Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease
Identifieur interne : 000293 ( Ncbi/Curation ); précédent : 000292; suivant : 000294Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease
Auteurs : Aleksander Kempny [Royaume-Uni, Allemagne] ; Gerhard-Paul Diller [Royaume-Uni, Allemagne] ; Rafael Alonso-Gonzalez [Royaume-Uni] ; Anselm Uebing [Royaume-Uni] ; Isma Rafiq [Royaume-Uni] ; Wei Li [Royaume-Uni] ; Lorna Swan [Royaume-Uni] ; James Hooper [Royaume-Uni] ; Jackie Donovan [Royaume-Uni] ; Stephen J. Wort [Royaume-Uni] ; Michael A. Gatzoulis [Royaume-Uni] ; Konstantinos Dimopoulos [Royaume-Uni]Source :
- Heart [ 1355-6037 ] ; 2015.
Abstract
In patients with acquired heart failure, hypoalbuminaemia is associated with increased risk of death. The prevalence of hypoproteinaemia and hypoalbuminaemia and their relation to outcome in adult patients with congenital heart disease (ACHD) remains, however, unknown.
Data on patients with ACHD who underwent blood testing in our centre within the last 14 years were collected. The relation between laboratory, clinical or demographic parameters at baseline and mortality was assessed using Cox proportional hazards regression analysis.
A total of 2886 patients with ACHD were included. Mean age was 33.3 years (23.6–44.7) and 50.1% patients were men. Median plasma albumin concentration was 41.0 g/L (38.0–44.0), whereas hypoalbuminaemia (<35 g/L) was present in 13.9% of patients. The prevalence of hypoalbuminaemia was significantly higher in patients with great complexity ACHD (18.2%) compared with patients with moderate (11.3%) or simple ACHD lesions (12.1%, p<0.001). During a median follow-up of 5.7 years (3.3–9.6), 327 (11.3%) patients died. On univariable Cox regression analysis, hypoalbuminaemia was a strong predictor of outcome (HR 3.37, 95% CI 2.67 to 4.25, p<0.0001). On multivariable Cox regression, after adjusting for age, sodium and creatinine concentration, liver dysfunction, functional class and disease complexity, hypoalbuminaemia remained a significant predictor of death.
Hypoalbuminaemia is common in patients with ACHD and is associated with a threefold increased risk of risk of death. Hypoalbuminaemia, therefore, should be included in risk-stratification algorithms as it may assist management decisions and timing of interventions in the growing ACHD population.
Url:
DOI: 10.1136/heartjnl-2014-306970
PubMed: 25736048
PubMed Central: 4413739
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<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Cardiology and Angiology</addr-line>
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<author><name sortKey="Alonso Gonzalez, Rafael" sort="Alonso Gonzalez, Rafael" uniqKey="Alonso Gonzalez R" first="Rafael" last="Alonso-Gonzalez">Rafael Alonso-Gonzalez</name>
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<author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
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<author><name sortKey="Swan, Lorna" sort="Swan, Lorna" uniqKey="Swan L" first="Lorna" last="Swan">Lorna Swan</name>
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<author><name sortKey="Hooper, James" sort="Hooper, James" uniqKey="Hooper J" first="James" last="Hooper">James Hooper</name>
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<author><name sortKey="Donovan, Jackie" sort="Donovan, Jackie" uniqKey="Donovan J" first="Jackie" last="Donovan">Jackie Donovan</name>
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,<addr-line>London</addr-line>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Wort, Stephen J" sort="Wort, Stephen J" uniqKey="Wort S" first="Stephen J" last="Wort">Stephen J. Wort</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gatzoulis, Michael A" sort="Gatzoulis, Michael A" uniqKey="Gatzoulis M" first="Michael A" last="Gatzoulis">Michael A. Gatzoulis</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dimopoulos, Konstantinos" sort="Dimopoulos, Konstantinos" uniqKey="Dimopoulos K" first="Konstantinos" last="Dimopoulos">Konstantinos Dimopoulos</name>
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,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hypoalbuminaemia predicts outcome in adult patients with congenital heart disease</title>
<author><name sortKey="Kempny, Aleksander" sort="Kempny, Aleksander" uniqKey="Kempny A" first="Aleksander" last="Kempny">Aleksander Kempny</name>
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,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Cardiology and Angiology</addr-line>
,<institution>Adult Congenital and Valvular Heart Disease Center, University Hospital of Münster</institution>
,<addr-line>Muenster</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Diller, Gerhard Paul" sort="Diller, Gerhard Paul" uniqKey="Diller G" first="Gerhard-Paul" last="Diller">Gerhard-Paul Diller</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Department of Cardiology and Angiology</addr-line>
,<institution>Adult Congenital and Valvular Heart Disease Center, University Hospital of Münster</institution>
,<addr-line>Muenster</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alonso Gonzalez, Rafael" sort="Alonso Gonzalez, Rafael" uniqKey="Alonso Gonzalez R" first="Rafael" last="Alonso-Gonzalez">Rafael Alonso-Gonzalez</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Uebing, Anselm" sort="Uebing, Anselm" uniqKey="Uebing A" first="Anselm" last="Uebing">Anselm Uebing</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rafiq, Isma" sort="Rafiq, Isma" uniqKey="Rafiq I" first="Isma" last="Rafiq">Isma Rafiq</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Swan, Lorna" sort="Swan, Lorna" uniqKey="Swan L" first="Lorna" last="Swan">Lorna Swan</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hooper, James" sort="Hooper, James" uniqKey="Hooper J" first="James" last="Hooper">James Hooper</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Donovan, Jackie" sort="Donovan, Jackie" uniqKey="Donovan J" first="Jackie" last="Donovan">Jackie Donovan</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wort, Stephen J" sort="Wort, Stephen J" uniqKey="Wort S" first="Stephen J" last="Wort">Stephen J. Wort</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gatzoulis, Michael A" sort="Gatzoulis, Michael A" uniqKey="Gatzoulis M" first="Michael A" last="Gatzoulis">Michael A. Gatzoulis</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dimopoulos, Konstantinos" sort="Dimopoulos, Konstantinos" uniqKey="Dimopoulos K" first="Konstantinos" last="Dimopoulos">Konstantinos Dimopoulos</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><institution>Adult Congenital Heart Centre and National Centre for Pulmonary Hypertension, Royal Brompton Hospital</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>NIHR Cardiovascular Biomedical Research Unit</addr-line>
,<institution>Royal Brompton Hospital and National Heart and Lung Institute, Imperial College London</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><institution>National Heart and Lung Institute, Imperial College School of Medicine</institution>
,<addr-line>London</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Heart</title>
<idno type="ISSN">1355-6037</idno>
<idno type="eISSN">1468-201X</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>In patients with acquired heart failure, hypoalbuminaemia is associated with increased risk of death. The prevalence of hypoproteinaemia and hypoalbuminaemia and their relation to outcome in adult patients with congenital heart disease (ACHD) remains, however, unknown.</p>
</sec>
<sec><title>Methods</title>
<p>Data on patients with ACHD who underwent blood testing in our centre within the last 14 years were collected. The relation between laboratory, clinical or demographic parameters at baseline and mortality was assessed using Cox proportional hazards regression analysis.</p>
</sec>
<sec><title>Results</title>
<p>A total of 2886 patients with ACHD were included. Mean age was 33.3 years (23.6–44.7) and 50.1% patients were men. Median plasma albumin concentration was 41.0 g/L (38.0–44.0), whereas hypoalbuminaemia (<35 g/L) was present in 13.9% of patients. The prevalence of hypoalbuminaemia was significantly higher in patients with great complexity ACHD (18.2%) compared with patients with moderate (11.3%) or simple ACHD lesions (12.1%, p<0.001). During a median follow-up of 5.7 years (3.3–9.6), 327 (11.3%) patients died. On univariable Cox regression analysis, hypoalbuminaemia was a strong predictor of outcome (HR 3.37, 95% CI 2.67 to 4.25, p<0.0001). On multivariable Cox regression, after adjusting for age, sodium and creatinine concentration, liver dysfunction, functional class and disease complexity, hypoalbuminaemia remained a significant predictor of death.</p>
</sec>
<sec><title>Conclusions</title>
<p>Hypoalbuminaemia is common in patients with ACHD and is associated with a threefold increased risk of risk of death. Hypoalbuminaemia, therefore, should be included in risk-stratification algorithms as it may assist management decisions and timing of interventions in the growing ACHD population.</p>
</sec>
</div>
</front>
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<author><name sortKey="Hagler, Dj" uniqKey="Hagler D">DJ Hagler</name>
</author>
<author><name sortKey="Sauer, U" uniqKey="Sauer U">U Sauer</name>
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