Three-dimensional histological specimen preparation for accurate imaging and spatial reconstruction of the middle and inner ear
Identifieur interne : 000175 ( Ncbi/Merge ); précédent : 000174; suivant : 000176Three-dimensional histological specimen preparation for accurate imaging and spatial reconstruction of the middle and inner ear
Auteurs : Thomas S. Rau [Allemagne] ; Waldemar Würfel [Allemagne] ; Thomas Lenarz [Allemagne] ; Omid Majdani [Allemagne]Source :
- International Journal of Computer Assisted Radiology and Surgery [ 1861-6410 ] ; 2013.
Abstract
This paper presents a highly accurate cross-sectional preparation technique. The research aim was to develop an adequate imaging modality for both soft and bony tissue structures featuring high contrast and high resolution. Therefore, the advancement of an already existing microgrinding procedure was pursued. The central objectives were to preserve spatial relations and to ensure the accurate three-dimensional reconstruction of histological sections.
Twelve human temporal bone specimens including middle and inner ear structures were utilized. They were embedded in epoxy resin, then dissected by serial grinding and finally digitalized. The actual abrasion of each grinding slice was measured using a tactile length gauge with an accuracy of one micrometre. The cross-sectional images were aligned with the aid of artificial markers and by applying a feature-based, custom-made auto-registration algorithm. To determine the accuracy of the overall reconstruction procedure, a well-known reference object was used for comparison. To ensure the compatibility of the histological data with conventional clinical image data, the image stacks were finally converted into the DICOM standard.
The image fusion of data from temporal bone specimens’ and from non-destructive flat-panel-based volume computed tomography confirmed the spatial accuracy achieved by the procedure, as did the evaluation using the reference object.
This systematic and easy-to-follow preparation technique enables the three-dimensional (3D) histological reconstruction of complex soft and bony tissue structures. It facilitates the creation of detailed and spatially correct 3D anatomical models. Such models are of great benefit for image-based segmentation and planning in the field of computer-assisted surgery as well as in finite element analysis. In the context of human inner ear surgery, three-dimensional histology will improve the experimental evaluation and determination of intra-cochlear trauma after the insertion of an electrode array of a cochlear implant system.
Url:
DOI: 10.1007/s11548-013-0825-7
PubMed: 23633112
PubMed Central: 3702969
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<series><title level="j">International Journal of Computer Assisted Radiology and Surgery</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p> This paper presents a highly accurate cross-sectional preparation technique. The research aim was to develop an adequate imaging modality for both soft and bony tissue structures featuring high contrast and high resolution. Therefore, the advancement of an already existing microgrinding procedure was pursued. The central objectives were to preserve spatial relations and to ensure the accurate three-dimensional reconstruction of histological sections.</p>
</sec>
<sec><title>Methods</title>
<p> Twelve human temporal bone specimens including middle and inner ear structures were utilized. They were embedded in epoxy resin, then dissected by serial grinding and finally digitalized. The actual abrasion of each grinding slice was measured using a tactile length gauge with an accuracy of one micrometre. The cross-sectional images were aligned with the aid of artificial markers and by applying a feature-based, custom-made auto-registration algorithm. To determine the accuracy of the overall reconstruction procedure, a well-known reference object was used for comparison. To ensure the compatibility of the histological data with conventional clinical image data, the image stacks were finally converted into the DICOM standard.</p>
</sec>
<sec><title>Results</title>
<p> The image fusion of data from temporal bone specimens’ and from non-destructive flat-panel-based volume computed tomography confirmed the spatial accuracy achieved by the procedure, as did the evaluation using the reference object.</p>
</sec>
<sec><title>Conclusion</title>
<p> This systematic and easy-to-follow preparation technique enables the three-dimensional (3D) histological reconstruction of complex soft and bony tissue structures. It facilitates the creation of detailed and spatially correct 3D anatomical models. Such models are of great benefit for image-based segmentation and planning in the field of computer-assisted surgery as well as in finite element analysis. In the context of human inner ear surgery, three-dimensional histology will improve the experimental evaluation and determination of intra-cochlear trauma after the insertion of an electrode array of a cochlear implant system.</p>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Comput Assist Radiol Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Comput Assist Radiol Surg</journal-id>
<journal-title-group><journal-title>International Journal of Computer Assisted Radiology and Surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">1861-6410</issn>
<issn pub-type="epub">1861-6429</issn>
<publisher><publisher-name>Springer Berlin Heidelberg</publisher-name>
<publisher-loc>Berlin/Heidelberg</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23633112</article-id>
<article-id pub-id-type="pmc">3702969</article-id>
<article-id pub-id-type="publisher-id">825</article-id>
<article-id pub-id-type="doi">10.1007/s11548-013-0825-7</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Three-dimensional histological specimen preparation for accurate imaging and spatial reconstruction of the middle and inner ear</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Rau</surname>
<given-names>Thomas S.</given-names>
</name>
<address><phone>+49-0511-5323025</phone>
<fax>+49-0511-5327274</fax>
<email>rau.thomas@mh-hannover.de</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Würfel</surname>
<given-names>Waldemar</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lenarz</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Majdani</surname>
<given-names>Omid</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1">Department of Otolaryngology, Institute for AudioNeurotechnology (VIANNA), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany</aff>
</contrib-group>
<pub-date pub-type="epub"><day>30</day>
<month>4</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>30</day>
<month>4</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>7</month>
<year>2013</year>
</pub-date>
<volume>8</volume>
<issue>4</issue>
<fpage>481</fpage>
<lpage>509</lpage>
<history><date date-type="received"><day>8</day>
<month>8</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>27</day>
<month>2</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2013</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Purpose</title>
<p> This paper presents a highly accurate cross-sectional preparation technique. The research aim was to develop an adequate imaging modality for both soft and bony tissue structures featuring high contrast and high resolution. Therefore, the advancement of an already existing microgrinding procedure was pursued. The central objectives were to preserve spatial relations and to ensure the accurate three-dimensional reconstruction of histological sections.</p>
</sec>
<sec><title>Methods</title>
<p> Twelve human temporal bone specimens including middle and inner ear structures were utilized. They were embedded in epoxy resin, then dissected by serial grinding and finally digitalized. The actual abrasion of each grinding slice was measured using a tactile length gauge with an accuracy of one micrometre. The cross-sectional images were aligned with the aid of artificial markers and by applying a feature-based, custom-made auto-registration algorithm. To determine the accuracy of the overall reconstruction procedure, a well-known reference object was used for comparison. To ensure the compatibility of the histological data with conventional clinical image data, the image stacks were finally converted into the DICOM standard.</p>
</sec>
<sec><title>Results</title>
<p> The image fusion of data from temporal bone specimens’ and from non-destructive flat-panel-based volume computed tomography confirmed the spatial accuracy achieved by the procedure, as did the evaluation using the reference object.</p>
</sec>
<sec><title>Conclusion</title>
<p> This systematic and easy-to-follow preparation technique enables the three-dimensional (3D) histological reconstruction of complex soft and bony tissue structures. It facilitates the creation of detailed and spatially correct 3D anatomical models. Such models are of great benefit for image-based segmentation and planning in the field of computer-assisted surgery as well as in finite element analysis. In the context of human inner ear surgery, three-dimensional histology will improve the experimental evaluation and determination of intra-cochlear trauma after the insertion of an electrode array of a cochlear implant system.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Microgrinding</kwd>
<kwd>3D Imaging</kwd>
<kwd>Reconstruction</kwd>
<kwd>Histological sectioning</kwd>
<kwd>Modelling</kwd>
<kwd>Cochlea</kwd>
<kwd>Middle ear </kwd>
<kwd>Temporal bone</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© CARS 2013</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Basse-Saxe</li>
</region>
<settlement><li>Hanovre</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Rau, Thomas S" sort="Rau, Thomas S" uniqKey="Rau T" first="Thomas S." last="Rau">Thomas S. Rau</name>
</region>
<name sortKey="Lenarz, Thomas" sort="Lenarz, Thomas" uniqKey="Lenarz T" first="Thomas" last="Lenarz">Thomas Lenarz</name>
<name sortKey="Majdani, Omid" sort="Majdani, Omid" uniqKey="Majdani O" first="Omid" last="Majdani">Omid Majdani</name>
<name sortKey="Wurfel, Waldemar" sort="Wurfel, Waldemar" uniqKey="Wurfel W" first="Waldemar" last="Würfel">Waldemar Würfel</name>
</country>
</tree>
</affiliations>
</record>
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