7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
Identifieur interne : 000774 ( Main/Merge ); précédent : 000773; suivant : 0007757,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases
Auteurs : Ibtissam Talhaoui [France] ; Sophie Couvé [France] ; Alexander A. Ishchenko [France] ; Christophe Kunz ; Primo Sch R ; Murat Saparbaev [France]Source :
- Nucleic Acids Research [ 0305-1048 ] ; 2012.
Abstract
Hydroxyl radicals predominantly react with the C8 of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway. Here, we report for the first time that human thymine-DNA glycosylase (hTDG) and
Url:
DOI: 10.1093/nar/gks1149
PubMed: 23209024
PubMed Central: 3553953
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PMC:3553953Le document en format XML
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<series><title level="j">Nucleic Acids Research</title>
<idno type="ISSN">0305-1048</idno>
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<front><div type="abstract" xml:lang="en"><p>Hydroxyl radicals predominantly react with the C<sub>8</sub>
of purines forming 7,8-dihydro-8-oxoguanine (8oxoG) and 7,8-dihydro-8-oxoadenine (8oxoA) adducts, which are highly mutagenic in mammalian cells. The majority of oxidized DNA bases are removed by DNA glycosylases in the base excision repair pathway. Here, we report for the first time that human thymine-DNA glycosylase (hTDG) and <italic>Escherichia coli</italic>
mismatch-specific uracil-DNA glycosylase (MUG) can remove 8oxoA from 8oxoA•T, 8oxoA•G and 8oxoA•C pairs. Comparison of the kinetic parameters of the reaction indicates that full-length hTDG excises 8oxoA, 3,<italic>N</italic>
<sup>4</sup>
-ethenocytosine (εC) and T with similar efficiency (<italic>k</italic>
<sub>max</sub>
= 0.35, 0.36 and 0.16 min<sup>−1</sup>
, respectively) and is more proficient as compared with its bacterial homologue MUG. The N-terminal domain of the hTDG protein is essential for 8oxoA–DNA glycosylase activity, but not for εC repair. Interestingly, the TDG status had little or no effect on the proliferation rate of mouse embryonic fibroblasts after exposure to γ-irradiation. Nevertheless, using whole cell-free extracts from the DNA glycosylase-deficient murine embryonic fibroblasts and <italic>E. coli</italic>
, we demonstrate that the excision of 8oxoA from 8oxoA•T and 8oxoA•G has an absolute requirement for TDG and MUG, respectively. The data establish that MUG and TDG can counteract the genotoxic effects of 8oxoA residues <italic>in vivo</italic>
.</p>
</div>
</front>
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