Medical and economic burden of influenza in the elderly population in central and eastern European countries
Identifieur interne : 000264 ( Pmc/Checkpoint ); précédent : 000263; suivant : 000265Medical and economic burden of influenza in the elderly population in central and eastern European countries
Auteurs : Gábor Kovács [Hongrie] ; Gábor Kovács [Hongrie] ; Zoltán Kal [Hongrie] ; Zoltán Kal [Hongrie] ; Karina Jahnz-Rozyk [Pologne] ; Karina Jahnz-Rozyk [Pologne] ; Jan Kyncl [République tchèque] ; Jan Kyncl [République tchèque] ; Agnes Csohan [Hongrie] ; Agnes Csohan [Hongrie] ; Adriana Pistol [Roumanie] ; Adriana Pistol [Roumanie] ; Mariya Leleka [Ukraine] ; Mariya Leleka [Ukraine] ; Rafail Kipshakbaev [Kazakhstan] ; Rafail Kipshakbaev [Kazakhstan] ; Laure Durand [France] ; Laure Durand [France] ; Bérengère Macabeo [France] ; Bérengère Macabeo [France]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2013.
Abstract
Influenza affects 5–15% of the population during an epidemic. In Western Europe, vaccination of at-risk groups forms the cornerstone of influenza prevention. However, vaccination coverage of the elderly (>65 y) is often low in Central and Eastern Europe (CEE); potentially because a paucity of country-specific data limits evidence-based policy making. Therefore the medical and economic burden of influenza were estimated in elderly populations in the Czech Republic, Hungary, Kazakhstan, Poland, Romania, and Ukraine. Data covering national influenza vaccination policies, surveillance and reporting, healthcare costs, populations, and epidemiology were obtained via literature review, open-access websites and databases, and interviews with experts. A simplified model of patient treatment flow incorporating cost, population, and incidence/prevalence data was used to calculate the influenza burden per country. In the elderly, influenza represented a large burden on the assessed healthcare systems, with yearly excess hospitalization rates of ~30/100 000. Burden varied between countries and was likely influenced by population size, surveillance system, healthcare provision, and vaccine coverage. The greatest burden was found in Poland, where direct costs were over EUR 5 million. Substantial differences in data availability and quality were identified, and to fully quantify the burden of influenza in CEE, influenza reporting systems should be standardized. This study most probably underestimates the real burden of influenza, however the public health problem is recognized worldwide, and will further increase with population aging. Extending influenza vaccination of the elderly may be a cost-effective way to reduce the burden of influenza in CEE.
Url:
DOI: 10.4161/hv.26886
PubMed: 24165394
PubMed Central: 4185899
Affiliations:
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<author><name sortKey="Durand, Laure" sort="Durand, Laure" uniqKey="Durand L" first="Laure" last="Durand">Laure Durand</name>
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<author><name sortKey="Macabeo, Berengere" sort="Macabeo, Berengere" uniqKey="Macabeo B" first="Bérengère" last="Macabeo">Bérengère Macabeo</name>
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<author><name sortKey="Macabeo, Berengere" sort="Macabeo, Berengere" uniqKey="Macabeo B" first="Bérengère" last="Macabeo">Bérengère Macabeo</name>
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<front><div type="abstract" xml:lang="en"><p>Influenza affects 5–15% of the population during an epidemic. In Western Europe, vaccination of at-risk groups forms the cornerstone of influenza prevention. However, vaccination coverage of the elderly (>65 y) is often low in Central and Eastern Europe (CEE); potentially because a paucity of country-specific data limits evidence-based policy making. Therefore the medical and economic burden of influenza were estimated in elderly populations in the Czech Republic, Hungary, Kazakhstan, Poland, Romania, and Ukraine. Data covering national influenza vaccination policies, surveillance and reporting, healthcare costs, populations, and epidemiology were obtained via literature review, open-access websites and databases, and interviews with experts. A simplified model of patient treatment flow incorporating cost, population, and incidence/prevalence data was used to calculate the influenza burden per country. In the elderly, influenza represented a large burden on the assessed healthcare systems, with yearly excess hospitalization rates of ~30/100 000. Burden varied between countries and was likely influenced by population size, surveillance system, healthcare provision, and vaccine coverage. The greatest burden was found in Poland, where direct costs were over EUR 5 million. Substantial differences in data availability and quality were identified, and to fully quantify the burden of influenza in CEE, influenza reporting systems should be standardized. This study most probably underestimates the real burden of influenza, however the public health problem is recognized worldwide, and will further increase with population aging. Extending influenza vaccination of the elderly may be a cost-effective way to reduce the burden of influenza in CEE.</p>
</div>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="publisher-id">HV</journal-id>
<journal-title-group><journal-title>Human Vaccines & Immunotherapeutics</journal-title>
</journal-title-group>
<issn pub-type="ppub">2164-5515</issn>
<issn pub-type="epub">2164-554X</issn>
<publisher><publisher-name>Landes Bioscience</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24165394</article-id>
<article-id pub-id-type="pmc">4185899</article-id>
<article-id pub-id-type="publisher-id">2013HV0346R</article-id>
<article-id pub-id-type="doi">10.4161/hv.26886</article-id>
<article-id pub-id-type="pii">26886</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Medical and economic burden of influenza in the elderly population in central and eastern European countries</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Kovács</surname>
<given-names>Gábor</given-names>
</name>
<xref ref-type="aff" rid="A1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kovács</surname>
<given-names>Gábor</given-names>
</name>
<xref ref-type="aff" rid="A1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaló</surname>
<given-names>Zoltán</given-names>
</name>
<xref ref-type="aff" rid="A1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kaló</surname>
<given-names>Zoltán</given-names>
</name>
<xref ref-type="aff" rid="A1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jahnz-Rozyk</surname>
<given-names>Karina</given-names>
</name>
<xref ref-type="aff" rid="A2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jahnz-Rozyk</surname>
<given-names>Karina</given-names>
</name>
<xref ref-type="aff" rid="A2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kyncl</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="A3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kyncl</surname>
<given-names>Jan</given-names>
</name>
<xref ref-type="aff" rid="A3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Csohan</surname>
<given-names>Agnes</given-names>
</name>
<xref ref-type="aff" rid="A4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Csohan</surname>
<given-names>Agnes</given-names>
</name>
<xref ref-type="aff" rid="A4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pistol</surname>
<given-names>Adriana</given-names>
</name>
<xref ref-type="aff" rid="A5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pistol</surname>
<given-names>Adriana</given-names>
</name>
<xref ref-type="aff" rid="A5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leleka</surname>
<given-names>Mariya</given-names>
</name>
<xref ref-type="aff" rid="A6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leleka</surname>
<given-names>Mariya</given-names>
</name>
<xref ref-type="aff" rid="A6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kipshakbaev</surname>
<given-names>Rafail</given-names>
</name>
<xref ref-type="aff" rid="A7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kipshakbaev</surname>
<given-names>Rafail</given-names>
</name>
<xref ref-type="aff" rid="A7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durand</surname>
<given-names>Laure</given-names>
</name>
<xref ref-type="aff" rid="A8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Durand</surname>
<given-names>Laure</given-names>
</name>
<xref ref-type="aff" rid="A8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Macabeo</surname>
<given-names>Bérengère</given-names>
</name>
<xref ref-type="aff" rid="A8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Macabeo</surname>
<given-names>Bérengère</given-names>
</name>
<xref ref-type="aff" rid="A8"><sup>8</sup>
</xref>
</contrib>
<aff id="A1"><label>1</label>
Syreon Research Institute; Budapest, Hungary</aff>
<aff id="A2"><label>2</label>
Military Institute of Medicine; Warsaw, Poland</aff>
<aff id="A3"><label>3</label>
National Institute of Public Health; Department of Infectious Diseases Epidemiology; Prague, Czech Republic</aff>
<aff id="A4"><label>4</label>
Bela Johan National Center for Epidemiology; Budapest, Hungary</aff>
<aff id="A5"><label>5</label>
National Institute of Public Health; Bucuresti, Romania</aff>
<aff id="A6"><label>6</label>
I. Ya.Horbachevsky Ternopil State Medical University; Ternopil, Ukraine</aff>
<aff id="A7"><label>7</label>
ISPOR Chapter Kazakhstan; Astana, Kazakhstan</aff>
<aff id="A8"><label>8</label>
Sanofi Pasteur; Lyon, France</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>*</label>
Correspondence to: Gábor Kovács, Email: <email xlink:href="gabor.kovacs@syreon.eu">gabor.kovacs@syreon.eu</email>
and Gábor Kovács, Email: <email xlink:href="gabor.kovacs@syreon.eu">gabor.kovacs@syreon.eu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>01</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>28</day>
<month>10</month>
<year>2013</year>
</pub-date>
<volume>10</volume>
<issue>2</issue>
<fpage>428</fpage>
<lpage>440</lpage>
<history><date date-type="received"><day>23</day>
<month>8</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>09</day>
<month>10</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>19</day>
<month>10</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Landes Bioscience</copyright-statement>
<copyright-year>2014</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Influenza affects 5–15% of the population during an epidemic. In Western Europe, vaccination of at-risk groups forms the cornerstone of influenza prevention. However, vaccination coverage of the elderly (>65 y) is often low in Central and Eastern Europe (CEE); potentially because a paucity of country-specific data limits evidence-based policy making. Therefore the medical and economic burden of influenza were estimated in elderly populations in the Czech Republic, Hungary, Kazakhstan, Poland, Romania, and Ukraine. Data covering national influenza vaccination policies, surveillance and reporting, healthcare costs, populations, and epidemiology were obtained via literature review, open-access websites and databases, and interviews with experts. A simplified model of patient treatment flow incorporating cost, population, and incidence/prevalence data was used to calculate the influenza burden per country. In the elderly, influenza represented a large burden on the assessed healthcare systems, with yearly excess hospitalization rates of ~30/100 000. Burden varied between countries and was likely influenced by population size, surveillance system, healthcare provision, and vaccine coverage. The greatest burden was found in Poland, where direct costs were over EUR 5 million. Substantial differences in data availability and quality were identified, and to fully quantify the burden of influenza in CEE, influenza reporting systems should be standardized. This study most probably underestimates the real burden of influenza, however the public health problem is recognized worldwide, and will further increase with population aging. Extending influenza vaccination of the elderly may be a cost-effective way to reduce the burden of influenza in CEE.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords: </title>
<kwd>influenza</kwd>
<kwd>elderly</kwd>
<kwd>public health</kwd>
<kwd>cost of illness</kwd>
<kwd>health care system</kwd>
<kwd>vaccination</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
<li>Hongrie</li>
<li>Kazakhstan</li>
<li>Pologne</li>
<li>Roumanie</li>
<li>République tchèque</li>
<li>Ukraine</li>
</country>
</list>
<tree><country name="Hongrie"><noRegion><name sortKey="Kovacs, Gabor" sort="Kovacs, Gabor" uniqKey="Kovacs G" first="Gábor" last="Kovács">Gábor Kovács</name>
</noRegion>
<name sortKey="Csohan, Agnes" sort="Csohan, Agnes" uniqKey="Csohan A" first="Agnes" last="Csohan">Agnes Csohan</name>
<name sortKey="Csohan, Agnes" sort="Csohan, Agnes" uniqKey="Csohan A" first="Agnes" last="Csohan">Agnes Csohan</name>
<name sortKey="Kal, Zoltan" sort="Kal, Zoltan" uniqKey="Kal Z" first="Zoltán" last="Kal">Zoltán Kal</name>
<name sortKey="Kal, Zoltan" sort="Kal, Zoltan" uniqKey="Kal Z" first="Zoltán" last="Kal">Zoltán Kal</name>
<name sortKey="Kovacs, Gabor" sort="Kovacs, Gabor" uniqKey="Kovacs G" first="Gábor" last="Kovács">Gábor Kovács</name>
</country>
<country name="Pologne"><noRegion><name sortKey="Jahnz Rozyk, Karina" sort="Jahnz Rozyk, Karina" uniqKey="Jahnz Rozyk K" first="Karina" last="Jahnz-Rozyk">Karina Jahnz-Rozyk</name>
</noRegion>
<name sortKey="Jahnz Rozyk, Karina" sort="Jahnz Rozyk, Karina" uniqKey="Jahnz Rozyk K" first="Karina" last="Jahnz-Rozyk">Karina Jahnz-Rozyk</name>
</country>
<country name="République tchèque"><noRegion><name sortKey="Kyncl, Jan" sort="Kyncl, Jan" uniqKey="Kyncl J" first="Jan" last="Kyncl">Jan Kyncl</name>
</noRegion>
<name sortKey="Kyncl, Jan" sort="Kyncl, Jan" uniqKey="Kyncl J" first="Jan" last="Kyncl">Jan Kyncl</name>
</country>
<country name="Roumanie"><noRegion><name sortKey="Pistol, Adriana" sort="Pistol, Adriana" uniqKey="Pistol A" first="Adriana" last="Pistol">Adriana Pistol</name>
</noRegion>
<name sortKey="Pistol, Adriana" sort="Pistol, Adriana" uniqKey="Pistol A" first="Adriana" last="Pistol">Adriana Pistol</name>
</country>
<country name="Ukraine"><noRegion><name sortKey="Leleka, Mariya" sort="Leleka, Mariya" uniqKey="Leleka M" first="Mariya" last="Leleka">Mariya Leleka</name>
</noRegion>
<name sortKey="Leleka, Mariya" sort="Leleka, Mariya" uniqKey="Leleka M" first="Mariya" last="Leleka">Mariya Leleka</name>
</country>
<country name="Kazakhstan"><noRegion><name sortKey="Kipshakbaev, Rafail" sort="Kipshakbaev, Rafail" uniqKey="Kipshakbaev R" first="Rafail" last="Kipshakbaev">Rafail Kipshakbaev</name>
</noRegion>
<name sortKey="Kipshakbaev, Rafail" sort="Kipshakbaev, Rafail" uniqKey="Kipshakbaev R" first="Rafail" last="Kipshakbaev">Rafail Kipshakbaev</name>
</country>
<country name="France"><noRegion><name sortKey="Durand, Laure" sort="Durand, Laure" uniqKey="Durand L" first="Laure" last="Durand">Laure Durand</name>
</noRegion>
<name sortKey="Durand, Laure" sort="Durand, Laure" uniqKey="Durand L" first="Laure" last="Durand">Laure Durand</name>
<name sortKey="Macabeo, Berengere" sort="Macabeo, Berengere" uniqKey="Macabeo B" first="Bérengère" last="Macabeo">Bérengère Macabeo</name>
<name sortKey="Macabeo, Berengere" sort="Macabeo, Berengere" uniqKey="Macabeo B" first="Bérengère" last="Macabeo">Bérengère Macabeo</name>
</country>
</tree>
</affiliations>
</record>
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