspan="2" rowspan="1">AIDS</td><td rowspan="1" colspan="1">Total</td><td rowspan="1" colspan="1">AIDS annual rate (<italic>r</italic><sub><italic>i</italic></sub>)<xref ref-type="table-fn" rid="TF1-1"><sup>a</sup></xref></td><td rowspan="1" colspan="1">SE (<italic>r</italic><sub><italic>i</italic></sub>)<xref ref-type="table-fn" rid="TF1-1"><sup>a</sup></xref></td><td rowspan="1" colspan="1"><italic>p</italic><sub><italic>i</italic></sub><sup>*</sup><italic>r</italic><sub><italic>i</italic></sub> (from original data)</td><td rowspan="1" colspan="1"><italic>p</italic><sub><italic>i</italic></sub><sup>*</sup><italic>r</italic><sub><italic>i</italic></sub> (from imputed data)</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1">% (<italic>p</italic><sub><italic>i</italic></sub>)</td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1">%</td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1">%</td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1">% (<italic>p</italic><sub><italic>i</italic></sub>)</td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1">%</td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1">%</td><td rowspan="1" colspan="1"><italic>N</italic></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr></thead><tbody><tr><td rowspan="1" colspan="1"><20</td><td rowspan="1" colspan="1">16</td><td rowspan="1" colspan="1">0.893</td><td rowspan="1" colspan="1">41</td><td rowspan="1" colspan="1">8.577</td><td rowspan="1" colspan="1">162</td><td rowspan="1" colspan="1">25.352</td><td rowspan="1" colspan="1">18</td><td rowspan="1" colspan="1">213</td><td rowspan="1" colspan="1">22</td><td rowspan="1" colspan="1">0.862</td><td rowspan="1" colspan="1">51</td><td rowspan="1" colspan="1">7.692</td><td rowspan="1" colspan="1">214</td><td rowspan="1" colspan="1">24.683</td><td rowspan="1" colspan="1">287</td><td rowspan="1" colspan="1">2.01517</td><td rowspan="1" colspan="1">0.41135</td><td rowspan="1" colspan="1">0.018</td><td rowspan="1" colspan="1">0.017</td></tr><tr><td rowspan="1" colspan="1">20–49</td><td rowspan="1" colspan="1">36</td><td rowspan="1" colspan="1">2.010</td><td rowspan="1" colspan="1">47</td><td rowspan="1" colspan="1">9.833</td><td rowspan="1" colspan="1">171</td><td rowspan="1" colspan="1">26.761</td><td rowspan="1" colspan="1">5</td><td rowspan="1" colspan="1">254</td><td rowspan="1" colspan="1">45</td><td rowspan="1" colspan="1">1.763</td><td rowspan="1" colspan="1">58</td><td rowspan="1" colspan="1">8.748</td><td rowspan="1" colspan="1">203</td><td rowspan="1" colspan="1">23.414</td><td rowspan="1" colspan="1">306</td><td rowspan="1" colspan="1">0.72072</td><td rowspan="1" colspan="1">0.11849</td><td rowspan="1" colspan="1">0.014</td><td rowspan="1" colspan="1">0.013</td></tr><tr><td rowspan="1" colspan="1">50–99</td><td rowspan="1" colspan="1">71</td><td rowspan="1" colspan="1">3.964</td><td rowspan="1" colspan="1">64</td><td rowspan="1" colspan="1">13.389</td><td rowspan="1" colspan="1">118</td><td rowspan="1" colspan="1">18.466</td><td rowspan="1" colspan="1">20</td><td rowspan="1" colspan="1">253</td><td rowspan="1" colspan="1">98</td><td rowspan="1" colspan="1">3.840</td><td rowspan="1" colspan="1">87</td><td rowspan="1" colspan="1">13.122</td><td rowspan="1" colspan="1">160</td><td rowspan="1" colspan="1">18.454</td><td rowspan="1" colspan="1">345</td><td rowspan="1" colspan="1">0.43625</td><td rowspan="1" colspan="1">0.05728</td><td rowspan="1" colspan="1">0.017</td><td rowspan="1" colspan="1">0.017</td></tr><tr><td rowspan="1" colspan="1">100–149</td><td rowspan="1" colspan="1">70</td><td rowspan="1" colspan="1">3.908</td><td rowspan="1" colspan="1">57</td><td rowspan="1" colspan="1">11.925</td><td rowspan="1" colspan="1">66</td><td rowspan="1" colspan="1">10.329</td><td rowspan="1" colspan="1">16</td><td rowspan="1" colspan="1">193</td><td rowspan="1" colspan="1">105</td><td rowspan="1" colspan="1">4.114</td><td rowspan="1" colspan="1">79</td><td rowspan="1" colspan="1">11.916</td><td rowspan="1" colspan="1">94</td><td rowspan="1" colspan="1">10.842</td><td rowspan="1" colspan="1">278</td><td rowspan="1" colspan="1">0.21992</td><td rowspan="1" colspan="1">0.03079</td><td rowspan="1" colspan="1">0.009</td><td rowspan="1" colspan="1">0.009</td></tr><tr><td rowspan="1" colspan="1">150–199</td><td rowspan="1" colspan="1">104</td><td rowspan="1" colspan="1">5.807</td><td rowspan="1" colspan="1">44</td><td rowspan="1" colspan="1">9.205</td><td rowspan="1" colspan="1">45</td><td rowspan="1" colspan="1">7.042</td><td rowspan="1" colspan="1">13</td><td rowspan="1" colspan="1">193</td><td rowspan="1" colspan="1">143</td><td rowspan="1" colspan="1">5.603</td><td rowspan="1" colspan="1">63</td><td rowspan="1" colspan="1">9.502</td><td rowspan="1" colspan="1">65</td><td rowspan="1" colspan="1">7.497</td><td rowspan="1" colspan="1">271</td><td rowspan="1" colspan="1">0.10771</td><td rowspan="1" colspan="1">0.01523</td><td rowspan="1" colspan="1">0.006</td><td rowspan="1" colspan="1">0.006</td></tr><tr><td rowspan="1" colspan="1">200–349</td><td rowspan="1" colspan="1">372</td><td rowspan="1" colspan="1">20.771</td><td rowspan="1" colspan="1">114</td><td rowspan="1" colspan="1">23.849</td><td rowspan="1" colspan="1">40</td><td rowspan="1" colspan="1">6.260</td><td rowspan="1" colspan="1">57</td><td rowspan="1" colspan="1">526</td><td rowspan="1" colspan="1">534</td><td rowspan="1" colspan="1">20.925</td><td rowspan="1" colspan="1">162</td><td rowspan="1" colspan="1">24.434</td><td rowspan="1" colspan="1">74</td><td rowspan="1" colspan="1">8.535</td><td rowspan="1" colspan="1">770</td><td rowspan="1" colspan="1">0.03318</td><td rowspan="1" colspan="1">0.00282</td><td rowspan="1" colspan="1">0.007</td><td rowspan="1" colspan="1">0.007</td></tr><tr><td rowspan="1" colspan="1">350–499</td><td rowspan="1" colspan="1">437</td><td rowspan="1" colspan="1">24.400</td><td rowspan="1" colspan="1">65</td><td rowspan="1" colspan="1">13.598</td><td rowspan="1" colspan="1">13</td><td rowspan="1" colspan="1">2.034</td><td rowspan="1" colspan="1">60</td><td rowspan="1" colspan="1">515</td><td rowspan="1" colspan="1">599</td><td rowspan="1" colspan="1">23.472</td><td rowspan="1" colspan="1">93</td><td rowspan="1" colspan="1">14.027</td><td rowspan="1" colspan="1">26</td><td rowspan="1" colspan="1">2.999</td><td rowspan="1" colspan="1">718</td><td rowspan="1" colspan="1">0.01563</td><td rowspan="1" colspan="1">0.0016</td><td rowspan="1" colspan="1">0.004</td><td rowspan="1" colspan="1">0.004</td></tr><tr><td rowspan="1" colspan="1">≥500</td><td rowspan="1" colspan="1">685</td><td rowspan="1" colspan="1">38.247</td><td rowspan="1" colspan="1">46</td><td rowspan="1" colspan="1">9.623</td><td rowspan="1" colspan="1">24</td><td rowspan="1" colspan="1">3.756</td><td rowspan="1" colspan="1">102</td><td rowspan="1" colspan="1">755</td><td rowspan="1" colspan="1">1006</td><td rowspan="1" colspan="1">39.420</td><td rowspan="1" colspan="1">70</td><td rowspan="1" colspan="1">10.558</td><td rowspan="1" colspan="1">31</td><td rowspan="1" colspan="1">3.576</td><td rowspan="1" colspan="1">1107</td><td rowspan="1" colspan="1">0.00779</td><td rowspan="1" colspan="1">0.00094</td><td rowspan="1" colspan="1">0.003</td><td rowspan="1" colspan="1">0.003</td></tr><tr><td rowspan="1" colspan="1">Total (<italic>N</italic>)</td><td rowspan="1" colspan="1">1791</td><td rowspan="1" colspan="1">100</td><td rowspan="1" colspan="1">478</td><td rowspan="1" colspan="1">100</td><td rowspan="1" colspan="1">639</td><td rowspan="1" colspan="1">100</td><td rowspan="1" colspan="1">291</td><td rowspan="1" colspan="1">3199</td><td rowspan="1" colspan="1">2552</td><td rowspan="1" colspan="1">100</td><td rowspan="1" colspan="1">663</td><td rowspan="1" colspan="1">100</td><td rowspan="1" colspan="1">867</td><td rowspan="1" colspan="1">100</td><td rowspan="1" colspan="1">4082</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">∑<italic>p</italic><sub><italic>i</italic></sub><italic>r</italic><sub><italic>i</italic></sub>=0.078</td><td rowspan="1" colspan="1">∑<italic>p</italic><sub><italic>i</italic></sub><italic>r</italic><sub><italic>i</italic></sub>=0.076</td></tr><tr><td rowspan="1" colspan="1">Missing</td><td rowspan="1" colspan="1">9</td><td rowspan="1" colspan="1">–</td><td rowspan="1" colspan="1">0</td><td rowspan="1" colspan="1">–</td><td rowspan="1" colspan="1">7</td><td rowspan="1" colspan="1">–</td><td rowspan="1" colspan="1">867</td><td rowspan="1" colspan="1">883</td><td rowspan="1" colspan="1">0</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">0</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">0</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">0</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr><tr><td rowspan="1" colspan="1">Total</td><td rowspan="1" colspan="1">1800</td><td rowspan="1" colspan="1">–</td><td rowspan="1" colspan="1">478</td><td rowspan="1" colspan="1">–</td><td rowspan="1" colspan="1">646</td><td rowspan="1" colspan="1">–</td><td rowspan="1" colspan="1">1158</td><td rowspan="1" colspan="1">4082</td><td rowspan="1" colspan="1">2552</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">663</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">867</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">4082</td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn fn-type="other"><p>∑<italic>p</italic><sub><italic>i</italic></sub><italic>r</italic><sub><italic>i</italic></sub>, estimated mean annual progression rate to AIDS for the undiagnosed HIV population; <italic>p</italic><sub><italic>i</italic></sub> = <italic>n</italic><sub><italic>i</italic></sub>/N<sup>*</sup>100, percentage of patients in CD4<sup>+</sup> stratum <italic>i</italic> among newly diagnosed asymptomatic HIV; <italic>r</italic><sub><italic>i</italic></sub>, annual AIDS rate in CD4<sup>+</sup> stratum <italic>i</italic>; SE, standard error.</p></fn><fn fn-type="other" id="TF1-1"><p><sup>a</sup>From Cascade collaboration (Guiget <italic>et al.</italic> Open AIDS J. 2008, and Professor K. Porter, personal communication).</p></fn><fn fn-type="other" id="TF1-2"><p><sup>b</sup>Mean values based on 1000 imputed datasets.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Estimated number (95%CI) of people living with undiagnosed HIV infection in Italy in 2012, in total, and by HIV exposure category, sex, country of birth and age.</p></caption><table frame="hsides" rules="groups"><thead><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">∑<italic>r</italic><sub><italic>i</italic></sub><sup>*</sup><italic>p</italic><sub><italic>i</italic></sub></td><td rowspan="1" colspan="1">Simultaneous HIV/clinical AIDS</td><td rowspan="1" colspan="1">Prevented clinical AIDS</td><td colspan="3" rowspan="1">Estimated number of undiagnosed HIV+</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">No under-reporting</td><td rowspan="1" colspan="1">10% under-reporting</td><td rowspan="1" colspan="1">20% under-reporting</td></tr></thead><tbody><tr><td rowspan="1" colspan="1">Total</td><td rowspan="1" colspan="1">0.076</td><td rowspan="1" colspan="1">867</td><td rowspan="1" colspan="1">170</td><td rowspan="1" colspan="1">13 729</td><td rowspan="1" colspan="1">15 102</td><td rowspan="1" colspan="1">16 475</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.065–0.086)</td><td rowspan="1" colspan="1">(842–893)</td><td rowspan="1" colspan="1">(152–187)</td><td rowspan="1" colspan="1">(12 152–15 592)</td><td rowspan="1" colspan="1">(13 366–17 151)</td><td rowspan="1" colspan="1">(14 581–18 710)</td></tr><tr><td rowspan="1" colspan="1">HET-F</td><td rowspan="1" colspan="1">0.085</td><td rowspan="1" colspan="1">169</td><td rowspan="1" colspan="1">36</td><td rowspan="1" colspan="1">2411</td><td rowspan="1" colspan="1">2652</td><td rowspan="1" colspan="1">2893</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.072–0.103)</td><td rowspan="1" colspan="1">(157–181)</td><td rowspan="1" colspan="1">(32–41)</td><td rowspan="1" colspan="1">(2000–2832)</td><td rowspan="1" colspan="1">(2220–3115)</td><td rowspan="1" colspan="1">(2400–3398)</td></tr><tr><td rowspan="1" colspan="1">HET-M</td><td rowspan="1" colspan="1">0.105</td><td rowspan="1" colspan="1">347</td><td rowspan="1" colspan="1">59</td><td rowspan="1" colspan="1">3880</td><td rowspan="1" colspan="1">4267</td><td rowspan="1" colspan="1">4656</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.087–0.128)</td><td rowspan="1" colspan="1">(330–367)</td><td rowspan="1" colspan="1">(51–67)</td><td rowspan="1" colspan="1">(3178–4609)</td><td rowspan="1" colspan="1">(3496–5071)</td><td rowspan="1" colspan="1">(3813–5532)</td></tr><tr><td rowspan="1" colspan="1">IDU</td><td rowspan="1" colspan="1">0.088</td><td rowspan="1" colspan="1">67</td><td rowspan="1" colspan="1">11.5</td><td rowspan="1" colspan="1">895</td><td rowspan="1" colspan="1">984</td><td rowspan="1" colspan="1">1074</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.068–0.121)</td><td rowspan="1" colspan="1">(60–75)</td><td rowspan="1" colspan="1">(9–14)</td><td rowspan="1" colspan="1">(653–1136)</td><td rowspan="1" colspan="1">(719–1251)</td><td rowspan="1" colspan="1">(784–1364)</td></tr><tr><td rowspan="1" colspan="1">MSM</td><td rowspan="1" colspan="1">0.054</td><td rowspan="1" colspan="1">284</td><td rowspan="1" colspan="1">62</td><td rowspan="1" colspan="1">6382</td><td rowspan="1" colspan="1">7020</td><td rowspan="1" colspan="1">7659</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.046–0.064)</td><td rowspan="1" colspan="1">(266–303)</td><td rowspan="1" colspan="1">(55–70)</td><td rowspan="1" colspan="1">(5406–7368)</td><td rowspan="1" colspan="1">(5947–8105)</td><td rowspan="1" colspan="1">(6487–8841)</td></tr><tr><td rowspan="1" colspan="1">Women</td><td rowspan="1" colspan="1">0.087</td><td rowspan="1" colspan="1">180.5</td><td rowspan="1" colspan="1">38</td><td rowspan="1" colspan="1">2500</td><td rowspan="1" colspan="1">2750</td><td rowspan="1" colspan="1">3000</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.075–0.106)</td><td rowspan="1" colspan="1">(168–193)</td><td rowspan="1" colspan="1">(34–44)</td><td rowspan="1" colspan="1">(2087–2919)</td><td rowspan="1" colspan="1">(2295–3210)</td><td rowspan="1" colspan="1">(2504–3502)</td></tr><tr><td rowspan="1" colspan="1">Men</td><td rowspan="1" colspan="1">0.072</td><td rowspan="1" colspan="1">687</td><td rowspan="1" colspan="1">131</td><td rowspan="1" colspan="1">11 352</td><td rowspan="1" colspan="1">12 488</td><td rowspan="1" colspan="1">13 623</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.062–0.084)</td><td rowspan="1" colspan="1">(665–711)</td><td rowspan="1" colspan="1">(117–144)</td><td rowspan="1" colspan="1">(9866–12 870)</td><td rowspan="1" colspan="1">(10 852–14 157)</td><td rowspan="1" colspan="1">(11 839–15 444)</td></tr><tr><td rowspan="1" colspan="1">Italy</td><td rowspan="1" colspan="1">0.070</td><td rowspan="1" colspan="1">604</td><td rowspan="1" colspan="1">121</td><td rowspan="1" colspan="1">10 416</td><td rowspan="1" colspan="1">11 457</td><td rowspan="1" colspan="1">12 499</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.060–0.08)</td><td rowspan="1" colspan="1">(585–625)</td><td rowspan="1" colspan="1">(108–133)</td><td rowspan="1" colspan="1">(9177–11 803)</td><td rowspan="1" colspan="1">(10 095–12 984)</td><td rowspan="1" colspan="1">(11 013–14 165)</td></tr><tr><td rowspan="1" colspan="1">Abroad</td><td rowspan="1" colspan="1">0.093</td><td rowspan="1" colspan="1">263</td><td rowspan="1" colspan="1">49</td><td rowspan="1" colspan="1">3358</td><td rowspan="1" colspan="1">3694</td><td rowspan="1" colspan="1">4030</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.077–0.112)</td><td rowspan="1" colspan="1">(247–279)</td><td rowspan="1" colspan="1">(43–55)</td><td rowspan="1" colspan="1">(2798–3963)</td><td rowspan="1" colspan="1">(3078–4360)</td><td rowspan="1" colspan="1">(3358–4756)</td></tr><tr><td rowspan="1" colspan="1">15–24</td><td rowspan="1" colspan="1">0.038</td><td rowspan="1" colspan="1">39</td><td rowspan="1" colspan="1">7</td><td rowspan="1" colspan="1">1189</td><td rowspan="1" colspan="1">1309</td><td rowspan="1" colspan="1">1428</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.028–0.056)</td><td rowspan="1" colspan="1">(32–46)</td><td rowspan="1" colspan="1">(5–9)</td><td rowspan="1" colspan="1">(812–1667)</td><td rowspan="1" colspan="1">(894–1834)</td><td rowspan="1" colspan="1">(975–2000)</td></tr><tr><td rowspan="1" colspan="1">25–34</td><td rowspan="1" colspan="1">0.072</td><td rowspan="1" colspan="1">183</td><td rowspan="1" colspan="1">49</td><td rowspan="1" colspan="1">3240</td><td rowspan="1" colspan="1">3564</td><td rowspan="1" colspan="1">3888</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.060–0.087)</td><td rowspan="1" colspan="1">(169–197)</td><td rowspan="1" colspan="1">(44–56)</td><td rowspan="1" colspan="1">(2714–3800)</td><td rowspan="1" colspan="1">(2986–4180)</td><td rowspan="1" colspan="1">(3258–4500)</td></tr><tr><td rowspan="1" colspan="1">35–44</td><td rowspan="1" colspan="1">0.078</td><td rowspan="1" colspan="1">272</td><td rowspan="1" colspan="1">54</td><td rowspan="1" colspan="1">4192</td><td rowspan="1" colspan="1">4611</td><td rowspan="1" colspan="1">5031</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.066–0.092)</td><td rowspan="1" colspan="1">(259–285)</td><td rowspan="1" colspan="1">(47–60)</td><td rowspan="1" colspan="1">(3578–4863)</td><td rowspan="1" colspan="1">(3936–5348)</td><td rowspan="1" colspan="1">(4294–5834)</td></tr><tr><td rowspan="1" colspan="1">45–54</td><td rowspan="1" colspan="1">0.097</td><td rowspan="1" colspan="1">230</td><td rowspan="1" colspan="1">43</td><td rowspan="1" colspan="1">2815</td><td rowspan="1" colspan="1">3097</td><td rowspan="1" colspan="1">3378</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.081–0.118)</td><td rowspan="1" colspan="1">(219–242)</td><td rowspan="1" colspan="1">(37–47)</td><td rowspan="1" colspan="1">(2336–3294)</td><td rowspan="1" colspan="1">(2570–3623)</td><td rowspan="1" colspan="1">(2804–3952)</td></tr><tr><td rowspan="1" colspan="1">>54</td><td rowspan="1" colspan="1">0.08</td><td rowspan="1" colspan="1">143</td><td rowspan="1" colspan="1">17</td><td rowspan="1" colspan="1">2013</td><td rowspan="1" colspan="1">2215</td><td rowspan="1" colspan="1">2416</td></tr><tr><td rowspan="1" colspan="1"></td><td rowspan="1" colspan="1">(0.064–0.105)</td><td rowspan="1" colspan="1">(134–152)</td><td rowspan="1" colspan="1">(15–20)</td><td rowspan="1" colspan="1">(1528–2492)</td><td rowspan="1" colspan="1">(1681–2742)</td><td rowspan="1" colspan="1">(1834–2991)</td></tr></tbody></table></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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