Can CT Screening Give Rise to a Beneficial Stage Shift in Lung Cancer Patients? Systematic Review and Meta-Analysis
Identifieur interne : 000063 ( Pmc/Checkpoint ); précédent : 000062; suivant : 000064Can CT Screening Give Rise to a Beneficial Stage Shift in Lung Cancer Patients? Systematic Review and Meta-Analysis
Auteurs : Zixing Wang [République populaire de Chine] ; Yaoda Hu [République populaire de Chine] ; Yuyan Wang [République populaire de Chine] ; Wei Han [République populaire de Chine] ; Lei Wang [République populaire de Chine] ; Fang Xue [République populaire de Chine] ; Xin Sui [République populaire de Chine] ; Wei Song [République populaire de Chine] ; Ruihong Shi [République populaire de Chine] ; Jingmei Jiang [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there’s universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach.
EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2. Pathology-confirmed stage information was carefully extracted by two reviewers. Stage I or limited stage proportions were pooled by random effect model with Freeman-Tukey double arcsine transformation.
Pooled stage I cancer proportion in CT screenings was 73.2% (95% confidence interval: 68.6%, 77.5%), with a significant rising trend (
CT screening can detect more early stage non-small cell lung cancers, but not all of them could be beneficial as there are a considerable number of indolent ones such as bronchioloalveolar adenocarcinomas. Still, current evidence is lacking regarding small cell lung cancers.
Url:
DOI: 10.1371/journal.pone.0164416
PubMed: 27736916
PubMed Central: 5063401
Affiliations:
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<author><name sortKey="Jiang, Jingmei" sort="Jiang, Jingmei" uniqKey="Jiang J" first="Jingmei" last="Jiang">Jingmei Jiang</name>
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<front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title>
<p>To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there’s universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach.</p>
</sec>
<sec id="sec002"><title>Materials and Methods</title>
<p>EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2. Pathology-confirmed stage information was carefully extracted by two reviewers. Stage I or limited stage proportions were pooled by random effect model with Freeman-Tukey double arcsine transformation.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>Pooled stage I cancer proportion in CT screenings was 73.2% (95% confidence interval: 68.6%, 77.5%), with a significant rising trend (<italic>P</italic>
<sub>trend</sub>
<0.05) from baseline (64.7%) to ≥5 repeat rounds (87.1%). Relative to chest radiograph and usual care, the increased stage I proportions in CT were 12.2% (<italic>P</italic>
>0.05), and 46.5% (<italic>P</italic>
<0.05), respectively. Pathology-specifically, adenocarcinomas (66%) and squamous cell lung cancers (17%) composed the majority of CT-detected lung cancers, and had significantly higher stage I proportions relative to chest radiograph (bronchioloalveolar adenocarcinomas, 80.9% vs 51.4%; other adenocarcinomas, 58.8% vs 38.3%; squamous cell lung cancers, 52.3% vs 38.3%; all <italic>P</italic>
<0.05). However, the percentage of small cell lung cancer was lower using CT than other detection routes, and no significant difference in limited stage proportion was observed (6.8% vs 10.8%, <italic>P</italic>
>0.05).</p>
</sec>
<sec id="sec004"><title>Conclusion</title>
<p>CT screening can detect more early stage non-small cell lung cancers, but not all of them could be beneficial as there are a considerable number of indolent ones such as bronchioloalveolar adenocarcinomas. Still, current evidence is lacking regarding small cell lung cancers.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Manser, R" uniqKey="Manser R">R Manser</name>
</author>
<author><name sortKey="Lethaby, A" uniqKey="Lethaby A">A Lethaby</name>
</author>
<author><name sortKey="Irving, Lb" uniqKey="Irving L">LB Irving</name>
</author>
<author><name sortKey="Stone, C" uniqKey="Stone C">C Stone</name>
</author>
<author><name sortKey="Byrnes, G" uniqKey="Byrnes G">G Byrnes</name>
</author>
<author><name sortKey="Abramson, Mj" uniqKey="Abramson M">MJ Abramson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seki, N" uniqKey="Seki N">N Seki</name>
</author>
<author><name sortKey="Eguchi, K" uniqKey="Eguchi K">K Eguchi</name>
</author>
<author><name sortKey="Kaneko, M" uniqKey="Kaneko M">M Kaneko</name>
</author>
<author><name sortKey="Ohmatsu, H" uniqKey="Ohmatsu H">H Ohmatsu</name>
</author>
<author><name sortKey="Kakinuma, R" uniqKey="Kakinuma R">R Kakinuma</name>
</author>
<author><name sortKey="Matsui, E" uniqKey="Matsui E">E Matsui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diederich, S" uniqKey="Diederich S">S Diederich</name>
</author>
<author><name sortKey="Thomas, M" uniqKey="Thomas M">M Thomas</name>
</author>
<author><name sortKey="Semik, M" uniqKey="Semik M">M Semik</name>
</author>
<author><name sortKey="Lenzen, H" uniqKey="Lenzen H">H Lenzen</name>
</author>
<author><name sortKey="Roos, N" uniqKey="Roos N">N Roos</name>
</author>
<author><name sortKey="Weber, A" uniqKey="Weber A">A Weber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name>
</author>
<author><name sortKey="Sone, S" uniqKey="Sone S">S Sone</name>
</author>
<author><name sortKey="Abe, H" uniqKey="Abe H">H Abe</name>
</author>
<author><name sortKey="Macmahon, H" uniqKey="Macmahon H">H MacMahon</name>
</author>
<author><name sortKey="Doi, K" uniqKey="Doi K">K Doi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shaham, D" uniqKey="Shaham D">D Shaham</name>
</author>
<author><name sortKey="Breuer, R" uniqKey="Breuer R">R Breuer</name>
</author>
<author><name sortKey="Copel, L" uniqKey="Copel L">L Copel</name>
</author>
<author><name sortKey="Agid, R" uniqKey="Agid R">R Agid</name>
</author>
<author><name sortKey="Makori, A" uniqKey="Makori A">A Makori</name>
</author>
<author><name sortKey="Kisselgoff, D" uniqKey="Kisselgoff D">D Kisselgoff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nawa, T" uniqKey="Nawa T">T Nawa</name>
</author>
<author><name sortKey="Nakagawa, T" uniqKey="Nakagawa T">T Nakagawa</name>
</author>
<author><name sortKey="Kusano, S" uniqKey="Kusano S">S Kusano</name>
</author>
<author><name sortKey="Kawasaki, Y" uniqKey="Kawasaki Y">Y Kawasaki</name>
</author>
<author><name sortKey="Sugawara, Y" uniqKey="Sugawara Y">Y Sugawara</name>
</author>
<author><name sortKey="Nakata, H" uniqKey="Nakata H">H Nakata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Swensen, Sj" uniqKey="Swensen S">SJ Swensen</name>
</author>
<author><name sortKey="Jett, Jr" uniqKey="Jett J">JR Jett</name>
</author>
<author><name sortKey="Hartman, Te" uniqKey="Hartman T">TE Hartman</name>
</author>
<author><name sortKey="Midthun, De" uniqKey="Midthun D">DE Midthun</name>
</author>
<author><name sortKey="Mandrekar, Sj" uniqKey="Mandrekar S">SJ Mandrekar</name>
</author>
<author><name sortKey="Hillman, Sl" uniqKey="Hillman S">SL Hillman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chong, S" uniqKey="Chong S">S Chong</name>
</author>
<author><name sortKey="Lee, Ks" uniqKey="Lee K">KS Lee</name>
</author>
<author><name sortKey="Chung, Mj" uniqKey="Chung M">MJ Chung</name>
</author>
<author><name sortKey="Kim, Ts" uniqKey="Kim T">TS Kim</name>
</author>
<author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name>
</author>
<author><name sortKey="Kwon, Oj" uniqKey="Kwon O">OJ Kwon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bastarrika, G" uniqKey="Bastarrika G">G Bastarrika</name>
</author>
<author><name sortKey="Garcia Velloso, Mj" uniqKey="Garcia Velloso M">MJ García-Velloso</name>
</author>
<author><name sortKey="Lozano, Md" uniqKey="Lozano M">MD Lozano</name>
</author>
<author><name sortKey="Montes, U" uniqKey="Montes U">U Montes</name>
</author>
<author><name sortKey="Torre, W" uniqKey="Torre W">W Torre</name>
</author>
<author><name sortKey="Spiteri, N" uniqKey="Spiteri N">N Spiteri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Veronesi, G" uniqKey="Veronesi G">G Veronesi</name>
</author>
<author><name sortKey="Maisonneuve, P" uniqKey="Maisonneuve P">P Maisonneuve</name>
</author>
<author><name sortKey="Rampinelli, C" uniqKey="Rampinelli C">C Rampinelli</name>
</author>
<author><name sortKey="Bertolotti, R" uniqKey="Bertolotti R">R Bertolotti</name>
</author>
<author><name sortKey="Petrella, F" uniqKey="Petrella F">F Petrella</name>
</author>
<author><name sortKey="Spaggiari, L" uniqKey="Spaggiari L">L Spaggiari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gohagan, Jk" uniqKey="Gohagan J">JK Gohagan</name>
</author>
<author><name sortKey="Marcus, Pm" uniqKey="Marcus P">PM Marcus</name>
</author>
<author><name sortKey="Fagerstrom, Rm" uniqKey="Fagerstrom R">RM Fagerstrom</name>
</author>
<author><name sortKey="Pinsky, Pf" uniqKey="Pinsky P">PF Pinsky</name>
</author>
<author><name sortKey="Kramer, Bs" uniqKey="Kramer B">BS Kramer</name>
</author>
<author><name sortKey="Prorok, Pc" uniqKey="Prorok P">PC Prorok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Infante, M" uniqKey="Infante M">M Infante</name>
</author>
<author><name sortKey="Cavuto, S" uniqKey="Cavuto S">S Cavuto</name>
</author>
<author><name sortKey="Lutman, Fr" uniqKey="Lutman F">FR Lutman</name>
</author>
<author><name sortKey="Brambilla, G" uniqKey="Brambilla G">G Brambilla</name>
</author>
<author><name sortKey="Chiesa, G" uniqKey="Chiesa G">G Chiesa</name>
</author>
<author><name sortKey="Ceresoli, G" uniqKey="Ceresoli G">G Ceresoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, Do" uniqKey="Wilson D">DO Wilson</name>
</author>
<author><name sortKey="Weissfeld, Jl" uniqKey="Weissfeld J">JL Weissfeld</name>
</author>
<author><name sortKey="Fuhrman, Cr" uniqKey="Fuhrman C">CR Fuhrman</name>
</author>
<author><name sortKey="Fisher, Sn" uniqKey="Fisher S">SN Fisher</name>
</author>
<author><name sortKey="Balogh, P" uniqKey="Balogh P">P Balogh</name>
</author>
<author><name sortKey="Landreneau, Rj" uniqKey="Landreneau R">RJ Landreneau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aberle, Dr" uniqKey="Aberle D">DR Aberle</name>
</author>
<author><name sortKey="Adams, Am" uniqKey="Adams A">AM Adams</name>
</author>
<author><name sortKey="Berg, Cd" uniqKey="Berg C">CD Berg</name>
</author>
<author><name sortKey="Black, Wc" uniqKey="Black W">WC Black</name>
</author>
<author><name sortKey="Clapp, Jd" uniqKey="Clapp J">JD Clapp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menezes, Rj" uniqKey="Menezes R">RJ Menezes</name>
</author>
<author><name sortKey="Roberts, Hc" uniqKey="Roberts H">HC Roberts</name>
</author>
<author><name sortKey="Paul, Ns" uniqKey="Paul N">NS Paul</name>
</author>
<author><name sortKey="Mcgregor, M" uniqKey="Mcgregor M">M McGregor</name>
</author>
<author><name sortKey="Chung, Tb" uniqKey="Chung T">TB Chung</name>
</author>
<author><name sortKey="Patsios, D" uniqKey="Patsios D">D Patsios</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Liang, M" uniqKey="Liang M">M Liang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Qin, P" uniqKey="Qin P">P Qin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Horeweg, N" uniqKey="Horeweg N">N Horeweg</name>
</author>
<author><name sortKey="Scholten, Et" uniqKey="Scholten E">ET Scholten</name>
</author>
<author><name sortKey="De Jong, Pa" uniqKey="De Jong P">PA de Jong</name>
</author>
<author><name sortKey="Van Der Aalst, Cm" uniqKey="Van Der Aalst C">CM van der Aalst</name>
</author>
<author><name sortKey="Weenink, C" uniqKey="Weenink C">C Weenink</name>
</author>
<author><name sortKey="Lammers, Jw" uniqKey="Lammers J">JW Lammers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lopes Pegna, A" uniqKey="Lopes Pegna A">A Lopes Pegna</name>
</author>
<author><name sortKey="Picozzi, G" uniqKey="Picozzi G">G Picozzi</name>
</author>
<author><name sortKey="Falaschi, F" uniqKey="Falaschi F">F Falaschi</name>
</author>
<author><name sortKey="Carrozzi, L" uniqKey="Carrozzi L">L Carrozzi</name>
</author>
<author><name sortKey="Falchini, M" uniqKey="Falchini M">M Falchini</name>
</author>
<author><name sortKey="Carozzi, Fm" uniqKey="Carozzi F">FM Carozzi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saghir, Z" uniqKey="Saghir Z">Z Saghir</name>
</author>
<author><name sortKey="Dirksen, A" uniqKey="Dirksen A">A Dirksen</name>
</author>
<author><name sortKey="Ashraf, H" uniqKey="Ashraf H">H Ashraf</name>
</author>
<author><name sortKey="Bach, Ks" uniqKey="Bach K">KS Bach</name>
</author>
<author><name sortKey="Brodersen, J" uniqKey="Brodersen J">J Brodersen</name>
</author>
<author><name sortKey="Clementsen, Pf" uniqKey="Clementsen P">PF Clementsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pelosi, G" uniqKey="Pelosi G">G Pelosi</name>
</author>
<author><name sortKey="Sonzogni, A" uniqKey="Sonzogni A">A Sonzogni</name>
</author>
<author><name sortKey="Veronesi, G" uniqKey="Veronesi G">G Veronesi</name>
</author>
<author><name sortKey="De Camilli, E" uniqKey="De Camilli E">E De Camilli</name>
</author>
<author><name sortKey="Maisonneuve, P" uniqKey="Maisonneuve P">P Maisonneuve</name>
</author>
<author><name sortKey="Spaggiari, L" uniqKey="Spaggiari L">L Spaggiari</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pastorino, U" uniqKey="Pastorino U">U Pastorino</name>
</author>
<author><name sortKey="Rossi, M" uniqKey="Rossi M">M Rossi</name>
</author>
<author><name sortKey="Rosato, V" uniqKey="Rosato V">V Rosato</name>
</author>
<author><name sortKey="Marchian, A" uniqKey="Marchian A">A Marchianò</name>
</author>
<author><name sortKey="Sverzellati, N" uniqKey="Sverzellati N">N Sverzellati</name>
</author>
<author><name sortKey="Morosi, C" uniqKey="Morosi C">C Morosi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Becker, N" uniqKey="Becker N">N Becker</name>
</author>
<author><name sortKey="Motsch, E" uniqKey="Motsch E">E Motsch</name>
</author>
<author><name sortKey="Gross, Ml" uniqKey="Gross M">ML Gross</name>
</author>
<author><name sortKey="Eigentopf, A" uniqKey="Eigentopf A">A Eigentopf</name>
</author>
<author><name sortKey="Heussel, Cp" uniqKey="Heussel C">CP Heussel</name>
</author>
<author><name sortKey="Dienemann, H" uniqKey="Dienemann H">H Dienemann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, W" uniqKey="Tang W">W Tang</name>
</author>
<author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Zhao, S" uniqKey="Zhao S">S Zhao</name>
</author>
<author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rzyman, W" uniqKey="Rzyman W">W Rzyman</name>
</author>
<author><name sortKey="Dziedzic, R" uniqKey="Dziedzic R">R Dziedzic</name>
</author>
<author><name sortKey="Jelitto G Rska, M" uniqKey="Jelitto G Rska M">M Jelitto-Górska</name>
</author>
<author><name sortKey="Biadacz, I" uniqKey="Biadacz I">I Biadacz</name>
</author>
<author><name sortKey="Ksi Ek, J" uniqKey="Ksi Ek J">J Książek</name>
</author>
<author><name sortKey="Siebert, J" uniqKey="Siebert J">J Siebert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mckee, Bj" uniqKey="Mckee B">BJ McKee</name>
</author>
<author><name sortKey="Hashim, Ja" uniqKey="Hashim J">JA Hashim</name>
</author>
<author><name sortKey="French, Rj" uniqKey="French R">RJ French</name>
</author>
<author><name sortKey="Mckee, Ab" uniqKey="Mckee A">AB McKee</name>
</author>
<author><name sortKey="Hesketh, Pj" uniqKey="Hesketh P">PJ Hesketh</name>
</author>
<author><name sortKey="Lamb, Cr" uniqKey="Lamb C">CR Lamb</name>
</author>
<author><name sortKey="Williamson, C" uniqKey="Williamson C">C Williamson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mulshine, Jl" uniqKey="Mulshine J">JL Mulshine</name>
</author>
<author><name sortKey="D Amico, Ta" uniqKey="D Amico T">TA D'Amico</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jones, Gs" uniqKey="Jones G">GS Jones</name>
</author>
<author><name sortKey="Baldwin, Dr" uniqKey="Baldwin D">DR Baldwin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seki, N" uniqKey="Seki N">N Seki</name>
</author>
<author><name sortKey="Eguchi, K" uniqKey="Eguchi K">K Eguchi</name>
</author>
<author><name sortKey="Kaneko, M" uniqKey="Kaneko M">M Kaneko</name>
</author>
<author><name sortKey="Ohmatsu, H" uniqKey="Ohmatsu H">H Ohmatsu</name>
</author>
<author><name sortKey="Kakinuma, R" uniqKey="Kakinuma R">R Kakinuma</name>
</author>
<author><name sortKey="Matsui, E" uniqKey="Matsui E">E Matsui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bach, Pb" uniqKey="Bach P">PB Bach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hillerdal, G" uniqKey="Hillerdal G">G Hillerdal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patz, Ef" uniqKey="Patz E">EF Patz</name>
</author>
<author><name sortKey="Pinsky, P" uniqKey="Pinsky P">P Pinsky</name>
</author>
<author><name sortKey="Gatsonis, C" uniqKey="Gatsonis C">C Gatsonis</name>
</author>
<author><name sortKey="Sicks, Jd" uniqKey="Sicks J">JD Sicks</name>
</author>
<author><name sortKey="Kramer, Bs" uniqKey="Kramer B">BS Kramer</name>
</author>
<author><name sortKey="Tammem Gi, Mc" uniqKey="Tammem Gi M">MC Tammemägi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Young, Rp" uniqKey="Young R">RP Young</name>
</author>
<author><name sortKey="Hopkins, Rj" uniqKey="Hopkins R">RJ Hopkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whiting, Pf" uniqKey="Whiting P">PF Whiting</name>
</author>
<author><name sortKey="Rutjes, Aw" uniqKey="Rutjes A">AW Rutjes</name>
</author>
<author><name sortKey="Westwood, Me" uniqKey="Westwood M">ME Westwood</name>
</author>
<author><name sortKey="Mallett, S" uniqKey="Mallett S">S Mallett</name>
</author>
<author><name sortKey="Deeks, Jj" uniqKey="Deeks J">JJ Deeks</name>
</author>
<author><name sortKey="Reitsma, Jb" uniqKey="Reitsma J">JB Reitsma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Edge, Sb" uniqKey="Edge S">SB Edge</name>
</author>
<author><name sortKey="Compton, Cc" uniqKey="Compton C">CC Compton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Travis, Wd" uniqKey="Travis W">WD Travis</name>
</author>
<author><name sortKey="Brambilla, E" uniqKey="Brambilla E">E Brambilla</name>
</author>
<author><name sortKey="Noguchi, M" uniqKey="Noguchi M">M Noguchi</name>
</author>
<author><name sortKey="Geisinger, K" uniqKey="Geisinger K">K Geisinger</name>
</author>
<author><name sortKey="Beer, D" uniqKey="Beer D">D Beer</name>
</author>
<author><name sortKey="Powell, Ca" uniqKey="Powell C">CA Powell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nyaga, Vn" uniqKey="Nyaga V">VN Nyaga</name>
</author>
<author><name sortKey="Arbyn, M" uniqKey="Arbyn M">M Arbyn</name>
</author>
<author><name sortKey="Aerts, M" uniqKey="Aerts M">M Aerts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Humphrey, Ll" uniqKey="Humphrey L">LL Humphrey</name>
</author>
<author><name sortKey="Deffebach, M" uniqKey="Deffebach M">M Deffebach</name>
</author>
<author><name sortKey="Pappas, M" uniqKey="Pappas M">M Pappas</name>
</author>
<author><name sortKey="Baumann, C" uniqKey="Baumann C">C Baumann</name>
</author>
<author><name sortKey="Artis, K" uniqKey="Artis K">K Artis</name>
</author>
<author><name sortKey="Mitchell, Jp" uniqKey="Mitchell J">JP Mitchell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Usman Ali, M" uniqKey="Usman Ali M">M Usman Ali</name>
</author>
<author><name sortKey="Miller, J" uniqKey="Miller J">J Miller</name>
</author>
<author><name sortKey="Peirson, L" uniqKey="Peirson L">L Peirson</name>
</author>
<author><name sortKey="Fitzpatrick Lewis, D" uniqKey="Fitzpatrick Lewis D">D Fitzpatrick-Lewis</name>
</author>
<author><name sortKey="Kenny, M" uniqKey="Kenny M">M Kenny</name>
</author>
<author><name sortKey="Sherifali, D" uniqKey="Sherifali D">D Sherifali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nawa, T" uniqKey="Nawa T">T Nawa</name>
</author>
<author><name sortKey="Nakagawa, T" uniqKey="Nakagawa T">T Nakagawa</name>
</author>
<author><name sortKey="Mizoue, T" uniqKey="Mizoue T">T Mizoue</name>
</author>
<author><name sortKey="Endo, K" uniqKey="Endo K">K Endo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Sj" uniqKey="Zhao S">SJ Zhao</name>
</author>
<author><name sortKey="Wu, N" uniqKey="Wu N">N Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henschke, Ci" uniqKey="Henschke C">CI Henschke</name>
</author>
<author><name sortKey="Yankelevitz, Df" uniqKey="Yankelevitz D">DF Yankelevitz</name>
</author>
<author><name sortKey="Libby, D" uniqKey="Libby D">D Libby</name>
</author>
<author><name sortKey="Kimmel, M" uniqKey="Kimmel M">M Kimmel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Young, Rp" uniqKey="Young R">RP Young</name>
</author>
<author><name sortKey="Duan, F" uniqKey="Duan F">F Duan</name>
</author>
<author><name sortKey="Chiles, C" uniqKey="Chiles C">C Chiles</name>
</author>
<author><name sortKey="Hopkins, Rj" uniqKey="Hopkins R">RJ Hopkins</name>
</author>
<author><name sortKey="Gamble, Gd" uniqKey="Gamble G">GD Gamble</name>
</author>
<author><name sortKey="Greco, Em" uniqKey="Greco E">EM Greco</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Braillon, A" uniqKey="Braillon A">A Braillon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Young, Rp" uniqKey="Young R">RP Young</name>
</author>
<author><name sortKey="Hopkins, Rj" uniqKey="Hopkins R">RJ Hopkins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Veronesi, G" uniqKey="Veronesi G">G Veronesi</name>
</author>
<author><name sortKey="Maisonneuve, P" uniqKey="Maisonneuve P">P Maisonneuve</name>
</author>
<author><name sortKey="Bellomi, M" uniqKey="Bellomi M">M Bellomi</name>
</author>
<author><name sortKey="Rampinelli, C" uniqKey="Rampinelli C">C Rampinelli</name>
</author>
<author><name sortKey="Durli, I" uniqKey="Durli I">I Durli</name>
</author>
<author><name sortKey="Bertolotti, R" uniqKey="Bertolotti R">R Bertolotti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, Do" uniqKey="Wilson D">DO Wilson</name>
</author>
<author><name sortKey="Ryan, A" uniqKey="Ryan A">A Ryan</name>
</author>
<author><name sortKey="Fuhrman, C" uniqKey="Fuhrman C">C Fuhrman</name>
</author>
<author><name sortKey="Schuchert, M" uniqKey="Schuchert M">M Schuchert</name>
</author>
<author><name sortKey="Shapiro, S" uniqKey="Shapiro S">S Shapiro</name>
</author>
<author><name sortKey="Siegfried, Jm" uniqKey="Siegfried J">JM Siegfried</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vazquez, M" uniqKey="Vazquez M">M Vazquez</name>
</author>
<author><name sortKey="Carter, D" uniqKey="Carter D">D Carter</name>
</author>
<author><name sortKey="Brambilla, E" uniqKey="Brambilla E">E Brambilla</name>
</author>
<author><name sortKey="Gazdar, A" uniqKey="Gazdar A">A Gazdar</name>
</author>
<author><name sortKey="Noguchi, M" uniqKey="Noguchi M">M Noguchi</name>
</author>
<author><name sortKey="Travis, Wd" uniqKey="Travis W">WD Travis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yousem, Sa" uniqKey="Yousem S">SA Yousem</name>
</author>
<author><name sortKey="Beasley, Mb" uniqKey="Beasley M">MB Beasley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silvestri, Ga" uniqKey="Silvestri G">GA Silvestri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silva, M" uniqKey="Silva M">M Silva</name>
</author>
<author><name sortKey="Galeone, C" uniqKey="Galeone C">C Galeone</name>
</author>
<author><name sortKey="Sverzellati, N" uniqKey="Sverzellati N">N Sverzellati</name>
</author>
<author><name sortKey="Marchian, A" uniqKey="Marchian A">A Marchianò</name>
</author>
<author><name sortKey="Calareso, G" uniqKey="Calareso G">G Calareso</name>
</author>
<author><name sortKey="Sestini, S" uniqKey="Sestini S">S Sestini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spiro, Sg" uniqKey="Spiro S">SG Spiro</name>
</author>
<author><name sortKey="Hackshaw, A" uniqKey="Hackshaw A">A Hackshaw</name>
</author>
</analytic>
</biblStruct>
</listBibl>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
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<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
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<article-meta><article-id pub-id-type="pmid">27736916</article-id>
<article-id pub-id-type="pmc">5063401</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0164416</article-id>
<article-id pub-id-type="publisher-id">PONE-D-16-24892</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
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<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Diagnostic Medicine</subject>
<subj-group><subject>Cancer Detection and Diagnosis</subject>
<subj-group><subject>Cancer Screening</subject>
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<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancer Detection and Diagnosis</subject>
<subj-group><subject>Cancer Screening</subject>
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</subj-group>
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<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Lung and Intrathoracic Tumors</subject>
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</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Carcinomas</subject>
<subj-group><subject>Adenocarcinomas</subject>
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</subj-group>
</subj-group>
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</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Lung and Intrathoracic Tumors</subject>
<subj-group><subject>Small Cell Lung Cancer</subject>
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</subj-group>
</subj-group>
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</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Clinical Medicine</subject>
<subj-group><subject>Clinical Trials</subject>
<subj-group><subject>Randomized Controlled Trials</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Pharmacology</subject>
<subj-group><subject>Drug Research and Development</subject>
<subj-group><subject>Clinical Trials</subject>
<subj-group><subject>Randomized Controlled Trials</subject>
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</subj-group>
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<subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject>
<subj-group><subject>Clinical Trials</subject>
<subj-group><subject>Randomized Controlled Trials</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancers and Neoplasms</subject>
<subj-group><subject>Lung and Intrathoracic Tumors</subject>
<subj-group><subject>Non-Small Cell Lung Cancer</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject>
<subj-group><subject>Imaging Techniques</subject>
<subj-group><subject>Neuroimaging</subject>
<subj-group><subject>Computed Axial Tomography</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Neuroscience</subject>
<subj-group><subject>Neuroimaging</subject>
<subj-group><subject>Computed Axial Tomography</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Diagnostic Medicine</subject>
<subj-group><subject>Diagnostic Radiology</subject>
<subj-group><subject>Tomography</subject>
<subj-group><subject>Computed Axial Tomography</subject>
</subj-group>
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</subj-group>
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<subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject>
<subj-group><subject>Imaging Techniques</subject>
<subj-group><subject>Diagnostic Radiology</subject>
<subj-group><subject>Tomography</subject>
<subj-group><subject>Computed Axial Tomography</subject>
</subj-group>
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</subj-group>
</subj-group>
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<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Radiology and Imaging</subject>
<subj-group><subject>Diagnostic Radiology</subject>
<subj-group><subject>Tomography</subject>
<subj-group><subject>Computed Axial Tomography</subject>
</subj-group>
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<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Diagnostic Medicine</subject>
<subj-group><subject>Cancer Detection and Diagnosis</subject>
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</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Oncology</subject>
<subj-group><subject>Cancer Detection and Diagnosis</subject>
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</article-categories>
<title-group><article-title>Can CT Screening Give Rise to a Beneficial Stage Shift in Lung Cancer Patients? Systematic Review and Meta-Analysis</article-title>
<alt-title alt-title-type="running-head">CT Screening & Lung Cancer Stage</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Wang</surname>
<given-names>Zixing</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Hu</surname>
<given-names>Yaoda</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Yuyan</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Han</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Lei</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xue</surname>
<given-names>Fang</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sui</surname>
<given-names>Xin</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Song</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shi</surname>
<given-names>Ruihong</given-names>
</name>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jiang</surname>
<given-names>Jingmei</given-names>
</name>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, Peking Union Medical College, Beijing, China</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing, China</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Gorlova</surname>
<given-names>Olga Y</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Dartmouth College Geisel School of Medicine, UNITED STATES</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceptualization:</bold>
JJ WS.</p>
</list-item>
<list-item><p><bold>Data curation:</bold>
LW.</p>
</list-item>
<list-item><p><bold>Formal analysis:</bold>
YW WH.</p>
</list-item>
<list-item><p><bold>Methodology:</bold>
FX WH.</p>
</list-item>
<list-item><p><bold>Resources:</bold>
ZW YH.</p>
</list-item>
<list-item><p><bold>Software:</bold>
YW.</p>
</list-item>
<list-item><p><bold>Supervision:</bold>
JJ WS.</p>
</list-item>
<list-item><p><bold>Validation:</bold>
LW RS.</p>
</list-item>
<list-item><p><bold>Visualization:</bold>
YW WH.</p>
</list-item>
<list-item><p><bold>Writing – original draft:</bold>
ZW YH.</p>
</list-item>
<list-item><p><bold>Writing – review & editing:</bold>
JJ XS.</p>
</list-item>
</list>
</p>
</fn>
<corresp id="cor001">* E-mail: <email>jingmeijiang238@hotmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>13</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="collection"><year>2016</year>
</pub-date>
<volume>11</volume>
<issue>10</issue>
<elocation-id>e0164416</elocation-id>
<history><date date-type="received"><day>21</day>
<month>6</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>23</day>
<month>9</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Wang et al</copyright-statement>
<copyright-year>2016</copyright-year>
<copyright-holder>Wang et al</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pone.0164416.pdf"></self-uri>
<abstract><sec id="sec001"><title>Objectives</title>
<p>To portray the stage characteristics of lung cancers detected in CT screenings, and explore whether there’s universal stage superiority over other methods for various pathological types using available data worldwide in a meta-analysis approach.</p>
</sec>
<sec id="sec002"><title>Materials and Methods</title>
<p>EMBASE and MEDLINE were searched for studies on lung cancer CT screening in natural populations through July 2015 without language or other filters. Twenty-four studies (8 trials and 16 cohorts) involving 1875 CT-detected lung cancer patients were enrolled and assessed by QUADAS-2. Pathology-confirmed stage information was carefully extracted by two reviewers. Stage I or limited stage proportions were pooled by random effect model with Freeman-Tukey double arcsine transformation.</p>
</sec>
<sec id="sec003"><title>Results</title>
<p>Pooled stage I cancer proportion in CT screenings was 73.2% (95% confidence interval: 68.6%, 77.5%), with a significant rising trend (<italic>P</italic>
<sub>trend</sub>
<0.05) from baseline (64.7%) to ≥5 repeat rounds (87.1%). Relative to chest radiograph and usual care, the increased stage I proportions in CT were 12.2% (<italic>P</italic>
>0.05), and 46.5% (<italic>P</italic>
<0.05), respectively. Pathology-specifically, adenocarcinomas (66%) and squamous cell lung cancers (17%) composed the majority of CT-detected lung cancers, and had significantly higher stage I proportions relative to chest radiograph (bronchioloalveolar adenocarcinomas, 80.9% vs 51.4%; other adenocarcinomas, 58.8% vs 38.3%; squamous cell lung cancers, 52.3% vs 38.3%; all <italic>P</italic>
<0.05). However, the percentage of small cell lung cancer was lower using CT than other detection routes, and no significant difference in limited stage proportion was observed (6.8% vs 10.8%, <italic>P</italic>
>0.05).</p>
</sec>
<sec id="sec004"><title>Conclusion</title>
<p>CT screening can detect more early stage non-small cell lung cancers, but not all of them could be beneficial as there are a considerable number of indolent ones such as bronchioloalveolar adenocarcinomas. Still, current evidence is lacking regarding small cell lung cancers.</p>
</sec>
</abstract>
<funding-group><funding-statement>The authors received no specific funding for this work.</funding-statement>
</funding-group>
<counts><fig-count count="5"></fig-count>
<table-count count="3"></table-count>
<page-count count="16"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper and its Supporting Information files.</p>
</notes>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Zixing" sort="Wang, Zixing" uniqKey="Wang Z" first="Zixing" last="Wang">Zixing Wang</name>
</noRegion>
<name sortKey="Han, Wei" sort="Han, Wei" uniqKey="Han W" first="Wei" last="Han">Wei Han</name>
<name sortKey="Hu, Yaoda" sort="Hu, Yaoda" uniqKey="Hu Y" first="Yaoda" last="Hu">Yaoda Hu</name>
<name sortKey="Jiang, Jingmei" sort="Jiang, Jingmei" uniqKey="Jiang J" first="Jingmei" last="Jiang">Jingmei Jiang</name>
<name sortKey="Shi, Ruihong" sort="Shi, Ruihong" uniqKey="Shi R" first="Ruihong" last="Shi">Ruihong Shi</name>
<name sortKey="Song, Wei" sort="Song, Wei" uniqKey="Song W" first="Wei" last="Song">Wei Song</name>
<name sortKey="Sui, Xin" sort="Sui, Xin" uniqKey="Sui X" first="Xin" last="Sui">Xin Sui</name>
<name sortKey="Wang, Lei" sort="Wang, Lei" uniqKey="Wang L" first="Lei" last="Wang">Lei Wang</name>
<name sortKey="Wang, Yuyan" sort="Wang, Yuyan" uniqKey="Wang Y" first="Yuyan" last="Wang">Yuyan Wang</name>
<name sortKey="Xue, Fang" sort="Xue, Fang" uniqKey="Xue F" first="Fang" last="Xue">Fang Xue</name>
</country>
</tree>
</affiliations>
</record>
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