Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis
Identifieur interne : 000023 ( Pmc/Corpus ); précédent : 000022; suivant : 000024Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis
Auteurs : Jonathan G. Stine ; Puja M. Shah ; Scott L. Cornella ; Sean R. Rudnick ; Marwan S. Ghabril ; George J. Stukenborg ; Patrick G. NorthupSource :
- World Journal of Hepatology [ 1948-5182 ] ; 2015.
Abstract
AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.
METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.
RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36,
CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.
Url:
DOI: 10.4254/wjh.v7.i27.2774
PubMed: 26644821
PubMed Central: 4663397
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PMC:4663397Le document en format XML
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<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Hepatol</journal-id><journal-id journal-id-type="publisher-id">WJH</journal-id><journal-title-group><journal-title>World Journal of Hepatology</journal-title></journal-title-group><issn pub-type="ppub">1948-5182</issn><issn pub-type="epub">1948-5182</issn><publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26644821</article-id><article-id pub-id-type="pmc">4663397</article-id><article-id pub-id-type="other">jWJH.v7.i27.pg2774</article-id><article-id pub-id-type="doi">10.4254/wjh.v7.i27.2774</article-id><article-categories><subj-group subj-group-type="heading"><subject>Meta-Analysis</subject></subj-group></article-categories><title-group><article-title>Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Stine</surname><given-names>Jonathan G</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shah</surname><given-names>Puja M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Cornella</surname><given-names>Scott L</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rudnick</surname><given-names>Sean R</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ghabril</surname><given-names>Marwan S</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stukenborg</surname><given-names>George J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Northup</surname><given-names>Patrick G</given-names></name></contrib><aff>Jonathan G Stine, Sean R Rudnick, Patrick G Northup, Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908, United States</aff><aff>Puja M Shah, Department of Surgery, University of Virginia, Charlottesville, VA 22908, United States</aff><aff>Scott L Cornella, Department of Medicine, University of Virginia, Charlottesville, VA 22908, United States</aff><aff>Marwan S Ghabril, Division of Gastroenterology and Hepatology, Indiana University, Indianapolis, IN 46202, United States</aff><aff>George J Stukenborg, Department of Public Health Science, University of Virginia, Charlottesville, VA 22908, United States</aff></contrib-group><author-notes><fn><p>Author contributions: Stine JG and Shah PM contributed equally to this work; Stine JG, Shah PM, Ghabril MS, Stukenborg GJ and Northup PG designed research; Stine JG, Shah PM, Cornella SL and Rudnick SR performed research; Stine JG and Shah PM analyzed data; Stine JG, Shah PM, Cornella SL, Rudnick SR, Ghabril MS, Stukenborg GJ and Northup PG wrote the paper.</p><p>Correspondence to: Jonathan G Stine, MD, MSc, Division of Gastroenterology and Hepatology, University of Virginia, JPA and Lee Street, MSB 2145, PO Box 800708, Charlottesville, VA 22908, United States. <email>jgs9f@virginia.edu</email></p><p>Telephone: +1-434-9242959 Fax: +1-434-2447529</p></fn></author-notes><pub-date pub-type="ppub"><day>28</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2015</year></pub-date><volume>7</volume><issue>27</issue><fpage>2774</fpage><lpage>2780</lpage><history><date date-type="received"><day>18</day><month>9</month><year>2015</year></date><date date-type="rev-recd"><day>2</day><month>11</month><year>2015</year></date><date date-type="accepted"><day>10</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis.</p><p>METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI.</p><p>RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36, <italic>P</italic> = 0.01). Portal vein thrombosis was associated with an increased risk of ascites (OR = 2.52, 95%CI: 1.63-3.89, <italic>P</italic> < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy.</p><p>CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.</p></abstract><kwd-group><kwd>Hepatology</kwd><kwd>Coagulopathy</kwd><kwd>Liver</kwd><kwd>Ascites</kwd><kwd>Hepatic encephalopathy</kwd><kwd>Portal hypertension</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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