Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia
Identifieur interne : 000165 ( Ncbi/Checkpoint ); précédent : 000164; suivant : 000166Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia
Auteurs : Tineke M. De Schutter [Belgique] ; Geert J. Behets [Belgique] ; Hilde Geryl [Belgique] ; Mirjam E. Peter [Allemagne] ; Sonja Steppan [Allemagne] ; Kristina Gundlach [Allemagne] ; Jutta Passlick-Deetjen [Allemagne] ; Patrick C. D'Haese [Belgique] ; Ellen Neven [Belgique]Source :
- Kidney International [ 0085-2538 ] ; 2013.
Abstract
Calcium-based phosphate binders are used to control hyperphosphatemia; however, they promote hypercalcemia and may accelerate aortic calcification. Here we compared the effect of a phosphate binder containing calcium acetate and magnesium carbonate (CaMg) to that of sevelamer carbonate on the development of medial calcification in rats with chronic renal failure induced by an adenine diet for 4 weeks. After 1 week, rats with chronic renal failure were treated with vehicle, 375 or 750 mg/kg CaMg, or 750 mg/kg sevelamer by daily gavage for 5 weeks. Renal function was significantly impaired in all groups. Vehicle-treated rats with chronic renal failure developed severe hyperphosphatemia, but this was controlled in treated groups, particularly by CaMg. Neither CaMg nor sevelamer increased serum calcium ion levels. Induction of chronic renal failure significantly increased serum PTH, dose-dependently prevented by CaMg but not sevelamer. The aortic calcium content was significantly reduced by CaMg but not by sevelamer. The percent calcified area of the aorta was significantly lower than vehicle-treated animals for all three groups. The presence of aortic calcification was associated with increased
Url:
DOI: 10.1038/ki.2013.34
PubMed: 23486515
PubMed Central: 3674404
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of a magnesium-based phosphate binder on medial calcification in a rat model of uremia</title><author><name sortKey="De Schutter, Tineke M" sort="De Schutter, Tineke M" uniqKey="De Schutter T" first="Tineke M" last="De Schutter">Tineke M. De Schutter</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Behets, Geert J" sort="Behets, Geert J" uniqKey="Behets G" first="Geert J" last="Behets">Geert J. Behets</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Geryl, Hilde" sort="Geryl, Hilde" uniqKey="Geryl H" first="Hilde" last="Geryl">Hilde Geryl</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peter, Mirjam E" sort="Peter, Mirjam E" uniqKey="Peter M" first="Mirjam E" last="Peter">Mirjam E. 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De Schutter</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Behets, Geert J" sort="Behets, Geert J" uniqKey="Behets G" first="Geert J" last="Behets">Geert J. Behets</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Geryl, Hilde" sort="Geryl, Hilde" uniqKey="Geryl H" first="Hilde" last="Geryl">Hilde Geryl</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peter, Mirjam E" sort="Peter, Mirjam E" uniqKey="Peter M" first="Mirjam E" last="Peter">Mirjam E. Peter</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Fresenius Medical Care Deutschland GmbH</institution>, Bad Homburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Steppan, Sonja" sort="Steppan, Sonja" uniqKey="Steppan S" first="Sonja" last="Steppan">Sonja Steppan</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Fresenius Medical Care Deutschland GmbH</institution>, Bad Homburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gundlach, Kristina" sort="Gundlach, Kristina" uniqKey="Gundlach K" first="Kristina" last="Gundlach">Kristina Gundlach</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Fresenius Medical Care Deutschland GmbH</institution>, Bad Homburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Passlick Deetjen, Jutta" sort="Passlick Deetjen, Jutta" uniqKey="Passlick Deetjen J" first="Jutta" last="Passlick-Deetjen">Jutta Passlick-Deetjen</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Nephrology, University of Dusseldorf</institution>, Dusseldorf,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="D Haese, Patrick C" sort="D Haese, Patrick C" uniqKey="D Haese P" first="Patrick C" last="D'Haese">Patrick C. D'Haese</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neven, Ellen" sort="Neven, Ellen" uniqKey="Neven E" first="Ellen" last="Neven">Ellen Neven</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp</institution>, Antwerp,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Kidney International</title><idno type="ISSN">0085-2538</idno><idno type="eISSN">1523-1755</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Calcium-based phosphate binders are used to control hyperphosphatemia; however, they promote hypercalcemia and may accelerate aortic calcification. Here we compared the effect of a phosphate binder containing calcium acetate and magnesium carbonate (CaMg) to that of sevelamer carbonate on the development of medial calcification in rats with chronic renal failure induced by an adenine diet for 4 weeks. After 1 week, rats with chronic renal failure were treated with vehicle, 375 or 750 mg/kg CaMg, or 750 mg/kg sevelamer by daily gavage for 5 weeks. Renal function was significantly impaired in all groups. Vehicle-treated rats with chronic renal failure developed severe hyperphosphatemia, but this was controlled in treated groups, particularly by CaMg. Neither CaMg nor sevelamer increased serum calcium ion levels. Induction of chronic renal failure significantly increased serum PTH, dose-dependently prevented by CaMg but not sevelamer. The aortic calcium content was significantly reduced by CaMg but not by sevelamer. The percent calcified area of the aorta was significantly lower than vehicle-treated animals for all three groups. The presence of aortic calcification was associated with increased <italic>sox9</italic>, <italic>bmp-2</italic>, and <italic>matrix gla protein</italic> expression, but this did not differ in the treatment groups. Calcium content in the carotid artery was lower with sevelamer than with CaMg but that in the femoral artery did not differ between groups. Thus, treatment with either CaMg or sevelamer effectively controlled serum phosphate levels in CRF rats and reduced aortic calcification.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Giachelli, Cm" uniqKey="Giachelli C">CM Giachelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guerin, Ap" uniqKey="Guerin A">AP Guérin</name></author><author><name sortKey="London, Gm" uniqKey="London G">GM London</name></author><author><name sortKey="Marchais, Sj" uniqKey="Marchais S">SJ Marchais</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qunibi, Wy" uniqKey="Qunibi W">WY Qunibi</name></author><author><name sortKey="Nolan, Ca" uniqKey="Nolan C">CA Nolan</name></author><author><name sortKey="Ayus, Jc" uniqKey="Ayus J">JC Ayus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phan, O" uniqKey="Phan O">O Phan</name></author><author><name 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Speer</name></author><author><name sortKey="Yang, Hy" uniqKey="Yang H">HY Yang</name></author><author><name sortKey="Brabb, T" uniqKey="Brabb T">T Brabb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neven, E" uniqKey="Neven E">E Neven</name></author><author><name sortKey="De Schutter, Tm" uniqKey="De Schutter T">TM De Schutter</name></author><author><name sortKey="De Broe, Me" uniqKey="De Broe M">ME De Broe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chertow, Gm" uniqKey="Chertow G">GM Chertow</name></author><author><name sortKey="Raggi, P" uniqKey="Raggi P">P Raggi</name></author><author><name sortKey="Chasan Taber, S" uniqKey="Chasan Taber S">S Chasan-Taber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pedersen, Ko" uniqKey="Pedersen K">KO Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarro, Jf" uniqKey="Navarro J">JF Navarro</name></author><author><name sortKey="Macia, Ml" uniqKey="Macia M">ML Macía</name></author><author><name sortKey="Gallego, E" uniqKey="Gallego E">E Gallego</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hammersley, Ap" uniqKey="Hammersley A">AP Hammersley</name></author><author><name sortKey="Svenssona, So" uniqKey="Svenssona S">SO Svenssona</name></author><author><name sortKey="Hanflanda, M" uniqKey="Hanflanda M">M Hanflanda</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Belgique</li></country></list><tree><country name="Belgique"><noRegion><name sortKey="De Schutter, Tineke M" sort="De Schutter, Tineke M" uniqKey="De Schutter T" first="Tineke M" last="De Schutter">Tineke M. De Schutter</name></noRegion><name sortKey="Behets, Geert J" sort="Behets, Geert J" uniqKey="Behets G" first="Geert J" last="Behets">Geert J. Behets</name><name sortKey="D Haese, Patrick C" sort="D Haese, Patrick C" uniqKey="D Haese P" first="Patrick C" last="D'Haese">Patrick C. D'Haese</name><name sortKey="Geryl, Hilde" sort="Geryl, Hilde" uniqKey="Geryl H" first="Hilde" last="Geryl">Hilde Geryl</name><name sortKey="Neven, Ellen" sort="Neven, Ellen" uniqKey="Neven E" first="Ellen" last="Neven">Ellen Neven</name></country><country name="Allemagne"><noRegion><name sortKey="Peter, Mirjam E" sort="Peter, Mirjam E" uniqKey="Peter M" first="Mirjam E" last="Peter">Mirjam E. Peter</name></noRegion><name sortKey="Gundlach, Kristina" sort="Gundlach, Kristina" uniqKey="Gundlach K" first="Kristina" last="Gundlach">Kristina Gundlach</name><name sortKey="Passlick Deetjen, Jutta" sort="Passlick Deetjen, Jutta" uniqKey="Passlick Deetjen J" first="Jutta" last="Passlick-Deetjen">Jutta Passlick-Deetjen</name><name sortKey="Steppan, Sonja" sort="Steppan, Sonja" uniqKey="Steppan S" first="Sonja" last="Steppan">Sonja Steppan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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