Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated
Identifieur interne : 000021 ( Pmc/Checkpoint ); précédent : 000020; suivant : 000022Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated
Auteurs : Frédéric Huet [France] ; Marieke Abrahamse-Berkeveld [Pays-Bas] ; Sebastian Tims [Pays-Bas] ; Umberto Simeoni [Suisse] ; Gérard Beley ; Christoph Savagner [France] ; Yvan Vandenplas [Belgique] ; Jonathan O Hourihane [Irlande (pays)]Source :
- Journal of Pediatric Gastroenterology and Nutrition [ 0277-2116 ] ; 2016.
Abstract
Fermented formulae (FERM) and a specific mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS compared with either 1 feature, in healthy term infants.
Four hundred thirty-two infants were enrolled before 28 days of age and followed up to 17 weeks of age and assigned to 1 of the 4 groups: (i) formula with scGOS/lcFOS, (ii) scGOS/lcFOS + 15% FERM, (iii) scGOS/lcFOS + 50% FERM, or (iv) 50% fermented formula (50% FERM). Primary outcome was daily weight gain during intervention (equivalence criterion: difference in daily weight gain ≤3 g/day). Infants’ anthropometrics, formula intake, number, and type of (serious) AEs were monitored monthly. Stool samples were collected at baseline and after 17 weeks for analysis of physiological and microbiological parameters.
Equivalence of weight gain per day was demonstrated in both the intention-to-treat and per-protocol population, with a mean weight gain (SD) of 29.7 (6.1), 28.2 (4.8), 28.5 (5.0), and 28.7 (5.9) g/day for the groups i to iv respectively. No differences were observed in other growth parameters, formula intake, and the number or severity of AEs. In all scGOS/lcFOS-containing formulae, a beneficial effect of scGOS/lcFOS was observed, indicated by the lower pH, lower
The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants.
Url:
DOI: 10.1097/MPG.0000000000001360
PubMed: 27472478
PubMed Central: 5051523
Affiliations:
- Belgique, France, Irlande (pays), Pays-Bas, Suisse
- Canton de Vaud, Région de Bruxelles-Capitale, Utrecht (province)
- Angers, Bruxelles, Dijon, Lausanne, Utrecht
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PMC:5051523Le document en format XML
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<series><title level="j">Journal of Pediatric Gastroenterology and Nutrition</title>
<idno type="ISSN">0277-2116</idno>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<sec><title>Objective:</title>
<p>Fermented formulae (FERM) and a specific mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS compared with either 1 feature, in healthy term infants.</p>
</sec>
<sec sec-type="methods"><title>Methods:</title>
<p>Four hundred thirty-two infants were enrolled before 28 days of age and followed up to 17 weeks of age and assigned to 1 of the 4 groups: (i) formula with scGOS/lcFOS, (ii) scGOS/lcFOS + 15% FERM, (iii) scGOS/lcFOS + 50% FERM, or (iv) 50% fermented formula (50% FERM). Primary outcome was daily weight gain during intervention (equivalence criterion: difference in daily weight gain ≤3 g/day). Infants’ anthropometrics, formula intake, number, and type of (serious) AEs were monitored monthly. Stool samples were collected at baseline and after 17 weeks for analysis of physiological and microbiological parameters.</p>
</sec>
<sec sec-type="results"><title>Results:</title>
<p>Equivalence of weight gain per day was demonstrated in both the intention-to-treat and per-protocol population, with a mean weight gain (SD) of 29.7 (6.1), 28.2 (4.8), 28.5 (5.0), and 28.7 (5.9) g/day for the groups i to iv respectively. No differences were observed in other growth parameters, formula intake, and the number or severity of AEs. In all scGOS/lcFOS-containing formulae, a beneficial effect of scGOS/lcFOS was observed, indicated by the lower pH, lower <italic>Clostridium difficile</italic>
levels, and higher secretory immunoglobulin A levels.</p>
</sec>
<sec sec-type="conclusion"><title>Conclusions:</title>
<p>The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Pediatr Gastroenterol Nutr</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Pediatr. Gastroenterol. Nutr</journal-id>
<journal-id journal-id-type="publisher-id">JPGA</journal-id>
<journal-title-group><journal-title>Journal of Pediatric Gastroenterology and Nutrition</journal-title>
</journal-title-group>
<issn pub-type="ppub">0277-2116</issn>
<issn pub-type="epub">1536-4801</issn>
<publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27472478</article-id>
<article-id pub-id-type="pmc">5051523</article-id>
<article-id pub-id-type="doi">10.1097/MPG.0000000000001360</article-id>
<article-id pub-id-type="art-access-id">00011</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article: Nutrition</subject>
</subj-group>
</article-categories>
<title-group><article-title>Partly Fermented Infant Formulae With Specific Oligosaccharides Support Adequate Infant Growth and Are Well-Tolerated</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Huet</surname>
<given-names>Frédéric</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>∗</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abrahamse-Berkeveld</surname>
<given-names>Marieke</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>†</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tims</surname>
<given-names>Sebastian</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>†</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Simeoni</surname>
<given-names>Umberto</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>‡</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beley</surname>
<given-names>Gérard</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>§</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Savagner</surname>
<given-names>Christoph</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>||</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vandenplas</surname>
<given-names>Yvan</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>¶</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hourihane</surname>
<given-names>Jonathan O’B.</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>#</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>∗</label>
Hôpital d’Enfants, Dijon, France</aff>
<aff id="aff2"><label>†</label>
Nutricia Research, Utrecht, The Netherlands</aff>
<aff id="aff3"><label>‡</label>
Center Hospitalier Universitaire Vaudois, Lausanne, Switzerland</aff>
<aff id="aff4"><label>§</label>
Maison de l’enfant Essey- lès- Nancy, Essey- lès- Nancy</aff>
<aff id="aff5"><label>||</label>
Center Hospitalier Universitaire d’Angers, Angers, France</aff>
<aff id="aff6"><label>¶</label>
Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium</aff>
<aff id="aff7"><label>#</label>
Department of Paediatrics and Child Health, University College, Cork, Ireland.</aff>
<author-notes><corresp>Address correspondence and reprint requests to Professor Jonathan O’B. Hourihane, Department of Paediatrics and Child Health, Clinical Investigation Unit, Cork University Hospital, Wilton, Cork, T12 DC4A Ireland (e-mail: <email>j.hourihane@ucc.ie</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>9</month>
<year>2016</year>
</pub-date>
<volume>63</volume>
<issue>4</issue>
<fpage>e43</fpage>
<lpage>e53</lpage>
<history><date date-type="received"><day>22</day>
<month>1</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>25</day>
<month>7</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>Copyright 2016 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.</copyright-statement>
<copyright-year>2016</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>
</license-p>
</license>
</permissions>
<self-uri xlink:type="simple" xlink:href="jpga-63-e43.pdf"></self-uri>
<abstract><title>ABSTRACT</title>
<sec><title>Objective:</title>
<p>Fermented formulae (FERM) and a specific mixture of 90% short-chain galacto-oligosaccharides and 10% long-chain fructo-oligosaccharides (scGOS/lcFOS; 9:1) have a potential beneficial effect on gastrointestinal function and microbiota development in infants. The present study assessed the safety and tolerance of the combination of partly fermented infant milk formulae and scGOS/lcFOS compared with either 1 feature, in healthy term infants.</p>
</sec>
<sec sec-type="methods"><title>Methods:</title>
<p>Four hundred thirty-two infants were enrolled before 28 days of age and followed up to 17 weeks of age and assigned to 1 of the 4 groups: (i) formula with scGOS/lcFOS, (ii) scGOS/lcFOS + 15% FERM, (iii) scGOS/lcFOS + 50% FERM, or (iv) 50% fermented formula (50% FERM). Primary outcome was daily weight gain during intervention (equivalence criterion: difference in daily weight gain ≤3 g/day). Infants’ anthropometrics, formula intake, number, and type of (serious) AEs were monitored monthly. Stool samples were collected at baseline and after 17 weeks for analysis of physiological and microbiological parameters.</p>
</sec>
<sec sec-type="results"><title>Results:</title>
<p>Equivalence of weight gain per day was demonstrated in both the intention-to-treat and per-protocol population, with a mean weight gain (SD) of 29.7 (6.1), 28.2 (4.8), 28.5 (5.0), and 28.7 (5.9) g/day for the groups i to iv respectively. No differences were observed in other growth parameters, formula intake, and the number or severity of AEs. In all scGOS/lcFOS-containing formulae, a beneficial effect of scGOS/lcFOS was observed, indicated by the lower pH, lower <italic>Clostridium difficile</italic>
levels, and higher secretory immunoglobulin A levels.</p>
</sec>
<sec sec-type="conclusion"><title>Conclusions:</title>
<p>The partly fermented infant milk formulae containing the specific mixture scGOS/lcFOS were well-tolerated and resulted in normal growth in healthy infants.</p>
</sec>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>fermented formula</kwd>
<kwd>microbiota</kwd>
<kwd>safety</kwd>
<kwd>scGOS/lcFOS</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name>
<meta-value>TRUE</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Belgique</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Pays-Bas</li>
<li>Suisse</li>
</country>
<region><li>Canton de Vaud</li>
<li>Région de Bruxelles-Capitale</li>
<li>Utrecht (province)</li>
</region>
<settlement><li>Angers</li>
<li>Bruxelles</li>
<li>Dijon</li>
<li>Lausanne</li>
<li>Utrecht</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Beley, Gerard" sort="Beley, Gerard" uniqKey="Beley G" first="Gérard" last="Beley">Gérard Beley</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Huet, Frederic" sort="Huet, Frederic" uniqKey="Huet F" first="Frédéric" last="Huet">Frédéric Huet</name>
</noRegion>
<name sortKey="Savagner, Christoph" sort="Savagner, Christoph" uniqKey="Savagner C" first="Christoph" last="Savagner">Christoph Savagner</name>
</country>
<country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Abrahamse Berkeveld, Marieke" sort="Abrahamse Berkeveld, Marieke" uniqKey="Abrahamse Berkeveld M" first="Marieke" last="Abrahamse-Berkeveld">Marieke Abrahamse-Berkeveld</name>
</region>
<name sortKey="Tims, Sebastian" sort="Tims, Sebastian" uniqKey="Tims S" first="Sebastian" last="Tims">Sebastian Tims</name>
</country>
<country name="Suisse"><region name="Canton de Vaud"><name sortKey="Simeoni, Umberto" sort="Simeoni, Umberto" uniqKey="Simeoni U" first="Umberto" last="Simeoni">Umberto Simeoni</name>
</region>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Vandenplas, Yvan" sort="Vandenplas, Yvan" uniqKey="Vandenplas Y" first="Yvan" last="Vandenplas">Yvan Vandenplas</name>
</region>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Hourihane, Jonathan O" sort="Hourihane, Jonathan O" uniqKey="Hourihane J" first="Jonathan O" last="Hourihane">Jonathan O Hourihane</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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