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Is Helicobacter pylori infection associated with glycemic control in diabetics?

Identifieur interne : 000019 ( Pmc/Corpus ); précédent : 000018; suivant : 000020

Is Helicobacter pylori infection associated with glycemic control in diabetics?

Auteurs : Yi-Ning Dai ; Wei-Lai Yu ; Hua-Tuo Zhu ; Jie-Xia Ding ; Chao-Hui Yu ; You-Ming Li

Source :

RBID : PMC:4419082

Abstract

AIM: To investigate whether Helicobacter pylori (H. pylori) infection is associated with glycemic control and whether hyperglycemia is modified by eradication therapy.

METHODS: The databases of PubMed, Cochrane Library, Chinese BioMedicine Web Base and Chinese Science and Technology Journals were searched from inception to June 2014. Studies examining the association between H. pylori infection and glycemic control and⁄or the effect of eradication treatment on glycemic control in diabetic humans were eligible for inclusion. Meta-analyses were conducted using the Review Manager software version 5.2. The outcome measures are presented as weighed mean differences (WMDs) with 95% confidence intervals (CIs). Statistical heterogeneity was assessed by the Cochran Q test and the I2 statistic.

RESULTS: A total of 21 relevant publications were identified. A meta-analysis of 11 studies with 513 patients with diabetes mellitus (DM) showed significantly lower glycosylated hemoglobin (HbA1c) levels in the H. pylori-negative than H. pylori-positive DM participants (WMD = 0.43, 95%CI: 0.07-0.79; P = 0.02). In children and adolescents with type 1 DM (T1DM), there was a positive association between H. pylori infection and HbA1c level (WMD = 0.35, 95%CI: 0.05-0.64; P = 0.02), but there was no difference in those with type 2 DM (T2DM, WMD = 0.51, 95%CI: -0.63-1.65; P = 0.38). A meta-analysis of six studies with 325 T2DM participants showed a significant difference in the fasting plasma glucose levels between H. pylori-positive and H. pylori-negative participants (WMD = 1.20, 95%CI: 0.17-2.23; P = 0.02). Eradication of H. pylori did not improve glycemic control in the T2DM participants in a three-month follow-up period (HbA1c decrease: WMD = -0.03, 95%CI = -0.14-0.08; P = 0.57; fasting plasma glucose decrease: WMD = -0.06, 95%CI: -0.36-0.23; P = 0.68). Glycemic control was significantly better in T1DM participants who were not reinfected than in those who were reinfected (HbA1c: WMD = 0.72, 95%CI: 0.32-1.13: P = 0.00).

CONCLUSION: H. pylori infection is associated with poorer glycemic control in T1DM patients, but eradication may not improve glycemic control in DM in a short-term follow-up period.


Url:
DOI: 10.3748/wjg.v21.i17.5407
PubMed: 25954115
PubMed Central: 4419082

Links to Exploration step

PMC:4419082

Le document en format XML

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<title xml:lang="en">Is
<italic>Helicobacter pylori</italic>
infection associated with glycemic control in diabetics?</title>
<author>
<name sortKey="Dai, Yi Ning" sort="Dai, Yi Ning" uniqKey="Dai Y" first="Yi-Ning" last="Dai">Yi-Ning Dai</name>
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<name sortKey="Yu, Wei Lai" sort="Yu, Wei Lai" uniqKey="Yu W" first="Wei-Lai" last="Yu">Wei-Lai Yu</name>
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<author>
<name sortKey="Zhu, Hua Tuo" sort="Zhu, Hua Tuo" uniqKey="Zhu H" first="Hua-Tuo" last="Zhu">Hua-Tuo Zhu</name>
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<name sortKey="Ding, Jie Xia" sort="Ding, Jie Xia" uniqKey="Ding J" first="Jie-Xia" last="Ding">Jie-Xia Ding</name>
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<name sortKey="Yu, Chao Hui" sort="Yu, Chao Hui" uniqKey="Yu C" first="Chao-Hui" last="Yu">Chao-Hui Yu</name>
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<author>
<name sortKey="Li, You Ming" sort="Li, You Ming" uniqKey="Li Y" first="You-Ming" last="Li">You-Ming Li</name>
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<title xml:lang="en" level="a" type="main">Is
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<name sortKey="Yu, Wei Lai" sort="Yu, Wei Lai" uniqKey="Yu W" first="Wei-Lai" last="Yu">Wei-Lai Yu</name>
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<name sortKey="Zhu, Hua Tuo" sort="Zhu, Hua Tuo" uniqKey="Zhu H" first="Hua-Tuo" last="Zhu">Hua-Tuo Zhu</name>
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<author>
<name sortKey="Ding, Jie Xia" sort="Ding, Jie Xia" uniqKey="Ding J" first="Jie-Xia" last="Ding">Jie-Xia Ding</name>
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<name sortKey="Yu, Chao Hui" sort="Yu, Chao Hui" uniqKey="Yu C" first="Chao-Hui" last="Yu">Chao-Hui Yu</name>
</author>
<author>
<name sortKey="Li, You Ming" sort="Li, You Ming" uniqKey="Li Y" first="You-Ming" last="Li">You-Ming Li</name>
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<series>
<title level="j">World Journal of Gastroenterology : WJG</title>
<idno type="ISSN">1007-9327</idno>
<idno type="eISSN">2219-2840</idno>
<imprint>
<date when="2015">2015</date>
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<div type="abstract" xml:lang="en">
<p>AIM: To investigate whether
<italic>Helicobacter pylori</italic>
(
<italic>H. pylori</italic>
) infection is associated with glycemic control and whether hyperglycemia is modified by eradication therapy.</p>
<p>METHODS: The databases of PubMed, Cochrane Library, Chinese BioMedicine Web Base and Chinese Science and Technology Journals were searched from inception to June 2014. Studies examining the association between
<italic>H. pylori</italic>
infection and glycemic control and⁄or the effect of eradication treatment on glycemic control in diabetic humans were eligible for inclusion. Meta-analyses were conducted using the Review Manager software version 5.2. The outcome measures are presented as weighed mean differences (WMDs) with 95% confidence intervals (CIs). Statistical heterogeneity was assessed by the Cochran
<italic>Q</italic>
test and the
<italic>I</italic>
<sup>2</sup>
statistic.</p>
<p>RESULTS: A total of 21 relevant publications were identified. A meta-analysis of 11 studies with 513 patients with diabetes mellitus (DM) showed significantly lower glycosylated hemoglobin (HbA1c) levels in the
<italic>H. pylori</italic>
-negative than
<italic>H. pylori</italic>
-positive DM participants (WMD = 0.43, 95%CI: 0.07-0.79;
<italic>P</italic>
= 0.02). In children and adolescents with type 1 DM (T1DM), there was a positive association between
<italic>H. pylori</italic>
infection and HbA1c level (WMD = 0.35, 95%CI: 0.05-0.64;
<italic>P</italic>
= 0.02), but there was no difference in those with type 2 DM (T2DM, WMD = 0.51, 95%CI: -0.63-1.65;
<italic>P</italic>
= 0.38). A meta-analysis of six studies with 325 T2DM participants showed a significant difference in the fasting plasma glucose levels between
<italic>H. pylori</italic>
-positive and
<italic>H. pylori</italic>
-negative participants (WMD = 1.20, 95%CI: 0.17-2.23;
<italic>P</italic>
= 0.02). Eradication of
<italic>H. pylori</italic>
did not improve glycemic control in the T2DM participants in a three-month follow-up period (HbA1c decrease: WMD = -0.03, 95%CI = -0.14-0.08;
<italic>P</italic>
= 0.57; fasting plasma glucose decrease: WMD = -0.06, 95%CI: -0.36-0.23;
<italic>P</italic>
= 0.68). Glycemic control was significantly better in T1DM participants who were not reinfected than in those who were reinfected (HbA1c: WMD = 0.72, 95%CI: 0.32-1.13:
<italic>P</italic>
= 0.00).</p>
<p>CONCLUSION:
<italic>H. pylori</italic>
infection is associated with poorer glycemic control in T1DM patients, but eradication may not improve glycemic control in DM in a short-term follow-up period.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id>
<journal-id journal-id-type="iso-abbrev">World J. Gastroenterol</journal-id>
<journal-id journal-id-type="publisher-id">WJG</journal-id>
<journal-title-group>
<journal-title>World Journal of Gastroenterology : WJG</journal-title>
</journal-title-group>
<issn pub-type="ppub">1007-9327</issn>
<issn pub-type="epub">2219-2840</issn>
<publisher>
<publisher-name>Baishideng Publishing Group Inc</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">25954115</article-id>
<article-id pub-id-type="pmc">4419082</article-id>
<article-id pub-id-type="other">jWJG.v21.i17.pg5407</article-id>
<article-id pub-id-type="doi">10.3748/wjg.v21.i17.5407</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Meta-Analysis</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Is
<italic>Helicobacter pylori</italic>
infection associated with glycemic control in diabetics?</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Dai</surname>
<given-names>Yi-Ning</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Wei-Lai</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhu</surname>
<given-names>Hua-Tuo</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ding</surname>
<given-names>Jie-Xia</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Yu</surname>
<given-names>Chao-Hui</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Li</surname>
<given-names>You-Ming</given-names>
</name>
</contrib>
<aff>Yi-Ning Dai, Wei-Lai Yu, Hua-Tuo Zhu, Jie-Xia Ding, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China</aff>
</contrib-group>
<author-notes>
<fn>
<p>Author contributions: Dai YN, Yu WL and Li YM proposed the study; Dai YN, Yu WL, Zhu HT and Ding JX collected the data; Dai YN, Yu WL, Zhu HT, Ding JX and Yu CH analyzed and interpreted the data; Dai YN and Yu WL drafted the manuscript; Yu CH and Li YM revised the manuscript; All the authors contributed to the design of the study and interpretation of its findings, and read and approved the final version to be published.</p>
<p>Correspondence to: You-Ming Li, MD, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China.
<email>li_youming1956@163.com</email>
</p>
<p>Telephone: +86-571-87236532 Fax: +86-571-87236532</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<day>7</day>
<month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub">
<day>7</day>
<month>5</month>
<year>2015</year>
</pub-date>
<volume>21</volume>
<issue>17</issue>
<fpage>5407</fpage>
<lpage>5416</lpage>
<history>
<date date-type="received">
<day>24</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="rev-recd">
<day>31</day>
<month>10</month>
<year>2014</year>
</date>
<date date-type="accepted">
<day>8</day>
<month>12</month>
<year>2014</year>
</date>
</history>
<permissions>
<copyright-statement>©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract>
<p>AIM: To investigate whether
<italic>Helicobacter pylori</italic>
(
<italic>H. pylori</italic>
) infection is associated with glycemic control and whether hyperglycemia is modified by eradication therapy.</p>
<p>METHODS: The databases of PubMed, Cochrane Library, Chinese BioMedicine Web Base and Chinese Science and Technology Journals were searched from inception to June 2014. Studies examining the association between
<italic>H. pylori</italic>
infection and glycemic control and⁄or the effect of eradication treatment on glycemic control in diabetic humans were eligible for inclusion. Meta-analyses were conducted using the Review Manager software version 5.2. The outcome measures are presented as weighed mean differences (WMDs) with 95% confidence intervals (CIs). Statistical heterogeneity was assessed by the Cochran
<italic>Q</italic>
test and the
<italic>I</italic>
<sup>2</sup>
statistic.</p>
<p>RESULTS: A total of 21 relevant publications were identified. A meta-analysis of 11 studies with 513 patients with diabetes mellitus (DM) showed significantly lower glycosylated hemoglobin (HbA1c) levels in the
<italic>H. pylori</italic>
-negative than
<italic>H. pylori</italic>
-positive DM participants (WMD = 0.43, 95%CI: 0.07-0.79;
<italic>P</italic>
= 0.02). In children and adolescents with type 1 DM (T1DM), there was a positive association between
<italic>H. pylori</italic>
infection and HbA1c level (WMD = 0.35, 95%CI: 0.05-0.64;
<italic>P</italic>
= 0.02), but there was no difference in those with type 2 DM (T2DM, WMD = 0.51, 95%CI: -0.63-1.65;
<italic>P</italic>
= 0.38). A meta-analysis of six studies with 325 T2DM participants showed a significant difference in the fasting plasma glucose levels between
<italic>H. pylori</italic>
-positive and
<italic>H. pylori</italic>
-negative participants (WMD = 1.20, 95%CI: 0.17-2.23;
<italic>P</italic>
= 0.02). Eradication of
<italic>H. pylori</italic>
did not improve glycemic control in the T2DM participants in a three-month follow-up period (HbA1c decrease: WMD = -0.03, 95%CI = -0.14-0.08;
<italic>P</italic>
= 0.57; fasting plasma glucose decrease: WMD = -0.06, 95%CI: -0.36-0.23;
<italic>P</italic>
= 0.68). Glycemic control was significantly better in T1DM participants who were not reinfected than in those who were reinfected (HbA1c: WMD = 0.72, 95%CI: 0.32-1.13:
<italic>P</italic>
= 0.00).</p>
<p>CONCLUSION:
<italic>H. pylori</italic>
infection is associated with poorer glycemic control in T1DM patients, but eradication may not improve glycemic control in DM in a short-term follow-up period.</p>
</abstract>
<kwd-group>
<kwd>Diabetes mellitus</kwd>
<kwd>Eradication</kwd>
<kwd>Glycemic control</kwd>
<kwd>
<italic>Helicobacter pylori</italic>
</kwd>
<kwd>Meta-analysis</kwd>
<kwd>Reinfection</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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